IMPPAT Phytochemical information: 
Indolo[2,1-b]quinazoline-6,12-dione
Indolo[2,1-b]quinazoline-6,12-dione
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Nerve growth factor receptor Trk-AHomo sapiensP04629= 9200.0 nMNPASS
Neurotrophic tyrosine kinase receptor type 2Homo sapiensQ16620= 7200.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 211.7 nM|= 275.6 nM= 288.0 nM|= 0.069 ug.mL-1|= 114.0 nMNPASS
Plasmodium yoeliiPlasmodium yoelii= 225.1 nMNPASS
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiensP09917200000 nM|150 nMBindingDB
Prostaglandin G/H synthase 2Homo sapiensP3535464 nMBindingDB
Protein RecAMycobacterium tuberculosisP9WHJ3= 643.0 nMNPASS
T47DHomo sapiens= 14290.0 nMNPASS
SH-SY5YHomo sapiens= 22000.0 nMNPASS
SK-N-DZHomo sapiens= 14000.0 nMNPASS
Tryptophan 2,3-dioxygenaseHomo sapiensP48775900 nM|194 nM|3940 nM|140 nM|= 900.0 nM|= 3940.0 nM|= 194.0 nM|= 140.0 nM581 nM|= 581.0 nMBindingDB, NPASS
U-937Homo sapiens= 3.1 ug.mL-1NPASS
VeroChlorocebus aethiops> 8.0 ug.mL-1|> 100.0 ug.mL-1NPASS
c-Jun N-terminal kinase 1Homo sapiensP45983= 23000.0 nMNPASS
NCI-H460Homo sapiens= 9000.0 nMNPASS
SF-268Homo sapiens= 24400.0 nMNPASS
Mitogen-activated protein kinase 8Homo sapiensP4598323000 nMBindingDB
Indoleamine 2,3-dioxygenase 2Homo sapiensQ6ZQW017300 nM|5000 nM|= 5000.0 nM|= 17300.0 nM15200 nM|= 15200.0 nMBindingDB, NPASS
MCF7Homo sapiens= 11100.0 nM|= 580.0 nMNPASS
MOLT-4Homo sapiens= 8000.0 nM|= 10000.0 nMNPASS
Arachidonate 5-lipoxygenaseHomo sapiensP09917= 150.0 nM|= 200000.0 nMNPASS
BDNF/NT-3 growth factors receptorHomo sapiensQ166207200 nMBindingDB
CCRF-CEMHomo sapiens= 44360.0 nMNPASS
Cyclooxygenase-2Homo sapiensP35354= 64.0 nMNPASS
DU-145Homo sapiens= 6220.0 nMNPASS
HCT-15Homo sapiens= 8490.0 nMNPASS
HEK293Homo sapiens= 4110.0 nMNPASS
A-431Homo sapiens= 9000.0 nMNPASS
HepG2Homo sapiens= 0.3054 ug.mL-1NPASS
High affinity nerve growth factor receptorHomo sapiensP046299200 nMBindingDB
Histone deacetylase 6Homo sapiensQ9UBN7= 3286.0 nMNPASS
Indoleamine 2,3-dioxygenaseHomo sapiensP14902= 53.7 nM|= 7150.0 nM|= 498700.0 nM= 4810.0 nMNPASS
Indoleamine 2,3-dioxygenase 1Homo sapiensP149025500 nM|498700 nM|54 nM|7150 nM4810 nMBindingDB
K562Homo sapiens= 5000.0 nM|= 15000.0 nM|= 8.8 ug.mL-1|= 6.3 ug.mL-1NPASS
HL-60Homo sapiens= 2000.0 nM|= 5000.0 nMNPASS