| Target name | Target organism | UniProt identifier | EC50 | IC50 | Kd | Ki | Source |
|---|
| Mu-type opioid receptor | Bos taurus | P79350 | | | | 0.5 nM|2.5 nM | BindingDB |
| Mu-type opioid receptor | Homo sapiens | P35372 | 34 nM | | | 2.06 nM|4 nM|0.32 nM | BindingDB |
| Mu-type opioid receptor | Mus musculus | P42866 | | | | 1 nM|5.64 nM | BindingDB |
| Mu-type opioid receptor | Rattus norvegicus | P33535 | | | | 6.55 nM|1.7 nM | BindingDB |
| Mu-type opioid receptor [N127C] | Homo sapiens | P35372 | | | | 52.0 nM | BindingDB |
| Nociceptin receptor | Cavia porcellus | P47748 | | | | = 13.9 nM | NPASS |
| Nociceptin receptor | Homo sapiens | P41146 | | | | >10000 nM | BindingDB |
| Nociceptin receptor | Mus musculus | P35377 | | | | 1000 nM | BindingDB |
| Opioid receptor | Mus musculus | P33534 | | = 258.0 nM|= 27.0 nM | | | NPASS |
| Opioid receptor | Rattus norvegicus | P33535 | = 3.0 nM | = 4.2 nM|= 27.0 nM|= 4.5 nM|= 73.0 nM|= 11.0 nM|= 22.0 nM|= 160.0 nM|= 8.6 nM|= 0.027 nM|= 10.0 nM|= 250.0 nM | | = 32.5 nM | NPASS |
| Opioid receptor delta 1 | Bos taurus | | | | | 278 nM | BindingDB |
| Opioid receptor, delta 1b | Danio rerio | B3DH72 | | | | = 1427.0 nM | NPASS |
| Mu opioid receptor/Alpha-2A adrenergic receptor | Homo sapiens | | = 3.0 nM | | | | NPASS |
| Opioid receptors; mu & delta | Homo sapiens | P35372 | | = 309.0 nM | | | NPASS |
| Opioid receptors; mu/kappa/delta | Homo sapiens | P35372 | | = 10.0 nM|= 250.0 nM|= 29.0 nM|= 65.0 nM|= 24.0 nM|= 28.0 nM | | | NPASS |
| P-glycoprotein 1 | Homo sapiens | P08183 | | > 50000.0 nM | | | NPASS |
| P-glycoprotein 1 | Mus musculus | P06795 | | > 50000.0 nM | | | NPASS |
| P-glycoprotein 3 | Mus musculus | P21447 | | > 50000.0 nM | | | NPASS |
| Rattus norvegicus | Rattus norvegicus | | | = 200.0 nM | | | NPASS |
| SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | | | > 20000.0 nM|> 19952.62 nM | | | NPASS |
| Sigma opioid receptor | Homo sapiens | Q99720 | | | | > 100000.0 nM|> 10000.0 nM | NPASS |
| Solute carrier family 22 member 1 | Homo sapiens | O15245 | | = 28000.0 nM|= 71790.0 nM | | | NPASS |
| Opioid receptor homologue | Danio rerio | O57585 | | | | = 223.0 nM | NPASS |
| Mu opioid receptor-like OR2 | Danio rerio | Q98UH1 | | | | = 187.4 nM|= 187.0 nM | NPASS |
