IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
MCF7	Homo sapiens			= 72000.0 nM\|= 70700.0 nM\|= 10780.0 nM\|= 3520.0 nM\|= 68330.0 nM\|= 16940.0 nM\|= 15270.0 nM			NPASS
Kallikrein-7	Homo sapiens	P49862	24845 nM				BindingDB
L02	Homo sapiens			= 25090.0 nM			NPASS
Leishmania donovani	Leishmadonovani			= 3700.0 nM\|= 230.0 nM			NPASS
Leishmania infantum	Leishmaitum			= 230.0 nM\|= 3700.0 nM			NPASS
LoVo	Homo sapiens			= 53200.0 nM			NPASS
MAP kinase ERK2	Homo sapiens	P28482		> 30000.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 54000.0 nM\|= 32000.0 nM\|= 21910.0 nM			NPASS
Muscarinic acetylcholine receptor	Homo sapiens	P08912				> 10000.0 nM	NPASS
Metabotropic glutamate receptor	Rattus norvegicus	P23385				> 10000.0 nM	NPASS
Metabotropic glutamate receptor 1/2/3/4/5/6/7/8	Rattus norvegicus	P23385\|P31421\|P31422\|P31423\|P31424\|P35349\|P35400\|P70579				>10000 nM	BindingDB
Mitogen-activated protein kinase 1	Rattus norvegicus	P63086		>30000 nM\|> 30000.0 nM			BindingDB, NPASS
Monoamine oxidase A	Homo sapiens	P21397		= 4.1 nM\|= 1.0 nM\|> 1000.0 nM\|= 5.0 nM		= 5.0 nM\|= 16.9 nM\|= 17.0 nM\|= 1.0 nM	NPASS
Monoamine oxidase B	Homo sapiens	P27338				= 120800.0 nM	NPASS
KB	Homo sapiens			= 57800.0 nM			NPASS
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5	Homo sapiens	P08172\|P08173\|P08912\|P11229\|P20309				>10000 nM	BindingDB
NCI-H2228	Homo sapiens			= 31060.0 nM			NPASS
MDA-MB-435	Homo sapiens			> 100000.0 nM\|= 17100.0 nM			NPASS
K562	Homo sapiens			= 45000.0 nM\|= 32000.0 nM\|= 14000.0 nM			NPASS
HepG2	Homo sapiens			= 46000.0 nM\|= 51200.0 nM\|= 53600.0 nM\|> 250000.0 nM\|= 49960.0 nM\|= 16800.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 520.0 nM				NPASS
NON-PROTEIN TARGET				> 130000.0 nM\|= 130000.0 nM\|= 32000.0 nM\|= 46700.0 nM\|= 42800.0 nM\|= 7200.0 nM\|= 70360.0 nM\|= 62450.0 nM			NPASS
Glycogen synthase kinase-3	Homo sapiens	P49840\|P49841		>10000 nM			BindingDB
Glycogen synthase kinase-3	Homo sapiens	P49841		> 10000.0 nM			NPASS
Glycogen synthase kinase-3	Sus scrofa			= 19000.0 nM\|> 10000.0 nM\|< 10000.0 nM			NPASS
Glycogen synthase kinase-3 alpha	Homo sapiens	P49840		>10000 nM\|> 10000.0 nM			BindingDB, NPASS
Glycogen synthase kinase-3 beta	Homo sapiens	P49841		>10000 nM\|>50000 nM\|32100 nM\|> 10000.0 nM\|> 50000.0 nM\|= 350.0 nM\|= 32100.0 nM	> 10000.0 nM\|= 3560.0 nM		BindingDB, NPASS
H9	Homo sapiens			= 26400.0 nM			NPASS
HCT-116	Homo sapiens			= 46700.0 nM\|= 43800.0 nM\|= 6940.0 nM			NPASS
HGC-27	Homo sapiens			= 3520.0 nM			NPASS
HL-60	Homo sapiens			= 7550.0 nM			NPASS
HT-22	Mus musculus			= 56500.0 nM			NPASS
HT-29	Homo sapiens			= 3520.0 nM\|= 41800.0 nM			NPASS
HeLa	Homo sapiens			= 60000.0 nM\|= 85280.0 nM\|= 16210.0 nM\|= 8000.0 nM\|= 9660.0 nM			NPASS
