IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Serotonin 1a (5-HT1a) receptor	Rattus norvegicus	P19327		= 11.0 nM		= 7.8 nM\|= 20.0 nM\|= 69.0 nM\|= 5.495 nM\|= 10.0 nM\|= 11.0 nM	NPASS
Serotonin 1a (5-HT1a) receptor	Homo sapiens	P08908	= 197.0 nM	= 15.0 nM		= 28.0 nM	NPASS
Serotonin 1 (5-HT1) receptor	Rattus norvegicus	P28565			= 83.18 nM	= 50.0 nM	NPASS
Serotonin (5-HT) receptor	Rattus norvegicus	P28565			= 83.18 nM		NPASS
Serotonin (5-HT) receptor	Homo sapiens	Q8WXA8			= 79.43 nM		NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Rattus norvegicus	Rattus norvegicus				= 83.18 nM		NPASS
Nischarin	Homo sapiens	Q9Y2I1				2498.000000 nM	BindingDB
Melatonin receptor 1A	Homo sapiens	P48039	= 257.0 nM			= 210.0 nM	NPASS
Muscarinic acetylcholine receptor M5	Homo sapiens	P08912				>10000 nM	BindingDB
Muscarinic acetylcholine receptor M4	Homo sapiens	P08173				>10000 nM	BindingDB
Muscarinic acetylcholine receptor M3	Homo sapiens	P20309				>10000 nM	BindingDB
Muscarinic acetylcholine receptor M2	Homo sapiens	P08172				>10000 nM	BindingDB
Muscarinic acetylcholine receptor M1	Homo sapiens	P11229				>10000 nM	BindingDB
Melatonin receptor type 1B	Homo sapiens	P49286	112 nM			16 nM	BindingDB
Melatonin receptor type 1A	Homo sapiens	P48039	257 nM			210 nM	BindingDB
Melatonin receptor 1B	Homo sapiens	P49286	= 112.0 nM			= 16.0 nM	NPASS
Serotonin 1b (5-HT1b) receptor	Homo sapiens	P28222		= 550.0 nM			NPASS
Serotonin 1b (5-HT1b) receptor	Rattus norvegicus	P28564				= 350.0 nM\|= 90.0 nM	NPASS
Serotonin 6 (5-HT6) receptor	Homo sapiens	P50406				= 16.0 nM\|= 78.0 nM\|= 13.0 nM\|= 70.0 nM	NPASS
Serotonin 1d (5-HT1d) receptor	Homo sapiens	P28221		= 49.0 nM		= 20.0 nM	NPASS
Voltage-dependent calcium channel subunit alpha-2/delta-1	Homo sapiens	P54289				>10000 nM	BindingDB
Sphingosine 1-phosphate receptor 3	Homo sapiens	Q99500	>40000 nM				BindingDB
Sodium-dependent serotonin transporter	Homo sapiens	P31645		7020 nM		2032.000000 nM	BindingDB
Sodium-dependent noradrenaline transporter	Homo sapiens	P23975				2859.000000 nM	BindingDB
Sodium-dependent dopamine transporter	Homo sapiens	Q01959				>10000 nM	BindingDB
Sigma non-opioid intracellular receptor 1	Homo sapiens	Q99720				>10000 nM	BindingDB
Sigma intracellular receptor 2	Homo sapiens	Q5BJF2				>10000 nM	BindingDB
Serotonin 7 (5-HT7) receptor	Rattus norvegicus	P32305				= 39.81 nM	NPASS
Serotonin 7 (5-HT7) receptor	Homo sapiens	P34969				= 30.0 nM	NPASS
Serotonin 2c (5-HT2c) receptor	Rattus norvegicus	P08909	= 77.8 nM	= 250.0 nM		= 960.0 nM	NPASS
Serotonin 2c (5-HT2c) receptor	Homo sapiens	P28335	= 36.31 nM\|= 30.7 nM	= 250.0 nM		= 42.0 nM	NPASS
Serotonin 2b (5-HT2b) receptor	Rattus norvegicus	P30994	= 240.0 nM		= 83.18 nM		NPASS
Serotonin 2b (5-HT2b) receptor	Homo sapiens	P41595	= 8.128 nM\|= 5.87 nM			= 52.0 nM	NPASS
Serotonin 2a (5-HT2a) receptor	Rattus norvegicus	P14842	= 462.0 nM	= 9.53 nM		= 1600.0 nM\|= 92.0 nM	NPASS
Serotonin 2a (5-HT2a) receptor	Homo sapiens	P28223	= 1.76 nM\|= 2.239 nM\|= 1.85 nM			= 620.0 nM\|= 15.0 nM	NPASS
Serotonin 2 (5-HT2) receptor	Rattus norvegicus	P14842		= 1900.0 nM\|= 60.0 nM\|= 130.0 nM\|= 1800.0 nM		= 620.0 nM\|= 15.0 nM\|= 1200.0 nM\|= 390.0 nM	NPASS
Serotonin 2 (5-HT2) receptor	Rattus norvegicus	P08909\|P14842\|P30994		130 nM\|1800 nM\|1900 nM\|60 nM		15 nM\|620 nM\|390 nM\|1200 nM	BindingDB
Serotonin 1d (5-HT1d) receptor	Cavia porcellus	Q60484		= 49.0 nM			NPASS
Histamine H2 receptor	Homo sapiens	P25021				>10000 nM	BindingDB
Kappa-type opioid receptor	Homo sapiens	P41145				>10000 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens	P14867				>10000 nM	BindingDB
5-hydroxytryptamine receptor 2C	Rattus norvegicus	P08909	78 nM	250 nM		960 nM	BindingDB
