IMPPAT Phytochemical information: 
Curcumin

Curcumin
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Mitochondrial import inner membrane translocase subunit TIM10Saccharomyces cerevisiae S288cP87108= 19700.0 nMNPASS
Monoamine oxidase AHomo sapiensP21397= 5020.0 nM|= 2740.0 nM= 710.0 nMNPASS
Monoamine oxidase BHomo sapiensP27338= 2560.0 nM|= 2580.0 nM= 21500.0 nMNPASS
NACHT, LRR and PYD domains-containing protein 3Homo sapiensQ96P2024200 nM|= 24200.0 nMBindingDB, NPASS
NCI-H1299Homo sapiens= 18930.0 nMNPASS
NCI-H1650Homo sapiens= 20700.0 nM|= 20500.0 nMNPASS
NCI-H1975Homo sapiens= 1400.0 nMNPASS
NCI-H460Homo sapiens= 8500.0 nM|= 15000.0 nM|= 17110.0 nM|= 17140.0 nM|= 20300.0 nM|= 5300.0 nM|= 20340.0 nMNPASS
NHDFHomo sapiens= 24100.0 nMNPASS
Proteasome Macropain subunit MB1Homo sapiensP28074= 10000.0 nMNPASS
NON-PROTEIN TARGET= 28100.0 nM|= 48600.0 nM|= 6200.0 nM= 7570.0 nM|= 3840.0 nM|= 82500.0 nM|= 31390.0 nM|= 24410.0 nM|= 12520.0 nM|= 27890.0 nM|= 10300.0 nM|= 48000.0 nM|= 50000.0 nM|= 100000.0 nM|= 25430.0 nM|= 26230.0 nM|= 49850.0 nM|= 44710.0 nM|= 15060.0 nM|= 24540.0 nM|= 38300.0 nM|= 72700.0 nM|= 51700.0 nM|= 42000.0 nM|= 24600.0 nM|= 30000.0 nM|= 7500.0 nM|> 25000.0 nMNPASS
Microtubule-associated protein tauHomo sapiensP106363000 nM|3500 nM|13000 nM|= 3000.0 nM|= 3500.0 nM|= 13000.0 nM|> 200000.0 nMBindingDB, NPASS
No relevant target= 28.0 ug.mL-1NPASS
Nuclear factor erythroid 2-related factor 2Homo sapiensQ1623621000 nM|= 21000.0 nMBindingDB, NPASS
PANC-1Homo sapiens= 53000.0 nMNPASS
PC-3Homo sapiens= 12220.0 nM|= 18800.0 nM|= 25430.0 nM|= 18650.0 nM|= 2000.0 nM|= 18710.0 nM|= 20900.0 nM|= 19980.0 nM|= 39000.0 nMNPASS
PWR-1EHomo sapiens= 8140.0 nM|= 8850.0 nMNPASS
Plasmodium falciparum 3D7Plasmodium falciparum 3D7= 25000.0 nMNPASS
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiensP0991730000 nMBindingDB
Prostaglandin E synthaseHomo sapiensO14684300 nM|220 nM|= 220.0 nM|= 200.0 nM|= 300.0 nMBindingDB, NPASS
Prostaglandin G/H synthase 1/2Bos taurusO62664|O626982000 nMBindingDB
NIH3T3Mus musculus= 9510.0 nMNPASS
MRC5Homo sapiens= 51230.0 nMNPASS
L02Homo sapiens= 25670.0 nM|= 7200.0 nM|= 23870.0 nM|= 22690.0 nM|= 32330.0 nMNPASS
MDA-MB-468Homo sapiens= 58550.0 nM|= 42890.0 nMNPASS
Histone deacetylase 2Homo sapiensQ9276997670 nM|= 97670.0 nMBindingDB, NPASS
Histone deacetylase 8Homo sapiensQ9BY4164980 nM|= 64980.0 nMBindingDB, NPASS
Hs-578THomo sapiens= 55450.0 nMNPASS
