IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Ki	Source
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha	Homo sapiens			= 110.0 nM\|= 83.0 nM		NPASS
Integrin alpha-L	Homo sapiens	P20701		>104000 nM		BindingDB
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)	Homo sapiens	P35398		260 nM\|357 nM		BindingDB
Hexose transporter 1	Plasmodium falciparum	O97467		= 90.0 nM		NPASS
LNCaP	Homo sapiens			= 37.0 nM\|= 27.0 nM\|= 31.6 nM		NPASS
Leishmania donovani	Leishmadonovani			= 0.03 ug.mL-1		NPASS
Leukocyte adhesion glycoprotein LFA-1 alpha	Homo sapiens	P20701		> 50.0 ug.mL-1		NPASS
Multidrug resistance-associated protein 4	Homo sapiens	O15439		> 133000.0 nM		NPASS
NON-PROTEIN TARGET				> 2000.0 nM\|= 50.0 nM\|= 290.0 nM		NPASS
NS5	Zika virus	A0A143MHK7	= 52.9 nM\|= 8.74 nM			NPASS
Orf1a protein	MERS-CoV		14 nM			BindingDB
P-glycoprotein 1	Homo sapiens	P08183		= 115600.0 nM\|= 130300.0 nM\|= 2400.0 nM\|= 207100.0 nM\|= 35100.0 nM\|= 9200.0 nM\|= 9600.0 nM		NPASS
P388	Mus musculus			= 7.0 nM		NPASS
PC-3	Homo sapiens			= 35.0 nM\|= 27.0 nM\|= 29.0 nM\|= 29.43 nM		NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM		NPASS
Plasmodium yoelii	Plasmodium yoelii			= 7.49 nM		NPASS
Procathepsin L	Homo sapiens	P07711		>50000 nM		BindingDB
Putative hydrolase RBBP9	Homo sapiens	O75884		= 7800.0 nM		NPASS
Replicase polyprotein 1ab	Human SARS coronavirus	P0C6X7	51 nM			BindingDB
Reverse transcriptase	Human immunodeficiency virus 1			>416000 nM		BindingDB
Heat shock factor protein 1	Mus musculus	P38532	<160 nM			BindingDB
Serine hydrolase RBBP9	Homo sapiens	O75884		7800 nM		BindingDB
Steroidogenic factor 1	Homo sapiens	Q13285		202 nM\|284 nM		BindingDB
Trypanosoma brucei	Trypanosoma brucei			= 40.0 nM		NPASS
Trypanosoma congolense	Trypanosoma congolense			= 430.0 nM		NPASS
Vaccinia virus	Vaccivirus		= 250.0 nM			NPASS
Vero	Chlorocebus aethiops			= 0.42 ug.mL-1\|= 176.0 nM		NPASS
Vero	Chlorocebus sabaeus			= 80.0 nM		NPASS
ZR-75-1	Homo sapiens			= 100.0 nM		NPASS
Plasmodium falciparum	Plasmodium falciparum		= 10.15 nM\|= 22.94 nM	= 0.0727 ug.mL-1\|= 0.078 ug.mL-1		NPASS
HeLa	Homo sapiens			= 370.0 nM\|= 400.0 nM\|= 15.0 nM\|= 13.0 nM		NPASS
KB	Homo sapiens			= 40.0 nM\|= 56.0 nM		NPASS
HL-60	Homo sapiens			= 0.38 ug.mL-1		NPASS
HT-29	Homo sapiens			= 33.0 nM		NPASS
ATP-binding cassette sub-family C member 2	Homo sapiens	Q92887		>133000 nM		BindingDB
ATP-binding cassette sub-family C member 3	Homo sapiens	O15438		>133000 nM		BindingDB
ATP-binding cassette sub-family C member 4	Homo sapiens	O15439		>133000 nM		BindingDB
