IMPPAT Phytochemical information: 
2,3,5,6-Tetramethylpyrazine
2,3,5,6-Tetramethylpyrazine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
MCF7Homo sapiens> 20000.0 nM|= 29850.0 nMNPASS
U-87 MGHomo sapiens= 16150.0 nMNPASS
Thoracic aortaRattus norvegicus= 2330000.0 nMNPASS
Thioredoxin reductase 3Homo sapiensQ86VQ6>200000 nMBindingDB
Thioredoxin reductaseHomo sapiensQ86VQ6> 200000.0 nMNPASS
SH-SY5YHomo sapiens= 17590.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
PC-12Rattus norvegicus= 60000.0 nM|= 64460.0 nMNPASS
MDA-MB-231Homo sapiens= 20440.0 nMNPASS
K562Homo sapiens= 5090.0 nMNPASS
NON-PROTEIN TARGET= 600000.0 nM|= 83400.0 nM= 265300.0 nMNPASS
HeLaHomo sapiens> 20000.0 nMNPASS
A549/CDDPHomo sapiens> 200000.0 nMNPASS
Bel-7402Homo sapiens> 20000.0 nMNPASS
Bile salt export pumpHomo sapiensO95342>1000000 nM|> 1000000.0 nMBindingDB, NPASS
ECV-304Homo sapiens= 452000.0 nM|= 154350.0 nM|= 600000.0 nM|= 549000.0 nMNPASS
A549Homo sapiens= 15220.0 nM|> 200000.0 nM|= 36460.0 nMNPASS
HT-29Homo sapiens> 20000.0 nMNPASS
HepG2Homo sapiens> 20000.0 nM|= 38250.0 nMNPASS
HUVECHomo sapiens= 788000.0 nM|= 600000.0 nMNPASS
HCT-116Homo sapiens= 8170.0 nMNPASS