IMPPAT Phytochemical information: 
Cryptotanshinone
Cryptotanshinone
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2P0DTD14200 nM|= 4200.0 nM|= 5630.0 nM|= 1336.0 nMBindingDB, NPASS
Protein-tyrosine phosphatase 1BHomo sapiensP18031= 33500.0 nMNPASS
Protein-tyrosine phosphatase 1CHomo sapiensP29350= 39500.0 nMNPASS
Protein-tyrosine phosphatase 2CHomo sapiensQ06124= 23900.0 nM|= 45180.0 nM|= 22500.0 nMNPASS
ProteaseHuman immunodeficiency virus 1Q9YQ12= 69600.0 nMNPASS
Receptor-type tyrosine-protein phosphatase F (LAR)Homo sapiensP10586= 36900.0 nMNPASS
Replicase polyprotein 1abHuman SARS coronavirusP0C6X7226700 nM9000 nMBindingDB
SARS coronavirus 3C-like proteinaseSARS coronavirusP0C6U8= 226700.0 nM|= 800.0 nM|= 87600.0 nM|= 10100.0 nM= 9000.0 nMNPASS
T-cell protein-tyrosine phosphataseHomo sapiensP17706= 55700.0 nMNPASS
Signal transducer and activator of transcription 3Homo sapiensP40763= 4600.0 nMNPASS
StreptococcusStreptococcus= 14089.0 nMNPASS
Streptococcus sp. 'group A'Streptococcus sp. 'group A'= 5172.0 nMNPASS
Tryptophan 2,3-dioxygenaseHomo sapiensP48775= 9800.0 nMNPASS
Tyrosine-protein phosphatase non-receptor type 11Homo sapiensQ0612422500 nMBindingDB
Tyrosine-protein phosphatase non-receptor type 9Homo sapiensP43378= 59400.0 nMNPASS
Plasmodium falciparumPlasmodium falciparum= 12500.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 200000.0 nM|= 700.0 nMNPASS
PapainCarica papayaP00784= 89800.0 nMNPASS
Streptokinase AStreptococcus pyogenes serotype M1P1052014816 nM|= 3953.0 nM|= 14816.0 nMBindingDB, NPASS
NON-PROTEIN TARGET> 30000.0 nM|= 6900.0 nM|= 7500.0 nM|= 17220.0 nMNPASS
AGSHomo sapiens= 13500.0 nM|= 10200.0 nMNPASS
AcetylcholinesteraseHomo sapiensP22303> 100000.0 nM|= 6410.0 nMNPASS
Acyl coenzyme A:cholesterol acyltransferaseHomo sapiensP23141= 544.0 nMNPASS
Aldo-keto reductase family 1 member B1Rattus norvegicusP079434786 nMBindingDB
Aldose reductaseRattus norvegicusP07943= 4786.3 nMNPASS
Carboxylesterase 2Homo sapiensO00748= 290.0 nM|= 141.0 nMNPASS
ECa-109 cell lineHomo sapiens= 5010.0 nMNPASS
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alphaHomo sapiensQ16665|Q998141360 nM|1580 nMBindingDB
PBMCHomo sapiens= 37400.0 nMNPASS
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alphaHomo sapiens= 1580.0 nM|= 1360.0 nMNPASS
Indoleamine 2,3-dioxygenaseHomo sapiensP14902= 10000.0 nMNPASS
Leishmania majorLeishmamajor= 18400.0 nMNPASS
Leukocyte common antigenHomo sapiensP08575= 41400.0 nMNPASS
Lysine-specific histone demethylase 1Homo sapiensO60341= 9020.0 nMNPASS
Lysine-specific histone demethylase 1AHomo sapiensO603419020 nMBindingDB
MIA PaCa-2Homo sapiens= 5800.0 nMNPASS
HepG2Homo sapiens= 29200.0 nMNPASS