IMPPAT Phytochemical information: 
4-Hydroxycinnamic acid
4-Hydroxycinnamic acid
Summary

SMILES: OC(=O)/C=C/c1ccc(cc1)O
InChI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChIKey: NGSWKAQJJWESNS-ZZXKWVIFSA-N
DeepSMILES: OC=O)/C=C/cccccc6))O
Scaffold Graph/Node/Bond level: c1ccccc1
Scaffold Graph/Node level: C1CCCCC1
Scaffold Graph level: C1CCCCC1
Functional groups: c/C=C/C(=O)O; cO
Chemical classification
ClassyFire Kingdom: Organic compounds
ClassyFire Superclass: Phenylpropanoids and polyketides
ClassyFire Class: Cinnamic acids and derivatives
ClassyFire Subclass: Hydroxycinnamic acids and derivatives
NP Classifier Biosynthetic pathway: Shikimates and Phenylpropanoids
NP Classifier Superclass: Phenylpropanoids (C6-C3)
NP Classifier Class: Cinnamic acids and derivatives
Synonymous chemical names:
hydroxycinnamate, 4-hydroxycinnamic acid, p-hydroxycinnamic acid, trans-p-coumaric acid, 4-coumaric acid, trans-p-hydroxycinnamic acid, p-hydroxycinnamate, beta coumaric acid, p-coumaric, p-coumaric acid, 4-coumarate, p-coumaric-acid, p-hydroxycinnamic, p-coumaric acids, hydroxycinnamic acid
External chemical identifiers:
CID:CID_637542; ChEMBL:CHEMBL66879; ChEBI:CHEBI:32374; ZINC:ZINC000000039811; FDASRS:IBS9D1EU3J; SureChEMBL:SCHEMBL39106; MolPort-000-860-894
Chemical structure download
2D:2D MOL2D MOL22D SDF
3D:3D MOL3D MOL23D SDF3D PDB3D PDBQT
4-Hydroxycinnamic acid
Physicochemical properties
Property name Tool Property value
Molecular weight (g/mol) RDKit 164.16
Log P RDKit 1.49
Topological polar surface area (Å2) RDKit 57.53
Number of hydrogen bond acceptors RDKit 2
Number of hydrogen bond donors RDKit 2
Number of carbon atoms RDKit 9
Number of heavy atoms RDKit 12
Number of heteroatoms RDKit 3
Number of nitrogen atoms RDKit 0
Number of sulfur atoms RDKit 0
Number of chiral carbon atoms RDKit 0
Stereochemical complexity RDKit 0
Number of sp hybridized carbon atoms RDKit 0
Number of sp2 hybridized carbon atoms RDKit 9
Number of sp3 hybridized carbon atoms RDKit 0
Shape complexity RDKit 0
Number of rotatable bonds RDKit 2
Number of aliphatic carbocycles RDKit 0
Number of aliphatic heterocycles RDKit 0
Number of aliphatic rings RDKit 0
Number of aromatic carbocycles RDKit 1
Number of aromatic heterocycles RDKit 0
Number of aromatic rings RDKit 1
Total number of rings RDKit 1
Number of saturated carbocycles RDKit 0
Number of saturated heterocycles RDKit 0
Number of saturated rings RDKit 0
Number of Smallest Set of Smallest Rings (SSSR) RDKit 1
4-Hydroxycinnamic acid
Drug-likeness properties
Property nameToolProperty value
Number of Lipinski’s rule of 5 violations RDKit 0
Lipinski’s rule of 5 RDKit Passed
Number of Ghose rule violations RDKit 0
Ghose rule RDKit Passed
Veber rule RDKit Good
Egan rule RDKit Good
GSK 4/400 rule RDKit Good
Pfizer 3/75 rule RDKit Bad
Weighted quantitative estimate of drug-likeness (QEDw) score RDKit 0.65
4-Hydroxycinnamic acid
ADME properties
Property nameToolProperty value
Bioavailability score SwissADME 0.85
Solubility class [ESOL] SwissADME Soluble
Solubility class [Silicos-IT] SwissADME Soluble
Blood Brain Barrier permeation SwissADME Yes
Gastrointestinal absorption SwissADME High
Log Kp (Skin permeation, cm/s) SwissADME -6.26
Number of PAINS structural alerts SwissADME 0
Number of Brenk structural alerts SwissADME 1
CYP1A2 inhibitor SwissADME No
CYP2C19 inhibitor SwissADME No
CYP2C9 inhibitor SwissADME No
CYP2D6 inhibitor SwissADME No
CYP3A4 inhibitor SwissADME No
P-glycoprotein substrate SwissADME No
4-Hydroxycinnamic acid
Human target proteins
Protein identifierHGNC symbolCombined score from STITCH database
ENSP00000369050CYP1A1728
ENSP00000342007CYP1A2728
ENSP00000321988SULT1A1700
ENSP00000311572PTGR1932
ENSP00000263321TYR872
ENSP00000262290LPO794
ENSP00000261208HAL781
ENSP00000318820TPO702
ENSP00000225275MPO705
ENSP00000225371EPX705
The human target proteins were predicted using STITCH, a database of Chemical-Protein interaction networks.