IMPPAT Phytochemical information: 
Progesterone
Progesterone
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Plasmodium falciparumPlasmodium falciparum= 24000.0 nM|= 12589.25 nM|= 10000.0 nM|= 6309.57 nMNPASS
Progesterone receptorOryctolagus cuniculusP061866 nM|= 6.0 nM10.4 nM|= 10.4 nMBindingDB, NPASS
Progesterone receptorHomo sapiensP06401>10000 nM|1.8 nM|2.9 nM|0.920000 nM|1.5 nM|2.0 nM|0.5 nM|2.2 nM|0.9 nM|0.1 nM|15.2 nM|0.900000 nM|50 nM|0.180000 nM|= 2.9 nM|= 1.8 nM|= 0.9 nM|= 0.92 nM|> 10000.0 nM|= 2.89 nM|= 1.5 nM|= 0.5 nM|= 2.2 nM|= 0.1 nM|= 15.2 nM|= 2.0 nM|= 50.0 nM|= 0.18 nM1.6 nM|5 nM|3.5 nM|0.2 nM|17 nM|>10000 nM|= 3.5 nM|= 17.0 nM|= 5.0 nM|< 10000.0 nM|> 10000.0 nM|= 0.2 nM3.5 nM|3.4 nM|3.8 nM|5.1 nM|= 3.5 nM|= 3.8 nM|= 3.467 nM|= 3.4 nM|= 5.1 nMBindingDB, NPASS
Progesterone receptorBos taurusQ690N0= 28.0 nM= 3.622 nMNPASS
P2X purinoceptor 3Homo sapiensP563731600 nM|= 1600.0 nMBindingDB, NPASS
Human breast cancer cell lines= 18700.0 nM|= 22300.0 nMNPASS
NON-PROTEIN TARGET= 27400.0 nM|= 36400.0 nM|= 10600.0 nMNPASS
Monoclonal antibody (mAb)= 36000.0 nMNPASS
Mineralocorticoid receptorHomo sapiensP0823530 nM|14 nM|>14 nM|= 14.0 nM|> 14.0 nM|= 30.0 nM0.390000 nM|= 0.39 nMBindingDB, NPASS
LiverRattus norvegicus> 100.0 nMNPASS
Lanosterol 14-alpha demethylaseHomo sapiensQ16850>200000 nMBindingDB
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
P-glycoprotein 1Homo sapiensP08183= 21200.0 nM= 48977.88 nM|= 47863.01 nM|= 192200.0 nM|= 88100.0 nM|= 96200.0 nMNPASS
Sex hormone-binding globulinHomo sapiensP04278115 nMBindingDB
Solute carrier family 22 member 1Homo sapiensO152453050 nM|= 3050.0 nMBindingDB, NPASS
Sigma non-opioid intracellular receptor 1Homo sapiensQ99720260 nMBindingDB
Sigma non-opioid intracellular receptor 1Rattus norvegicusQ9R0C9239 nMBindingDB
Sigma opioid receptorHomo sapiensQ99720= 3055.0 nM= 260.0 nM|= 1284.0 nMNPASS
Sigma opioid receptorRattus norvegicusQ9R0C9= 239.0 nMNPASS
HeLaHomo sapiens> 50.0 ug.mL-1NPASS
Solute carrier family 22 member 2Homo sapiensO1524426700 nM|= 26700.0 nMBindingDB, NPASS
Solute carrier family 22 member 2Rattus norvegicusQ9R0W21600 nM|= 1600.0 nMBindingDB, NPASS
Solute carrier family 22 member 3Homo sapiensO757514280 nM|= 4280.0 nMBindingDB, NPASS
Solute carrier family 22 member 3Rattus norvegicusO8844610500 nM|= 10500.0 nMBindingDB, NPASS
Solute carrier organic anion transporter family member [3-691]Zebrafish9.06e+3 nMBindingDB
Steroid 5-alpha-reductaseRattus norvegicusP31214= 2600.0 nM|= 1600.0 nMNPASS
Sterol O-acyltransferase 1Homo sapiensP3561017000 nMBindingDB
