IMPPAT Phytochemical information: 
Podofilox
Podofilox
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Plasmodium falciparum 3D7Plasmodium falciparum 3D7= 9200.0 nMNPASS
Plasmodium falciparum (isolate K1 / Thailand)Plasmodium falciparum K1= 12.0 nMNPASS
Rattus norvegicusRattus norvegicus= 12.0 nMNPASS
Paracentrotus lividusParacentrotus lividus= 20.0 nM|= 50.0 nM|= 500.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 15848.93 nM|= 12589.25 nM|= 10000.0 nM|= 8300.0 nMNPASS
Prostaglandin G/H synthase 1Ovis ariesP05979>4000 nMBindingDB
RajiHomo sapiens= 18.0 nMNPASS
Prostaglandin G/H synthase 2MouseQ05769>2.5e+4 nMBindingDB
Prostaglandin G/H synthase 2Mus musculusQ05769>4000 nMBindingDB
RAW264.7Mus musculus= 61.3 ug.mL-1NPASS
RKOHomo sapiens= 29.0 nM|> 500.0 nMNPASS
PC-3MHomo sapiens= 234.9 nMNPASS
Prostaglandin G/H synthase 1SheepP05979>2.5e+4 nMBindingDB
PC-3Homo sapiens= 13.0 nM|= 10.0 nM|= 34.0 nM|= 18900.0 nM|= 12.5 nM|= 70.0 nM|= 120.0 nM|= 3060.0 nM|= 200.0 nM|= 60.0 nM|= 15.8 nMNPASS
NCI-H1299Homo sapiens= 1330.0 nMNPASS
OVCAR-3Homo sapiens= 460.0 nMNPASS
Nuclear receptor subfamily 0 group B member 1Homo sapiensP518432145 nM|>67547 nM|= 2145.0 nMBindingDB, NPASS
NON-PROTEIN TARGET= 2.97 nM|= 8980.0 nM= 12.0 nM|= 7.0 nM|= 3880.0 nM|= 20500.0 nM|= 10000.0 nM|= 6100.0 nM|= 170.0 nM|= 0.017 ug.mL-1|= 1.05 ug.mL-1|= 85.0 nM|= 10.0 nM|= 250.0 nM|= 120.0 nM|= 50.0 nM|= 20.0 nM|= 480.0 nM|= 90.0 nM|= 18.0 nM|= 15.0 nM|= 3.0 nM|= 16.0 nMNPASS
NIH3T3Mus musculus= 3060.0 nMNPASS
NCI-H1975Homo sapiens= 12560.0 nMNPASS
Mus musculusMus musculus< 0.128 ug.mL-1NPASS
MRC5Homo sapiens= 10600.0 nMNPASS
MOLT-3Homo sapiens= 14.0 nMNPASS
MCF-10AHomo sapiens= 16580.0 nMNPASS
MG-63Homo sapiens= 18300.0 nM|= 7.0 nMNPASS
MDA-MB-231Homo sapiens= 26.0 nM|= 8.0 nM|= 35700.0 nM|< 100.0 nM|= 79.0 nM|= 9760.0 nM|= 5730.0 nM|= 9490.0 nM|= 17.0 nM|= 20220.0 nMNPASS
MCF7Homo sapiens= 15.0 nM|= 8500.0 nM|= 1180.0 nM|= 3500.0 nM|= 64990.0 nM|= 0.1 nM|= 0.4 nM|= 3.52 ug.mL-1|= 17.0 nM|= 3340.0 nM|= 230.0 nM|= 1110.0 nM|= 20.0 nM|= 200.0 nM|= 300.0 nM|= 7130.0 nM|= 2210.0 nM|= 4160.0 nM|= 3060.0 nM|> 100000.0 nM|= 28.0 nM|= 3750.0 nM|= 280.0 nM|= 2400.0 nM|= 5.0 nM|= 10860.0 nM|= 15.8 nM|= 16670.0 nM|= 2130.0 nM|> 200000.0 nM|= 10040.0 nM|= 39.0 nMNPASS
