IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Ki	Source
N2a	Mus musculus			= 2688.0 nM		NPASS
Monoamine oxidase B	Homo sapiens	P27338			= 400.0 nM	NPASS
Monoamine oxidase A	Homo sapiens	P21397			= 26000.0 nM	NPASS
MONO-MAC-6	Homo sapiens			= 6200.0 nM		NPASS
MIA PaCa-2	Homo sapiens			= 6200.0 nM		NPASS
MGC-803	Homo sapiens			= 11850.0 nM		NPASS
MDA-MB-231	Homo sapiens			= 12680.0 nM		NPASS
M-phase inducer phosphatase 3	Homo sapiens	P30307		19000 nM\|18800 nM		BindingDB
Vero	Chlorocebus aethiops			= 6.5 ug.mL-1		NPASS
NON-PROTEIN TARGET			= 17700.0 nM\|= 27500.0 nM\|= 94000.0 nM			NPASS
M-phase inducer phosphatase 2	Homo sapiens	P30305		3380 nM\|2200 nM\|3900 nM		BindingDB
M-phase inducer phosphatase 1	Homo sapiens	P30304		6900 nM		BindingDB
LS174T	Homo sapiens			= 26600.0 nM		NPASS
Jurkat	Homo sapiens			= 5000.0 nM		NPASS
Indoleamine 2,3-dioxygenase 1	Homo sapiens	P14902		1100 nM\|370 nM		BindingDB
Indoleamine 2,3-dioxygenase	Homo sapiens	P14902		= 1000.0 nM\|= 1100.0 nM\|= 370.0 nM		NPASS
MCF7	Homo sapiens			= 9000.0 nM		NPASS
PBMC	Homo sapiens			= 14500.0 nM		NPASS
Protein-glutamine gamma-glutamyltransferase 2	Homo sapiens	P21980		2.2e+3 nM		BindingDB
Perilipin-5	Homo sapiens	Q00G26		9468 nM		BindingDB
HeLa	Homo sapiens		= 3700.0 nM	= 24700.0 nM\|= 18000.0 nM		NPASS
Ubiquitin carboxyl-terminal hydrolase isozyme L3	Mus musculus	Q9JKB1		7.1e+4 nM		BindingDB
Ubiquitin carboxyl-terminal hydrolase isozyme L3	Homo sapiens	P15374		71000 nM\|= 71000.0 nM		BindingDB, NPASS
Ubiquitin carboxyl-terminal hydrolase isozyme L1	Mus musculus	Q9R0P9		2.90e+5 nM		BindingDB
Ubiquitin carboxyl-terminal hydrolase isozyme L1	Homo sapiens	P09936		290000 nM\|= 290000.0 nM		BindingDB, NPASS
U-937	Homo sapiens			= 6300.0 nM		NPASS
Trypanothione reductase	Trypanosoma cruzi	P28593		55000 nM\|= 55000.0 nM		BindingDB, NPASS
Perilipin-1	Homo sapiens	O60240		7895 nM		BindingDB
Thiosulfate sulfurtransferase	Homo sapiens	Q16762		1000 nM\|= 1000.0 nM		BindingDB, NPASS
SW982	Homo sapiens			= 9300.0 nM		NPASS
SAS	Homo sapiens			= 14000.0 nM		NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM		NPASS
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1		7960 nM\|= 7960.0 nM		BindingDB, NPASS
Replicase polyprotein 1ab	2019-nCoV	P0DTD1		7960 nM		BindingDB
Rattus norvegicus	Rattus norvegicus			= 12240.0 nM		NPASS
Pyruvate kinase isozymes M1/M2	Homo sapiens	P14618		= 150000.0 nM		NPASS
THP-1	Homo sapiens			= 6300.0 nM		NPASS
HaCaT	Homo sapiens			= 15800.0 nM		NPASS
Dual specificity protein phosphatase 1	Mus musculus	P28563		24000 nM\|= 24000.0 nM		BindingDB, NPASS
HSP60/HSP10	Homo sapiens			= 15000.0 nM		NPASS
Alpha-synuclein	Homo sapiens	P37840		15000 nM\|= 15000.0 nM		BindingDB, NPASS
Aldehyde oxidase 1	Rattus norvegicus	Q9Z0U5		190 nM		BindingDB
