IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
GABA-A receptor; anion channel	Rattus norvegicus	Q9ES14				= 1000.0 nM\|= 4200.0 nM	NPASS
GABA-A receptor; anion channel	Homo sapiens	Q16445				= 1000.0 nM\|= 17.0 nM	NPASS
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 50.0 ug.mL-1			NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		224000 nM			BindingDB
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 170.0 nM			NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		170 nM			BindingDB
Dihydroorotate dehydrogenase (fumarate)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28272		>10000 nM			BindingDB
Dihydroorotate dehydrogenase (quinone), mitochondrial	Plasmodium falciparum			>10000 nM			BindingDB
H9	Homo sapiens			= 68000.0 nM			NPASS
Dihydroorotate dehydrogenase	Saccharomyces cerevisiae S288c	P28272		> 10000.0 nM			NPASS
Dihydroorotate dehydrogenase	Plasmodium falciparum	Q54A96		> 10000.0 nM			NPASS
Dermatophagoides pteronyssinus	Dermatophagoides pteronyssinus		= 0.5 g/m2				NPASS
Dipeptidyl peptidase 3	Homo sapiens	Q9NY33		2.925e+5 nM			BindingDB
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 50000.0 nM				NPASS
P-glycoprotein 1	Homo sapiens	P08183			= 33884.42 nM		NPASS
MCF7	Homo sapiens			= 300.0 nM			NPASS
NON-PROTEIN TARGET				= 287100.0 nM			NPASS
DNA-dependent protein kinase catalytic subunit	Homo sapiens	P78527		>10000 nM			BindingDB
Plasmodium falciparum	Plasmodium falciparum			= 60800.0 nM\|= 2.0 nM\|> 10000.0 nM			NPASS
Poly [ADP-ribose] polymerase 1	Homo sapiens	P09874		1400 nM			BindingDB
Poly [ADP-ribose] polymerase tankyrase-1	Homo sapiens	O95271		320 nM			BindingDB
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens	Q9H2K2		140 nM			BindingDB
Poly [ADP-ribose] polymerase-1	Homo sapiens	P09874		= 1380.38 nM\|= 1400.0 nM			NPASS
RAW264.7	Mus musculus			= 500.0 nM			NPASS
Radical scavenging activity				> 100.0 ug.mL-1			NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			< 30000.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Tankyrase-1	Homo sapiens	O95271		= 323.59 nM\|= 320.0 nM\|= 330.0 nM			NPASS
Tankyrase-2	Homo sapiens	Q9H2K2		= 147.91 nM\|= 140.0 nM			NPASS
Liver microsome	Rattus norvegicus			= 100.0 ug.mL-1			NPASS
DNA-dependent protein kinase	Homo sapiens	P78527		> 10000.0 nM			NPASS
Adenosine A2 receptor	Rattus norvegicus	P30543				= 3450.0 nM	NPASS
Cytochrome P450 19A1	Homo sapiens	P11511		= 8.0 nM\|= 10000.0 nM\|= 8000.0 nM\|= 47973.34 nM			NPASS
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 17000.0 nM\|= 26000.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183			33884 nM		BindingDB
Adenosine A1 receptor	Rattus norvegicus	P25099				= 3280.0 nM	NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678		600 nM\|= 600.0 nM			BindingDB, NPASS
Adenosine A3 receptor	Homo sapiens	P0DMS8				= 16900.0 nM	NPASS
Adenosine receptor A1	Rattus norvegicus	P25099				3311 nM\|3280 nM	BindingDB
Adenosine receptor A2a	Rattus norvegicus	P30543				3467 nM\|3450 nM	BindingDB
Adenosine receptor A3	Homo sapiens	P0DMS8				16982 nM\|16900 nM	BindingDB
Amine oxidase [flavin-containing] A	Homo sapiens	P21397				2.5e+3 nM	BindingDB
Amine oxidase [flavin-containing] B	Homo sapiens	P27338				1.06e+3 nM	BindingDB
Androgen Receptor	Homo sapiens	P10275		= 5900.0 nM			NPASS
Androgen Receptor	Rattus norvegicus	P15207		= 77624.71 nM			NPASS
Androgen receptor	Homo sapiens	P10275		5900 nM			BindingDB
Androgen receptor	Rattus norvegicus	P15207		77624.71 nM			BindingDB
Adenosine A2a receptor	Rattus norvegicus	P30543				= 3450.0 nM	NPASS
Aromatase	Homo sapiens	P11511		8000 nM\|8 nM\|10000 nM			BindingDB
Aorta	Rattus norvegicus			= 46000.0 nM\|= 203000.0 nM			NPASS
Carbonic anhydrase IX	Homo sapiens	Q16790				= 4130.0 nM\|= 4220.0 nM	NPASS
Carbonic anhydrase II	Homo sapiens	P00918				= 8710.0 nM\|= 8800.0 nM	NPASS
Carbonic anhydrase I	Homo sapiens	P00915				= 1890.0 nM\|= 1880.0 nM	NPASS
Carbonic anhydrase 9	Homo sapiens	Q16790				4130 nM\|4220 nM	BindingDB
Carbonic anhydrase 2	Homo sapiens	P00918				8710 nM\|8800 nM	BindingDB
Carbonic anhydrase XII	Homo sapiens	O43570				= 7220.0 nM\|= 7330.0 nM	NPASS
Carbonic anhydrase 1	Homo sapiens	P00915				1880 nM\|1890 nM	BindingDB
Calmodulin-1	Homo sapiens	P0DP23		102280 nM			BindingDB
Calmodulin	Homo sapiens	P62158		= 102280.0 nM			NPASS
Caco-2	Homo sapiens			= 21010.0 nM			NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		17000 nM			BindingDB
Carbonic anhydrase 12	Homo sapiens	O43570				7330 nM\|7220 nM	BindingDB

a curated database

IMPPAT Phytochemical information:
Flavone

Bioactivity information

IMPPAT Phytochemical information: Flavone

Bioactivity information

IMPPAT Phytochemical information:
Flavone