IMPPAT Phytochemical information: 
Ellipticine
Ellipticine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
RT-4Homo sapiens= 1210.0 nMNPASS
Plasmodium falciparum 3D7Plasmodium falciparum 3D7= 350.0 nMNPASS
Plasmodium falciparum (isolate K1 / Thailand)Plasmodium falciparum K1= 73.0 nM|= 810.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 0.56 nM|= 0.93 nM|= 1.78 nM|= 1.41 nM|= 0.4 nM|= 1.66 nM|= 0.52 nM|= 501.19 nM|= 1000.0 nM|= 1584.89 nM|= 1258.93 nM|= 398.11 nM|= 1130.0 nMNPASS
P388Mus musculus= 1840.0 nM|= 1340.0 nM|= 1700.0 nM|= 1790.0 nMNPASS
P338Mus musculus= 0.44 ug.mL-1NPASS
NON-PROTEIN TARGET= 0.1 ug.mL-1|= 1.0 ug.mL-1|= 0.13 ug.mL-1|= 0.26 ug.mL-1|= 15000.0 nM|= 0.6 ug.mL-1|= 490.0 nM|= 1200.0 nM|= 0.4 ug.mL-1|= 0.3 ug.mL-1|= 0.27 ug.mL-1|= 0.2 ug.mL-1|= 0.14 ug.mL-1|= 5930.0 nM|= 0.36 ug.mL-1|= 0.22 ug.mL-1|= 800.0 nM|= 0.32 ug.mL-1|= 682.0 nM|= 1100.0 nM|= 7.11 ug.mL-1|= 1.21 ug.mL-1|= 2.02 ug.mL-1|= 0.21 ug.mL-1|= 1010.0 nM|= 1620.0 nM|= 9340.0 nM|= 4500.0 nM|= 25210.0 nM|= 600.0 nM|= 1.82 nM|= 2100.0 nM|= 1.8 nM|= 37920.0 nM|= 6580.0 nM|= 18270.0 nM|= 3820.0 nM|= 2200.0 nM|= 0.63 ug.mL-1|= 2000.0 nM|= 1750.0 nM|= 2030.0 nM|= 1000.0 nM|= 1390.0 nM|= 1950.0 nM|= 530.0 nM|= 1270.0 nM|= 750.0 nM|= 520.0 nMNPASS
NIH3T3Mus musculus= 3.0 nMNPASS
Mast/stem cell growth factor receptor KitHomo sapiensP10721>10000 nMBindingDB
NCI-H69Homo sapiens= 1800.0 nMNPASS
NCI-H460Homo sapiens= 510.0 nMNPASS
NCI-H417Homo sapiens= 870.0 nMNPASS
NCI-H358Homo sapiens= 200.0 nM|= 800.0 nMNPASS
NCI-H292= 1000.0 nMNPASS
NCI-H1993Homo sapiens= 200.0 nMNPASS
NCI-H187Homo sapiens= 0.32 ug.mL-1|= 0.52 ug.mL-1|= 1710.0 nM|= 2000.0 nM|= 0.4 ug.mL-1|= 0.3 ug.mL-1|= 1590.0 nM|= 800.0 nM|= 0.26 ug.mL-1|= 2230.0 nM|= 4400.0 nM|= 0.44 ug.mL-1|= 3600.0 nM|= 0.68 ug.mL-1|= 1500.0 nM|= 2770.0 nM|= 2760.0 nM|= 1820.0 nM|= 3100.0 nM|= 1160.0 nM|= 950.0 nM|= 9300.0 nM|= 13700.0 nM|= 9100.0 nMNPASS
Mus musculusMus musculus= 320.0 nM|= 300.0 nMNPASS
Reverse transcriptaseHuman immunodeficiency virus 1<608000 nM|182000 nMBindingDB
NHDFHomo sapiens> 10000.0 nMNPASS
Rho-associated protein kinase 2Homo sapiensO751166680 nMBindingDB
SH-SY5YHomo sapiens= 2130.0 nMNPASS
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiensO951803990 nMBindingDB
VeroChlorocebus sabaeus= 4500.0 nM|= 7900.0 nM|= 2900.0 nM|= 4.0 ug.mL-1|= 2400.0 nMNPASS