Histone deacetylase	Homo sapiens	O15379\|P56524\|Q13547\|Q8WUI4\|Q92769\|Q969S8\|Q96DB2\|Q9BY41\|Q9UBN7\|Q9UKV0\|Q9UQL6		>10000 nM			BindingDB
Histone deacetylase	Homo sapiens	Q969S8		> 10000.0 nM			NPASS
Histone deacetylase 1	Homo sapiens	Q13547		>1000 nM\|> 1000.0 nM			BindingDB, NPASS
Hs 683	Homo sapiens			= 37000.0 nM			NPASS
IMR-32	Homo sapiens			= 68000.0 nM\|= 38000.0 nM			NPASS
Nischarin	Homo sapiens	Q9Y2I1				22 nM\|13800 nM\|= 13800.0 nM\|= 22.0 nM	BindingDB, NPASS
GABA-A receptor; anion channel	Rattus norvegicus	Q9ES14				> 10000.0 nM	NPASS
OE33	Homo sapiens			= 18000.0 nM			NPASS
Serotonin 3 (5-HT3) receptor	Homo sapiens	Q8WXA8				> 10000.0 nM	NPASS
Serotonin 5a (5-HT5a) receptor	Homo sapiens	P47898				> 10000.0 nM	NPASS
Serotonin 6 (5-HT6) receptor	Homo sapiens	P50406				= 1480.0 nM	NPASS
Serotonin 7 (5-HT7) receptor	Homo sapiens	P34969				= 5500.0 nM	NPASS
Serotonin transporter	Homo sapiens	P31645				> 10000.0 nM	NPASS
Sodium-dependent dopamine transporter	Bos taurus	P27922				>10000 nM	BindingDB
Sodium-dependent noradrenaline transporter	Homo sapiens	P23975				3260 nM	BindingDB
Sodium-dependent serotonin transporter	Homo sapiens	P31645				>10000 nM	BindingDB
T98G	Homo sapiens			= 24000.0 nM			NPASS
Trypanosoma brucei	Trypanosoma brucei			= 74000.0 nM			NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 74000.0 nM			NPASS
Tyrosine-protein kinase FYN	Homo sapiens	P06241		> 250000.0 nM			NPASS
Tyrosine-protein kinase Fyn	Homo sapiens	P06241		>250000 nM			BindingDB
Tyrosine-protein kinase LCK	Homo sapiens	P06239		> 250000.0 nM			NPASS
Tyrosine-protein kinase Lck	Homo sapiens	P06239		>250000 nM			BindingDB
Tyrosine-protein kinase Lyn	Homo sapiens	P07948		>250000 nM\|> 250000.0 nM			BindingDB, NPASS
cAMP-dependent protein kinase (PKA)	Homo sapiens	P22694\|P17612\|P22612		> 250000.0 nM			NPASS
Serotonin 2c (5-HT2c) receptor	Homo sapiens	P28335				= 9340.0 nM	NPASS
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139	Homo sapiens	O94806\|P05129\|P05771\|P17252\|P24723\|P41743\|Q02156\|Q04759\|Q05513\|Q05655\|Q15139		>250000 nM			BindingDB
Serotonin 2a (5-HT2a) receptor	Rattus norvegicus	P14842				= 7790.0 nM	NPASS
Serotonin 1b (5-HT1b) receptor	Homo sapiens	P28222				> 10000.0 nM	NPASS
PC-3	Homo sapiens			= 3520.0 nM			NPASS
Pancreatic beta cells			= 7480.0 nM				NPASS
Plasmodium falciparum	Plasmodium falciparum		= 22000.0 nM	= 50.1 nM\|= 28.0 nM\|= 182.4 nM\|= 8250.0 nM\|> 27700.0 nM\|= 27777.8 nM			NPASS
Protein kinase C (PKC)	Homo sapiens	O94806\|P41743\|P17252\|P05129\|Q05655\|P05771\|Q05513\|Q02156\|P24723\|Q15139\|Q04759		> 250000.0 nM			NPASS
Protein kinase C (PKC)	Homo sapiens	Q04759		> 250000.0 nM			NPASS
Rho-associated protein kinase 1	Homo sapiens	Q13464		= 1500.0 nM			NPASS
Rho-associated protein kinase 2	Homo sapiens	O75116		> 40000.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
SGC-7901	Homo sapiens			= 40820.0 nM			NPASS
