IMPPAT Phytochemical information: 
Riboflavin

Riboflavin
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
RIBOGENE: Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood PressureRIBOGENE: Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood PressureNCT02463513
The effect of riboflavin supplementation on Faecalibacterium prausnitzii in Crohn's diseaseThe effect of riboflavin supplementation on Faecalibacterium prausnitzii in Crohn's disease - Riboflavin in Crohn's disease / RISE-UP studyNL-OMON41902
Study to see if riboflavin reduces neuronal damage in patients with acute ischemic stroke"""Randomized clinical trial with two parallel groups, double-blind, placebo-controlled trial to investigate whether administration of CBG000592 (riboflavin/vitamin B2) in patients with acute ischemic stroke causes a reduction of glutamate-mediated excitotoxicity"""EUCTR2014-003123-22-ES
Administration of CBG000592 (Riboflavin/Vitamin B2) in Patients With Acute Ischemic StrokeRandomized Clinical Trial to Investigate Whether Administration of CBG000592 (Riboflavin/Vitamin B2) in Patients With Acute Ischemic Stroke Causes a Reduction of Glutamate-mediated ExcitotoxicityNCT02540980
Administration of CBG000592 (Riboflavin/Vitamin B2) in Patients With Acute Ischemic StrokeRandomized Clinical Trial to Investigate Whether Administration of CBG000592 (Riboflavin/Vitamin B2) in Patients With Acute Ischemic Stroke Causes a Reduction of Glutamate-mediated ExcitotoxicityNCT02446977
Riboflavin and thiamine dietary nutrition supplementation or reduction of anxiety, stress condition and improvement of sleep quality: A randomized double-blind, placebo-controlled trialAssociation between thiamine (vitamin B1) and riboflavin (vitamin B2) nutrition intervention on anxiety, stress and sleep qualityChiCTR2500096497
Safety and efficacy of photodynamic therapy (with riboflavin as sensitizer) for treatment of malaria in adult Nigerian populationSafety and efficacy of photodynamic therapy (with riboflavin as sensitizer) for treatment of malaria in adult Nigerian population: a Phase II studyPACTR201912897645869
Effect of Riboflavin in treatment of irritable bowel syndromeThe effect of Riboflavin supplement on mental health and clinical outcomes in patients with irritable bowel syndromeIRCT20090901002394N52
Effectiveness of chlorhexidine varnish and riboflavin in reducing oral bacteria in people with braces.COMPARING THE EFFICACY OF RIBOFLAVIN A PHOTOSENSITISING COMPOUND AND CHLORHEXIDINE VARNISH IN CONTROLLING ORAL MICROFLORA IN ORTHODONTIC PATIENTSA RANDOMISED CONTROLLED TRIAL - NilCTRI/2025/04/085485
A food supplement based on probiotics, vitamin PP and vitamin B2 can improve heartburn symptoms/dyspeptic disorders and heartburn-related quality of life in subjects with mild to moderate gastroesophageal reflux disease (GERD)Evaluation of the efficacy of a food supplement based on probiotics, vitamin PP and vitamin B2 in improving heartburn symptom/dyspeptic disorders and heartburn-related quality of life in subjects with mild to moderate gastroesophageal reflux disease (GERD): a randomized, double-blind, placebo-controlled clinical studyISRCTN96068143
Antimicrobial property and bracket failure rate of modified orthodontic bonding resin with vitamin b2Evaluation of antimicrobial capacity and bracket failure rate of riboflavin photosensitizer modified orthodontic bonding agentCTRI/2023/03/050647
Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic RiboflavinCorneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic RiboflavinNCT01152541
A clinical trial to compare the effects of riboflavin and propranolol in preventive therapy of migraineRandomized, double-blind, placebo-controlled study to compare the efficacy of riboflavin versus propranolol in prophylaxis of migraineAcronym: RiMiProCTRI/2010/091/000539
Riboflavin Corneal Crosslinking for Brittle Cornea Syndrome and Ehlers-Danlos Syndrome Type VINCT01307527
UVA-Riboflavin Crosslinking Treatment of Corneal EctasiaUVA-Riboflavin Crosslinking Treatment of Corneal EctasiaNCT01325298
Riboflavin and multiple sclerosisA study on nutritional status of riboflavin and the effect of riboflavin supplementation on disability and quality of life scores in patients with multiple sclerosisIRCT201102175855N1