5-hydroxytryptamine receptor 2C	Homo sapiens	P28335		250 nM		538.000000 nM\|42 nM	BindingDB
5-hydroxytryptamine receptor 2B	Rattus norvegicus	P30994	240 nM		83.18 nM		BindingDB
5-hydroxytryptamine receptor 2B	Homo sapiens	P41595				3884.000000 nM\|52 nM	BindingDB
5-hydroxytryptamine receptor 2B	Bos taurus					1300 nM	BindingDB
5-hydroxytryptamine receptor 2A	Rattus norvegicus	P14842	462 nM	9.5 nM		14 nM\|1600 nM\|92 nM	BindingDB
5-hydroxytryptamine receptor 2A	Homo sapiens	P28223	<10000 nM\|1.8 nM	<2000 nM\|<500 nM		90 nM\|1325 nM\|39.0 nM\|2011.000000 nM\|620 nM\|15 nM	BindingDB
5-hydroxytryptamine receptor 1F	Homo sapiens	P30939				37.15 nM\|37 nM	BindingDB
5-hydroxytryptamine receptor 3A	Homo sapiens	P46098				>10000 nM	BindingDB
5-hydroxytryptamine receptor 1E	Homo sapiens	P28566	92 nM			528 nM\|524.8 nM\|360.200000 nM	BindingDB
5-hydroxytryptamine receptor 1D	Cavia porcellus	Q60484		49 nM			BindingDB
5-hydroxytryptamine receptor 1D	Canis lupus familiaris	P11614				5.12 nM	BindingDB
5-hydroxytryptamine receptor 1B	Rattus norvegicus	P28564				350 nM\|90 nM	BindingDB
5-hydroxytryptamine receptor 1B	Homo sapiens	P28222		550 nM		23.44 nM\|74.000000 nM	BindingDB
5-hydroxytryptamine receptor 1A/1B/1D/1F	Rattus norvegicus	P19327\|P28564\|P28565\|P30940				50 nM	BindingDB
5-hydroxytryptamine receptor 1A	Rattus norvegicus	P19327		11 nM		39.81 nM\|288.40 nM\|69 nM\|10 nM\|7.8 nM\|11 nM\|20 nM\|5.5 nM	BindingDB
5-hydroxytryptamine receptor 1A	Homo sapiens	P08908	1063 nM\|197 nM	15 nM		1.900000 nM\|28 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1/Adenosine receptor A1	Homo sapiens	P14867\|P30542				>10000 nM	BindingDB
5-hydroxytryptamine receptor 1D	Homo sapiens	P28221		49 nM		6.300000 nM\|20 nM	BindingDB
5-hydroxytryptamine receptor 5A	Homo sapiens	P47898				276.600000 nM	BindingDB
D(1B) dopamine receptor	Homo sapiens	P21918				>10000 nM	BindingDB
5-hydroxytryptamine receptor 6	Rattus norvegicus	P31388				79.8 nM\|79.43 nM	BindingDB
D(4) dopamine receptor	Homo sapiens	P21917				3120.000000 nM	BindingDB
D(1A) dopamine receptor	Homo sapiens	P21728				79.500000 nM	BindingDB
Carnitine O-palmitoyltransferase 2, mitochondrial	Homo sapiens	P23786				497.600000 nM	BindingDB
Cannabinoid receptor 2	Homo sapiens	P34972				>10000 nM	BindingDB
Cannabinoid receptor 1	Homo sapiens	P21554				>10000 nM	BindingDB
Beta-2 adrenergic receptor	Homo sapiens	P07550				>10000 nM	BindingDB
Beta-1 adrenergic receptor	Homo sapiens	P08588				>10000 nM	BindingDB
D(2) dopamine receptor	Homo sapiens	P14416				3562.000000 nM	BindingDB
Alpha-2C adrenergic receptor	Homo sapiens	P18825				508.100000 nM	BindingDB
Alpha-2A adrenergic receptor	Homo sapiens	P08913				1890.000000 nM	BindingDB
Alpha-1B adrenergic receptor	Homo sapiens	P35368				>10000 nM	BindingDB
Alpha-1A adrenergic receptor	Homo sapiens	P35348				>10000 nM	BindingDB
Acetylcholinesterase	Electrophorus electricus	O42275		14000 nM\|= 14000.0 nM			BindingDB, NPASS
5-hydroxytryptamine receptor 7	Rattus norvegicus	P32305				20.89 nM\|8.31 nM\|20.9 nM\|8.26 nM\|40 nM	BindingDB
5-hydroxytryptamine receptor 7	Homo sapiens	P34969				3.900000 nM\|30 nM	BindingDB
5-hydroxytryptamine receptor 7	Cavia porcellus	P50407				107.15 nM\|13.18 nM	BindingDB
Alpha-2B adrenergic receptor	Homo sapiens	P18089				2640.000000 nM	BindingDB
5-hydroxytryptamine receptor 6	Homo sapiens	P50406				70 nM\|35.500000 nM\|78 nM\|16 nM\|13 nM	BindingDB

a curated database

IMPPAT Phytochemical information:
N,N-Dimethyl-5-methoxytryptamine

Bioactivity information

IMPPAT Phytochemical information: N,N-Dimethyl-5-methoxytryptamine

Bioactivity information

IMPPAT Phytochemical information:
N,N-Dimethyl-5-methoxytryptamine