IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
No relevant target				= 0.4 ug.mL-1			NPASS
PC-3	Homo sapiens			> 10000.0 nM			NPASS
Polyphenol oxidase 2	Agaricus bisporus	O42713		250000 nM			BindingDB
Proto-oncogene c-JUN	Homo sapiens	P05412		= 16200.0 nM			NPASS
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens	P12931		26000 nM			BindingDB
RAW264.7	Mus musculus			= 34200.0 nM			NPASS
Radical scavenging activity			= 8000.0 nM				NPASS
Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	K9N7C7		> 10000.0 nM			NPASS
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1		= 3860.0 nM			NPASS
Reverse transcriptase	Human immunodeficiency virus 1			100000 nM			BindingDB
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM\|= 0.02547 ug.mL-1			NPASS
SH-SY5Y	Homo sapiens			> 10000.0 nM			NPASS
Estradiol 17-beta-dehydrogenase 2	Homo sapiens	P37059		= 3720.0 nM			NPASS
Transthyretin	Homo sapiens	P02766	8600 nM\|= 8600.0 nM				BindingDB, NPASS
Tyrosinase	Agaricus bisporus	O42713		= 250000.0 nM			NPASS
Tyrosine-protein kinase FYN	Homo sapiens	P06241		= 1300.0 nM\|= 3600.0 nM\|= 17000.0 nM\|= 36000.0 nM\|= 74000.0 nM\|= 63000.0 nM		= 7500.0 nM\|= 10200.0 nM	NPASS
Tyrosine-protein kinase Fyn	Homo sapiens	P06241		1300 nM\|36000 nM\|3600 nM\|63000 nM\|74000 nM\|17000 nM		10200 nM\|7500 nM	BindingDB
Tyrosine-protein kinase Fyn	Human	P06241		1300 nM			BindingDB
Tyrosine-protein kinase LCK	Homo sapiens	P06239		= 24000.0 nM\|= 55000.0 nM			NPASS
Tyrosine-protein kinase Lck	Homo sapiens	P06239		24000 nM\|55000 nM			BindingDB
Tyrosine-protein kinase SRC	Homo sapiens	P12931		= 26000.0 nM			NPASS
UDP-galactopyranose mutase	Klebsiella pneumo	Q48485			69000 nM\|= 69000.0 nM		BindingDB, NPASS
UDP-galactopyranose mutase	Mycobacterium tuberculosis	P9WIQ1			= 653000.0 nM		NPASS
UDP-galactopyranose mutase	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	P9WIQ1			653000 nM		BindingDB
NON-PROTEIN TARGET			= 3.1 ug.mL-1	= 1810.0 nM			NPASS
Transcription factor Jun	Homo sapiens	P05412		16200 nM			BindingDB
Mus musculus	Mus musculus			= 150.0 nM			NPASS
Alpha-synuclein	Homo sapiens	P37840		210 nM\|= 210.0 nM			BindingDB, NPASS
MV4-11	Homo sapiens			> 10000.0 nM			NPASS
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens	P37059		3720 nM			BindingDB
72 kDa type IV collagenase	Rattus norvegicus	P33436		27200 nM\|= 27200.0 nM			BindingDB, NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		3910 nM			BindingDB
Aldo-keto reductase family 1 member B1	Rattus norvegicus	P07943		3890 nM			BindingDB
Aldose reductase	Homo sapiens	P15121		= 3910.0 nM			NPASS
Aldose reductase	Rattus norvegicus	P07943		= 3890.45 nM			NPASS
Matrix metalloproteinase-1	Homo sapiens	P03956		= 5600.0 nM			NPASS
Amyloid-beta precursor protein	Homo sapiens	P05067	20300 nM\|57200 nM\|68100 nM	71900 nM			BindingDB
Bifunctional protein glmU	Mycobacterium tuberculosis	P9WMN3		= 84940.0 nM			NPASS
HT-22	Mus musculus		= 86000.0 nM				NPASS
HeLa	Homo sapiens			= 960.0 nM			NPASS
Beta amyloid A4 protein	Homo sapiens	P05067	= 68100.0 nM\|= 57200.0 nM	= 71900.0 nM			NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 9000.0 nM\|= 4000.0 nM\|= 63500.0 nM\|= 550.0 nM			NPASS
MOLM-14	Homo sapiens			= 7100.0 nM			NPASS
MOLM-13	Homo sapiens			= 2900.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		> 55000.0 nM				NPASS
Lysine-specific histone demethylase 1	Homo sapiens	O60341		= 20930.0 nM			NPASS
Linoleate 9S-lipoxygenase-4	Glycine max	P38417		1150000 nM			BindingDB
Lysine-specific histone demethylase 1A	Homo sapiens	O60341		20930 nM			BindingDB
Integrase	Human immunodeficiency virus 1			4000 nM\|9000 nM\|63500 nM\|550 nM			BindingDB
Induced myeloid leukemia cell differentiation protein Mcl-1	Homo sapiens	Q07820		2025.721712 nM\|= 2025.72 nM			BindingDB, NPASS
Hyaluronidase-1	Homo sapiens	Q12794		545000 nM\|= 545000.0 nM			BindingDB, NPASS
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		= 100000.0 nM			NPASS
Interstitial collagenase	Homo sapiens	P03956		5600 nM			BindingDB

a curated database

IMPPAT Phytochemical information:
Rosmarinic acid

Bioactivity information

IMPPAT Phytochemical information: Rosmarinic acid

Bioactivity information

IMPPAT Phytochemical information:
Rosmarinic acid