SK-OV-3	Homo sapiens			= 74600.0 nM			NPASS
SMMC-7721	Homo sapiens			= 55300.0 nM\|= 47600.0 nM\|= 59440.0 nM			NPASS
Serine/threonine-protein kinase PIM1	Homo sapiens	P11309		> 10000.0 nM			NPASS
Serine/threonine-protein kinase PIM3	Homo sapiens	Q86V86		= 4300.0 nM			NPASS
Serine/threonine-protein kinase haspin	Homo sapiens	Q8TF76		590 nM\|= 590.0 nM			BindingDB, NPASS
Serine/threonine-protein kinase pim-1	Homo sapiens	P11309		>10000 nM			BindingDB
Serine/threonine-protein kinase pim-3	Homo sapiens	Q86V86		4300 nM			BindingDB
Serotonin 1a (5-HT1a) receptor	Homo sapiens	P08908				> 10000.0 nM	NPASS
Serotonin 1d (5-HT1d) receptor	Homo sapiens	P28221				> 10000.0 nM	NPASS
GABA-A receptor; anion channel	Homo sapiens	P14867\|P47870\|P18507\|P28472\|P48169\|Q99928\|Q9UN88\|P34903\|O00591\|O14764\|Q8N1C3\|P18505\|P78334\|P47869\|P31644\|Q16445		> 100000.0 nM			NPASS
Norepinephrine transporter	Homo sapiens	P23975				= 3260.0 nM	NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 3	Homo sapiens	O43781		= 800.0 nM\|= 210.0 nM\|= 410.0 nM\|= 2857.0 nM			NPASS
Alpha-2b adrenergic receptor	Homo sapiens	P18089				= 1130.0 nM	NPASS
Alpha-2c adrenergic receptor	Homo sapiens	P18825				= 810.0 nM	NPASS
Amine oxidase [flavin-containing] A	Homo sapiens	P21397		5.0 nM		5 nM\|17 nM	BindingDB
Amine oxidase [flavin-containing] B	Homo sapiens	P27338				120800 nM	BindingDB
BGC-823	Homo sapiens			= 68000.0 nM\|= 63200.0 nM\|= 15630.0 nM			NPASS
Bel-7402	Homo sapiens			= 54000.0 nM			NPASS
Beta-1 adrenergic receptor	Homo sapiens	P08588				>10000 nM\|> 10000.0 nM	BindingDB, NPASS
Beta-2 adrenergic receptor	Homo sapiens	P07550				>10000 nM\|> 10000.0 nM	BindingDB, NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		5080 nM			BindingDB
CDK9/cyclin T1	Homo sapiens	P50750		= 720.0 nM			NPASS
COLO 205	Homo sapiens			= 46000.0 nM\|= 26000.0 nM\|= 8000.0 nM			NPASS
Casein kinase I delta	Homo sapiens	P48730		= 1500.0 nM			NPASS
Casein kinase I delta/epsilon	Homo sapiens	P48730\|P49674		1500 nM			BindingDB
Casein kinase I delta/epsilon	Homo sapiens			= 1500.0 nM			NPASS
Casein kinase I epsilon	Homo sapiens	P49674		> 10000.0 nM			NPASS
Casein kinase I isoform delta	Homo sapiens	P48730		1500 nM			BindingDB
Chitinase	Onchocerca volvulus			7060 nM		3780 nM	BindingDB
Alpha-2a adrenergic receptor	Homo sapiens	P08913				= 2540.0 nM	NPASS
Chitinase	Onchocerca volvulus	Q25615		= 7060.0 nM		= 3780.0 nM	NPASS
Alpha-2C adrenergic receptor	Homo sapiens	P18825				810 nM	BindingDB
Alpha-2A adrenergic receptor	Homo sapiens	P08913				2540 nM	BindingDB
5-hydroxytryptamine receptor 1A	Homo sapiens	P08908				>10000 nM	BindingDB
5-hydroxytryptamine receptor 1B	Homo sapiens	P28222				>10000 nM	BindingDB
5-hydroxytryptamine receptor 1D	Homo sapiens	P28221				>10000 nM	BindingDB
5-hydroxytryptamine receptor 2A	Rattus norvegicus	P14842				7790 nM	BindingDB