Aldehyde oxidase 1	Oryctolagus cuniculus	P80456		2000 nM		BindingDB
Aldehyde oxidase 1	Mus musculus	O54754		150 nM		BindingDB
Aldehyde oxidase 1	Macaca fascicularis	Q5FB27		110 nM		BindingDB
Aldehyde oxidase 1	Cavia porcellus	H9TB17		3.18e+4 nM	7.23e+3 nM	BindingDB
Aldehyde oxidase	Rattus norvegicus	Q9Z0U5		= 190.0 nM		NPASS
Amine oxidase	Homo sapiens			3.02e+3 nM		BindingDB
Aldehyde oxidase	Oryctolagus cuniculus	P80456		= 2000.0 nM		NPASS
Aldehyde oxidase	Macaca fascicularis	Q5FB27		= 110.0 nM		NPASS
Aldehyde oxidase	Homo sapiens	Q06278		200 nM\|= 200.0 nM	1500 nM\|470 nM\|= 1500.0 nM\|= 470.0 nM	BindingDB, NPASS
A549	Homo sapiens			= 25100.0 nM\|= 15890.0 nM		NPASS
A2780	Homo sapiens			= 2600.0 nM		NPASS
A2058	Homo sapiens			= 13400.0 nM		NPASS
60 kDa heat shock protein, mitochondrial	Homo sapiens	P10809		15000 nM		BindingDB
60 kDa chaperonin	Escherichia coli (strain K12)	P0A6F5		> 250000.0 nM		NPASS
HT-29	Homo sapiens			= 9690.0 nM\|= 13600.0 nM		NPASS
Amine oxidase [flavin-containing] A	Homo sapiens	P21397		1.02e+4 nM	26000 nM	BindingDB
Aldehyde oxidase	Mus musculus	O54754		= 150.0 nM		NPASS
Chaperonin GroEL	Escherichia coli			>250000 nM		BindingDB
HL-60	Homo sapiens			= 5600.0 nM\|= 7510.0 nM		NPASS
HGC-27	Homo sapiens			= 9700.0 nM		NPASS
HFF-1	Homo sapiens			> 50000.0 nM		NPASS
HCT-116	Homo sapiens			= 12370.0 nM		NPASS
GroEL/GroES	Escherichia coli			= 2500.0 nM\|= 9000.0 nM		NPASS
Glutathione reductase, mitochondrial	Homo sapiens	P00390			16100 nM\|12100 nM	BindingDB
Glutathione reductase	Homo sapiens	P00390			= 16100.0 nM\|= 12100.0 nM	NPASS
Dual specificity protein phosphatase 6	Rattus norvegicus	Q64346		20500 nM\|= 20500.0 nM		BindingDB, NPASS
Dual specificity phosphatase Cdc25B	Homo sapiens	P30305		= 3380.0 nM\|= 2200.0 nM\|= 3900.0 nM		NPASS
Dual specificity phosphatase Cdc25A	Homo sapiens	P30304		= 6900.0 nM		NPASS
Danio rerio	Danio rerio		= 3000.0 nM			NPASS
DU-145	Homo sapiens			= 11000.0 nM\|= 9860.0 nM		NPASS
DNA gyrase subunit A/DNA gyrase subunit B	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)			> 200000.0 nM		NPASS
DNA gyrase subunit A	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	P9WG47		>2.00e+5 nM		BindingDB
Co-chaperonin GroES	Escherichia coli			2500 nM\|9000 nM		BindingDB
Dual specificity phosphatase Cdc25C	Homo sapiens	P30307		= 18800.0 nM\|= 19000.0 nM		NPASS
Amine oxidase [flavin-containing] B	Homo sapiens	P27338			400 nM	BindingDB

a curated database

IMPPAT Phytochemical information:
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Bioactivity information

IMPPAT Phytochemical information: Menadione

Bioactivity information

IMPPAT Phytochemical information:
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