P388Mus musculus= 50.0 nM|= 0.0043 ug.mL-1|= 2900.0 nM|= 0.013 ug.mL-1|= 12.0 nM|= 5.9 nM|= 10.4 nM|= 10400.0 nMNPASS
Regulatory protein E2Human papillomavirus 11P0401520100 nMBindingDB
VeroChlorocebus sabaeus= 1040.0 nMNPASS
Regulatory protein E2Human papillomavirus type 11P04015= 20100.0 nMNPASS
LNCaPHomo sapiens= 31.0 nMNPASS
n.a.> 67538.0 nMNPASS
WRL68Homo sapiens= 4800.0 nM|= 1.989 ug.mL-1|= 3020.0 nMNPASS
Vesicular stomatitis virusVesicular stomatitis virus= 100.0 nMNPASS
VeroChlorocebus aethiops= 16.0 nM|= 23.0 nM|= 1780.0 nM|= 17.0 nMNPASS
Tubulin beta-2B chainBos taurusQ6B856460 nM|1300 nMBindingDB
Tubulin beta chainSus scrofaP02554350 nM|1560 nM|560 nM|3710 nM2180 nMBindingDB
Tubulin beta chainBos taurusQ6B856= 460.0 nM|= 1300.0 nMNPASS
Tubulin alpha-1A chainSus scrofaP025501.4e+3 nM|460 nMBindingDB
Tubulin alpha chainSus scrofaP02550= 460.0 nMNPASS
TubulinSus scrofaP02550= 1650.0 nM|= 350.0 nM|= 1560.0 nM|= 560.0 nM|= 3710.0 nM= 600.0 nM= 2180.0 nMNPASS
TubulinHomo sapiensQ9BUF5= 460000.0 nM|= 1000.0 nM|= 1700.0 nM|= 4000.0 nM|= 350.0 nM|= 3030.0 nM|= 260.0 nM= 21500.0 nMNPASS
TubulinHomo sapiensP68371|Q9H4B7|P0DPH7|P68366|Q13509|Q71U36|P04350|Q3ZCM7|P07437|P68363|Q9BQE3|Q6PEY2|Q13885|Q9BVA1|Q9BUF5= 76500.0 nMNPASS
TubulinBos taurusQ862F3= 2100.0 nM|= 2500.0 nM|= 1200.0 nM|= 590.0 nM|= 460.0 nM|= 1700.0 nM|= 810.0 nM|= 830.0 nMNPASS
Trypanosoma brucei bruceiTrypanosoma brucei brucei> 50000.0 nMNPASS
THP-1Homo sapiens= 19550.0 nMNPASS
Steroidogenic factor 1Homo sapiensQ1328545.35 nM|>67538 nM|>67547 nMBindingDB
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chainBos taurusQ6B8562100 nMBindingDB
Similar to alpha-tubulin isoform 1Bos taurus810 nM|830 nM|2500 nM|2100 nM|460 nM|1200 nM|590 nM|1700 nMBindingDB
SiHaHomo sapiens= 100.0 nMNPASS
SK-N-SHHomo sapiens< 100.0 nM|= 7920.0 nMNPASS
SH-SY5YHomo sapiens= 7.0 nM|= 2540.0 nMNPASS
SGC-7901Homo sapiens= 2950.0 nM|= 340.0 nMNPASS
SF-295Homo sapiens= 5690.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
Regulatory protein E2Human papillomavirus type 1aP03118= 24100.0 nM|> 400000.0 nM|= 1050.0 nMNPASS
Regulatory protein E2Human papillomavirus type 16P0312070500 nMBindingDB