Influenza A virusInflueA virus= 6700.0 nMNPASS
Intestinal alkaline phosphataseHomo sapiensP09923> 100000.0 nMNPASS
Intestinal alkaline phosphataseMus musculusP24822= 18700.0 nMNPASS
JurkatHomo sapiens= 4290.0 nMNPASS
K562Homo sapiens= 23120.0 nM|= 36000.0 nM|= 46760.0 nMNPASS
KM12Homo sapiens= 16000.0 nMNPASS
Proteasome subunit beta type-5Homo sapiensP2807410000 nMBindingDB
MGC-803Homo sapiens> 20000.0 nM|= 21200.0 nMNPASS
LN-229Homo sapiens= 15000.0 nMNPASS
Lactoylglutathione lyaseHomo sapiensQ047605.00 nMBindingDB
Leishmania amazonensisLeishmaamazonensis> 100000.0 nMNPASS
Lymphocyte antigen 96Homo sapiensQ9Y6Y9379000 nM|= 379000.0 nMBindingDB, NPASS
Lysine-specific histone demethylase 1Homo sapiensO60341= 9600.0 nMNPASS
Lysine-specific histone demethylase 1AHomo sapiensO603419600 nMBindingDB
MCF7Homo sapiens= 32200.0 nM|= 46250.0 nM|= 42890.0 nM|= 22100.0 nM|= 9800.0 nM|= 19900.0 nM|= 9280.0 nM|= 17100.0 nM|= 68250.0 nM|= 22500.0 nM|= 83100.0 nM|= 2940.0 nM|= 2080.0 nM|= 2030.0 nM|= 29300.0 nM|= 13700.0 nM|= 61710.0 nM|= 88.0 nM|= 41900.0 nMNPASS
MCF7RHomo sapiens= 26200.0 nMNPASS
MDA-MB-157Homo sapiens= 40380.0 nMNPASS
MDA-MB-231Homo sapiens= 15810.0 nM|= 16230.0 nM|= 12000.0 nM|> 10000.0 nM|= 11450.0 nM|= 26500.0 nM|= 75300.0 nM|= 31390.0 nM|= 53510.0 nMNPASS
MDA-MB-453Homo sapiens= 32400.0 nMNPASS
LNCaPHomo sapiens= 13610.0 nM|= 2000.0 nMNPASS
Proto-oncogene tyrosine-protein kinase SrcMus musculusP054802200 nMBindingDB
SW480Homo sapiens= 17940.0 nM|= 15000.0 nMNPASS
RAW264.7Mus musculus= 14700.0 nM|> 100000.0 nM|= 15950.0 nM|= 19100.0 nM|= 800.0 nM|= 3000.0 nM|= 3500.0 nM|= 2200.0 nM|= 11200.0 nM|= 1890.0 nM|= 12300.0 nMNPASS
Thioredoxin reductase 3Homo sapiensQ86VQ639420 nM|41420 nM|40560 nMBindingDB
Thiosulfate sulfurtransferaseHomo sapiensQ1676256000 nM|= 56000.0 nMBindingDB, NPASS
Tissue factorHomo sapiensP1372613 nMBindingDB
Toll-like receptor 9Homo sapiensQ9NR96= 8362.0 nMNPASS
Trichomonas vaginalisTrichomonas vaginalis= 100.0 ug.mL-1NPASS
Trypanosoma bruceiTrypanosoma brucei= 1780.0 nM= 3600.0 nMNPASS
Trypanosoma brucei bruceiTrypanosoma brucei brucei= 3120.0 nMNPASS
Trypanosoma cruziTrypanosoma cruzi= 15000.0 nM= 67300.0 nMNPASS
TyrosinaseHomo sapiensP146795000 nM|= 5000.0 nMBindingDB, NPASS
Tyrosine-protein kinase SRCMus musculusP05480= 2200.0 nMNPASS
Thioredoxin reductaseHomo sapiensQ86VQ6= 39420.0 nM|= 41420.0 nM|= 40560.0 nMNPASS
U-251Homo sapiens= 15260.0 nM|= 25810.0 nMNPASS