| Mus musculus | Mus musculus | | = 19700.0 nM|= 11.6 mg kg-1 | = 492.0 nM|= 244.0 nM|= 500.0 nM|= 644.0 nM|= 1420.0 nM|= 194.0 nM|= 1722.0 nM | > 1000.0 nM | = 1.0 nM|= 0.09 nM | NPASS |
| Mu opioid receptor | Mus musculus | P42866 | = 395.0 nM|= 85.5 nM|= 30.0 nM|= 120.0 nM|= 489.78 nM|= 12.1 nM|= 208.93 nM|= 491.0 nM|= 12.02 nM|= 207.0 nM | = 1420.0 nM|= 1.27 nM|= 1.271 nM|= 1215.0 nM | | = 1.8 nM|= 4.6 nM | NPASS |
| Acetylcholinesterase | Electrophorus electricus | O42275 | | | | = 109000.0 nM | NPASS |
| Bile salt export pump | Homo sapiens | O95342 | | > 135000.0 nM | | | NPASS |
| Mu opioid receptor | Rattus norvegicus | P33535 | = 21.3 nM|= 123.5 nM|= 194.0 nM | = 1.94 nM|= 0.14 nM|= 1.6 nM|= 3.9 nM|= 9770.0 nM|= 5.64 nM | | = 2.1 nM|= 5.7 nM|= 0.78 nM|= 4.8 nM|= 1.8 nM|= 11.0 nM|= 1.0 nM|= 2.15 nM|= 2.8 nM|= 6.55 nM|= 8.14 nM|= 36.0 nM|= 2.0 nM|= 3.0 nM|= 116.8 nM|> 10000.0 nM|= 6.3 nM|= 1.45 nM|= 6.9 nM | NPASS |
| Cytochrome P450 3A4 | Homo sapiens | P08684 | | > 50000.0 nM | | | NPASS |
| Delta opioid receptor | Homo sapiens | P41143 | = 316.0 nM|= 15.6 nM|= 500.0 nM|> 593.0 nM|= 780.0 nM|= 79.12 nM | = 430.0 nM|= 150.0 nM|= 185.0 nM | | = 140.0 nM|= 456.0 nM|= 375.0 nM|= 629.51 nM|= 299.0 nM|= 150.0 nM|= 416.87 nM|= 460.0 nM|= 51.0 nM|= 132.0 nM|= 113.3 nM|= 710.0 nM|= 280.0 nM|= 510.0 nM|= 58.0 nM|= 104.57 nM|= 605.0 nM|= 295.0 nM|= 340.0 nM|= 104.1 nM | NPASS |
| Delta opioid receptor | Mus musculus | P32300 | | = 736.0 nM|= 390.0 nM|= 644.0 nM|= 1600.0 nM|= 155000.0 nM|< 500.0 nM|> 1000.0 nM|= 155.0 nM | | | NPASS |
| Delta opioid receptor | Rattus norvegicus | P33533 | | = 684.0 nM|= 7.37 nM|= 205.0 nM|= 112200.0 nM|= 404.0 nM | | = 90.0 nM|= 157.0 nM|= 280.0 nM|= 217.0 nM|= 684.0 nM|= 15.0 nM|= 76.9 nM|> 10000.0 nM|= 113.0 nM|= 1.8 nM|= 171.0 nM|= 82.5 nM|= 2.0 nM|= 116.8 nM | NPASS |
| Delta-type opioid receptor | Homo sapiens | P41143 | | | | >10000 nM|104.57 nM|1800 nM | BindingDB |
| Delta-type opioid receptor | Rattus norvegicus | P33533 | | | | 217 nM | BindingDB |
| HERG | Homo sapiens | Q12809 | | = 1000000.0 nM | | | NPASS |
| Kappa opioid receptor | Cavia porcellus | P41144 | | = 271.0 nM|= 130.0 nM|= 1.82 nM|= 2390.0 nM|= 530.0 nM|< 500.0 nM|= 213.1 nM | | = 167.0 nM|= 24.0 nM|= 301.0 nM|= 1870.0 nM|= 151.0 nM|= 188.0 nM|= 467.74 nM|= 86.0 nM|= 69.1 nM|= 330.0 nM|= 110.0 nM|= 49.0 nM|= 6424.0 nM|= 113.0 nM|= 33.9 nM|> 10000.0 nM|= 54.3 nM|= 46.9 nM|= 468.0 nM|= 28.1 nM|= 35.0 nM | NPASS |
