IMPPAT Phytochemical information: 
Vincristine
Vincristine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
NCI/ADR-RESHomo sapiens= 2930.0 ug.mL-1|= 10050.0 nMNPASS
P-glycoprotein 1Homo sapiensP08183= 213000.0 nMNPASS
OVCAR-3Homo sapiens= 20.0 nMNPASS
P388/ADRMus musculus= 4.5 nM|= 299.0 nMNPASS
OE33Homo sapiens= 30.0 nMNPASS
OE19Homo sapiens= 50.0 nMNPASS
NON-PROTEIN TARGET= 366.6 nM|= 60.88 nM|> 1.0 nM= 0.025 ug.mL-1|= 58.0 nM|= 2035.0 nM|= 100.0 nM|= 9.3 nM|= 5300.0 nM|> 100.0 nM|= 90.0 nM|= 895.0 nM|= 311.0 nM|= 1335.0 nM|= 1200.0 nM|= 0.0007 ug.mL-1|= 5720.0 nM|= 5.4 nM|= 20.0 nM|= 1.37 ug.mL-1|= 840.0 nM|= 1483.48 nM|= 1489.58 nM|= 100000.0 nM|= 90.1 nM|= 1.2 nM|= 17.6 nM|= 12.7 nM|= 21.2 nM|= 7.2 nM|= 28.2 nM|= 22.1 nM|= 35.9 nM|= 303.2 nM|= 80.0 nM|= 96.4 nM|= 2.1 nM|= 1.5 nM|= 5.4 ug.mL-1|= 570.0 nM|= 1900.0 nM|= 0.87 nM|= 387.43 nM|= 7500.0 nM|= 350.0 nM|= 168.0 nM|= 7860.0 nM|= 561.0 nM|= 1261.0 nM|= 900.0 nM|= 300.0 nM|= 1300.0 nM|= 800.0 nM|= 4100.0 nM|= 4.0 nM|= 926.0 nM|= 36.0 nM|= 871.0 nM|= 29.0 nM|= 10.0 nMNPASS
P388Mus musculus= 20.0 nM= 4.7 nM|= 190.0 nM|= 2.0 nM|= 2.2 nM|= 1.2 nMNPASS
NCI-H460Homo sapiens= 0.13 nMNPASS
MIA PaCa-2Homo sapiens= 15.0 nMNPASS
NCI-H292= 0.04 ug.mL-1NPASS
NCI-H157Homo sapiens= 1030.0 nMNPASS
Multidrug resistance-associated protein 1Homo sapiensP3352770000 nM|= 70000.0 nMBindingDB, NPASS
MX1Homo sapiens= 75.0 nM|= 12.0 nMNPASS
MOLT-4Homo sapiens= 0.00063 ug.mL-1NPASS
MKN-28Homo sapiens= 7100.0 nMNPASS
MES-SA/DxSHomo sapiens= 0.02 nMNPASS
MDA-MB-435Homo sapiens= 26.0 nM|= 0.63 nM|= 0.29 nM|= 20.0 nMNPASS
PA-1Homo sapiens= 0.01 ug.mL-1|= 1.0 ug.mL-1NPASS
MDA-MB-231Homo sapiens= 4.5 nM|= 6.0 nM|= 15.0 nM|= 1.6 nM|= 20.0 nM|= 9860.0 nMNPASS
NCI-H295RHomo sapiens= 90.0 nMNPASS
PC-3Homo sapiens= 70.0 nM|> 25000.0 nM|= 5310.0 nMNPASS
Tubulin alpha-1A chainPigP02550680 nMBindingDB
Plasmodium falciparumPlasmodium falciparum= 1.0 nMNPASS
MCF7Homo sapiens= 0.84 nM|= 20.0 nM|= 0.15 ug.mL-1|= 0.05 ug.mL-1|= 0.6 nM|= 2.0 nM|= 13.0 nM|= 4300.0 nM|= 98.0 nM|= 890.0 nM|= 920.0 nMNPASS
ZR-75-1Homo sapiens= 40.0 nMNPASS
WRL68Homo sapiens= 1.42 ug.mL-1|= 8.5 ug.mL-1NPASS
VeroChlorocebus aethiops= 1.1 ug.mL-1NPASS
