IMPPAT Phytochemical information: 
Omacetaxine mepesuccinate
Omacetaxine mepesuccinate
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
MOLT-4Homo sapiens= 7.0 nMNPASS
MV4-11Homo sapiens= 5.0 nMNPASS
NCI-H1299Homo sapiens= 22.0 nMNPASS
NCI-H1975Homo sapiens= 22.0 nMNPASS
NCI-H716Homo sapiens= 65.0 nMNPASS
NON-PROTEIN TARGET= 510.0 nM|= 20.0 nMNPASS
OCI-Ly3Homo sapiens= 5.0 nMNPASS
Orf1a proteinMERS-CoV71 nMBindingDB
P388Mus musculus= 0.017 ug.mL-1NPASS
Reverse transcriptaseHuman immunodeficiency virus 1>366000 nMBindingDB
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2= 60.0 nM|= 2100.0 nM= 4710.0 nM|> 20000.0 nM|> 19952.62 nMNPASS
U-937Homo sapiens= 12.0 nMNPASS
MDA-MB-453Homo sapiens= 21.0 nMNPASS
HL-60Homo sapiens= 22.0 nM|= 21.8 nM|= 13.0 nMNPASS
L02Homo sapiens= 64.0 nMNPASS
KBHomo sapiens= 4.0 nMNPASS
K562Homo sapiens= 0.04389 ug.mL-1|= 21.0 nM|= 14.0 nMNPASS
Human immunodeficiency virus type 1 reverse transcriptaseHuman immunodeficiency virus 1Q72547> 200.0 ug.mL-1NPASS
Huh-7Homo sapiens= 40.0 nMNPASS
HepG2Homo sapiens= 34.5 nMNPASS
HeLaHomo sapiens= 400.0 nM|= 1700.0 nMNPASS
HCT-116Homo sapiens= 13.0 nMNPASS
BaF3Mus musculus= 81.0 nMNPASS
A549Homo sapiens= 30.0 nM|= 31.6 nMNPASS
A204Homo sapiens= 4.0 nMNPASS
4T1Mus musculus= 60.0 nMNPASS
MCF7Homo sapiens= 0.87 nMNPASS