IMPPAT Phytochemical information: 
(1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
(1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
11-beta-hydroxysteroid dehydrogenase 1Homo sapiensP2884570901 nM|257 nM|= 70901.0 nM|= 257.0 nMBindingDB, NPASS
NCI-H460Homo sapiens= 1530.0 nMNPASS
NON-PROTEIN TARGET= 3700.0 nM|= 830.0 nM|= 1990.0 nM|= 18380.0 nM|= 36290.0 nMNPASS
Nuclear factor NF-kappa-B complexHomo sapiensQ04206= 1800.0 nMNPASS
Nuclear factor erythroid 2-related factor 2Homo sapiensQ16236900 nM|9900 nM|= 900.0 nM|= 9900.0 nMBindingDB, NPASS
OVCAR-3Homo sapiens= 2200.0 nMNPASS
PANC-1Homo sapiens= 4620.0 nMNPASS
PBMCHomo sapiens= 34700.0 nM|= 46.9 ug.mL-1NPASS
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiensP099175200 nM|800 nMBindingDB
Radical scavenging activity= 257350.0 nMNPASS
Signal transducer and activator of transcription 3Homo sapiensP407636000 nM|= 6000.0 nMBindingDB, NPASS
Staphylococcus aureusStaphylococcus aureus= 141.0 ug.mL-1|= 111.3 ug.mL-1|= 133.4 ug.mL-1|= 123.8 ug.mL-1|= 184.9 ug.mL-1|= 202.4 ug.mL-1|= 194.7 ug.mL-1|= 303.1 ug.mL-1NPASS
Tissue factorHomo sapiensP13726>200 nMBindingDB
Trypanosoma bruceiTrypanosoma brucei= 840.0 nMNPASS
TyrosinaseHomo sapiensP14679>250000 nM|> 250000.0 nMBindingDB, NPASS
UACC-62Homo sapiens= 90.0 nMNPASS
VeroChlorocebus aethiops= 5.7 ug.mL-1NPASS
n.a.> 500000.0 nMNPASS
MDA-MB-231Homo sapiens= 2800.0 nMNPASS
MCF7Homo sapiens= 2400.0 nM|= 120.0 nM|= 22530.0 nMNPASS
PC-3Homo sapiens= 2400.0 nM|= 3900.0 nM|= 1250.0 nM|= 4200.0 nMNPASS
LNCaPHomo sapiens= 1400.0 nM|= 2700.0 nM|= 10000.0 nMNPASS
LS174THomo sapiens= 3700.0 nMNPASS
Arachidonate 5-lipoxygenaseHomo sapiensP09917= 800.0 nM|= 5200.0 nMNPASS
B16-F10Mus musculus= 21470.0 nMNPASS
CNEHomo sapiens= 6800.0 nMNPASS
Ca-SkiHomo sapiens= 1030.0 nMNPASS
Coagulation factor IIIHomo sapiensP13726> 200.0 nMNPASS
Cytochrome P450 1A2Homo sapiensP0517741500 nM|= 41500.0 nM|= 41495404.26 nMBindingDB, NPASS
Cytochrome P450 2D6Homo sapiensP10635600 nM|= 600.0 nM|= 599791.08 nMBindingDB, NPASS
Escherichia coliEscherichia coli> 1000.0 ug.mL-1NPASS
11-beta-hydroxysteroid dehydrogenase 1Rattus norvegicusP1623216077 nM|292 nM|= 16077.0 nM|= 292.0 nMBindingDB, NPASS
HT-29Homo sapiens= 2300.0 nM|= 2940.0 nMNPASS
HUVECHomo sapiens= 400.0 nMNPASS
HeLaHomo sapiens= 1030.0 nMNPASS
Human immunodeficiency virus type 1 integraseHuman immunodeficiency virus 1Q7ZJM1= 37000.0 nM|= 37153.52 nMNPASS
IntegraseHuman immunodeficiency virus 137000 nM|37154 nMBindingDB
K562Homo sapiens= 1840.0 nMNPASS
L1210Mus musculus= 56100.0 nMNPASS
GCIYHomo sapiens= 7320.0 nMNPASS