IMPPAT Phytochemical information: 
4,5-Dihydroniveusin A
4,5-Dihydroniveusin A
Summary

SMILES: OCC1C[C@H]2OC(=O)C(=C)[C@H]2[C@@H](C[C@]2(O[C@]1(O)C[C@@H]2O)C)OC(=O)/C(=C\C)/C
InChI: InChI=1S/C20H28O8/c1-5-10(2)17(23)27-14-7-19(4)15(22)8-20(25,28-19)12(9-21)6-13-16(14)11(3)18(24)26-13/h5,12-16,21-22,25H,3,6-9H2,1-2,4H3/b10-5-/t12?,13-,14-,15+,16-,19-,20-/m1/s1
InChIKey: SNUZCOSRHAIVKC-KABXGVFYSA-N
DeepSMILES: OCCC[C@H]OC=O)C=C)[C@H]5[C@@H]C[C@]O[C@]%12O)C[C@@H]5O)))))C)))OC=O)/C=C\C))/C
Scaffold Graph/Node/Bond level: C=C1C(=O)OC2CCC3CCC(CCC12)O3
Scaffold Graph/Node level: CC1C(O)OC2CCC3CCC(CCC21)O3
Scaffold Graph level: CC1CC2CCC3CCC(CCC2C1C)C3
Functional groups: CO; C=C1CCOC1=O; C[C@@](O)(C)OC; C/C=C(/C)C(=O)OC
Chemical classification
ClassyFire Kingdom: Organic compounds
ClassyFire Superclass: Lipids and lipid-like molecules
ClassyFire Class: Prenol lipids
ClassyFire Subclass: Terpene lactones
NP Classifier Biosynthetic pathway: Terpenoids
NP Classifier Superclass: Sesquiterpenoids
NP Classifier Class: Germacrane sesquiterpenoids
Synonymous chemical names:
4,5-dihydroniveusin A, 4,5-dihydroniveusin a
External chemical identifiers:
CID:CID_101637361; ChEBI:CHEBI:175970
Chemical structure download
2D:2D MOL2D MOL22D SDF
3D:3D MOL3D MOL23D SDF3D PDB3D PDBQT
4,5-Dihydroniveusin A
Physicochemical properties
Property name Tool Property value
Molecular weight (g/mol) RDKit 396.44
Log P RDKit 0.59
Topological polar surface area (Å2) RDKit 122.52
Number of hydrogen bond acceptors RDKit 8
Number of hydrogen bond donors RDKit 3
Number of carbon atoms RDKit 20
Number of heavy atoms RDKit 28
Number of heteroatoms RDKit 8
Number of nitrogen atoms RDKit 0
Number of sulfur atoms RDKit 0
Number of chiral carbon atoms RDKit 7
Stereochemical complexity RDKit 0.35
Number of sp hybridized carbon atoms RDKit 0
Number of sp2 hybridized carbon atoms RDKit 6
Number of sp3 hybridized carbon atoms RDKit 14
Shape complexity RDKit 0.7
Number of rotatable bonds RDKit 4
Number of aliphatic carbocycles RDKit 0
Number of aliphatic heterocycles RDKit 3
Number of aliphatic rings RDKit 3
Number of aromatic carbocycles RDKit 0
Number of aromatic heterocycles RDKit 0
Number of aromatic rings RDKit 0
Total number of rings RDKit 3
Number of saturated carbocycles RDKit 0
Number of saturated heterocycles RDKit 3
Number of saturated rings RDKit 3
Number of Smallest Set of Smallest Rings (SSSR) RDKit 3
4,5-Dihydroniveusin A
Drug-likeness properties
Property nameToolProperty value
Number of Lipinski’s rule of 5 violations RDKit 0
Lipinski’s rule of 5 filter RDKit Passed
Number of Ghose filter violations RDKit 0
Ghose filter RDKit Passed
Veber filter RDKit Good
Pfizer 3/75 filter RDKit Good
GSK 4/400 filter RDKit Good
Weighted quantitative estimate of drug-likeness (QEDw) score RDKit 0.468053
4,5-Dihydroniveusin A
ADME properties
Property nameToolProperty value
Bioavailability score SwissADME 0.55
Solubility class [ESOL] SwissADME Soluble
Solubility class [Silicos-IT] SwissADME Soluble
Blood Brain Barrier permeation SwissADME No
Gastrointestinal absorption SwissADME High
Log Kp (Skin permeation, cm/s) SwissADME -7.80
Number of PAINS structural alerts SwissADME 0
Number of Brenk structural alerts SwissADME 2
CYP1A2 inhibitor SwissADME No
CYP2C19 inhibitor SwissADME No
CYP2C9 inhibitor SwissADME No
CYP2D6 inhibitor SwissADME No
CYP3A4 inhibitor SwissADME No
P-glycoprotein substrate SwissADME Yes