IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Protein-tyrosine phosphatase 2C	Homo sapiens	Q06124		= 3300.0 nM\|= 4100.0 nM			NPASS
Regulator of G-protein signaling 17	Homo sapiens	Q9UGC6		= 6000.0 nM\|= 10500.0 nM\|> 100000.0 nM			NPASS
Replicase polyprotein 1ab	Human SARS coronavirus	P0C6X7		10300 nM		4200 nM	BindingDB
Receptor-type tyrosine-protein phosphatase eta	Homo sapiens	Q12913		= 111500.0 nM			NPASS
Receptor-type tyrosine-protein phosphatase epsilon	Homo sapiens	P23469		> 500000.0 nM			NPASS
RPMI-8226	Homo sapiens			= 3000.0 nM\|= 520.0 nM\|= 730.0 nM			NPASS
SAOS-2	Homo sapiens			= 1050.0 nM			NPASS
RCC4	Homo sapiens			= 1880.0 nM			NPASS
RAW264.7	Mus musculus			= 230.0 nM\|= 270.0 nM\|= 1000.0 nM\|> 50000.0 nM\|= 800.0 nM			NPASS
QGY-7703	Homo sapiens			= 2430.0 nM			NPASS
Protein-tyrosine phosphatase LC-PTP	Homo sapiens	P35236		= 75700.0 nM			NPASS
Protein-tyrosine phosphatase 1C	Homo sapiens	P29350		= 27800.0 nM\|= 3100.0 nM			NPASS
NON-PROTEIN TARGET				= 580.0 nM\|= 150.0 nM\|= 2130.0 nM\|= 2480.0 nM\|= 2020.0 nM\|= 2010.0 nM			NPASS
Plasmodium falciparum (isolate K1 / Thailand)	Plasmodium falciparum K1			= 0.1809 ug.mL-1			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 0.2542 ug.mL-1			NPASS
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Homo sapiens	P60484		= 13300.0 nM			NPASS
PC-3	Homo sapiens			= 1680.0 nM\|= 1520.0 nM			NPASS
PC-12	Rattus norvegicus			= 3150.0 nM			NPASS
PANC-1	Homo sapiens			= 3000.0 nM			NPASS
OVCAR-3	Homo sapiens			= 1930.0 nM			NPASS
Nuclear receptor subfamily 4 group A member 1	Homo sapiens	P22736			= 320.0 nM\|= 290.0 nM		NPASS
NSCLC	Homo sapiens			= 1480.0 nM			NPASS
NCI-H929	Homo sapiens			= 310.0 nM			NPASS
SCC-38	Homo sapiens			= 1700.0 nM			NPASS
NCI-H460	Homo sapiens			= 12300.0 nM\|= 2200.0 nM			NPASS
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 13200.0 nM\|= 4800.0 nM\|= 2100.0 nM	= 3.62 10'-4/s\|= 59.46 /M/s\|= 6080.0 nM		NPASS
SCC-4	Homo sapiens			= 2800.0 nM			NPASS
UMSCC1	Homo sapiens			= 760.0 nM			NPASS
SH-SY5Y	Homo sapiens		= 37.64 nM				NPASS
NCI-H2228	Homo sapiens			= 1950.0 nM			NPASS
Ubiquitin carboxyl-terminal hydrolase isozyme L5	Human	Q9Y5K5		56600 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase isozyme L3	Homo sapiens	P15374		32100 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase isozyme L1	Homo sapiens	P09936		6800 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase 2	Homo sapiens	O75604		28700 nM			BindingDB
Ubiquitin carboxyl-terminal hydrolase 15	Human	Q9Y4E8		32800 nM			BindingDB