U-937Homo sapiens= 1880.0 nMNPASS
U2OSHomo sapiens= 22800.0 nM|= 34400.0 nMNPASS
U373 MGHomo sapiens> 50000.0 nMNPASS
VeroChlorocebus aethiops> 25000.0 nM|= 25000.0 nM|= 17870.0 nM|= 10970.0 nMNPASS
Voltage-dependent L-type calcium channel subunit alpha-1SRattus norvegicusQ02485>100000 nMBindingDB
Voltage-gated L-type calcium channelRattus norvegicusP27732> 100000.0 nMNPASS
WRL68Homo sapiens= 27800.0 nMNPASS
WiDrHomo sapiens= 26820.0 nMNPASS
Y79Homo sapiens= 30000.0 nMNPASS
Histone deacetylase 1Homo sapiensQ1354750790 nM|= 50790.0 nMBindingDB, NPASS
U-87 MGHomo sapiens= 16000.0 nM|= 7150.0 nMNPASS
QGY-7703Homo sapiens= 21440.0 nM|= 23910.0 nM|= 22500.0 nMNPASS
THP-1Homo sapiens= 22540.0 nMNPASS
T47DHomo sapiens= 47910.0 nM|= 19000.0 nM|= 11000.0 nMNPASS
RWPE-1Homo sapiens= 15620.0 nMNPASS
RajiHomo sapiens= 97.0 molar ratioNPASS
Rattus norvegicusRattus norvegicus= 53.4 nMNPASS
Replicase polyprotein 1abHuman SARS coronavirusP0C6X7>10000 nM23500 nM|40000 nMBindingDB
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2P0DTD15100 nMBindingDB
RhodesainTrypanosoma brucei rhodesienseQ95PM0= 7750.0 nMNPASS
SGC-7901Homo sapiens= 26200.0 nM|> 20000.0 nM|= 22500.0 nMNPASS
SH-SY5YHomo sapiens= 5290.0 nM= 16100.0 nMNPASS
SK-BR-3Homo sapiens= 42830.0 nMNPASS
SK-MEL-2Homo sapiens= 36000.0 nMNPASS
T98GHomo sapiens= 10000.0 nM|= 25000.0 nMNPASS
SK-OV-3Homo sapiens= 43630.0 nM|= 6700.0 nMNPASS
SW-620Homo sapiens= 14000.0 nM|> 50000.0 nMNPASS
Sarcoplasmic/endoplasmic reticulum calcium ATP-aseOryctolagus cuniculusP04191= 3000.0 nM= 5800.0 nMNPASS
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculusP041913000 nM5800 nMBindingDB
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Homo sapiensP166157000 nM|= 7000.0 nM53000 nM|= 53000.0 nMBindingDB, NPASS
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3Homo sapiensQ930847000 nM|= 7000.0 nM8600 nM|= 8600.0 nMBindingDB, NPASS
Serine/threonine-protein kinase PAK 1Homo sapiensQ1315316000 nM|= 16000.0 nMBindingDB, NPASS
SortaseStreptococcus mutans10200 nMBindingDB
Sortase AStaphylococcus aureusQ9S446= 37500.0 nMNPASS
Sortase AStreptococcus mutansQ8CM62= 10200.0 nMNPASS
Sortase family proteinStaphylococcus aureus37500 nMBindingDB
SMMC-7721Homo sapiens= 19470.0 nM|= 16680.0 nM|= 12570.0 nM|= 18800.0 nMNPASS
Histone deacetylaseHomo sapiensQ969S8= 187000.0 nMNPASS
Amyloid-beta A4 proteinHomo sapiensP05067= 24400.0 nM|= 8270.0 nM|= 5400.0 nM|> 20000.0 nM|= 3850.0 nM|= 900.0 nM|= 1000.0 nM|= 107.0 nMNPASS
