IMPPAT Phytochemical information: 
Spermine
Spermine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Glutamate [NMDA] receptor subunit epsilon 2Homo sapiensQ13224= 127000.0 nM|= 125000.0 nMNPASS
ZR-75-1Homo sapiens= 200.0 nMNPASS
Glutamate NMDA receptor; Grin1/Grin2bRattus norvegicusQ00960= 100000.0 nMNPASS
Glutamate NMDA receptorRattus norvegicusQ9R1M7= 5200.0 nM= 232000.0 nMNPASS
DNA topoisomerase 2-alphaHomo sapiensP11388>1000000 nMBindingDB
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1BBos taurusP14100|Q01061>500000 nMBindingDB
DNA topoisomerase II alphaHomo sapiensP11388> 1000000.0 nMNPASS
Glutamate [NMDA] receptor subunit epsilon 2Rattus norvegicusQ00960= 81000.0 nMNPASS
Coagulation factor XIIIHomo sapiensP00488= 100000.0 nMNPASS
Caspase-2Homo sapiensP425758500 nM|= 8500.0 nMBindingDB, NPASS
FibroblastHomo sapiens> 500000.0 nM|= 422100.0 nM|= 14900.0 nM|= 356700.0 nM|= 14600.0 nMNPASS
Glutamate receptor ionotropic, NMDA 1Rattus norvegicusP354392000 nMBindingDB
Hepatitis C virusHepatitis C virus> 50000.0 nMNPASS
Glutamate receptor ionotropic, NMDA 2BHomo sapiensQ13224127000 nM|125000 nMBindingDB
Glutamate receptor ionotropic, NMDA 2BRattus norvegicusQ0096081000 nMBindingDB
HeLaHomo sapiens= 70000.0 nM|= 50000.0 nMNPASS
Ionotropic glutamate receptor subunit Delta2Xenopus laevis>10000 nMBindingDB
L1210Mus musculus= 390.0 nM|= 54500.0 nMNPASS
MDA-MB-231Homo sapiens= 280.0 nMNPASS
NON-PROTEIN TARGET> 100000.0 nMNPASS
Nucleic Acid= 3000.0 nM|= 17000.0 nM|= 2800.0 nM|= 6000.0 nMNPASS
Phosphodiesterase 1Bos taurusP14100> 500000.0 nMNPASS
T47DHomo sapiens= 650.0 nM|= 920.0 nM|= 2700.0 nM|= 2100.0 nMNPASS
Ubiquitin-conjugating enzyme E2 NHomo sapiensP6108814303 nM|15610 nMBindingDB
Carbonic anhydrase XIVHomo sapiensQ9ULX7= 860.0 nMNPASS
Glutamate receptor ionotropic, NMDA 1/2BRattus norvegicusP35439|Q00960100000 nMBindingDB
Carbonic anhydrase XIIIMus musculusQ9D6N1= 22600.0 nMNPASS
Carbonic anhydrase 9Homo sapiensQ1679013300 nMBindingDB
Carbonic anhydrase VIIHomo sapiensP43166= 710.0 nMNPASS
Carbonic anhydrase XIIHomo sapiensO43570= 27600.0 nMNPASS
Bcl-2-related protein A1Mus musculusQ07440>20000 nMBindingDB
CHOCricetulus griseus> 100000.0 nMNPASS
CHO-MGCricetulus griseus> 100000.0 nMNPASS
Calf thymus DNABos taurus= 4300.0 nMNPASS
Carbonic anhydrase 1Homo sapiensP00915231000 nMBindingDB
Carbonic anhydrase 13Mus musculusQ9D6N122600 nMBindingDB
Carbonic anhydrase 14Homo sapiensQ9ULX7860 nMBindingDB
Carbonic anhydrase 15Mus musculusQ99N2374000 nM|= 74000.0 nMBindingDB, NPASS
Carbonic anhydrase 2Homo sapiensP0091884000 nMBindingDB
Carbonic anhydrase 3Homo sapiensP07451167000 nMBindingDB
Carbonic anhydrase 4Homo sapiensP2274810 nMBindingDB
Carbonic anhydrase 12Homo sapiensO4357027600 nMBindingDB
Carbonic anhydrase 5B, mitochondrialHomo sapiensQ9Y2D0830 nMBindingDB
Carbonic anhydrase 5A, mitochondrialHomo sapiensP35218840 nMBindingDB
Carbonic anhydrase VIHomo sapiensP23280= 990.0 nMNPASS
Carbonic anhydrase VBHomo sapiensQ9Y2D0= 830.0 nMNPASS
Carbonic anhydrase VAHomo sapiensP35218= 840.0 nMNPASS
Carbonic anhydrase IVHomo sapiensP22748= 10.0 nMNPASS
Carbonic anhydrase IXHomo sapiensQ16790= 13300.0 nMNPASS
Carbonic anhydrase IIHomo sapiensP00918= 84000.0 nMNPASS
Carbonic anhydrase IHomo sapiensP00915= 231000.0 nMNPASS
Carbonic anhydrase 7Homo sapiensP43166710 nMBindingDB
Carbonic anhydrase 6Homo sapiensP23280990 nMBindingDB
Carbonic anhydrase IIIHomo sapiensP07451= 167000.0 nMNPASS