Tubulin alpha-1A chainSus scrofaP02550220 nMBindingDB
Tubulin alpha chainSus scrofaP02550= 220.0 nMNPASS
TubulinHomo sapiensQ9BUF5= 500.0 nMNPASS
TubulinBos taurusQ862F3= 1800.0 nMNPASS
Trypanosoma brucei bruceiTrypanosoma brucei brucei= 30.0 nMNPASS
PT-45Homo sapiens= 4.0 nMNPASS
T47DHomo sapiens= 43.0 nMNPASS
Solute carrier organic anion transporter family member 1B1Homo sapiensQ9Y6L644000 nM|= 44000.0 nM42000 nM|= 42000.0 nMBindingDB, NPASS
Similar to alpha-tubulin isoform 1Bos taurus1800 nMBindingDB
SNU-475Homo sapiens= 29.3 nMNPASS
SNU-449Homo sapiens> 100.0 nMNPASS
SNU-423Homo sapiens= 10.0 nM|= 18.4 nMNPASS
SNU-398Homo sapiens= 12.0 nM= 46.7 nM|< 0.13 nMNPASS
SNU-387Homo sapiens= 40.9 nMNPASS
SMMC-7721Homo sapiens< 120.0 nM|= 20.74 ug.mL-1|= 52210.0 nM|= 6.5 nM|= 3.0 nM|= 10.3 nM|= 270.0 nMNPASS
Reverse transcriptaseHuman immunodeficiency virus 1>242000 nMBindingDB
Solute carrier organic anion transporter family member 1B3Homo sapiensQ9NPD536780 nM|11000 nM|= 11000.0 nM|= 36780.0 nM17600 nM|9800 nM|= 9800.0 nM|= 17600.0 nMBindingDB, NPASS
LNCaPHomo sapiens= 2600.0 nMNPASS
Beta tubulinLeishmadonovaniQ25270< 1000.0 nMNPASS
L02Homo sapiens= 200.0 nM|= 60.0 nM|= 300.0 nMNPASS
CCRF-CEMHomo sapiens= 597.2 nM= 0.025 ug.mL-1|= 0.06 ug.mL-1|= 0.17 nM|= 2.32 nM|= 2128.0 nM|= 2.13 nM|= 3.0 nMNPASS
Bile salt export pumpHomo sapiensO95342>133000 nMBindingDB
Bel-7402Homo sapiens= 40.0 nM|= 4.2 nMNPASS
BXPC-3Homo sapiens> 500.0 nMNPASS
BNLMus musculus= 80.0 nMNPASS
BHK-21Cricetulus griseus= 1.51 nM|= 9.42 nM|= 1080.0 nMNPASS
BGC-823Homo sapiens= 0.066 ug.mL-1NPASS
B16Mus musculus= 500.0 nMNPASS
Agrobacterium tumefaciensAgrobacterium tumefaciens= 0.003 ppmNPASS
ATP-dependent translocase ABCB1Homo sapiensP08183213000 nMBindingDB
ATP-binding cassette sub-family C member 3Homo sapiensO15438>133000 nMBindingDB
ATP-binding cassette sub-family C member 2Homo sapiensQ92887>133000 nM802000 nMBindingDB
AROHomo sapiens= 0.1 nM|= 0.3 nMNPASS
AGSHomo sapiens< 120.0 nMNPASS
A549Homo sapiens= 18.0 nM|= 30.0 nM|= 40.0 nM|= 360.0 nM|= 2500.0 nM|= 53.0 nM|= 56.0 nM|= 36.83 nM|= 61.0 nM|= 560.0 nM|= 60.0 nMNPASS