Histone acetyltransferase p300Homo sapiensQ094726500 nM|25000 nM|= 6500.0 nM|= 25000.0 nMBindingDB, NPASS
BT-549Homo sapiens= 24930.0 nMNPASS
BV-2Mus musculus= 520.0 nM|= 1420.0 nM|= 4770.0 nM|= 2360.0 nM|= 4500.0 nM|= 6000.0 nM|= 4000.0 nM|= 3000.0 nM|= 8600.0 nM|= 2690.0 nMNPASS
BXPC-3Homo sapiens= 29000.0 nM|= 18250.0 nMNPASS
Bel-7402Homo sapiens= 6.496 ug.mL-1NPASS
Beta LactamasePseudomonas aeruginosaQ932Y6= 7751.0 nMNPASS
Beta amyloid A4 proteinHomo sapiensP05067= 11300.0 nM|= 3100.0 nM|= 1500.0 nM|= 21810.0 nMNPASS
Beta-secretase 1Homo sapiensP56817343000 nM|= 343000.0 nMBindingDB, NPASS
Bile acid transporterHomo sapiensQ14973= 64300.0 nMNPASS
Bone marrow cell= 7500.0 nMNPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiensQ9UNQ01630 nMBindingDB
ButyrylcholinesteraseHomo sapiensP06276> 5000.0 nMNPASS
CCD-841CoNHomo sapiens= 105110.0 nMNPASS
CDGSH iron-sulfur domain-containing protein 1Homo sapiensQ9NZ452360 nM|= 2360.0 nM101 nM|= 101.0 nMBindingDB, NPASS
CHOCricetulus griseus= 29081.0 nMNPASS
CHO-K1Cricetulus griseus= 21300.0 nMNPASS
COLO 201Homo sapiens= 18000.0 nMNPASS
CREB-binding proteinHomo sapiensQ9279325000 nM|= 25000.0 nMBindingDB, NPASS
CREB-binding protein/Histone acetyltransferase p300Homo sapiensQ09472|Q9279325000 nMBindingDB
CREB-binding protein/Histone acetyltransferase p300Homo sapiens= 25000.0 nMNPASS
CT26Mus musculus= 7700.0 nM|> 20000.0 nMNPASS
Caco-2Homo sapiens= 28000.0 nM|= 47600.0 nMNPASS
BT-474Homo sapiens= 30140.0 nM|= 11000.0 nMNPASS
BGC-823Homo sapiens= 6.806 ug.mL-1|= 19500.0 nM|> 20000.0 nM|= 17500.0 nMNPASS
Arachidonate 5-lipoxygenaseHomo sapiensP09917= 30000.0 nMNPASS
Amyloid-beta precursor proteinHomo sapiensP0506711300 nM|3100 nM|1500 nM|21810 nM|22510 nM|14990 nM|18730 nM|3400 nM|9000 nM|800 nM|10000 nM|6385 nM|16250 nM|3850 nM|8270 nMBindingDB
Histone deacetylaseHomo sapiensO15379|P56524|Q13547|Q8WUI4|Q92769|Q969S8|Q96DB2|Q9BY41|Q9UBN7|Q9UKV0|Q9UQL6187000 nMBindingDB
11-beta-hydroxysteroid dehydrogenase 1Homo sapiensP28845= 2295.0 nMNPASS
11-beta-hydroxysteroid dehydrogenase 1Rattus norvegicusP16232= 5785.0 nMNPASS
11-beta-hydroxysteroid dehydrogenase 2Homo sapiensP80365= 14560.0 nMNPASS
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiensP370591730 nMBindingDB
4T1Mus musculus= 49400.0 nMNPASS
60 kDa chaperoninEscherichia coli (strain K12)P0A6F5> 250000.0 nMNPASS
A-431Homo sapiens> 100000.0 nMNPASS