UDP-glucuronosyltransferase 2B7	Homo sapiens	P16662				= 45.0 nM	NPASS
UDP-glucuronosyltransferase 1-6	Homo sapiens	P19224				= 490.0 nM	NPASS
U2OS	Homo sapiens			= 1860.0 nM\|= 2110.0 nM			NPASS
U-937	Homo sapiens			= 2000.0 nM			NPASS
U-87 MG	Homo sapiens			= 2230.0 nM			NPASS
U-266	Homo sapiens			= 470.0 nM			NPASS
SGC-7901	Homo sapiens			= 870.0 nM			NPASS
U-251	Homo sapiens			= 690.0 nM\|= 4430.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1 [1-321]	Homo sapiens	P18031				10000 nM	BindingDB
Tryptophan 2,3-dioxygenase	Homo sapiens	P48775		> 100000.0 nM			NPASS
Telomerase reverse transcriptase	Homo sapiens	O14746		= 780.0 nM			NPASS
THP-1	Homo sapiens		= 15000.0 nM				NPASS
T47D	Homo sapiens			> 20000.0 nM			NPASS
T-cell protein-tyrosine phosphatase	Homo sapiens	P17706		= 23000.0 nM\|= 18800.0 nM			NPASS
T-ALL				< 1000.0 nM			NPASS
SW13	Homo sapiens			= 100.0 nM			NPASS
SMMC-7721	Homo sapiens			= 1070.0 nM\|= 6040.0 nM			NPASS
SK-OV-3	Homo sapiens			= 1160.0 nM\|= 1680.0 nM\|= 2290.0 nM			NPASS
SK-MEL-28	Homo sapiens			= 1720.0 nM			NPASS
SK-BR-3	Homo sapiens			= 720.0 nM			NPASS
Tyrosine-protein phosphatase non-receptor type 1 [1-405]	Homo sapiens	P18031				10000 nM	BindingDB
NCI-H1975	Homo sapiens			= 600.0 nM\|= 1660.0 nM			NPASS
L-ornithine N(5)-monooxygenase	Neosartorya fumigata (Aspergillus fumigatus)	E9QYP0		1.1e+4 nM	1.4e+3 nM		BindingDB
NCI-H1299	Homo sapiens			< 1000.0 nM\|= 1490.0 nM			NPASS
Heat shock factor protein 1	Homo sapiens	Q00613	= 1100.0 nM\|= 2600.0 nM				NPASS
HeLa	Homo sapiens			= 840.0 nM\|= 1700.0 nM\|= 1210.0 nM\|= 1900.0 nM			NPASS
HT-29	Homo sapiens			= 1.3 ug.mL-1\|= 1280.0 nM\|= 600.0 nM			NPASS
HOS	Homo sapiens			= 930.0 nM\|= 1460.0 nM\|= 2550.0 nM			NPASS
HL-60	Homo sapiens			< 1000.0 nM			NPASS
HEK-293T	Homo sapiens			= 670.0 nM			NPASS
HCT-116	Homo sapiens			= 5260.0 nM\|= 1810.0 nM\|= 1900.0 nM			NPASS
HCC827	Homo sapiens			= 1300.0 nM			NPASS
H4	Homo sapiens			= 2090.0 nM			NPASS
Daudi	Homo sapiens			< 1000.0 nM			NPASS
DU-145	Homo sapiens			= 1480.0 nM			NPASS
Cytochrome b-245 heavy chain	Homo sapiens	P04839		= 590.0 nM			NPASS
Cytochrome P450 3A2	Rattus norvegicus	P05183		= 23200.0 nM		= 14200.0 nM	NPASS
Cytochrome P450 2C11	Rattus norvegicus	P08683		= 10200.0 nM		= 7050.0 nM	NPASS
Cytochrome P450 1A2	Rattus norvegicus	P04799		= 52800.0 nM		= 39200.0 nM	NPASS
Caspase-3	Homo sapiens	P42574	= 1400.0 nM				NPASS
C3A	Homo sapiens			= 3600.0 nM			NPASS
Bel-7402	Homo sapiens			= 440.0 nM\|= 1810.0 nM\|= 1550.0 nM			NPASS
