IMPPAT Phytochemical information: 
Isoliquiritigenin
Isoliquiritigenin
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
PC-12Rattus norvegicus= 17800.0 nMNPASS
PANC-1Homo sapiens= 3300.0 nMNPASS
Nuclear factor NF-kappa-B complexHomo sapiensQ04206= 32000.0 nMNPASS
Neuronal acetylcholine receptor protein alpha-7 subunitHomo sapiensP36544= 11600.0 nMNPASS
NeuraminidaseInflueA virusB4URF0= 3.42 ug.mL-1|= 3.48 ug.mL-1|= 8.41 ug.mL-1|= 9.69 ug.mL-1|= 10.56 ug.mL-1NPASS
NON-PROTEIN TARGET= 21800.0 nM|= 80500.0 nM|= 84000.0 nM|= 27300.0 nM|= 68000.0 nM|= 48000.0 nM|= 72000.0 nM|> 30000.0 nMNPASS
Matrix metalloproteinase-2Homo sapiensP08253= 10.0 nMNPASS
Monoamine oxidase BRattus norvegicusP19643= 47200.0 nMNPASS
Matrix metalloproteinase-1Homo sapiensP03956= 16.0 nMNPASS
Matrix metalloproteinase 9Homo sapiensP14780= 10.0 nMNPASS
Matrix metalloproteinase 7Homo sapiensP09237= 8.0 nMNPASS
Matrix metalloproteinase 3Homo sapiensP08254= 81.0 nMNPASS
NACHT, LRR and PYD domains-containing protein 3Homo sapiensQ96P20= 1540.0 nM|= 10100.0 nMNPASS
PC-3Homo sapiens= 46400.0 nM|= 99000.0 nMNPASS
n.a.> 91140.0 nMNPASS
Probable global transcription activator SNF2L2Homo sapiensP51531> 91140.0 nMNPASS
Proteasome Macropain subunit MB1Homo sapiensP28074= 4880.0 nMNPASS
Protein disulfide-isomeraseHomo sapiensP07237= 36100.0 nMNPASS
Protein-tyrosine phosphatase 1BHomo sapiensP18031> 60000.0 nM|> 50000.0 nMNPASS
RAW264.7Mus musculus= 3.4 ug.mL-1NPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
SK-MEL-28Homo sapiens= 75000.0 nMNPASS
SiHaHomo sapiens= 53800.0 nM|= 53760.0 nMNPASS
SialidaseClostridium perfringensP10481= 11.28 ug.mL-1NPASS
Trypanosoma brucei bruceiTrypanosoma brucei brucei= 32800.0 nMNPASS
Tyrosyl-DNA phosphodiesterase 1Homo sapiensQ9NUW8= 55000.0 nMNPASS
VeroChlorocebus aethiops= 65600.0 nM|= 31.25 ug.mL-1NPASS
Xanthine dehydrogenaseBos taurusP80457= 47300.0 nMNPASS
Matrix metalloproteinase 13Homo sapiensP45452= 14.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 7800.0 nM|= 32000.0 nM|= 12589.25 nM|= 10000.0 nMNPASS
MDA-MB-231Homo sapiens> 10000.0 nM|= 10860.0 nM|= 25000.0 nMNPASS
Monoamine oxidase ARattus norvegicusP21396= 13900.0 nM|= 17300.0 nMNPASS
MCF-10AHomo sapiens= 25000.0 nMNPASS
3T3-L1Mus musculus= 96400.0 nMNPASS
A549Homo sapiens= 98900.0 nM|= 85000.0 nM|= 52580.0 nMNPASS
Aldose reductaseHomo sapiensP15121= 320.0 nMNPASS
Aldose reductaseRattus norvegicusP07943= 400.0 nMNPASS
Arachidonate 5-lipoxygenaseRattus norvegicusP12527= 35000.0 nMNPASS
BV-2Mus musculus> 100000.0 nMNPASS
Beta amyloid A4 proteinHomo sapiensP05067= 19700.0 nMNPASS
Beta-secretase 1Homo sapiensP568173.300e+4 nM|= 33000.0 nM|= 51500.0 nMBindingDB, NPASS
C-33-AHomo sapiens= 32830.0 nMNPASS
C2C12Mus musculus= 26.34 ug.mL-1NPASS
CHOCricetulus griseus= 45900.0 nMNPASS
Ca-SkiHomo sapiens= 39090.0 nMNPASS
CyclooxygenaseHomo sapiensP23219= 130000.0 nMNPASS
CyclooxygenaseRattus norvegicusQ63921= 35000.0 nMNPASS
Estradiol 17-beta-dehydrogenase 1Homo sapiensP14061= 2830.0 nMNPASS
Cytochrome P450 19A1Homo sapiensP11511= 3800.0 nMNPASS
MCF7Homo sapiens> 10000.0 nM|= 17670.0 nMNPASS
Estrogen receptor alphaHomo sapiensP03372= 1870.0 nMNPASS
Estrogen receptor betaHomo sapiensQ92731= 269.0 nMNPASS
HT-1080Homo sapiens= 76700.0 nMNPASS
HUVECHomo sapiens= 41170.0 nMNPASS
HeLaHomo sapiens= 82600.0 nM|= 58100.0 nMNPASS
HepG2Homo sapiens= 27710.0 nMNPASS
Hepatitis C virusHepatitis C virus= 36100.0 nMNPASS
Estradiol 17-beta-dehydrogenase 2Homo sapiensP37059= 360.0 nMNPASS
Human immunodeficiency virus type 1 integraseHuman immunodeficiency virus 1Q7ZJM1> 100000.0 nM|= 100000.0 nMNPASS
J774.1Mus musculus= 29300.0 nMNPASS
K562Homo sapiens= 29270.0 nMNPASS
L02Homo sapiens> 1000000.0 nMNPASS
Leishmania donovaniLeishmadonovani= 20700.0 nMNPASS
LoVoHomo sapiens= 57000.0 nMNPASS