Regulatory protein E2Human papillomavirus type 1P0311824100 nM|>400000 nM|1050 nMBindingDB
L929Mus musculus= 1370.0 nMNPASS
K562/AdrHomo sapiens= 25.0 nMNPASS
L1210Mus musculus= 0.0036 ug.mL-1NPASS
DMS-79Homo sapiens= 23.0 nMNPASS
DLD-1Homo sapiens= 110.0 nMNPASS
Cytochrome P450 3A4Homo sapiensP08684= 600.0 nMNPASS
Cytochrome P450 2C9Homo sapiensP11712= 4000.0 nMNPASS
Cytochrome P450 2C19Homo sapiensP33261= 5000.0 nMNPASS
Cyclooxygenase-2Mus musculusQ05769> 4000.0 nMNPASS
Cyclooxygenase-1Ovis ariesP05979> 4000.0 nMNPASS
Calu-1Homo sapiens= 2680.0 nMNPASS
Caco-2Homo sapiens= 2.0 nM|= 500.0 nMNPASS
Ca-SkiHomo sapiens= 300.0 nMNPASS
CV-1Chlorocebus aethiops= 29.0 nMNPASS
COLO 205Homo sapiens= 5000.0 nMNPASS
DU-145Homo sapiens= 52.0 nM|= 2970.0 nM|> 100000.0 nM|< 100.0 nM|= 3210.0 nM|= 63.0 nM|= 3110.0 nM|= 4150.0 nM|= 3060.0 nM|= 60.0 nMNPASS
CCRF-CEMHomo sapiens= 7.2 nMNPASS
Bel7402/5-FUHomo sapiens= 44.0 nMNPASS
Bel-7402Homo sapiens= 9.1 nM|= 9.0 nM|= 52.0 nMNPASS
BJHomo sapiens> 50000.0 nM|= 5000.0 nMNPASS
BGC-823Homo sapiens= 4310.0 nMNPASS
BEAS-2BHomo sapiens= 14300.0 nMNPASS
B16Mus musculus= 2500.0 nM|= 2120.0 nMNPASS
AGSHomo sapiens= 50800.0 nMNPASS
ACHNHomo sapiens= 2120.0 nM|= 2300.0 nM|= 1930.0 nMNPASS
A549Homo sapiens= 16.5 nM= 50.0 nM|= 2900.0 nM|= 0.0043 ug.mL-1|= 12.0 nM|= 7630.0 nM|= 7380.0 nM|= 500.0 nM|= 7.47 nM|= 3750.0 nM|= 13620.0 nM|= 3600.0 nM|< 100.0 nM|= 3090.0 nM|= 59.0 nM|= 2550.0 nM|= 128610.0 nM|= 14.0 nM|= 1360.0 nM|= 90.0 nM|= 9340.0 nM|= 5610.0 nM|= 3760.0 nM|= 4600.0 nM|= 3060.0 nM|= 2600.0 nM|= 7340.0 nM|= 105.0 nM|= 291.0 nM|= 338.0 nM|= 4310.0 nM|= 16.0 nM|= 2130.0 nM|= 5.37 nM|= 15.8 nMNPASS
A498Homo sapiens= 0.034 ug.mL-1NPASS
A2780Homo sapiens= 15.0 nM|= 20.0 nMNPASS
A-431Homo sapiens> 100000.0 nMNPASS
C8166Homo sapiens< 150.0 nMNPASS
A-375Homo sapiens= 2620.0 nMNPASS
FaDuHomo sapiens= 7.2 nMNPASS
Glucocorticoid receptorHomo sapiensP0415014 nM|= 14.0 nMBindingDB, NPASS
L02Homo sapiens= 22.0 nM|= 3720.0 nM|= 5000.0 nM|= 85.0 nM|= 4310.0 nM|= 3160.0 nM|= 2970.0 nMNPASS
KBHomo sapiens= 3.6 nM|= 0.006 ug.mL-1|= 4.8 nM|= 0.00621 ug.mL-1|= 0.005 ug.mL-1|= 3.0 nM|= 8.0 nM|= 56.0 nM|= 0.5 nM|= 0.7 nM|= 11.7 nM|= 58.0 nM|= 0.002 ug.mL-1NPASS
K562/VCRHomo sapiens= 50.0 nMNPASS