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With KeratoconusA Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With KeratoconusNCT01344187
Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive SurgeryMulti-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive SurgeryNCT01459679
The effect of cross linking on infectious corneal ulcerRiboflavin-UV A chollagen crosslinking for treatment of recalcitrant infectious corneal ulcersIRCT201105074166N3
Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and RiboflavinCorneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Hypo-osmolar Riboflavin Solution in Thin CorneasNCT01485211
Does the B-vitamin riboflavin lower blood pressure in individuals with high blood pressure who have a specific genetic make up?An interventional study to investigate the effect of riboflavin supplementation (1.6mg/d/16weeks) on blood pressure in hypertensive individuals who are homozygous for the 677Câ T polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR)ISRCTN23620802
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With KeratoconusA Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With KeratoconusNCT01643226
Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive SurgeryA Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive SurgeryNCT01643252
Ultraviolet-A and Riboflavin Treatment for Infectious KeratitisUltraviolet-A and Riboflavin Treatment for Infectious KeratitisNCT01739673
The effect of riboflavin to prevent the migraine in 5-13 year-old childrenThe effect of riboflavin to prevent the migraine in 5-13 year-old childrenIRCT2013020412361N1
Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic AstigmatismA Multi-Center, Randomized, Controlled Evaluation of the Safety and Efficacy of LASIK With Cross-linking Performed With the KXL System and Photrexa ZD™ (Riboflavin Ophthalmic Solution) Compared to LASIK Alone for Hyperopia and Hyperopic AstigmatismNCT01893359
Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With KeratoconusA Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With KeratoconusNCT01972854
Comparison of of two pharmaceutical products of Riboflavin for keratoconusComparison of clinical results of two pharmaceutical products of Riboflavin in corneal collagen Cross-Linking for keratoconusIRCT201212034333N2
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive EctasiaEvaluation of Two Riboflavin Dosing Regimens for Corneal Collagen Cross-Linking in Eyes With Progressive Keratoconus or EctasiaNCT01143389
The Impact of Riboflavin on the Severity and Duration of Sports Related ConcussionThe Impact of Riboflavin on the Severity and Duration of Sports Related ConcussionNCT02235337
Clinical Study on the Effectiveness of Vitamin B2 Treatment for Obstructive Sleep Apnea SyndromeClinical Study on the Effectiveness of Vitamin B2 Treatment for Obstructive Sleep Apnea SyndromeChiCTR2100050810
Evaluation of efficacy and safety of riboflavin/UVA treatment for keratoconus/keratectasiaEvaluation of efficacy and safety of riboflavin/UVA treatment for keratoconus/keratectasia - efficacy and safety of riboflavin/UVA for keratoconusJPRN-UMIN000002947
Effect of methyl donor supplementation in treatment of overweight and obesityProcessing and production of a methyl donor supplement (choline,folic acid, cobalamine, pyrodoxine and riboflavin) and the assessment of its effects on the anthropometric measurements, glycemic indices, lipid profile, appetite regulating hormones and the level of gene expression of leptin in overweight and obese subjectsIRCT20180528039881N1
Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine ProphylaxisReal World, Open Label Prospective Experience of Supplementation With a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine ProphylaxisNCT04463875
D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)Randomized, Open-Label Study of Continued Stavudine Versus Abacavir Substitution With or Without Riboflavin and Thiamine Supplementation in HIV-Infected Patients Who Have Elevated Venous Lactic Acid While on Stavudine-Based Therapy (DAVE)NCT00143702
