IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Sodium/potassium-transporting ATPase	Homo sapiens	P54710		= 400.0 nM\|= 270.0 nM			NPASS
Sodium/potassium-transporting ATPase	Homo sapiens	P05023\|P14415\|P05026\|P50993\|P54709\|P13637\|Q13733\|P54710		= 160.0 nM			NPASS
Signal transducer and activator of transcription 3 [702-738,740-752]	Homo sapiens	P40763		1862 nM			BindingDB
Signal transducer and activator of transcription 3	Homo sapiens	P40763		= 1862.0 nM			NPASS
Signal transducer and activator of transcription 1-alpha/beta	Homo sapiens	P42224		>55700 nM\|> 55700.0 nM			BindingDB, NPASS
SUM185PE	Homo sapiens			= 280.0 nM			NPASS
PBMC	Homo sapiens			> 20000.0 nM			NPASS
SK-BR-3	Homo sapiens			= 1080.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			= 190.0 nM\|> 20000.0 nM\|> 19952.62 nM			NPASS
Replicase polyprotein 1ab	2019-nCoV	P0DTD1		190 nM			BindingDB
PC-3	Homo sapiens			= 75.0 nM			NPASS
Sodium/potassium-transporting ATPase alpha-1 chain	Canis lupus familiaris	P50997		= 500.0 nM			NPASS
P-glycoprotein 3	Mus musculus	P21447		> 50000.0 nM			NPASS
SK-MEL-28	Homo sapiens			= 266.0 nM			NPASS
Sodium/potassium-transporting ATPase alpha-1 chain	Homo sapiens	P05023		= 290.0 nM			NPASS
Sodium/potassium-transporting ATPase subunit alpha-2/beta-2	Human	P14415\|P50993				58.0 nM	BindingDB
Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens	P05023		290 nM			BindingDB
Sodium/potassium-transporting ATPase subunit alpha-2/alpha-3	Rattus norvegicus			= 220.0 nM			NPASS
Sodium/potassium-transporting ATPase subunit alpha-2/beta-1	Human	P05026\|P50993				55 nM\|58.7 nM	BindingDB
P-glycoprotein 1	Mus musculus	P06795		> 50000.0 nM			NPASS
Sodium/potassium-transporting ATPase subunit alpha-2/beta-3	Human	P50993\|P54709				42.8 nM	BindingDB
Sodium/potassium-transporting ATPase subunit alpha-4/beta-1	Rattus norvegicus	P07340\|Q64541		5.5 nM			BindingDB
Solute carrier organic anion transporter family member 1A4	Rattus norvegicus	O35913				580 nM\|37 nM\|= 37.0 nM\|= 580.0 nM	BindingDB, NPASS
Solute carrier organic anion transporter family member 1B1	Homo sapiens	Q9Y6L6		3236 nM\|= 3235.94 nM			BindingDB, NPASS
Solute carrier organic anion transporter family member 1B3	Homo sapiens	Q9NPD5		13183 nM\|= 13182.57 nM			BindingDB, NPASS
T47D	Homo sapiens			= 660.0 nM			NPASS
TK-10	Homo sapiens			= 14.6 nM			NPASS
UACC-62	Homo sapiens			= 29.5 nM			NPASS
Vaccinia virus	Vaccivirus		= 250.0 nM				NPASS
Vero	Chlorocebus aethiops			< 50.0 nM			NPASS
Sodium/potassium-transporting ATPase subunit alpha-1	Canis lupus familiaris	P50997		180 nM\|500 nM			BindingDB
P-glycoprotein 1	Homo sapiens	P08183		> 50000.0 nM			NPASS
Sodium/potassium-transporting ATPase subunit alpha-1/beta-1	Human	P05023\|P05026				189 nM\|268 nM	BindingDB
Nuclear receptor ROR-gamma	Mus musculus	P51450		= 2000.0 nM			NPASS
OVCAR-3	Homo sapiens			= 100.0 nM			NPASS
A549	Homo sapiens			= 50.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183		>50000 nM			BindingDB
ATP-dependent translocase ABCB1	Mus musculus	P06795		>50000 nM			BindingDB
ATP-dependent translocase ABCB1	Mus musculus	P21447		>50000 nM			BindingDB
B16-F10	Mus musculus			> 10000.0 nM			NPASS
BJ	Homo sapiens		< 104.0 nM				NPASS
Bile salt export pump	Homo sapiens	O95342		264100 nM\|= 264100.0 nM			BindingDB, NPASS
CAL-51	Homo sapiens			= 130.0 nM			NPASS
Cavia porcellus	Cavia porcellus		= 380.0 nM\|= 400.0 nM				NPASS
Cytochrome P450 3A4	Homo sapiens	P08684		>50000 nM\|> 50000.0 nM			BindingDB, NPASS
D283 Med	Homo sapiens			= 10.0 nM			NPASS
HCC1806	Homo sapiens			= 280.0 nM			NPASS
HCC1937	Homo sapiens			= 550.0 nM			NPASS
HCC70	Homo sapiens			= 640.0 nM			NPASS
BT-549	Homo sapiens			= 51.0 nM			NPASS
HT-29	Homo sapiens			= 1400.0 nM\|= 380.0 nM\|= 280.0 nM			NPASS
HCT-116	Homo sapiens			= 270.0 nM			NPASS
NON-PROTEIN TARGET				= 100.0 nM\|= 240.0 nM\|> 10000.0 nM\|= 146.0 nM\|= 40.0 nM\|= 420.0 nM			NPASS
NCI-H1299	Homo sapiens			= 460.0 nM			NPASS
N+/K+ ATPase alpha-4/beta-1	Rattus norvegicus			= 5.5 nM			NPASS
MV4-11	Homo sapiens			= 111.0 nM			NPASS
MDA-MB-468	Homo sapiens			= 230.0 nM			NPASS
MDA-MB-453	Homo sapiens			= 230.0 nM			NPASS
Monoclonal antibody (mAb)					= 3.1 nM	= 1.2 nM\|= 0.8 nM	NPASS
MDA-MB-231	Homo sapiens			= 310.0 nM\|= 480.0 nM			NPASS
MCF7	Homo sapiens			= 24.1 nM\|= 4700.0 nM\|= 426.0 nM			NPASS
K562	Homo sapiens			= 28.2 nM			NPASS
Hs-578T	Homo sapiens			= 251.0 nM\|= 93500.0 nM\|= 69.0 nM			NPASS
HeLa	Homo sapiens			= 2200.0 nM			NPASS
MDA-MB-435	Homo sapiens			= 170.0 nM			NPASS
Nuclear receptor ROR-gamma	Homo sapiens	P51449		4100 nM\|1980 nM\|2000 nM\|85400 nM\|33620 nM\|7012 nM\|2307 nM\|>10000 nM\|= 2000.0 nM\|= 4000.0 nM\|= 4100.0 nM\|= 1980.0 nM\|= 33620.0 nM\|= 7012.0 nM\|= 85400.0 nM\|= 2307.0 nM\|> 10000.0 nM\|= 1800.0 nM	109 nM\|= 109.0 nM		BindingDB, NPASS

a curated database

IMPPAT Phytochemical information:
Digoxin

Bioactivity information

IMPPAT Phytochemical information: Digoxin

Bioactivity information

IMPPAT Phytochemical information:
Digoxin