IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens	O15296		>40000 nM			BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens	P09917		24800 nM			BindingDB
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens	Q13526		>10000 nM\|> 10000.0 nM			BindingDB, NPASS
Pancreatic alpha-amylase	Sus scrofa	P00690		>200000 nM\|> 200000.0 nM			BindingDB, NPASS
PC-3	Homo sapiens			> 20000.0 nM\|= 105240.0 nM			NPASS
PC-12	Rattus norvegicus		= 890.0 nM				NPASS
PANC-1	Homo sapiens			= 132200.0 nM			NPASS
NON-PROTEIN TARGET			= 83920.0 nM	= 7300.0 nM\|= 83920.0 nM\|= 80780.0 nM\|= 81440.0 nM\|= 27310.0 nM\|> 20000.0 nM			NPASS
NIH3T3	Mus musculus		= 18700.0 nM				NPASS
NCI/ADR-RES	Homo sapiens			= 74490.0 nM			NPASS
MGC-803	Homo sapiens			> 50000.0 nM\|> 200000.0 nM			NPASS
Prostaglandin G/H synthase 2	Homo sapiens	P35354		>40000 nM			BindingDB
K562/Adr	Homo sapiens			= 86460.0 nM			NPASS
MG-63	Homo sapiens			> 50000.0 nM			NPASS
MDCK	Canis lupus familiaris			> 40000.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 146600.0 nM			NPASS
MCF7	Homo sapiens		= 84700.0 nM\|> 30000.0 nM	= 84700.0 nM\|> 100000.0 nM\|= 74750.0 nM\|> 200000.0 nM\|> 40000.0 nM\|= 32600.0 nM			NPASS
Liver carboxylesterase 1	Homo sapiens	P23141		20970 nM			BindingDB
Lactoylglutathione lyase	Mus musculus	Q9CPU0				290 nM	BindingDB
L02	Homo sapiens			> 200000.0 nM\|> 50000.0 nM			NPASS
NCI-H460	Homo sapiens			= 62.0 ug.mL-1\|= 37650.0 nM			NPASS
Protein kinase C eta	Homo sapiens	P24723			= 250.0 nM		NPASS
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens	P18031		>20000 nM\|45800 nM			BindingDB
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		> 20000.0 nM\|= 45800.0 nM			NPASS
K562	Homo sapiens			> 200000.0 nM			NPASS
n.a.			= 16000.0 nM				NPASS
Tyrosine-protein phosphatase non-receptor type 7	Homo sapiens	P35236		>300000 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 6	Homo sapiens	P29350		65400 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens	P17706		>20000 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens	Q06124		9600 nM			BindingDB
Tyrosine-protein phosphatase non-receptor type 1 [1-405]	Homo sapiens	P18031				10000 nM	BindingDB
Tyrosine-protein phosphatase non-receptor type 1 [1-321]	Homo sapiens	P18031				10000 nM	BindingDB
T-cell protein-tyrosine phosphatase	Homo sapiens	P17706		> 20000.0 nM			NPASS
Protein kinase C eta type	Homo sapiens	P24723			250 nM		BindingDB
T-24	Homo sapiens			= 56780.0 nM			NPASS
Solute carrier organic anion transporter family member 1B1	Homo sapiens	Q9Y6L6		525 nM\|= 524.81 nM		290 nM\|= 290.0 nM	BindingDB, NPASS
SW480	Homo sapiens			= 86800.0 nM			NPASS
SW-1736	Homo sapiens			= 76930.0 nM			NPASS
SK-OV-3	Homo sapiens			= 45620.0 nM			NPASS
Raji	Homo sapiens			> 80000.0 nM			NPASS
RAW264.7	Mus musculus			= 1300.0 nM\|= 187880.0 nM			NPASS
Protein-tyrosine phosphatase LC-PTP	Homo sapiens	P35236		> 300000.0 nM			NPASS
Protein-tyrosine phosphatase 2C	Homo sapiens	Q06124		= 9600.0 nM			NPASS
Protein-tyrosine phosphatase 1C	Homo sapiens	P29350		= 65400.0 nM			NPASS
Solute carrier organic anion transporter family member 1B3	Homo sapiens	Q9NPD5		550 nM\|= 549.54 nM		420 nM\|= 420.0 nM	BindingDB, NPASS
Hypoxia-inducible factor prolyl hydroxylase	Homo sapiens		> 50000.0 nM				NPASS
A549/TR	Homo sapiens			= 99850.0 nM			NPASS
Hepatitis B virus	Hepatitis B virus			= 20860.0 nM\|= 130490.0 nM\|= 39280.0 nM\|= 805500.0 nM\|= 509800.0 nM			NPASS
Arachidonate 15-lipoxygenase, type II	Homo sapiens	O15296		> 40000.0 nM			NPASS
Aldose reductase	Homo sapiens	P15121		= 280000.0 nM			NPASS
