IMPPAT Phytochemical information: 
9H-Pyrido[3,4-B]indole
9H-Pyrido[3,4-B]indole
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
NON-PROTEIN TARGET> 130000.0 nM|> 100000.0 nM|= 130000.0 nMNPASS
Inhibitor of nuclear factor kappa B kinase alpha subunitHomo sapiensO15111= 15000.0 nMNPASS
Inhibitor of nuclear factor kappa B kinase beta subunitHomo sapiensO14920= 7943.28 nMNPASS
Inhibitor of nuclear factor kappa-B kinase subunit alphaHomo sapiensO1511115000 nMBindingDB
Monoamine oxidase AHomo sapiensP21397= 260.0 nMNPASS
Monoamine oxidase BHomo sapiensP27338= 1200.0 nM|= 1120.0 nMNPASS
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139Homo sapiensO94806|P05129|P05771|P17252|P24723|P41743|Q02156|Q04759|Q05513|Q05655|Q15139>25000 nMBindingDB
Serine/threonine-protein kinase Aurora-AHomo sapiensO14965= 15848.93 nMNPASS
Protein kinase C (PKC)Homo sapiensQ04759> 25000.0 nMNPASS
Rho-associated protein kinase 2Homo sapiensO75116>19880 nMBindingDB
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
Indoleamine 2,3-dioxygenase 1Homo sapiensP1490290000 nM120 nM|180000 nMBindingDB
Serine/threonine-protein kinase PIM1Homo sapiensP11309= 6309.57 nMNPASS
Tryptophan 2,3-dioxygenaseHomo sapiensP48775= 1200.0 nMNPASS
cAMP-dependent protein kinase (PKA)Homo sapiensP22612> 25000.0 nMNPASS
cAMP-dependent protein kinase catalytic subunit alpha/beta/gammaHomo sapiensP17612|P22612|P22694>25000 nMBindingDB
P388Mus musculus= 25.0 ug.mL-1NPASS
Indoleamine 2,3-dioxygenaseHomo sapiensP14902= 90000.0 nM= 120.0 nM|= 180000.0 nMNPASS
MCF7Homo sapiens> 100000.0 nMNPASS
HeLaHomo sapiens> 100000.0 nMNPASS
Human immunodeficiency virus 1Human immunodeficiency virus 1= 44100.0 nMNPASS
A549Homo sapiens> 100000.0 nMNPASS
AcetylcholinesteraseHomo sapiensP22303> 40000.0 nMNPASS
Amine oxidase [flavin-containing] AHomo sapiensP21397260 nMBindingDB
Bovine viral diarrhea virusBovine viral diarrhea virus 1= 8800.0 nMNPASS
Bovine viral diarrhea virus 1Bovine viral diarrhea virus 1= 8800.0 nMNPASS
ButyrylcholinesteraseHomo sapiensP06276> 40000.0 nMNPASS
Casein kinase IIHomo sapiensP19784> 25000.0 nMNPASS
Amine oxidase [flavin-containing] BHomo sapiensP273381200 nM|1120 nMBindingDB
ChitinaseOnchocerca volvulusQ25615= 8460.0 nMNPASS
DNA topoisomerase IHomo sapiensP11387= 31000.0 nMNPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 1AHomo sapiensQ13627> 1800.0 nMNPASS
GABA-A receptor; anion channelHomo sapiensP14867|P47870|P18507|P28472|P48169|Q99928|Q9UN88|P34903|O00591|O14764|Q8N1C3|P18505|P78334|P47869|P31644|Q16445= 1600.0 nMNPASS
GABA-A receptor; anion channelHomo sapiensQ16445= 1621.81 nMNPASS
GABA-A receptor; anion channelRattus norvegicusQ9ES14= 1621.81 nM|= 1620.0 nM= 1620.0 nMNPASS
ChitinaseOnchocerca volvulus8460 nMBindingDB
H9Homo sapiens= 141700.0 nMNPASS