IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
SUP-B15	Homo sapiens		= 103000.0 nM				NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2		= 1690.0 nM\|= 5150.0 nM\|= 2940.0 nM\|= 2900.0 nM\|= 4500.0 nM\|= 1200.0 nM	= 5100.0 nM			NPASS
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1	= 1690.0 nM	940 nM\|= 20.0 nM\|= 50600.0 nM\|= 966.0 nM\|= 940.0 nM\|= 900.0 nM\|= 980.0 nM\|= 5160.0 nM\|= 340.0 nM\|= 939.72 nM\|= 1100.0 nM\|= 390.0 nM\|= 5100.0 nM	= 11500.0 nM\|= 12400.0 nM\|= 31300.0 nM		BindingDB, NPASS
Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	K9N7C7		> 10000.0 nM			NPASS
Replicase polyprotein 1ab	2019-nCoV	P0DTD1	2940 nM	20 nM\|940 nM			BindingDB
Receptor-type tyrosine-protein phosphatase S	Homo sapiens	Q13332		10300 nM\|= 10300.0 nM			BindingDB, NPASS
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens	P36888		>10000 nM			BindingDB
Radical scavenging activity				= 18.2 ug.mL-1			NPASS
RBL-2H3	Rattus norvegicus			= 179000.0 nM			NPASS
RAW264.7	Mus musculus			= 13010.0 nM\|> 100000.0 nM\|= 30400.0 nM			NPASS
Pseudomonas aeruginosa	Pseudomonas aeruginosa			> 400000.0 nM			NPASS
Prostaglandin G/H synthase 1/2	Rattus norvegicus	P35355\|Q63921		50000 nM			BindingDB
Prostaglandin G/H synthase 1	Ovis aries	P05979		>1.50e+5 nM			BindingDB
Prolyl endopeptidase	Homo sapiens	P48147		36000 nM\|= 36000.0 nM			BindingDB, NPASS
Polyunsaturated fatty acid lipoxygenase ALOX15B	Rattus norvegicus	Q8K4F2		260 nM			BindingDB
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens	O15296		7.1e+4 nM\|>1.00e+5 nM\|>100000 nM			BindingDB
Polyunsaturated fatty acid lipoxygenase ALOX15	Rattus norvegicus	Q02759		15 nM			BindingDB
Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens	P16050		1.15e+4 nM\|9100 nM		600 nM	BindingDB
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens	P18054		3.3e+3 nM\|860 nM		1600 nM	BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus	P12527		>10000 nM\|10000 nM			BindingDB
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens	P09917	>370000 nM	8.5e+2 nM			BindingDB
P-glycoprotein 1	Homo sapiens	P08183		= 41000.0 nM			NPASS
NON-PROTEIN TARGET				= 2720.0 nM\|= 342300.0 nM\|= 19100.0 nM\|= 27880.0 nM\|> 20000.0 nM			NPASS
dengue virus type 3	dengue virus type 3			= 17240.0 nM			NPASS
MCF7	Homo sapiens			= 5.3 ug.mL-1			NPASS
SW480	Homo sapiens			= 14050.0 nM\|= 16950.0 nM\|= 11550.0 nM			NPASS
Progesterone receptor	Homo sapiens	P06401		15000 nM\|= 15000.0 nM			BindingDB, NPASS
Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium			> 400000.0 nM			NPASS
Lysosomal alpha-glucosidase	Homo sapiens	P10253		500000 nM\|= 500000.0 nM			BindingDB, NPASS
Serine/threonine-protein kinase PLK1	Homo sapiens	P53350		9000 nM\|= 9000.0 nM			BindingDB, NPASS
Zika virus	Zika virus			= 19600.0 nM			NPASS
ZR-75-1	Homo sapiens		= 35000.0 nM\|= 25000.0 nM				NPASS
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		2790 nM			BindingDB
Xanthine dehydrogenase/oxidase	Bos taurus	P80457		3300 nM\|71500 nM			BindingDB
Xanthine dehydrogenase	Homo sapiens	P47989		= 2790.0 nM			NPASS
Xanthine dehydrogenase	Bos taurus	P80457		= 3300.0 nM\|= 71500.0 nM			NPASS