| Cavia porcellus | Cavia porcellus | | = 51.0 nM|= 127.4 nM | = 68.2 nM|= 79.0 nM|= 79.8 nM|= 0.13 nM|= 69.7 nM|= 75.0 nM|= 58.6 nM|= 292.0 nM|= 24.0 nM|= 2.92 nM|= 33.1 nM|= 140.0 nM | = 6.31 nM | = 0.13 nM | NPASS |
| Kappa opioid receptor | Mus musculus | P33534 | = 400.0 nM | = 145.1 nM | | = 1549.49 nM|= 301.0 nM | NPASS |
| Kappa opioid receptor | Rattus norvegicus | P34975 | | | | = 113.0 nM|= 27.0 nM | NPASS |
| Kappa-type opioid receptor | Bos taurus | Q2KIP6 | | | | 32.8 nM | BindingDB |
| Kappa-type opioid receptor | Cavia porcellus | P41144 | | | | 49 nM | BindingDB |
| Kappa-type opioid receptor | Homo sapiens | P41145 | | | | 134 nM|65.5 nM|32.0 nM|1200 nM | BindingDB |
| Kappa-type opioid receptor | Rattus norvegicus | P34975 | | | | 113 nM | BindingDB |
| Mas-related G-protein coupled receptor member X2 | Human | Q96LB1 | 6.6e+3 nM|6.2e+3 nM | | | | BindingDB |
| Mu opioid receptor | Bos taurus | P79350 | | | | = 0.9 nM|= 0.5 nM|= 2.5 nM | NPASS |
| Mu opioid receptor | Cavia porcellus | P97266 | | = 71.6 nM|= 8.5 nM|= 57.3 nM|= 70.0 nM|= 4.0 nM|= 77.0 nM|= 38.0 nM|= 58.8 nM|= 311.0 nM|= 29300.0 nM|= 29.3 nM|= 150.0 nM | | = 0.88 nM|= 3.3 nM|= 38.0 nM|= 7.71 nM|= 3.0 nM|= 3.467 nM|= 1.8 nM|= 6.51 nM|= 2.5 nM|= 2.2 nM|= 1.98 nM|= 1.1 nM|= 3.5 nM|= 3.9 nM|= 5.2 nM | NPASS |
| Mu opioid receptor | Homo sapiens | P35372 | = 15.6 nM|= 316.0 nM|= 6.0 nM|= 6.4 nM|= 7.0 nM|= 3.7 nM|= 50.0 nM|= 501.19 nM|= 39.81 nM|= 10.0 nM|= 64.0 nM|= 379.0 nM|= 147.0 nM|= 4.7 nM|= 379.6 nM|= 5.0 nM|= 380.0 nM|= 203.97 nM|= 8.71 nM|= 71.6 nM|= 70.79 nM|= 416.87 nM|= 79.43 nM|= 21.0 nM | = 0.57 nM|= 4.3 nM|= 2.5 nM|= 6.3 nM|= 410.0 nM | | = 3.0 nM|= 1.8 nM|= 0.88 nM|= 17.0 nM|= 38.0 nM|= 3.96 nM|= 1.1 nM|= 4.0 nM|= 1.7 nM|= 2.55 nM|= 4.6 nM|= 2.52 nM|= 1.92 nM|= 2.6 nM|= 2.2 nM|= 0.14 nM|= 5.2 nM|= 22.0 nM|= 0.53 nM|= 4.2 nM|= 6.08 nM|= 4.19 nM|= 2.84 nM | NPASS |
| Kappa opioid receptor | Homo sapiens | P41145 | = 484.0 nM|= 400.0 nM|= 330.0 nM | = 1705.1 nM | | = 64.0 nM|= 86.0 nM|= 24.0 nM|= 260.0 nM|= 1900.0 nM|= 52.14 nM|= 33.0 nM|= 113.0 nM|= 46.9 nM|= 65.5 nM|= 6.9 nM|= 33.7 nM|= 299.0 nM|= 13.3 nM|= 60.9 nM|= 120.0 nM|= 36.8 nM|= 61.0 nM|= 76.9 nM | NPASS |