BJ	Homo sapiens			= 2740.0 nM			NPASS
NCI-H1650	Homo sapiens			= 790.0 nM			NPASS
BEAS-2B	Homo sapiens			= 454.0 nM			NPASS
AGS	Homo sapiens			= 250.0 nM			NPASS
A549	Homo sapiens			= 2120.0 nM\|= 1560.0 nM\|= 690.0 nM\|= 6590.0 nM\|= 1430.0 nM\|= 1480.0 nM\|= 1280.0 nM\|= 980.0 nM\|= 1990.0 nM\|= 4990.0 nM\|= 1100.0 nM\|= 2830.0 nM\|> 100000.0 nM\|= 1680.0 nM\|= 1800.0 nM			NPASS
A2780	Homo sapiens			= 1840.0 nM\|= 2110.0 nM			NPASS
A 172	Homo sapiens			= 2310.0 nM			NPASS
Hep 3B2	Homo sapiens			= 760.0 nM			NPASS
HepG2	Homo sapiens			= 4010.0 nM\|= 580.0 nM\|= 6170.0 nM\|= 1620.0 nM\|= 3180.0 nM\|= 1330.0 nM\|= 1300.0 nM\|= 1500.0 nM\|= 2400.0 nM\|= 940.0 nM\|= 3730.0 nM			NPASS
BGC-823	Homo sapiens			= 1100.0 nM			NPASS
Huh-7	Homo sapiens			= 4700.0 nM\|= 4450.0 nM			NPASS
Homo sapiens	Homo sapiens			= 40.0 nM\|= 210.0 nM\|= 80.0 nM\|= 110.0 nM			NPASS
NADPH oxidase 5	Homo sapiens	Q96PH1		= 3130.0 nM			NPASS
NADPH oxidase 4	Homo sapiens	Q9NPH5		= 2790.0 nM			NPASS
NADPH oxidase 1	Homo sapiens	Q9Y5S8		= 410.0 nM			NPASS
MRC5	Homo sapiens			= 4400.0 nM			NPASS
MM1.S	Homo sapiens			= 630.0 nM			NPASS
MKN-45	Homo sapiens			= 3400.0 nM			NPASS
MKN-28	Homo sapiens			= 2300.0 nM			NPASS
MIA PaCa-2	Homo sapiens			= 460.0 nM			NPASS
MGC-803	Homo sapiens			= 1550.0 nM			NPASS
MG-63	Homo sapiens			= 1970.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 1320.0 nM\|= 670.0 nM\|= 1980.0 nM\|= 900.0 nM\|= 1080.0 nM			NPASS
MCF7	Homo sapiens			= 153.0 nM\|= 1350.0 nM\|= 6840.0 nM\|= 1560.0 nM\|= 2040.0 nM\|= 1060.0 nM\|= 2230.0 nM\|= 1580.0 nM\|= 1700.0 nM\|= 1200.0 nM			NPASS
Mesenchymal stem cells	Homo sapiens			= 700.0 nM			NPASS
LP-1	Homo sapiens			= 880.0 nM			NPASS
LNCaP	Homo sapiens			= 2500.0 nM\|= 1760.0 nM			NPASS
LN-229	Homo sapiens			= 3130.0 nM			NPASS
L02	Homo sapiens			= 1940.0 nM\|= 780.0 nM\|= 830.0 nM\|= 640.0 nM\|= 1120.0 nM			NPASS
L-ornithine N(5)-monooxygenase	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus)	E9QYP0		= 11000.0 nM	= 1400.0 nM		NPASS
Hypoxia-inducible factor 1 alpha	Homo sapiens	Q16665		= 250.0 nM			NPASS
Kasumi 1	Homo sapiens			= 2200.0 nM			NPASS
KBM5	Homo sapiens			= 520.0 nM\|= 500.0 nM			NPASS
KB	Homo sapiens			= 1700.0 nM			NPASS
K562	Homo sapiens			= 400.0 nM			NPASS
Indoleamine 2,3-dioxygenase	Homo sapiens	P14902		= 8410.0 nM			NPASS
MCF-10A	Homo sapiens			= 5450.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Celastrol

Bioactivity information

IMPPAT Phytochemical information: Celastrol

Bioactivity information

IMPPAT Phytochemical information:
Celastrol