West Nile virus	West Nile virus			= 14500.0 nM			NPASS
Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	P22002		= 85100.0 nM			NPASS
Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695)	P69996		291000 nM			BindingDB
Urease subunit alpha/Urease subunit beta	Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)			= 291000.0 nM			NPASS
UDP-glucuronosyltransferase 1A1	Homo sapiens	P22309		4400 nM\|7000 nM			BindingDB
UDP-glucuronosyltransferase 1-1	Homo sapiens	P22309		= 4400.0 nM\|= 7000.0 nM			NPASS
Tyrosine-protein kinase receptor FLT3	Homo sapiens	P36888		> 10000.0 nM			NPASS
Tyrosine-protein kinase Yes	Homo sapiens	P07947		3300 nM			BindingDB
Tyrosine-protein kinase YES	Homo sapiens	P07947		= 3300.0 nM			NPASS
Trypsin	Homo sapiens	P35030		= 3700.0 nM			NPASS
Trypsin	Homo sapiens	P07477\|P07478\|P35030		3700 nM			BindingDB
Sucrase-isomaltase, intestinal	Rattus norvegicus	P23739		260000 nM\|52000 nM			BindingDB
Sucrase-isomaltase, intestinal	Homo sapiens	P14410		35000 nM\|52000 nM			BindingDB
Sucrase-isomaltase	Rattus norvegicus	P23739		= 52000.0 nM\|= 260000.0 nM			NPASS
Sucrase-isomaltase	Homo sapiens	P14410		= 52000.0 nM\|= 35000.0 nM			NPASS
Staphylococcus aureus	Staphylococcus aureus			> 400000.0 nM			NPASS
Sialidase-2	Homo sapiens	Q9Y3R4		130000 nM			BindingDB
Sialidase 2	Homo sapiens	Q9Y3R4		= 130000.0 nM			NPASS
Serotonin 7 (5-HT7) receptor	Homo sapiens	P34969		> 350000.0 nM			NPASS
Serine/threonine-protein kinase PLK3	Homo sapiens	Q9H4B4		40000 nM\|= 40000.0 nM			BindingDB, NPASS
Serine/threonine-protein kinase PLK2	Homo sapiens	Q9NYY3		314000 nM\|= 314000.0 nM			BindingDB, NPASS
Seed linoleate 13S-lipoxygenase-1	Glycine max	P08170		2.26e+4 nM			BindingDB
Lysine-specific histone demethylase 1A	Homo sapiens	O60341		12500 nM			BindingDB
Linoleate 9S-lipoxygenase-4	Glycine max	P38417		2.20e+4 nM			BindingDB
Lysine-specific demethylase 4E	Homo sapiens	B2RXH2		3000 nM		4330 nM	BindingDB
Cyclooxygenase	Rattus norvegicus	Q63921		= 50000.0 nM			NPASS
Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	P14635		= 6530.0 nM			NPASS
Cyclin-dependent kinase 1	Homo sapiens	P06493		6530 nM			BindingDB
Chikungunya virus	Chikunguvirus			= 16900.0 nM			NPASS
Casein kinase II subunit alpha 3	Homo sapiens	Q8NEV1		10000 nM			BindingDB
Casein kinase 2	Rattus norvegicus			= 10000.0 nM			NPASS
Casein kinase 2	Homo sapiens			= 10000.0 nM			NPASS
Candida albicans	Candida albicans			= 6.0 ug.mL-1			NPASS
BJ	Homo sapiens		> 86206.9 nM				NPASS
Aurora kinase B	Homo sapiens	Q96GD4		4.06e+3 nM			BindingDB
Arachidonate 5-lipoxygenase	Rattus norvegicus	P12527		= 10000.0 nM\|> 10000.0 nM			NPASS
Arachidonate 5-lipoxygenase	Homo sapiens	P09917	> 100.0 mg kg-1				NPASS
Cytochrome P450 1A1	Homo sapiens	P04798				1220 nM\|= 1220.0 nM	BindingDB, NPASS
Arachidonate 15-lipoxygenase, type II	Rattus norvegicus	Q8K4F2		= 260.0 nM			NPASS
Arachidonate 15-lipoxygenase	Homo sapiens	P16050		= 9100.0 nM		= 600.0 nM	NPASS
Arachidonate 12-lipoxygenase	Rattus norvegicus	Q02759		= 15.0 nM			NPASS
Arachidonate 12-lipoxygenase	Homo sapiens	P18054		= 860.0 nM		= 1600.0 nM	NPASS
Alpha-synuclein	Homo sapiens	P37840		8200 nM\|= 8200.0 nM			BindingDB, NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183		41000 nM			BindingDB
