IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Mu opioid receptor	Homo sapiens	P35372	= 41700.0 nM	= 1800.0 nM\|= 311.0 nM		= 1300.0 nM	NPASS
Mu-type opioid receptor	Homo sapiens	P35372				1300 nM	BindingDB
Mus musculus	Mus musculus		= 120.0 mg kg-1\|= 144.0 mg kg-1\|= 80.0 mg kg-1				NPASS
NON-PROTEIN TARGET			= 1000.0 nM\|= 3000.0 nM\|= 2000.0 nM\|= 4000.0 nM				NPASS
N-acylsphingosine-amidohydrolase	Homo sapiens	Q02083		> 100000.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 6000.0 nM			NPASS
N-acylethanolamine-hydrolyzing acid amidase	Homo sapiens	Q02083		>100000 nM			BindingDB
MCF7	Homo sapiens			= 55000.0 nM			NPASS
Histamine H3 receptor	Homo sapiens	Q9Y5N1				3100 nM\|= 3100.0 nM	BindingDB, NPASS
L-lactate dehydrogenase A chain	Homo sapiens	P00338				24000 nM\|= 24000.0 nM	BindingDB, NPASS
Kappa-type opioid receptor	Homo sapiens	P41145				2300 nM	BindingDB
Kappa opioid receptor	Homo sapiens	P41145				= 2300.0 nM	NPASS
OVCAR	Homo sapiens			= 50000.0 nM			NPASS
HepG2	Homo sapiens			= 42800.0 nM			NPASS
Hemozoin	Plasmodium falciparum			= 51100.0 nM			NPASS
Heat sensitive channel TRPV3	Rattus norvegicus	Q4QYD9	= 510.0 nM	= 750.0 nM			NPASS
Heat sensitive channel TRPV3	Rattus norvegicus		510 nM	750 nM			BindingDB
HCT-116	Homo sapiens			= 18000.0 nM			NPASS
LNCaP	Homo sapiens			= 18000.0 nM\|= 2600.0 nM			NPASS
PC-3	Homo sapiens			= 12000.0 nM\|= 10500.0 nM\|= 2900.0 nM			NPASS
RWPE-1	Homo sapiens			= 1100.0 nM			NPASS
Peroxisome proliferator-activated receptor gamma	Homo sapiens	P37231	>25000 nM\|> 25000.0 nM				BindingDB, NPASS
G-protein coupled receptor 55	Homo sapiens	Q9Y2T6	445 nM\|= 445.0 nM				BindingDB, NPASS
Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	P22002		= 100.0 nM			NPASS
Vanilloid receptor	Homo sapiens	Q8NER1	= 4100.0 nM\|= 38530.0 nM	= 3700.0 nM	= 110400.0 nM		NPASS
Transient receptor potential cation channel subfamily V member 4	Rattus norvegicus	Q9ERZ8	900 nM\|= 900.0 nM	5900 nM\|= 5900.0 nM			BindingDB, NPASS
Transient receptor potential cation channel subfamily V member 2	Rattus norvegicus	Q9WUD2	1200 nM\|= 1200.0 nM	1100 nM\|= 1100.0 nM			BindingDB, NPASS
Transient receptor potential cation channel subfamily V member 1	Homo sapiens	Q8NER1	4100 nM	3700 nM			BindingDB
Transient receptor potential cation channel subfamily M member 8	Rattus norvegicus	Q8R455		2800 nM\|= 2800.0 nM			BindingDB, NPASS
Transient receptor potential cation channel subfamily M member 8	Homo sapiens	Q7Z2W7		= 60.0 nM			NPASS
PWR-1E	Homo sapiens			= 900.0 nM			NPASS
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus	Q6RI86	96 nM\|480 nM\|= 96.0 nM\|= 480.0 nM	450 nM\|= 450.0 nM			BindingDB, NPASS
Sn1-specific diacylglycerol lipase alpha	Homo sapiens	Q9Y4D2		> 100000.0 nM			NPASS
Sigma intracellular receptor 2	Homo sapiens	Q5BJF2				3400 nM\|= 3400.0 nM	BindingDB, NPASS
Serotonin 2c (5-HT2c) receptor	Homo sapiens	P28335				= 1100.0 nM	NPASS
Serotonin 2a (5-HT2a) receptor	Rattus norvegicus	P14842	= 32000.0 nM				NPASS
Serotonin 1a (5-HT1a) receptor	Homo sapiens	P08908	= 8000.0 nM				NPASS
SH-SY5Y	Homo sapiens			= 48000.0 nM			NPASS
RBL-2H3	Rattus norvegicus			= 25300.0 nM			NPASS
Plasmodium falciparum	Plasmodium falciparum			= 4100.0 nM			NPASS
Steroid 17-alpha-hydroxylase/17,20 lyase	Rattus norvegicus	P11715				124000 nM	BindingDB
Fatty-acid amide hydrolase 1 [30-579]	Rattus norvegicus	P97612		53200 nM			BindingDB
Alpha-2c adrenergic receptor	Homo sapiens	P18825				= 3700.0 nM	NPASS
Dopamine D1 receptor	Homo sapiens	P21728				= 2700.0 nM	NPASS