Folate and Protection Against Cervical CancerA Randomised Placebo-Controlled Trial to Evaluate Interactions Between Riboflavin and Folate Intake and Genotype in Reducing Risk of Cervical CancerNCT00220532
Medical therapy of keratoconus with Riboflavin/Ultraviolet-A collagen Cross-Linking and investigation of the corneal stromal and Keratocytes modifications apoptosis and stromal repopulation with confocal microscopy and topo-aberrometric link firstly in vivo. Validation of the previous results ex vivo in animal and human enucleated eyes in human patients affected from progressive keratoconus. - X LinkingMedical therapy of keratoconus with Riboflavin/Ultraviolet-A collagen Cross-Linking and investigation of the corneal stromal and Keratocytes modifications apoptosis and stromal repopulation with confocal microscopy and topo-aberrometric link firstly in vivo. Validation of the previous results ex vivo in animal and human enucleated eyes in human patients affected from progressive keratoconus. - X LinkingEUCTR2006-000908-17-IT
A randomised prospective study to investigate the efficacy of corneal collagen cross-linkage with riboflavin (vitamin B2) and ultraviolet A light (UVA) (370nm) to halt the progression of keratoconus. - UVA/B2A randomised prospective study to investigate the efficacy of corneal collagen cross-linkage with riboflavin (vitamin B2) and ultraviolet A light (UVA) (370nm) to halt the progression of keratoconus. - UVA/B2EUCTR2006-000348-26-GB
An investigation of the functional significance of marginal riboflavin status in young womenAn investigation of the functional significance of marginal riboflavin status in young womenISRCTN35811298
A randomised prospective study to investigate the efficacy of corneal collagen cross linkage with riboflavin (vitamin B2) and ultraviolet A light (UVA) (370nm) to halt the progression of keratoconusISRCTN08013636
Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of KeratoconusRiboflavin Mediated Corneal Crosslinking for Stabilizing Progression of KeratoconusNCT00626717
Corneal Collagen Cross-linking with Riboflavin (C3R) with orthokeratologyPilot study of corneal collagen cross-linking with riboflavin (C3R) with pre-operative orthokeratologyISRCTN29378493
Collagen cross linking with riboflavin and ultraviolet A for the treatment of conical ectasia (progression) in keratoconic corneas: Analysis of clinical outcomes and micro structural changes.Collagen cross linking with riboflavin and ultraviolet A for the treatment of conical ectasia (progression) in keratoconic corneas: Analysis of clinical outcomes and micro structural changes.ACTRN12608000367347
Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate KeratoconusThe Safety and Effectiveness of Collagen Cross Linking With Riboflavin and Ultraviolet-A Light in Progressive Mild and Moderate Grades of Keratoconus.NCT00815256
Treatment of Keratoconus Using Collagen Cross-LinkingTreatment of Keratoconus Using Collagen Cross-Linking By Means of Topical Riboflavin and UV Light.NCT00841386
Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 MicronsCollagen Cross-linking With Riboflavin in a Hypotonic Solution, With UV Light, on Corneas Less Than 400 Microns Thick: an Exploratory Study.NCT00890266
Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal EctasiaRiboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal EctasiaNCT01123057
Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having KeratoconusA Study Evaluating the Safety and Efficacy of the KXL System With vibeX Rapid (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes Having Keratoconus and Post LASIK EctasiaNCT02638376
Use of Cross-linked Donor Corneas as Carriers for the Boston KeratoprosthesisThe Use of Riboflavin/Ultraviolet A Cross-linked Human Donor Corneas as Carriers for the Boston KeratoprosthesisNCT01582880
Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of RiboflavinComparative Study of Results of Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Riboflavin: a Randomized Control TrialNCT02456961
Theranostic Guided Riboflavin/UV-A Corneal Cross-linkingAssessment of Theranostic Guided Riboflavin/UV-A Corneal Cross-linking for Treatment of KeratoconusNCT05457647