Aldo-keto reductase family 1 member B10	Homo sapiens	O60218		4900 nM\|= 4900.0 nM			BindingDB, NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		280000 nM			BindingDB
Acyl coenzyme A:cholesterol acyltransferase	Homo sapiens	P23141		= 20970.0 nM			NPASS
Acetylcholinesterase	Electrophorus electricus	O42275				>100000 nM\|> 100000.0 nM	BindingDB, NPASS
A549	Homo sapiens		= 82760.0 nM\|> 30000.0 nM	= 82760.0 nM\|= 78.0 ug.mL-1\|> 100000.0 nM\|= 84250.0 nM\|= 94970.0 nM\|> 200000.0 nM\|> 40000.0 nM\|= 36150.0 nM			NPASS
A2780	Homo sapiens		> 30000.0 nM	= 74570.0 nM			NPASS
A-431	Homo sapiens			= 79580.0 nM			NPASS
Arachidonate 5-lipoxygenase	Homo sapiens	P09917		= 24800.0 nM			NPASS
A-375	Homo sapiens			= 98140.0 nM			NPASS
518A2	Homo sapiens		> 30000.0 nM				NPASS
4T1	Mus musculus			= 174500.0 nM			NPASS
11-beta-hydroxysteroid dehydrogenase type 2	Rattus norvegicus	P50233		360 nM			BindingDB
11-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens	P80365		1.2 nM\|257 nM\|1.3 nM			BindingDB
11-beta-hydroxysteroid dehydrogenase 2	Rattus norvegicus	P50233		= 360.0 nM			NPASS
11-beta-hydroxysteroid dehydrogenase 2	Homo sapiens	P80365		= 257.0 nM\|= 1.22 nM\|= 1.2 nM\|= 1.3 nM			NPASS
11-beta-hydroxysteroid dehydrogenase 1	Rattus norvegicus	P16232		90 nM\|= 90.0 nM			BindingDB, NPASS
11-beta-hydroxysteroid dehydrogenase 1	Mus musculus	P50172		40 nM\|5 nM\|10.58 nM\|7.4 nM\|2.0 nM\|9.4 nM\|= 10.58 nM\|= 5.0 nM\|= 2.0 nM\|= 40.2 nM\|= 7.4 nM\|= 9.4 nM			BindingDB, NPASS
11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	P28845		29 nM\|13 nM\|778 nM\|8.6 nM\|11.78 nM\|11 nM\|8.8 nM\|= 11.78 nM\|= 13.0 nM\|= 778.0 nM\|= 8.6 nM\|= 29.1 nM\|= 11.3 nM\|= 8.8 nM\|= 779.0 nM			BindingDB, NPASS
8505C	Homo sapiens		= 86500.0 nM\|> 30000.0 nM	= 86500.0 nM			NPASS
B16-F10	Mus musculus			= 138800.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1			= 28800.0 nM			NPASS
Bel7402/5-FU	Homo sapiens			= 69770.0 nM			NPASS
HepG2	Homo sapiens			> 50000.0 nM\|> 20000.0 nM\|= 94450.0 nM\|> 40000.0 nM\|= 44510.0 nM\|= 81420.0 nM			NPASS
HeLa	Homo sapiens			> 100000.0 nM\|> 40000.0 nM			NPASS
HT-29	Homo sapiens		= 80090.0 nM\|> 30000.0 nM	= 80090.0 nM			NPASS
HL-60	Homo sapiens			= 63200.0 nM\|= 55280.0 nM			NPASS
HCT-8	Homo sapiens			= 78850.0 nM			NPASS
HCT-116	Homo sapiens			= 78830.0 nM\|= 91250.0 nM			NPASS
Glyoxalase I	Mus musculus	Q9CPU0				= 290.0 nM	NPASS
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus	P00489		= 66000.0 nM			NPASS
FaDu	Homo sapiens		> 30000.0 nM	= 84550.0 nM			NPASS
Egl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase	Homo sapiens	Q96KS0\|Q9GZT9\|Q9H6Z9\|Q9NXG6	>50000 nM				BindingDB
Epidermoid carcinoma cell line				>= 300.0 nM			NPASS
DLD-1	Homo sapiens			= 81210.0 nM			NPASS
Cyclooxygenase-2	Homo sapiens	P35354		> 40000.0 nM			NPASS
Bel-7402	Homo sapiens			> 50000.0 nM\|> 200000.0 nM			NPASS
Cocaine esterase	Homo sapiens	O00748		69260 nM			BindingDB
Cholinesterase	Equus caballus	P81908				>100000 nM\|> 100000.0 nM	BindingDB, NPASS
Carboxylesterase 2	Homo sapiens	O00748		= 69260.0 nM			NPASS
Brugia malayi	Brugia malayi			= 1200.0 nM			NPASS
Beta-glucuronidase	Rattus norvegicus	P06760		97210 nM\|= 97210.0 nM			BindingDB, NPASS
Beta-glucuronidase	Escherichia coli (strain K12)	P05804		12150 nM\|= 12150.0 nM			BindingDB, NPASS
ECV-304	Homo sapiens			= 101000.0 nM\|= 292000.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Enoxolone

Bioactivity information

IMPPAT Phytochemical information: Enoxolone

Bioactivity information

IMPPAT Phytochemical information:
Enoxolone