Cannabinoid receptor 1	Rattus norvegicus	P20272				1265 nM\|>10000 nM	BindingDB
Cannabinoid CB2 receptor	Mus musculus	P47936				= 230.0 nM	NPASS
Cannabinoid CB2 receptor	Homo sapiens	P34972	= 31.62 nM\|= 630.96 nM\|= 398.11 nM\|= 39.81 nM\|= 325.2 nM\|= 291.1 nM\|= 25.12 nM\|= 7.943 nM\|= 12.59 nM\|= 501.19 nM\|= 15.85 nM\|= 73.0 nM\|= 50.12 nM\|= 251.19 nM			= 10000.0 nM\|= 2860.0 nM\|= 372.0 nM	NPASS
Cannabinoid CB1 receptor	Rattus norvegicus	P20272				= 1265.0 nM\|> 10000.0 nM	NPASS
Cannabinoid CB1 receptor	Homo sapiens	P21554				= 2400.0 nM\|= 4350.0 nM\|= 1459.0 nM	NPASS
Caco-2	Homo sapiens			= 3730.0 nM			NPASS
BV-2	Mus musculus			= 12300.0 nM\|= 8500.0 nM\|= 10300.0 nM\|= 8000.0 nM			NPASS
Anandamide amidohydrolase	Rattus norvegicus	P97612		= 53200.0 nM			NPASS
Cannabinoid receptor 2	Homo sapiens	P34972	50 nM\|40 nM\|25 nM\|16 nM\|7.9 nM\|13 nM\|32 nM\|501 nM\|631 nM\|251 nM\|398 nM\|0.000000 nM			2860 nM\|10000 nM\|2900 nM\|372 nM	BindingDB
Alpha-2b adrenergic receptor	Homo sapiens	P18089				= 3200.0 nM	NPASS
Alpha-2B adrenergic receptor	Homo sapiens	P18089				3200 nM	BindingDB
Acetylcholinesterase	Electrophorus electricus	O42275		17070 nM\|= 17070.0 nM			BindingDB, NPASS
A549	Homo sapiens			= 40000.0 nM			NPASS
5-hydroxytryptamine receptor 2C	Homo sapiens	P28335				1100 nM	BindingDB
5-hydroxytryptamine receptor 2A	Rattus norvegicus	P14842	32000 nM				BindingDB
5-hydroxytryptamine receptor 1A	Homo sapiens	P08908	8000 nM				BindingDB
4T1	Mus musculus			= 1800.0 nM			NPASS
Fatty acid-binding protein, liver	Mus musculus	P12710				167 nM	BindingDB
Alpha-2C adrenergic receptor	Homo sapiens	P18825				3700 nM	BindingDB
Cannabinoid receptor 2	Mus musculus	P47936				1260 nM	BindingDB
Cannabinoid receptor 1	Homo sapiens	P21554				4350 nM\|2400 nM\|4400 nM\|1459 nM	BindingDB
Cholinesterase	Equus caballus	P81908		670 nM\|= 670.0 nM			BindingDB, NPASS
Diacylglycerol lipase-alpha	Homo sapiens	Q9Y4D2		>100000 nM			BindingDB
Delta-type opioid receptor	Homo sapiens	P41143				6400 nM	BindingDB
Delta opioid receptor	Homo sapiens	P41143				= 6400.0 nM	NPASS
DU-145	Homo sapiens			= 1500.0 nM\|= 5400.0 nM\|= 12300.0 nM			NPASS
D(1A) dopamine receptor	Homo sapiens	P21728				2700 nM	BindingDB
Cytochrome P450 3A7	Homo sapiens	P24462				12300 nM\|= 12300.0 nM	BindingDB, NPASS
Cytochrome P450 3A5	Homo sapiens	P20815				190 nM\|= 190.0 nM	BindingDB, NPASS
Caspase-1	Homo sapiens	P29466			188000 nM\|= 18.8 nM\|= 0.078 1/s		BindingDB, NPASS
Cytochrome P450 2D6	Homo sapiens	P10635				2420 nM\|= 2420.0 nM	BindingDB, NPASS
Cytochrome P450 2C9	Homo sapiens	P11712				5600 nM\|= 5600.0 nM	BindingDB, NPASS
Cytochrome P450 3A4	Homo sapiens	P08684				1000 nM\|= 1000.0 nM	BindingDB, NPASS
Cytochrome P450 2C19	Homo sapiens	P33261				790 nM\|= 790.0 nM	BindingDB, NPASS
Cytochrome P450 2C11	Rattus norvegicus	P08683				20700 nM\|= 20700.0 nM	BindingDB, NPASS
Cytochrome P450 2B6	Homo sapiens	P20813				690 nM\|= 690.0 nM	BindingDB, NPASS
Cytochrome P450 2A6	Homo sapiens	P11509				55000 nM\|= 55000.0 nM	BindingDB, NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678				3630 nM\|= 3630.0 nM	BindingDB, NPASS
Cytochrome P450 1A2	Homo sapiens	P05177				2690 nM\|= 2690.0 nM	BindingDB, NPASS
Cytochrome P450 1A1	Homo sapiens	P04798				150 nM\|160 nM\|= 150.0 nM\|= 160.0 nM	BindingDB, NPASS
Cytochrome P450 17A1	Rattus norvegicus	P11715				= 124000.0 nM	NPASS

a curated database

IMPPAT Phytochemical information:
Cannabidiol

Bioactivity information

IMPPAT Phytochemical information: Cannabidiol

Bioactivity information

IMPPAT Phytochemical information:
Cannabidiol