ATP-dependent translocase ABCB1	Homo sapiens	P08183		35100 nM\|9200 nM\|9600 nM\|207100 nM\|2400 nM\|115600 nM\|130300 nM		BindingDB
Alpha-1a adrenergic receptor	Rattus norvegicus	P43140		= 6527.0 nM	= 2642.0 nM	NPASS
Alpha-1b adrenergic receptor	Rattus norvegicus	P15823		= 1934.0 nM	= 1071.0 nM	NPASS
Alpha-2a adrenergic receptor	Homo sapiens	P08913		= 38.0 nM	= 14.0 nM	NPASS
Alpha-2c adrenergic receptor	Homo sapiens	P18825		= 182.0 nM	= 26.0 nM	NPASS
Bcl-2-like protein 11	Homo sapiens	O43521	>350000 nM			BindingDB
Bile salt export pump	Homo sapiens	O95342		>135000 nM\|>133000 nM\|> 135000.0 nM\|> 133000.0 nM		BindingDB, NPASS
CHO	Cricetulus griseus			= 108.0 nM\|= 120.0 nM\|= 0.19 nM\|= 127.0 nM\|= 190.0 nM\|= 80.0 nM\|= 140.0 nM\|= 19.77 nM\|= 300.0 nM\|= 124830.0 nM\|= 170.0 nM\|= 330.0 nM\|= 129.0 nM\|= 41.0 nM\|= 92.0 nM\|= 100.0 nM\|= 50.0 nM\|= 400.0 nM\|= 61.0 nM\|= 125.0 nM\|= 30.0 nM\|= 104.0 nM\|= 95.0 nM\|= 178.0 nM\|= 130.0 nM\|= 33.0 nM\|= 16.2 nM\|= 59.0 nM\|= 290.0 nM\|= 40.0 nM\|= 950.0 nM\|= 20.0 nM		NPASS
CHO-K1	Cricetulus griseus			= 20.0 nM\|= 400.0 nM		NPASS
CWR22R	Homo sapiens			= 30.8 nM		NPASS
A549	Homo sapiens			= 40.0 nM		NPASS
Canalicular multispecific organic anion transporter 2	Homo sapiens	O15438		> 133000.0 nM		NPASS
Canalicular multispecific organic anion transporter 1	Homo sapiens	Q92887		> 133000.0 nM		NPASS
HEK293	Homo sapiens			= 10.0 nM		NPASS
Glucose transporter	Leishmamexicana	O61059		= 81.0 nM		NPASS
Glucose transporter	Homo sapiens	P11166		= 108.0 nM		NPASS
Giardia intestinalis	Giardia intestinalis			= 0.41 ug.mL-1\|= 830.0 nM\|= 800.0 nM		NPASS
G-protein coupled receptor 35	Homo sapiens	Q9HC97		= 352.52 nM		NPASS
Genome polyprotein	Zika virus		53 nM\|8.7 nM			BindingDB
Entamoeba histolytica	Eoeba histolytica			= 1.05 ug.mL-1\|= 2200.0 nM		NPASS
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha	Homo sapiens	Q16665\|Q99814		83 nM\|110 nM		BindingDB
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor	Q4QEW7		= 1074000.0 nM\|= 1000000.0 nM		NPASS
Dihydroorotate dehydrogenase (fumarate)	Leishmamajor			1074000 nM\|1000000 nM		BindingDB
DU-145	Homo sapiens			= 60.0 nM\|= 33.0 nM\|= 25.0 nM\|= 24.0 nM		NPASS
Cathepsin S	Homo sapiens	P25774		>50000 nM		BindingDB
Entamoeba histolytica HM-1:IMSS	Eoeba histolytica HM-1:IMSS			= 2180.0 nM		NPASS

a curated database

IMPPAT Phytochemical information:
Emetine

Bioactivity information

IMPPAT Phytochemical information: Emetine

Bioactivity information

IMPPAT Phytochemical information:
Emetine