VeroChlorocebus aethiops= 2030.0 nM|= 0.4 ug.mL-1|= 1940.0 nM|= 2100.0 nM|= 0.6 ug.mL-1|= 0.2 ug.mL-1|= 800.0 nM|= 2440.0 nM|= 1690.0 nM|= 1.16 ug.mL-1|= 0.7 ug.mL-1|= 1750.0 nM|= 5500.0 nM|= 0.48 ug.mL-1|= 1.18 ug.mL-1|= 3800.0 nM|= 2290.0 nM|= 4470.0 nM|= 3820.0 nM|= 12000.0 nM|= 9800.0 nM|= 1190.0 nM|= 6480.0 nM|= 15510.0 nM|= 4050.0 nM|= 3300.0 nM|= 4260.0 nM|= 4060.0 nM|= 3100.0 nM|= 4100.0 nM|= 400.0 nM|= 7470.0 nM|= 0.87 ug.mL-1NPASS
Tyrosine-protein kinase LckHomo sapiensP0623918500 nMBindingDB
Tyrosine-protein kinase LCKHomo sapiensP06239= 18500.0 nMNPASS
Streptokinase AStreptococcus pyogenes serotype M1P10520150000 nM|= 3024.0 nM|> 150000.0 nMBindingDB, NPASS
Streptococcus sp. 'group A'Streptococcus sp. 'group A'= 2251.0 nMNPASS
StreptococcusStreptococcus= 7702.0 nMNPASS
Steroidogenic factor 1Homo sapiensQ13285>3667 nMBindingDB
Stem cell growth factor receptorHomo sapiensP10721> 10000.0 nM|= 200.0 nMNPASS
SW480Homo sapiens= 3170.0 nM|= 0.38 ug.mL-1NPASS
SNU-638Homo sapiens= 2000.0 nM|= 2200.0 nM|= 1640.0 nM|= 2700.0 nMNPASS
SK-MES-1Homo sapiens= 200.0 nMNPASS
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiensP176124089 nMBindingDB
SK-MEL-2Homo sapiens= 1140.0 nM|= 2150.0 nM|= 1910.0 nMNPASS
SK-LU-1Homo sapiens= 1380.0 nM|= 1540.0 nMNPASS
SK-HEP1Homo sapiens= 400.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
MRC5Homo sapiens= 1300.0 nMNPASS
DNA topoisomerase II alphaHomo sapiensP11388= 3300.0 nMNPASS
MCF7Homo sapiens= 430.0 nM|= 1600.0 nM|= 16720.0 nM|= 2.15 nM|= 2.1 nM|= 1800.0 nM|= 1950.0 nM|= 0.44 ug.mL-1|= 1540.0 nM|= 900.0 nM|= 1250.0 nM|= 2000.0 nM|= 1340.0 nM|= 1990.0 nM|= 2400.0 nM|= 1530.0 nM|= 800.0 nM|= 1700.0 nM|= 1790.0 nM|= 2180.0 nM|= 1580.0 nM|= 9850.0 nM|= 2480.0 nM|= 1050.0 nMNPASS
G protein-activated inward rectifier potassium channel 1Rattus norvegicusP632511.486 nMBindingDB
FaDuHomo sapiens= 1850.0 nMNPASS
Diphosphomevalonate decarboxylaseStreptococcus pneumo serotype 2 (strain D39 / NCTC 7466)119231.9 nMBindingDB
DNA topoisomerase 2-alphaHomo sapiensP113883300 nMBindingDB
Cytochrome P450 1A1Homo sapiensP0479819 nM|= 19.3 nMBindingDB, NPASS
Col2Homo sapiens= 1220.0 nM|= 1820.0 nM|= 2300.0 nMNPASS
Calf thymus DNABos taurus= 22200.0 nM> 200000.0 nMNPASS
Galanin receptor 2Homo sapiensO43603> 55700.0 nMNPASS
CHOCricetulus griseus= 20.0 nMNPASS
BC1 cell line= 0.3 ug.mL-1NPASS
A549Homo sapiens= 1220.0 nM|= 10000.0 nM|= 2070.0 nM|= 1900.0 nM|= 3400.0 nM|= 470.0 nM|= 1100.0 nM|= 1960.0 nM|= 1200.0 nM|= 400.0 nM|= 2250.0 nM|= 2130.0 nM|= 1160.0 nM|= 3450.0 nM|= 850.0 nMNPASS
A498Homo sapiens= 1740.0 nMNPASS
A-431Homo sapiens= 470.0 nMNPASS
