IMPPAT Phytochemical information: 
Thiocolchicine
Thiocolchicine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
P388Mus musculus= 5.0 nMNPASS
RPMI-7951Homo sapiens= 0.024 nMNPASS
Similar to alpha-tubulin isoform 1Bos taurus1400 nM|640 nM|4900 nM|2100 nMBindingDB
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chainBos taurusQ6B8561400 nMBindingDB
TE-671Homo sapiens= 0.024 nMNPASS
Tubulin alpha chainSus scrofaP02550= 645.65 nM= 700.0 nMNPASS
TubulinBos taurusQ6B856|Q862L2|Q862F3= 2100.0 nM|= 1400.0 nM|= 640.0 nM|= 4900.0 nMNPASS
TubulinHomo sapiensP68371|Q9H4B7|P0DPH7|P68366|Q13509|Q71U36|P04350|Q3ZCM7|P07437|P68363|Q9BQE3|Q6PEY2|Q13885|Q9BVA1|Q9BUF5= 650.0 nM|= 2100.0 nMNPASS
MDA-MB-468Homo sapiens= 200.0 nMNPASS
Tubulin alpha-1A chainSus scrofaP02550645.65 nM700 nMBindingDB
Tubulin beta chainBos taurusQ6B856= 1300.0 nMNPASS
Tubulin beta-2B chainBos taurusQ6B8561300 nMBindingDB
TubulinBos taurusQ6B856|Q862F3= 1400.0 nMNPASS
MDA-MB-231Homo sapiens= 81.2 nM|= 0.6 nM|= 100.0 nMNPASS
T47DHomo sapiens= 4100.0 nMNPASS
LoVoHomo sapiens= 21.0 nM|= 13.6 nM|= 1.0 nMNPASS
MCF7Homo sapiens= 400.0 nM|= 100.0 nM|= 1.1 nM|= 9.6 nM|= 55.5 nMNPASS
A549Homo sapiens= 72.0 nM|= 11.3 nM|= 600.0 nM|= 500.0 nM|= 0.9 nMNPASS
BALB/3T3Mus musculus= 9.6 nM|= 137.0 nMNPASS
CA46Homo sapiens= 4500.0 nMNPASS
Caco-2Homo sapiens= 500.0 nMNPASS
DLD-1Homo sapiens= 4.2 nMNPASS
H9Homo sapiens= 1.8 nMNPASS
NON-PROTEIN TARGET= 10000.0 nMNPASS
HepG2Homo sapiens= 500.0 nMNPASS
Human immunodeficiency virus 1Human immunodeficiency virus 1= 1.7 nMNPASS
IGROV-1Homo sapiens= 12.0 nMNPASS
KBHomo sapiens= 0.04 nMNPASS
L1210Mus musculus= 8.0 nMNPASS
HCT-8Homo sapiens= 15.0 nMNPASS