A2780Homo sapiens= 6.52 ug.mL-1NPASS
A549Homo sapiens= 17300.0 nM|= 60200.0 nM|= 23540.0 nM|= 27800.0 nM|= 6.521 ug.mL-1|= 6800.0 nM|= 18000.0 nM|> 10000.0 nM|= 43900.0 nM|= 23000.0 nM|= 17900.0 nM|= 28000.0 nM|= 25330.0 nM|= 52300.0 nM|= 38120.0 nM|= 24180.0 nM|= 44750.0 nM|= 32500.0 nMNPASS
Casein kinase I epsilonHomo sapiensP49674> 10000.0 nMNPASS
A549/CDDPHomo sapiens= 32390.0 nMNPASS
ATP-binding cassette sub-family G member 2Homo sapiensQ9UNQ0= 1630.0 nMNPASS
AcetylcholinesteraseElectrophorus electricusO42275132130 nM|= 132130.0 nMBindingDB, NPASS
AcetylcholinesteraseHomo sapiensP22303>5000 nM|> 5000.0 nMBindingDB, NPASS
Alkaline phosphatase placental-likeHomo sapiensP10696> 100000.0 nMNPASS
Alkaline phosphatase, tissue-nonspecific isozymeHomo sapiensP05186> 100000.0 nMNPASS
Alpha-glucosidaseSaccharomyces cerevisiae S288cP53341|P38158|P07265= 44800.0 nMNPASS
Alpha-synucleinHomo sapiensP37840220 nM|161800 nM|= 220.0 nM|= 161800.0 nM|= 3300.0 nM500 nM|2000 nM|5000 nM|6500 nM|= 500.0 nM|= 2000.0 nM|= 5000.0 nM|= 6500.0 nMBindingDB, NPASS
Amine oxidase [flavin-containing] AHomo sapiensP213975020 nM710 nMBindingDB
Amine oxidase [flavin-containing] BHomo sapiensP273382560 nM21500 nMBindingDB
Aminopeptidase NHomo sapiensP1514415500 nM|= 15500.0 nMBindingDB, NPASS
AGSHomo sapiens= 9770.0 nM|= 20760.0 nMNPASS
Chaperonin GroELEscherichia coli>250000 nMBindingDB
60 kDa heat shock protein, mitochondrialHomo sapiensP108098300 nMBindingDB
CholinesteraseHomo sapiensP06276>5000 nMBindingDB
HepG2Homo sapiens= 50000.0 nM|= 4430.0 nM|= 52300.0 nM|= 10000.0 nM|= 13780.0 nM|= 16010.0 nM|= 17370.0 nM|= 20300.0 nM|= 9440.0 nM|= 36770.0 nM|= 22750.0 nM|= 17300.0 nM|= 27230.0 nMNPASS
Glycogen synthase kinase-3 betaHomo sapiensP4984117950 nM|= 17950.0 nM|> 10000.0 nM> 10000.0 nMBindingDB, NPASS
Glycogen synthase kinase-3 betaRattus norvegicusP1826666 nM|= 66.0 nMBindingDB, NPASS
Glyoxalase IHomo sapiensQ04760= 5.0 nMNPASS
GroEL/GroESEscherichia coli= 2900.0 nM|= 3100.0 nMNPASS
H9c2Rattus norvegicus> 79000.0 nMNPASS
CholinesteraseEquus caballusP81908>300000 nM|> 300000.0 nMBindingDB, NPASS
HCT-8Homo sapiens= 6.278 ug.mL-1NPASS
HEK-293THomo sapiens> 400000.0 nMNPASS
HEK293Homo sapiens> 400000.0 nM|= 94100.0 nMNPASS
Glutathione-S-transferaseSchistosoma japonicumQ26513> 20000.0 nMNPASS
HEp-2Homo sapiens= 21370.0 nMNPASS
HSC-2Homo sapiens= 7800.0 nM|= 3100.0 nMNPASS
HSC-3Homo sapiens= 11000.0 nMNPASS