Evaluation of photodynamic therapy (a treatment that involves light-sensitive medicine and a light source to destroy abnormal cells) as a safe and effective treatment for malariaEvaluation of anti-microbial photodynamic therapy (using riboflavin as sensitizer) as a safe and effective treatment option for malariaISRCTN80135736
Estimation of salivary levels of Riboflavin, Vitamin C levels and analyzing oral health parameters in chronic psychiatric rehabilitation patientsEstimation of salivary levels of Riboflavin, vitamin C levels and analyzing oral health parameters in chronic psychiatric rehabilitation patientsCTRI/2022/12/048299
Effect of Colon Delivered Vitamin B2 on Gut Microbiota and Related Health Biomarkers in Healthy Older AdultsEffect of Colon Delivered Vitamin B2 on Gut Microbiota and Related Health Biomarkers in Healthy Older AdultsNCT05803811
Evaluating the effect of UV-A/Riboflavin Collagen Cross-Linking in treatment of bacterial corneal ulcerEvaluating the effect of UV-A/Riboflavin Collagen Cross-Linking in treatment of bacterial corneal ulcerIRCT2014101919581N1
Evaluation of riboflavin in the treatment of mild to moderate obstructive sleep apnea: a multicenter, randomized, double-blind, placebo-controlled trialEvaluation of riboflavin in the treatment of mild to moderate obstructive sleep apnea: a multicenter, randomized, double-blind, placebo-controlled trialChiCTR2300077603
Efficacy of Riboflavin and Amitriptyline in Migraine AttackEfficacy of Riboflavin and Amitriptyline in Frequency and Intensity of migraine Attack in Patients with Migraine HeadacheIRCT20230823059240N1
Comparison of two different methods of crosslinking for pediatric Keratoconus patients with thin corneasComparison of efficacy of corneal collagen crosslinking using contact lens versus hypoosmolar riboflavin in pediatric keratoconus patients. - NILCTRI/2024/01/062144
Magnesium and Riboflavin Treatment for Post-Concussion HeadacheMagnesium and Riboflavin Treatment for Post-Concussion HeadacheNCT06260072
Comparison of the effects of the photodynamic therapy using different photosensitizers on oral hygiene.To evaluate and compare the effects of methylene blue and riboflavin photodynamic therapy on gingival and periodontal health. - NILCTRI/2024/03/064860
The Effects of Riboflavin Photodynamic Therapy after cleaning on teeth and their surrounding structures of patients undergoing braces treatmentComparative Evaluation of the Effects of Riboflavin Photodynamic Therapy as an Adjunct to Ultrasonic Scaling on Periodontal Health in Orthodontic Patients: A Split-Mouth Randomized Controlled TrialCTRI/2025/02/080178
To Compare the Outcomes of Accelerated Transepithelial Corneal Cross Linking using HPMC riboflavin versus riboflavin containing Vitamin E Tocopheryl Polyethylene Glycol Succinate(TPGS) in patients with progressive Keratoconus( comparison between two dyes used in corneal cross linking in keratoconus)To Compare the Outcomes of Accelerated Transepithelial Corneal Cross Linking using HPMC riboflavin versus riboflavin containing Vitamin E Tocopheryl Polyethylene Glycol Succinate(TPGS) in patients with progressive Keratoconus - NILCTRI/2025/04/084324
Clinical study of intraoperative pulmonary sentinel lymph nodes mapping using Vitamin B2 for lung cancer surgeryClinical study of intraoperative pulmonary sentinel lymph nodes mapping using Vitamin B2 for lung cancer surgery - Sentinel lymph nodes mapping using Vitamin B2JPRN-UMIN000025816
Vitamin B2 use prior to cystoscopyUse of orally administered riboflavin to confirm ureteral patency during cystoscopy at the time of gynaecologic surgeryACTRN12616001367437
The experimental study of novel lung segmentectomy using vitamin B2 and photodynamic thoracoscopid system.The experimental study of novel lung segmentectomy using vitamin B2 and photodynamic thoracoscopid system. - The experimental study of novel lung segmentectomy.JPRN-UMIN000021259
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal UlcersSafety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal UlcersNCT05255107
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal UlcersSafety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal UlcersNCT05255016
Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye DiseaseModified Sodium Hyaluronate Conjugated to Riboflavin (HAr® 0.1%) as Lubricant Eyedrops in the Treatment of Dry EyeNCT06122428
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal EctasiaRandomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking Using Two Different Riboflavin Administration ProtocolsNCT04905108
The Effect of Riboflavin in Crohn's DiseaseThe Effect of Riboflavin Supplementation on Faecalibacterium Prausnitzii in Crohn's DiseaseNCT02538354
The Impact of Riboflavin on Sports-related ConcussionThe Impact of Riboflavin on Sports-related Concussion: A Randomized Control TrialNCT02772237
A clinical study to assess the effect of riboflavin supplementation with antidepressant treatment in patients with major depressionA randomized controlled trial to assess the effect of riboflavin supplementation with antidepressant treatment in persons with major depressive disorder.CTRI/2022/01/039469
Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).A Randomized Study of Clinical and Structural Outcome of Corneal Collagen Crosslinking (CXL) With Conventional Versus Accelerated Ultraviolet-A Irradiation Using Riboflavin With Hydroxypropyl Methylcellulose (HPMC).NCT02883478
Effects of oral riboflavin supplementation on the growth of Faecalibacterium prausnitzii and the impact on the gut microbiota: A randomized, double-blind, placebo-controlled human intervention trial.Effects of oral riboflavin supplementation on the growth of Faecalibacterium prausnitzii and the impact on the gut microbiota: A randomized, double-blind, placebo-controlled human intervention trial. - Riboflavin in human Gut (RIBO-GUT).NL-OMON43887
Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut MicrobiotaEffects of Oral Riboflavin Supplementation on the Growth of Faecalibacterium Prausnitzii and the Impact on the Gut Microbiota: A Randomized, Double-blind, Placebo-controlled Human Intervention TrialNCT02929459
Dietary Riboflavin (Vitamin B-2) and Cornea Cross-LinkingDietary Riboflavin (Vitamin B-2) and Cornea Cross-LinkingNCT03095235
Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T GenotypePilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T GenotypeNCT03151096
Accelerated Corneal Cross-linking With Different Riboflavin SolutionsEffect-evaluation of an Accelerated Corneal Cross-linking Protocol With Different Riboflavin SolutionsNCT03187912
Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon AthletesA Randomized Placebo-controlled Trial Investigating the Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon AthletesNCT05907850
Comparative Study of Photodynamic Therapy with Riboflavin-Tryptophan Gel and 13% 5-Aminolevulinic Acid in the Treatment of Mild to Moderate Acne VulgarisComparative Study of Photodynamic Therapy with Riboflavin-Tryptophan Gel and 13% 5-Aminolevulinic Acid in the Treatment of Mild to Moderate Acne VulgarisTCTR20190907005
A COMPARITIVE STUDY OF TWO DIFFERENT O.1 % VITAMIN B12 DYE FOR STRENGTHENING OF CORNEA IN THIN AND CONICAL CORNEASA prospective clinical Study to evaluate the Safety and Efficacy of two different 0.1% Riboflavin used in Corneal Cross-linking treatment for patients with KeratoconusCTRI/2019/11/021841
Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin SolutionEvaluation of the Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions Using Peschke Riboflavin SolutionNCT04177082
Riboflavin for Glutamate Reduction in Alcohol WithdrawalRiboflavin for Glutamate Reduction in Alcohol WithdrawalNCT04232800
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin SolutionSafety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning ConditionsNCT04667572
Treating Corneal Thinning Conditions With CCL Vario Riboflavin (CXL)Safety and Effectiveness of the CCL Vario System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning ConditionsNCT04731727
Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/MethylcelluloseRandomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking Using Riboflavin/Dextran or Riboflavin/MethylcelluloseNCT04897503
Evaluation of Progression of Myopia in Children Treated With Vitamin B2 and Outdoor Sunlight ExposureEvaluation of Progression of Myopia in Children Treated With Vitamin B2 and Outdoor Sunlight ExposureNCT03552016