A2780Homo sapiens= 3.4 nM|= 3.9 nM= 0.9 nM|= 3.1 nM|= 930.0 nM|= 26.0 nM|= 30.0 nM|= 170.0 nMNPASS
786-0Homo sapiens= 37.0 nM|= 1.2 nMNPASS
4T1Mus musculus= 20.0 nMNPASS
L1210Mus musculus= 3.4 nM|= 4.85 nM|= 0.73 nM|= 6.0 nMNPASS
COLO 205Homo sapiens= 2.6 nMNPASS
COLO 320DMHomo sapiens= 0.46 ug.mL-1|= 1.5 ug.mL-1NPASS
ATP-binding cassette sub-family C member 4Homo sapiensO15439>133000 nMBindingDB
DU-145Homo sapiens= 1.12 nM|= 8.5 nMNPASS
Canalicular multispecific organic anion transporter 1Homo sapiensQ92887= 802000.0 nMNPASS
KB/VJ300Homo sapiens= 5900.0 nM|= 3900.0 nM|= 800.0 nM|= 6600.0 nM|= 2600.0 nMNPASS
KB-V1Homo sapiens= 8571.0 nMNPASS
KB 3-1Homo sapiens= 1230.48 nMNPASS
KBHomo sapiens= 0.014 ug.mL-1|= 1.05 ug.mL-1|= 1.0 nM|= 350.0 nM|= 50.0 nM|= 35.0 nM|= 5.0 nM|= 4.0 nM|= 1000.0 nM|= 200.0 nM|= 0.02 ug.mL-1|= 0.25 ug.mL-1|= 2.2 nM|= 6.0 nM|= 16.7 nM|= 2.8 nM|= 7.9 nM|= 0.4 nM|= 90.1 nM|= 17.6 nM|= 1.2 nM|= 10.0 nM|= 6.07 nM|> 25.0 ug.mL-1|= 20.0 nM|= 1290.0 nM|= 3.0 nM|= 1610.0 nM|= 2.11 nM|> 100000.0 nM|= 139.0 nM|= 0.6 nM|= 0.9 nM|= 0.007 ug.mL-1|= 3.3 nM|= 0.72 nM|= 0.2 nM|= 0.65 nM|= 0.46 ug.mL-1|= 0.21 nM|= 0.8 nM|= 800.0 nM|= 6.7 nMNPASS
K562/VCRHomo sapiens= 4737.0 nM|= 5060.0 nM|= 4730.0 nMNPASS
K562Homo sapiens= 6.0 nM|= 0.1 nM|= 178.0 nM|= 5360.0 nM|= 21.0 nMNPASS
JurkatHomo sapiens= 0.0031 ug.mL-1NPASS
Human immunodeficiency virus type 1 reverse transcriptaseHuman immunodeficiency virus 1Q72547> 200.0 ug.mL-1NPASS
HepG2Homo sapiens= 200.0 nM|= 3700.0 nM|> 100.0 nM|= 210.0 nM|= 70.0 nM|= 0.042 ug.mL-1|= 93670.0 nMNPASS
Huh-7Homo sapiens= 20.0 nMNPASS
HeLaHomo sapiens= 0.014 ug.mL-1|= 0.051 ug.mL-1|= 5.0 nM|= 0.05 ug.mL-1|= 4.3 nM|= 15.0 nM|= 40.0 nMNPASS
HaCaTHomo sapiens= 650.0 nMNPASS
HT-29Homo sapiens= 0.01 nM|= 1.0 nM|= 17.0 nM|= 2.06 nM|= 10.0 nM|= 210.0 nM|= 7.0 nM|= 5300.0 nM|= 12.0 nM|= 1740.0 nMNPASS
HL-60Homo sapiens= 0.87 nM|= 60.0 nM|= 1800.0 nM|= 0.008 ug.mL-1NPASS
HEp-2Homo sapiens= 0.003 ug.mL-1NPASS
HELHomo sapiens= 5970.0 nMNPASS
HEK-293THomo sapiens= 94950.0 nMNPASS
HCT-8Homo sapiens= 173.0 nM|= 350.0 nM|= 7860.0 nM|= 217.0 nMNPASS
HCT-116Homo sapiens= 58.0 nM= 7.0 nMNPASS
HeLa S3Homo sapiens< 40000.0 nMNPASS