HSC-4Homo sapiens= 7100.0 nMNPASS
HSP60/HSP10Homo sapiens= 8300.0 nMNPASS
HT-1080Homo sapiens= 13100.0 nM|= 10000.0 nM|= 21920.0 nMNPASS
HT-22Mus musculus= 52400.0 nMNPASS
HT-29Homo sapiens= 14000.0 nM|= 20730.0 nM|= 132370.0 nM|= 23400.0 nM|= 18740.0 nMNPASS
HaCaTHomo sapiens= 13000.0 nMNPASS
HeLaHomo sapiens= 21800.0 nM|= 12110.0 nM|= 51870.0 nM|= 25410.0 nM|= 31890.0 nM|= 8200.0 nM|= 4330.0 nM|= 14030.0 nM|= 5390.0 nM|= 3570.0 nM|= 3560.0 nM|= 32400.0 nMNPASS
Hep 3B2Homo sapiens= 10000.0 nMNPASS
HL-60Homo sapiens= 6300.0 nMNPASS
Glutathione S-transferase PHumanP092116.9e+4 nMBindingDB
HCT-116Homo sapiens= 13770.0 nM|= 10910.0 nM|= 50000.0 nM|>= 5510.0 nM|= 10500.0 nM|= 3830.0 nM|= 2670.0 nM|= 2400.0 nM|= 10000.0 nM|= 34700.0 nMNPASS
GES1Homo sapiens= 29100.0 nMNPASS
Co-chaperonin GroESEscherichia coli2900 nM|3100 nMBindingDB
Coagulation factor IIIHomo sapiensP13726= 13.16 nMNPASS
Colon 26Mus musculus= 30340.0 nMNPASS
Glutathione S-transferase Mu 2Homo sapiensP28161= 1810.0 nMNPASS
CyclooxygenaseBos taurusO62698= 2000.0 nMNPASS
Cysteine proteaseTrypanosoma brucei rhodesiense7750 nMBindingDB
D-amino-acid oxidaseSus scrofaP00371= 1070.0 nMNPASS
DLD-1Homo sapiens> 40000.0 nM|= 145500.0 nM|= 10000.0 nMNPASS
DU-145Homo sapiens= 28410.0 nM|= 26230.0 nM|= 33150.0 nM|= 2000.0 nM|= 33120.0 nM|= 31700.0 nM|= 41000.0 nMNPASS
Dengue virus 2Dengue virus 2= 11510.0 nMNPASS
Dual specificity protein kinase CLK1Homo sapiensP49759= 4921.0 nM|> 10000.0 nM> 1000.0 nMNPASS
Cyclin-dependent kinase 5/CDK5 activator 1Homo sapiensQ00535|Q15078> 10000.0 nMNPASS
Dual specificity protein kinase CLK3Homo sapiensP49761> 10000.0 nMNPASS
Dual specificity protein kinase CLK4Homo sapiensQ9HAZ1= 9749.0 nMNPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiensQ9Y463> 10000.0 nM|= 147.7 nMNPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 4Homo sapiensQ9NR20> 10000.0 nMNPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 1AHomo sapiensQ13627> 10000.0 nM|= 300.0 nM> 1000.0 nMNPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 2Homo sapiensQ92630= 1058.0 nM|= 2.5 nM|= 5.0 nMNPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 3Homo sapiensO43781= 4264.0 nMNPASS
EA.hy 926Homo sapiens= 20000.0 nMNPASS
Epidermal growth factor receptorHomo sapiensP005338650 nMBindingDB
Estradiol 17-beta-dehydrogenase 2Homo sapiensP37059= 1730.0 nMNPASS
Dual specificity protein kinase CLK2Homo sapiensP49760> 10000.0 nMNPASS