IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Protein-arginine deiminase type-4	Homo sapiens	Q9UM07		39000 nM			BindingDB
Protein RecA	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	P9WHJ3	7303 nM\|3010 nM				BindingDB
Potassium voltage-gated channel subfamily H member 2	Homo sapiens	Q12809		7244.36 nM			BindingDB
Phosphodiesterase; PDE3 & PDE4	Homo sapiens	Q08493		= 6600.0 nM			NPASS
Phosphodiesterase 4A	Sus scrofa	O77823		= 1700.0 nM			NPASS
Phosphodiesterase 4D	Homo sapiens	Q08499		= 1400.0 nM			NPASS
Phosphodiesterase 4A	Homo sapiens	P27815		= 1600.0 nM			NPASS
Phosphodiesterase 3B	Homo sapiens	Q13370		= 1030.0 nM		= 417.0 nM	NPASS
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens	O76074		8800 nM			BindingDB
Phosphodiesterase 5A	Homo sapiens	O76074		= 8800.0 nM			NPASS
Rattus norvegicus	Rattus norvegicus			= 1550.0 nM			NPASS
Uterus	Rattus norvegicus			= 420.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens	Q9Y233		36 nM\|56.9 nM\|17 nM\|210 nM\|21 nM\|40 nM\|97 nM\|38 nM\|76 nM			BindingDB
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Rattus norvegicus	Q9QYJ6		36 nM\|= 36.0 nM		17 nM	BindingDB, NPASS
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens	P27815		1600 nM			BindingDB
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Rattus norvegicus	P14646				>10000 nM\|8821.4 nM	BindingDB
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Rattus norvegicus	P14644				8000 nM	BindingDB
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens	Q08499		1400 nM			BindingDB
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens	O00408		17000 nM\|2300 nM			BindingDB
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A	Homo sapiens	Q14432		917 nM\|284 nM\|1300 nM\|287 nM		279 nM	BindingDB
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Homo sapiens	Q13370		1030 nM		417 nM	BindingDB
Phosphodiesterase 3A	Homo sapiens	Q14432		= 917.0 nM\|= 284.0 nM\|= 1300.0 nM\|= 287.0 nM		= 279.0 nM	NPASS
Reverse transcriptase	Human immunodeficiency virus 1			<589000 nM			BindingDB
Phosphodiesterase 10A	Homo sapiens	Q9Y233		= 56.9 nM\|= 76.0 nM\|= 17.0 nM\|= 210.0 nM\|= 21.0 nM\|= 36.0 nM\|= 40.0 nM\|= 92.3 nM\|= 97.0 nM\|= 38.0 nM			NPASS
Phosphodiesterase 3A	Sus scrofa	Q9XSW7		= 620.0 nM			NPASS
Phosphodiesterase 2A	Homo sapiens	O00408		= 2300.0 nM\|= 17000.0 nM			NPASS
Phosphodiesterase 1	Rattus norvegicus	Q01066		= 12000.0 nM\|= 21000.0 nM			NPASS
3',5'-cyclic-AMP phosphodiesterase	Sus scrofa			1700 nM			BindingDB
ATP-binding cassette sub-family C member 2	Homo sapiens	Q92887		>133000 nM			BindingDB
ATP-binding cassette sub-family C member 3	Homo sapiens	O15438		>133000 nM			BindingDB
ATP-binding cassette sub-family C member 4	Homo sapiens	O15439		23130 nM			BindingDB
Acetylcholinesterase	Electrophorus electricus	O42275		24300 nM\|= 24300.0 nM			BindingDB, NPASS
Acetylcholinesterase	Homo sapiens	P22303		24330 nM\|= 24330.0 nM			BindingDB, NPASS
Bile salt export pump	Homo sapiens	O95342		>135000 nM\|<10000 nM\|>133000 nM\|> 135000.0 nM\|< 10000.0 nM\|> 133000.0 nM			BindingDB, NPASS
Canalicular multispecific organic anion transporter 1	Homo sapiens	Q92887		> 133000.0 nM			NPASS
Canalicular multispecific organic anion transporter 2	Homo sapiens	O15438		> 133000.0 nM			NPASS
Cytochrome P450 2C19	Homo sapiens	P33261		= 762.0 nM			NPASS
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C	Homo sapiens	P54750\|Q01064\|Q14123		9000 nM\|21600 nM			BindingDB
HERG	Homo sapiens	Q12809		= 7244.36 nM			NPASS
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		< 200.0 ug.mL-1			NPASS
Ileum	Cavia porcellus			= 4230.0 nM			NPASS
Ileum	Rattus norvegicus			= 1550.0 nM\|= 9.44 nM\|= 6.2 nM\|= 7.07 nM\|= 0.059 nM			NPASS
Influenza A virus	InflueA virus			= 2000.0 nM			NPASS
Influenza B virus	InflueB virus			= 2000.0 nM			NPASS
Intestine	Rattus norvegicus				= 15848.93 nM		NPASS
Multidrug resistance-associated protein 4	Homo sapiens	O15439		= 23130.0 nM			NPASS
Parainfluenza virus 5	Parainfluevirus 5			= 2000.0 nM			NPASS
Phosphodiesterase	Sus scrofa			620 nM			BindingDB
Phosphodiesterase	Trypanosoma cruzi			2.5e+4 nM			BindingDB
Phosphodiesterase 1	Bos taurus	P14100		= 8800.0 nM			NPASS
Phosphodiesterase 1	Homo sapiens	Q14123		= 21600.0 nM\|= 9000.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Papaverine

Bioactivity information

IMPPAT Phytochemical information: Papaverine

Bioactivity information

IMPPAT Phytochemical information:
Papaverine