A-427Homo sapiens= 890.0 nMNPASS
5637Homo sapiens= 890.0 nMNPASS
3T3Mus musculus= 1260 nMNPASS
Breast carcinoma cellsHomo sapiens= 0.1 ug.mL-1NPASS
Glucocorticoid receptorHomo sapiensP0415090000 nM|= 90000.0 nMBindingDB, NPASS
Galanin receptor type 2Homo sapiensO43603>55700 nMBindingDB
HEK293Homo sapiens= 1900.0 nM|= 1690.0 nM|= 6580.0 nMNPASS
MCF-10AHomo sapiens= 1200.0 nMNPASS
Lu1Homo sapiens= 80.0 nM|= 2720.0 nM|= 2310.0 nM|= 1200.0 nM|= 1600.0 nM|= 1700.0 nMNPASS
LNCaPHomo sapiens= 3250.0 nM|= 3210.0 nM|= 1990.0 nM|= 1950.0 nMNPASS
L1210Mus musculus= 500.0 nM|= 190.0 nMNPASS
KBHomo sapiens= 0.3 ug.mL-1|= 2400.0 nM|= 5300.0 nM|= 0.67 ug.mL-1|= 0.36 ug.mL-1|= 0.41 ug.mL-1|= 0.1 ug.mL-1|= 0.46 ug.mL-1|= 1990.0 nM|= 2200.0 nM|= 0.4 ug.mL-1|= 160.0 nM|= 0.21 ug.mL-1|= 0.2 ug.mL-1|= 5410.0 nM|= 0.26 ug.mL-1|= 0.24 ug.mL-1|= 800.0 nM|= 812.0 nM|= 1380.0 nM|= 0.37 ug.mL-1|= 2500.0 nM|= 0.48 ug.mL-1|= 0.45 ug.mL-1|= 1790.0 nM|= 1100.0 nM|= 0.19 ug.mL-1|= 1780.0 nM|= 1250.0 nM|= 5200.0 nM|= 4870.0 nM|= 1190.0 nM|= 1.26 nM|= 2250.0 nM|= 1200.0 nM|= 1980.0 nM|= 3980.0 nM|= 1300.0 nM|= 2070.0 nM|= 1660.0 nM|= 1400.0 nM|= 1260.0 nM|= 8280.0 nM|= 2810.0 nM|= 2150.0 nM|= 1870.0 nM|= 1950.0 nM|= 810.0 nM|= 8200.0 nM|= 1920.0 nM|= 1750.0 nM|= 6100.0 nMNPASS
K562Homo sapiens= 380.0 nMNPASS
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)Homo sapiensP3539816680 nMBindingDB
HCT-116Homo sapiens= 300.0 nM|= 410.0 nM|= 1000.0 nMNPASS
Human immunodeficiency virus type 1 reverse transcriptaseHuman immunodeficiency virus 1Q72547< 150.0 ug.mL-1|= 182000.0 nMNPASS
IshikawaHomo sapiens= 1500.0 nM|= 1050.0 nMNPASS
HepG2Homo sapiens= 1.26 nM|= 1200.0 nM|= 3500.0 nM|= 1300.0 nM|= 1710.0 nM|= 0.36 ug.mL-1|= 2070.0 nM|= 1500.0 nM|= 2900.0 nM|= 1460.0 nM|= 1380.0 nM|= 2720.0 nM|= 930.0 nM|= 850.0 nM|= 1660.0 nM|= 1340.0 nM|= 1050.0 nMNPASS
HeLaHomo sapiens= 0.4 ug.mL-1|= 290.0 nM|= 310.0 nM|= 9810.0 nM|= 1000.0 nM|= 1600.0 nM|= 2000.0 nM|= 9850.0 nM|= 1050.0 nMNPASS
HUVECHomo sapiens= 370.0 nMNPASS
HT-29Homo sapiens= 15000.0 nM|= 14900.0 nM|= 2000.0 nM|= 2060.0 nM|= 2160.0 nM|= 2590.0 nM|= 1950.0 nMNPASS
HT-1080Homo sapiens= 5010.0 nM|= 4300.0 nM|= 210.0 nMNPASS
HL-60Homo sapiens= 2600.0 nM|= 5800.0 nM|= 660.0 nM|= 640.0 nM|= 2930.0 nM|= 2000.0 nM|= 1700.0 nMNPASS
HEp-2Homo sapiens= 0.4 ug.mL-1|= 9850.0 nMNPASS
HuCC-A1Homo sapiens= 2430.0 nMNPASS
MDA-MB-231Homo sapiens= 2300.0 nM|= 3210.0 nM|= 1820.0 nM|= 1850.0 nM|= 100.0 nM|= 2030.0 nM|= 1050.0 nMNPASS