L6Rattus norvegicus= 14.0 nM|= 12.0 nM|= 9.0 nM|= 17.0 nM|= 0.007 ug.mL-1|= 0.005 ug.mL-1= 150.0 nM|= 12.0 nM|= 0.005 ug.mL-1|= 18.6 nM|= 10.0 nM|= 7.0 nM|= 0.009 ug.mL-1|= 19.0 nM|= 0.006 ug.mL-1|= 0.007 ug.mL-1|= 20.0 nM|= 0.018 ug.mL-1|= 14.0 nM|= 17.0 nM|= 0.004 ug.mL-1|= 0.008 ug.mL-1|= 21.0 nM|= 9.0 nM|= 22.0 nM|= 1.7 nM|= 14.5 nM|= 19.3 nM|= 8.0 nM|= 1.0 nM|= 19000.0 nM|= 6.0 nM|= 5.0 nM|= 0.02 ug.mL-1|= 9.7 nM|= 2.0 nM|= 16.9 nM|= 8.2 nM|= 16.0 nM|= 41.0 nM|= 18.0 nM|= 11.0 nM|= 24.0 nMNPASS
K562Homo sapiens> 100000.0 nM|= 30.0 nM|= 4510.0 nM|= 0.013 ug.mL-1|= 6.0 nM|= 25.0 nM|= 18390.0 nMNPASS
JurkatHomo sapiens= 25.0 nMNPASS
J774.2= 13.4 nM|= 11.3 nMNPASS
J774Mus musculus= 16.4 nM|= 18.0 nM|= 23.0 nMNPASS
Isoform 2 of Nuclear receptor ROR-alpha (Alpha-2)Homo sapiensP3539881 nMBindingDB
Human papillomavirus regulatory protein E2Human papillomavirus type 16P03120= 70500.0 nMNPASS
Human immunodeficiency virus 1Human immunodeficiency virus 1= 2.9 nMNPASS
Human herpesvirus 1Human herpesvirus 1= 50.0 nMNPASS
GLC4 cell line= 60.0 nM|= 150.0 nMNPASS
HepG2Homo sapiens= 4800.0 nM|= 500.0 nM|= 24.0 nM|= 2270.0 nM|= 510.0 nM|< 100.0 nM|= 14.0 nM|= 5810.0 nM|= 8.0 nM|= 6630.0 nM|= 3060.0 nM|= 2400.0 nM|= 209.0 nM|= 83.0 nM|= 19.6 ug.mL-1|= 4310.0 nM|> 200000.0 nMNPASS
HUVECHomo sapiens= 14.0 nMNPASS
HT-29Homo sapiens= 50.0 nM|= 2900.0 nM|= 0.0043 ug.mL-1|= 24.0 nM|= 29.0 nM|= 12.0 nM|= 2.9 nM|= 11.0 nM|= 780.0 nM|= 1020.0 nM|= 2290.0 nM|= 2990.0 nM|= 4780.0 nM|= 66.0 nM|> 100000.0 nM|= 1260.0 nM|= 1750.0 nM|= 23.0 nMNPASS
HT-1080Homo sapiens= 8100.0 nMNPASS
HOP-62Homo sapiens= 13100.0 nMNPASS
HMECHomo sapiens= 5600.0 nM|= 1338.0 nMNPASS
HL-60Homo sapiens= 2750.0 nMNPASS
HEp-2Homo sapiens= 1420.0 nMNPASS
HEK293Homo sapiens= 17.0 nM|= 50000.0 nM|= 0.12 ug.mL-1NPASS
HEK-293THomo sapiens= 20.0 ug.mL-1NPASS
HCT-8Homo sapiens= 1680.0 nMNPASS
HCT-15Homo sapiens= 1000.0 nM|= 61.0 nMNPASS
HCT-116Homo sapiens> 20000.0 nMNPASS
HeLaHomo sapiens= 69.0 nM|= 100.0 nM|= 7580.0 nM|= 140.0 nM|= 2800.0 nM|= 2810.0 nM|= 3.14 ug.mL-1|= 1920.0 nM|= 12.0 nM|= 1450.0 nM|= 7450.0 nM|= 3040.0 nM|= 3450.0 nM|= 2360.0 nM|= 3060.0 nM|= 6900.0 nM|= 14.0 nM|= 2130.0 nM|= 44.0 nM|= 15.5 nM|= 18.0 nM|= 17.0 nMNPASS
1A9Homo sapiens= 3.0 nMNPASS