5-hydroxytryptamine receptor 2C	Homo sapiens	P28335				9340 nM	BindingDB
5-hydroxytryptamine receptor 5A	Homo sapiens	P47898				>10000 nM	BindingDB
5-hydroxytryptamine receptor 6	Homo sapiens	P50406				1480 nM	BindingDB
5-hydroxytryptamine receptor 7	Homo sapiens	P34969				5500 nM	BindingDB
769-P	Homo sapiens			= 48900.0 nM			NPASS
A-375	Homo sapiens			= 72500.0 nM			NPASS
A549	Homo sapiens			= 52560.0 nM\|= 7760.0 nM\|= 5890.0 nM\|= 42250.0 nM\|= 17120.0 nM\|= 5230.0 nM			NPASS
Acetylcholinesterase	Electrophorus electricus	O42275		22890 nM\|= 22890.0 nM\|= 10100.0 nM			BindingDB, NPASS
Acetylcholinesterase	Homo sapiens	P22303		= 11300.0 nM			NPASS
Alpha-1A adrenergic receptor	Homo sapiens	P35348				>10000 nM	BindingDB
Alpha-1B adrenergic receptor	Homo sapiens	P35368				>10000 nM	BindingDB
Alpha-1a adrenergic receptor	Homo sapiens	P35348				> 10000.0 nM	NPASS
Alpha-1b adrenergic receptor	Homo sapiens	P35368				> 10000.0 nM	NPASS
Alpha-2B adrenergic receptor	Homo sapiens	P18089				1130 nM	BindingDB
FM3A	Mus musculus		= 18000.0 nM				NPASS
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 5080.0 nM			NPASS
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2	Homo sapiens	P20248\|P24941\|P78396		35000 nM			BindingDB
Dual specificity protein kinase CLK1	Homo sapiens	P49759		220 nM\|72 nM\|26 nM\|= 242.3 nM\|= 298.9 nM	= 12.11 nM		BindingDB, NPASS
Dual specificity protein kinase CLK1	Mus musculus	P22518		72 nM\|= 72.0 nM			BindingDB, NPASS
Dual specificity protein kinase CLK2	Homo sapiens	P49760		= 1152.0 nM\|= 120.0 nM			NPASS
Dual specificity protein kinase CLK2	Mus musculus	O35491		280 nM\|= 280.0 nM			BindingDB, NPASS
Dual specificity protein kinase CLK3	Homo sapiens	P49761		= 8811.0 nM\|= 3000.0 nM			NPASS
Dual specificity protein kinase CLK3	Mus musculus	O35492		>10000 nM\|> 10000.0 nM			BindingDB, NPASS
Dual specificity protein kinase CLK4	Homo sapiens	Q9HAZ1		= 102.2 nM\|= 24.0 nM			NPASS
Dual specificity protein kinase CLK4	Mus musculus	O35493		50 nM\|= 50.0 nM			BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens	Q13627		60 nM\|33 nM\|80 nM\|130 nM\|400 nM\|29 nM\|30 nM\|41 nM\|85 nM\|56 nM\|8.8 nM\|48 nM\|700 nM\|27 nM\|22 nM\|200 nM\|32 nM		33 nM	BindingDB
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus	Q63470		34 nM\|56 nM\|29 nM\|= 34.0 nM\|= 56.0 nM\|= 29.0 nM			BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens	Q9Y463		166 nM\|180 nM\|160 nM\|28 nM\|57 nM\|= 28.0 nM\|= 166.0 nM\|= 180.0 nM\|= 160.0 nM\|= 57.4 nM\|= 292.9 nM\|= 94.0 nM		166 nM\|= 166.0 nM	BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 3	Homo sapiens	O43781		410 nM\|800 nM\|210 nM			BindingDB
Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens	Q9NR20		74000 nM\|80000 nM\|9500 nM\|= 9500.0 nM\|= 74000.0 nM\|= 80000.0 nM\|= 8356.0 nM			BindingDB, NPASS