A549	Homo sapiens			= 13000.0 nM			NPASS
5-hydroxytryptamine receptor 7	Homo sapiens	P34969		>350000 nM			BindingDB
4-aminobutyrate aminotransferase, mitochondrial	Homo sapiens	P80404		12800000 nM			BindingDB
3T3-L1	Mus musculus			= 29810.0 nM			NPASS
17-beta-hydroxysteroid dehydrogenase type 3	Homo sapiens	P37058		9.3e+3 nM\|185920 nM			BindingDB
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli (strain K12)	P45568		2.2e+3 nM			BindingDB
Lysine-specific histone demethylase 1	Homo sapiens	O60341		= 12500.0 nM			NPASS
Arachidonate 15-lipoxygenase, type II	Homo sapiens	O15296		> 100000.0 nM			NPASS
Cytochrome P450 3A4	Homo sapiens	P08684		9200 nM\|= 9200.0 nM			BindingDB, NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678				260 nM\|= 260.0 nM	BindingDB, NPASS
Glyoxalase I	Homo sapiens	Q04760		= 11000.0 nM			NPASS
Lactoylglutathione lyase	Homo sapiens	Q04760		11000 nM			BindingDB
KOPN-8	Homo sapiens		= 16000.0 nM				NPASS
KB 3-1	Homo sapiens		= 41000.0 nM	= 87100.0 nM			NPASS
KB	Homo sapiens			= 62300.0 nM\|= 87100.0 nM			NPASS
Integrase	Human immunodeficiency virus 1			1200 nM\|7500 nM\|780 nM\|2700 nM\|4300 nM			BindingDB
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		= 1200.0 nM\|= 4300.0 nM\|= 7500.0 nM\|= 780.0 nM\|= 2700.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 1.67 ug.mL-1				NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 1204.0 nM			NPASS
Hepatitis C virus	Hepatitis C virus		= 33900.0 nM				NPASS
HepG2	Homo sapiens		= 60000.0 nM	= 28300.0 nM\|= 28090.0 nM			NPASS
HT-29	Homo sapiens			= 18050.0 nM\|> 20000.0 nM\|= 18360.0 nM			NPASS
DNA polymerase eta	Homo sapiens	Q9Y253		= 11800.0 nM			NPASS
Lysine-specific demethylase 4D-like	Homo sapiens	B2RXH2		= 3000.0 nM		= 4330.0 nM	NPASS
Glyceraldehyde-3-phosphate dehydrogenase liver	Homo sapiens	P04406		= 43930.0 nM			NPASS
Gamma-amino-N-butyrate transaminase	Homo sapiens	P80404		= 12800000.0 nM			NPASS
GABA-A receptor; anion channel	Homo sapiens	Q16445				= 5623.41 nM	NPASS
G-protein coupled receptor 35	Homo sapiens	Q9HC97	10300 nM\|22700 nM\|= 10300.0 nM\|= 22700.0 nM	28200 nM\|= 28200.0 nM			BindingDB, NPASS
G protein-coupled receptor kinase 6	Homo sapiens	P43250		8700 nM\|= 8700.0 nM			BindingDB, NPASS
Fructose-1,6-bisphosphatase 1	Homo sapiens	P09467		29000 nM			BindingDB
Fructose-1,6-bisphosphatase	Homo sapiens	P09467		= 29000.0 nM			NPASS
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
Estradiol 17-beta-dehydrogenase 3	Homo sapiens	P37058		= 185920.0 nM			NPASS
Dipeptidyl peptidase IV	Homo sapiens	P27487		> 200000.0 nM			NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		>200000 nM			BindingDB
Dengue virus 2	Dengue virus 2			= 6.46 ug.mL-1			NPASS
Death-associated protein kinase 1	Homo sapiens	P53355		120000 nM\|= 120000.0 nM			BindingDB, NPASS
Glucocorticoid receptor	Homo sapiens	P04150		19000 nM\|= 19000.0 nM			BindingDB, NPASS

a curated database

IMPPAT Phytochemical information:
Baicalein

Bioactivity information

IMPPAT Phytochemical information: Baicalein

Bioactivity information

IMPPAT Phytochemical information:
Baicalein