IMPPAT Phytochemical information: 
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Sodium-dependent noradrenaline transporterHomo sapiensP23975128900 nMBindingDB
Sodium-dependent dopamine transporterHomo sapiensQ01959>10000000 nMBindingDB
Serotonin transporterHomo sapiensP31645= 46700.0 nMNPASS
Norepinephrine transporterHomo sapiensP23975= 128900.0 nMNPASS
Nicotinic acetylcholine receptor alpha-4/beta-2Mus musculusQ8R493= 12000.0 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta4Rattus norvegicusP12392= 300000.0 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta2Rattus norvegicusP12390= 870.0 nMNPASS
Neuronal acetylcholine receptor; alpha3/beta4Rattus norvegicusP12392= 100000.0 nM= 300000.0 nMNPASS
Neuronal acetylcholine receptor subunit beta-2/beta-4Mus musculusQ8R493|Q9ERK712000 nMBindingDB
Neuronal acetylcholine receptor subunit beta-2Mus musculusQ9ERK712000 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-2Rattus norvegicusP09483|P12390870 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-4Rattus norvegicusP09483|P12392300000 nMBindingDB
Sodium-dependent serotonin transporterHomo sapiensP3164546700 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3/beta-4Rattus norvegicusP04757|P12392100000 nM300000 nMBindingDB
Neuronal acetylcholine receptor protein alpha-7 subunitHomo sapiensP36544> 100000.0 nM> 100000.0 nMNPASS
Monoamine oxidase BHomo sapiensP27338= 29000.0 nMNPASS
Monoamine oxidase AHomo sapiensP21397= 27000.0 nMNPASS
ECa-109 cell lineHomo sapiens= 891.2 nMNPASS
Dopamine transporterHomo sapiensQ01959> 10000000.0 nMNPASS
Amine oxidase [flavin-containing] BHomo sapiensP2733829000 nMBindingDB
Amine oxidase [flavin-containing] AHomo sapiensP2139727000 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-7Homo sapiensP36544>100000 nM>100000 nMBindingDB