IMPPAT Phytochemical information: 
Licochalcone a
Licochalcone a
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
WI-38Homo sapiens= 90200.0 nMNPASS
NeuraminidaseInflueA virus (A/WSN/1933(H1N1))P0347056100 nM|12400 nM|15900 nM|53100 nMBindingDB
P-glycoprotein 1Homo sapiensP08183= 94920.0 nM|= 114810.0 nM|= 121200.0 nM|= 105410.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 2.2 ug.mL-1|= 10300.0 nM|= 4.2 nM|= 4100.0 nM|= 1.43 ug.mL-1|= 1.4 ug.mL-1NPASS
NeuraminidaseInflueA virusB4URF0= 4.2 ug.mL-1|= 5.42 ug.mL-1|= 17.98 ug.mL-1|= 18.23 ug.mL-1|= 19.09 ug.mL-1NPASS
Plasmodium yoelii yoeliiPlasmodium yoelii yoelii= 0.927 nMNPASS
Protein-tyrosine phosphatase 1BHomo sapiensP18031= 19100.0 nMNPASS
S1Homo sapiens= 4.44 nM|= 4.53 nM|= 4.55 nM|= 4.73 nM|= 9.73 nM|= 11.01 nM|= 10.7 nM|= 11.74 nM|= 10000.0 nMNPASS
Toxoplasma gondiiToxoplasma gondii= 0.848 ug.mL-1NPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
SiHaHomo sapiens= 42200.0 nMNPASS
SialidaseClostridium perfringensP1048120300 nM|= 6.9 ug.mL-1BindingDB, NPASS
Tyrosine-protein phosphatase non-receptor type 1Homo sapiensP1803119100 nMBindingDB
U-87 MGHomo sapiens> 50000.0 nMNPASS
UDP-glucuronosyltransferase 1-1Homo sapiensP22309= 970.0 nMNPASS
UDP-glucuronosyltransferase 1A1Homo sapiensP22309970 nMBindingDB
NON-PROTEIN TARGET= 17000.0 nMNPASS
S1-M1-80Homo sapiens= 10000.0 nMNPASS
NCI-H460Homo sapiens= 25.91 nM|= 19.84 nM|= 20.1 nM|= 20.34 nM|= 25.54 nM|= 22.41 nM|= 21.69 nM|= 22.52 nM|= 10000.0 nMNPASS
MDA-MB-231Homo sapiens= 22000.0 nMNPASS
Multidrug resistance-associated protein 1Homo sapiensP3352753570 nM|49260 nM|66650 nM|56470 nM|= 53570.0 nM|= 49260.0 nM|= 66650.0 nM|= 56470.0 nMBindingDB, NPASS
NCI-H28Homo sapiens= 30000.0 nMNPASS
ATP-dependent translocase ABCB1Homo sapiensP0818394920 nM|114810 nM|121200 nM|105410 nMBindingDB
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiensQ9UNQ014000 nM19 nM|7.1 nM|7.8 nM|6.2 nM|90 nM|51 nM|44 nM|42 nM|39470 nM|6800 nM|2630 nM|1530 nM|1030 nM|610 nM|410 nM|310 nM|442 nM|86 nM|75 nM|70 nM|367 nM|144 nM|148 nM|130 nMBindingDB
CHO-K1Cricetulus griseus= 508300.0 nMNPASS
Cytochrome P450 3A4Homo sapiensP08684~ 3000.0 nMNPASS
Dipeptidyl peptidase IVHomo sapiensP27487= 30390.0 nMNPASS
GES1Homo sapiens> 180000.0 nMNPASS
HEK293Homo sapiens= 8.67 nM|= 7.99 nM|= 8.9 nM|= 9.03 nM|= 0.31 nM|= 0.3 nM|= 0.28 nM|= 5.11 nM|= 4.6 nM|= 4.74 nM|= 4.78 nM|= 26.83 nM|= 24.72 nM|= 25.89 nM|= 25.55 nM|= 10000.0 nMNPASS
ATP-binding cassette sub-family G member 2Homo sapiensQ9UNQ0= 14000.0 nM= 18.75 nM|= 7.09 nM|= 7.83 nM|= 6.22 nM|= 90.05 nM|= 51.47 nM|= 44.11 nM|= 42.41 nM|= 39470.0 nM|= 6800.0 nM|= 2630.0 nM|= 1530.0 nM|= 1030.0 nM|= 610.0 nM|= 410.0 nM|= 310.0 nM|= 441.96 nM|= 86.46 nM|= 74.77 nM|= 69.86 nM|= 366.91 nM|= 143.89 nM|= 147.56 nM|= 130.38 nMNPASS
HT-1080Homo sapiens= 10750.0 nMNPASS
HeLaHomo sapiens= 48500.0 nMNPASS
Isocitrate dehydrogenase [NADP] cytoplasmicHomo sapiensO75874>100000 nM|5176 nM|76870 nM|> 100000.0 nM|= 5176.0 nM|= 76870.0 nM>50000 nM|2810 nM|12810 nM|> 50000.0 nM|= 2810.0 nM|= 12810.0 nMBindingDB, NPASS
Leishmania donovaniLeishmadonovani= 13000.0 nM|= 650.0 nM|= 2700.0 nM|= 900.0 nM|= 0.9 ug.mL-1|= 4.0 ug.mL-1NPASS
Leishmania majorLeishmamajor= 4000.0 nM|= 14000.0 nM|= 2.5 ug.mL-1|= 7200.0 nM|= 0.5 ug.mL-1|= 7.2 ug.mL-1NPASS
MCF7Homo sapiens= 22000.0 nMNPASS
MSTO-211HHomo sapiens= 26000.0 nMNPASS
HK-2Homo sapiens= 88700.0 nMNPASS