Dual specificty protein kinase CLK1	Homo sapiens	P49759		= 26.0 nM\|= 220.0 nM			NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	Q13627		= 80.0 nM\|= 30.0 nM\|= 60.0 nM\|= 85.0 nM\|= 33.0 nM\|= 130.0 nM\|= 400.0 nM\|= 29.0 nM\|= 41.0 nM\|= 8.81 nM\|= 56.0 nM\|= 700.0 nM\|= 48.0 nM\|= 27.0 nM\|= 21.83 nM\|= 200.0 nM\|= 61.7 nM\|< 100.0 nM\|= 22.0 nM\|= 270.0 nM\|= 150.0 nM\|= 12.0 nM\|= 192.2 nM\|= 32.0 nM	= 13.4 nM\|= 5.474 nM	= 33.0 nM	NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Q92630		= 900.0 nM\|= 690.0 nM\|= 120.0 nM\|= 2000.0 nM\|= 3000.0 nM\|= 1900.0 nM\|= 3166.0 nM			NPASS
Cholinesterase	Equus caballus	P81908		= 13600.0 nM			NPASS
Dopamine transporter	Bos taurus	P27922				> 10000.0 nM	NPASS
Dopamine receptor	Homo sapiens	P21728				> 10000.0 nM	NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens	Q92630		2000 nM\|3000 nM\|900 nM\|690 nM\|120 nM			BindingDB
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor	Homo sapiens	P14416\|P21728\|P21917\|P21918\|P35462				>10000 nM	BindingDB
Cyclin-A2/Cyclin-dependent kinase 2	Homo sapiens	P20248\|P24941		<10000 nM			BindingDB
DU-145	Homo sapiens			= 12020.0 nM\|= 9630.0 nM			NPASS
Cyclin-H/Cyclin-dependent kinase 7	Homo sapiens	P50613\|P51946		>10000 nM			BindingDB
Cyclin-T1/Cyclin-dependent kinase 9	Homo sapiens	O60563\|P50750		720 nM			BindingDB
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3	Homo sapiens	O95067\|P06493\|P14635\|Q8WWL7		18000 nM			BindingDB
Cyclin-dependent kinase 1/cyclin B	Homo sapiens	O95067		= 18000.0 nM			NPASS
Cyclin-dependent kinase 1/cyclin B	Homo sapiens	P06493\|P14635\|Q8WWL7\|O95067		= 17000.0 nM			NPASS
Cyclin-dependent kinase 2	Homo sapiens	P24941		= 33000.0 nM			NPASS
Cyclin-dependent kinase 2/cyclin A	Homo sapiens	P24941\|P20248\|P78396		= 33000.0 nM			NPASS
Cyclin-dependent kinase 1	Homo sapiens	P06493		= 17000.0 nM			NPASS
Cyclin-dependent kinase 5	Homo sapiens	Q00535		= 8000.0 nM			NPASS
Cytochrome P450 2D6	Homo sapiens	P10635				50000 nM\|= 50000.0 nM	BindingDB, NPASS
Cyclin-dependent kinase 5 activator 1	Homo sapiens	Q00535\|Q15078		21000 nM\|>10000 nM\|8000 nM			BindingDB
Cyclin-dependent kinase 9	Homo sapiens	P50750		= 720.0 nM			NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q00535\|Q15078		= 20000.0 nM\|> 10000.0 nM			NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q15078		= 21000.0 nM\|= 8000.0 nM\|> 10000.0 nM			NPASS
Cyclin-dependent kinase 2/cyclin A	Homo sapiens	P78396		= 35000.0 nM\|> 30000.0 nM			NPASS
Cyclin-dependent kinase 7	Homo sapiens	P50613		> 10000.0 nM			NPASS
Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	P50613		> 10000.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Harmine

Bioactivity information

IMPPAT Phytochemical information: Harmine

Bioactivity information

IMPPAT Phytochemical information:
Harmine