Testis-specific androgen-binding proteinHomo sapiensP04278= 114.82 nMNPASS
Sigma non-opioid intracellular receptor 1Cavia porcellusQ60492660 nM|661 nMBindingDB
Glucocorticoid receptorHomo sapiensP04150>1000 nM|> 1000.0 nM|= 330.0 nM31 nM|30.5 nM|= 30.5 nM|= 150.0 nMBindingDB, NPASS
Sigma-1 receptorCavia porcellusQ60492= 660.0 nM|= 661.0 nMNPASS
Fatty acid-binding protein, liverRattus norvegicusP0269227 nM|= 27.0 nMBindingDB, NPASS
G-protein coupled bile acid receptor 1Homo sapiensQ8TDU62770 nM|= 2770.0 nMBindingDB, NPASS
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiensQ15125>100000 nMBindingDB
3-beta-hydroxysteroid-delta(8),delta(7)-isomeraseHomo sapiensQ15125> 100000.0 nMNPASS
3-oxo-5-alpha-steroid 4-dehydrogenase 1/2Rattus norvegicusP24008|P312142600 nM|1600 nMBindingDB
ATP-binding cassette sub-family G member 2Homo sapiensQ9UNQ0= 125892.54 nMNPASS
ATP-dependent translocase ABCB1Homo sapiensP0818321200 nM192200 nM|88100 nM|96200 nM|47863 nM|48978 nMBindingDB
Acyl coenzyme A:cholesterol acyltransferase 1Homo sapiensP35610= 17000.0 nMNPASS
Androgen ReceptorHomo sapiensP10275= 37.0 nM|= 13.7 nM= 8.5 nM|= 35.0 nMNPASS
Androgen ReceptorMus musculusP19091= 37.0 nMNPASS
Androgen receptorHomo sapiensP1027537 nM|14 nM8.5 nM|35 nMBindingDB
Androgen receptorMus musculusP1909137 nMBindingDB
Androgen receptorRattus norvegicusP152071548.82 nMBindingDB
Bile salt export pumpHomo sapiensO95342<10000 nM|17300 nM|224600 nM|= 17300.0 nM|= 224600.0 nM|< 10000.0 nMBindingDB, NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiensQ9UNQ0125892.54 nMBindingDB
Androgen ReceptorRattus norvegicusP15207= 1548.82 nM|= 214.0 nM= 143.0 nMNPASS
C-8 sterol isomerase ERG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c)P323524430 nMBindingDB
Fatty acid-binding protein, intestinalHomo sapiensP1210420000 nMBindingDB
C-8 sterol isomeraseSaccharomyces cerevisiae S288cP32352= 4430.0 nMNPASS
Estrogen receptor betaRattus norvegicusP06211|Q629863.9 nMBindingDB
Estrogen receptor betaHomo sapiensP03372|Q92731>1000 nMBindingDB
Estrogen receptor alphaHomo sapiensP03372> 1000.0 nMNPASS
Estrogen receptorRattus norvegicusQ62986= 3.9 nMNPASS
Fatty acid binding protein intestinalHomo sapiensP12104= 20000.0 nMNPASS
Cytochrome P450 51Homo sapiensQ16850> 200000.0 nMNPASS
Cytochrome P450 2C9Homo sapiensP117125500 nM|= 5500.0 nMBindingDB, NPASS
CV-1Chlorocebus aethiops> 10000.0 nMNPASS
Corticosteroid-binding globulinHomo sapiensP0818510000 nM|42 nMBindingDB
Corticosteroid binding globulinHomo sapiensP08185= 41.69 nMNPASS
Estrogen receptorHomo sapiensP03372>1000 nM|> 1000.0 nM|> 10000.0 nM|< 10000.0 nM> 10000.0 nMBindingDB, NPASS