| BIG STEP | Benefit of glucosyl Hesperidin in patients with primary biliary cholangitis: amulticenter, open-label, randomized control study | JPRN-jRCTs051210210 |
| A verification study of the reduction on swollen face with the intake of lemon-derived polyphenol (enzyme-treated hesperidin): a randomized, double-blind, placebo-controlled, crossover trial | A verification study of the reduction on swollen face with the intake of lemon-derived polyphenol (enzyme-treated hesperidin): a randomized, double-blind, placebo-controlled, crossover trial - A verification study of the reduction on swollen face with the intake of lemon-derived polyphenol (enzyme-treated hesperidin) | JPRN-UMIN000031609 |
| The Effects of Hesperidin and Flaxseed in Prediabetes | Evaluation of the Effects of Hesperidin and Flaxseed Supplementation in Patients With Prediabetes | NCT03737422 |
| The Effects of Hesperidin on Metabolic Syndrome | Evaluation of the Effects of Hesperidin Supplementation in Patients With Metabolic Syndrome | NCT03734874 |
| The Effect of Supplementation of Flaxseed, Hesperidin, Flaxseed and Hesperidin Together in Metabolic Syndrome | The Effect of Supplementation of Flaxseed, Hesperidin, Flaxseed and Hesperidin Together in Metabolic Syndrome and Its Components: A Randomized, Controlled Study | NCT03734835 |
| effect of hesperidin on depression | Effects of Hesperidin on serum homocysteine, cortisol and tryptophan kynurenine pathway in major depressive disorder | IRCT20090901002394N40 |
| Effect of Hesperidin on depression | Effect of Hesperidin on severity of depression, cognitive function, serum level of F2 isoprostanes, GDNF and hs-CRP in major depressive disorder | IRCT20090901002394N41 |
| Study of the Bioavailability of Three Hesperidin Extracts. | Interventional Study for the Comparison of the Bioavailability of Three Hesperidin Extracts (HESPERIDIN). | NCT03984916 |
| The effect of hesperidin use on the clinical condition of patients with the new coronavirus | Investigating the effectiveness of the use of hesperidin on the clinical conditions of patients with the new coronavirus (SARS-COV-2) | IRCT20150725023332N5 |
| Vascular Effects of Hesperidin in Metabolic Syndrome | Positive Vascular Effect of Hesperidin in Subjects Affected by Metabolic Syndrome | NCT00914251 |
| Clinical performance of Flavonoid incorporated dentin adhesive in bonding- A Randomised Clinical trial | Clinical Performance of Hesperidin incorporated dentin adhesive-A Randomised Clinical Trial | CTRI/2022/06/042958 |
| Evaluation of the prophilatic effects of the flavonoid Hesperidin Methyl Chalcone on Delayed Onset Muscle Soreness in humans | Evaluation of the prophilatic effects of the flavonoid Hesperidin Methyl Chalcone on Delayed Onset Muscle Soreness in humans | RBR-7wvr64k |
| The beneficial effect on cardiovascular function of a food supplement based on a mixture of Mentha spicata L. extract, Amaranthus caudatus L. seed flour, flavonoids and vitamins. | Efficacy study of a food supplement based on a mixture of Mentha spicata L. leaves extract, Amaranthus caudatus L. seed flour, flavonoids (naringin, hesperidin), and vitamins B3, B6, B9, B12, for the maintaining of physiological cardiovascular function in subjects with mildly altered cholesterol levels: a single-center, controlled, randomized, parallel-group, double-blind clinical trial with a run-in period | ISRCTN11708820 |
| The Effect of Supplementation of Flaxseed, Hesperidin, Flaxseed and Hesperidin Together in Non-alcoholic Fatty Liver Disease: A Randomized, Controlled Study | Evaluation of the Effects of Supplementation of Flaxseed, Hesperidin, Flaxseed and Hesperidin Together on Hepatic Enzymes, Inflammatory Factors, Lipid Profile, Blood Glucose, Insulin Sensitivity, and Hepatic Steatosis Grade in Patients With Non-alcoholic Fatty Liver Disease | NCT03734510 |
| Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN) | A Phase 2, Randomized, Double-blind, Placebo-controlled Study of Hesperidin Therapy on COVID-19 Symptoms: The Hesperidin Coronavirus Study (Hesperidin) | NCT04715932 |
| Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women | | NCT00330096 |
| Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency | Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study | NCT03471910 |
| Effects of Hesperidin on Insulin Sensitivity | An Exploratory Study to Evaluate the Ability of the Citrus Polyphenol Hesperidin to Improve Insulin Sensitivity in Healthy Subjects and to Ameliorate Insulin Resistance in Obese Subjects | NCT01773486 |
| A multicenter, randomized, parallel patients’ group, comparative clinical trial for the assessement of efficacy and safety of Pelethrocin®/HELP 500 mg (generic diosmin & hesperidin MPFF) versus Daflon®/Servier 500 mg (original diosmin & hesperidin MPFF) in the treatment of chronic venous insufficiency patients (a therapeutic equivalence trial). | A multicenter, randomized, parallel patients’ group, comparative clinical trial for the assessement of efficacy and safety of Pelethrocin®/HELP 500 mg (generic diosmin & hesperidin MPFF) versus Daflon®/Servier 500 mg (original diosmin & hesperidin MPFF) in the treatment of chronic venous insufficiency patients (a therapeutic equivalence trial). | EUCTR2007-001947-23-GR |
| Clinical and Histological Evaluation of Hesperidin as a Direct Pulp Capping Material | Clinical and Histological Evaluation of Hesperidin Versus Mineral Trioxide Aggregate (MTA) as a Direct Pulp Capping Material: A Randomized Controlled Trial | NCT06402032 |
| Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators | Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators | NCT06672952 |
| Hesperidin and Bone Health in Postmenopausal Women | Hesperidin and Bone Health in Postmenopausal Women | NCT01881204 |
| Evaluation of the effect of Hesperidin supplementation in patients with myocardial infarction | Evaluation of the effect of Hesperidin supplementation on the serum levels of inflammatory markers (E-selectin, Interlukin 6, hs-CRP) and Adipocytokines (leptin and adiponectin) in patients with myocardial infarction | IRCT2012100210181N2 |
| The effect of hesperidin in the treatment of diabetes | Effect of Supplementation of Hesperidin on Serum Glucose, Insulin, Insulin Resistance, Lipid Profile, Hemoglobin A1C, hs-CRP and IL6 in Type II Diabetic Mellitus Patients | IRCT201407242602N12 |
| Effects of treatment with FOPCON in patients with Fibrodysplasia Ossificans Progressiva | Clinical, biochemical and molecular aspects in patients with Fibrodysplasia Ossificans Progressiva before and after treatment with ascorbic acid, propranolol, hesperidine and epigallocatechin | RBR-9dkn9ry |
| Effect of oral hesperidin supplementation on glycemic and lipidemicin risk factors and inflammatory and oxidant markers in type 2 diabetes | Assessment of the effect of oral hesperidin supplement on glycemic and lipidemic risk factors, visceral adiposity index, serum levels of oxidant, inflammatory and oxidative DNA damage markers in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial | IRCT2015081810181N6 |
| The Effect of Hesperidin on Glucose / Insulin Metabolism | The Effect of Hesperidin Administration on Glucose / Insulin Metabolism | NCT02610491 |
| Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency | A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months | NCT02927483 |
| Establishing the effect of long-term hesperidin supplementation on exercise-specific performance in moderately trained athletes | Establishing the effect of long-term hesperidin supplementation on exercise-specific performance in moderately trained athletes - The effect of an orange peel extract on exercise performance | NL-OMON46296 |
| The effect of hesperidin in myocardial infarction | Effect of hesperidin supplementation on depressive symptoms, serum levels of BDNF and cortisol in patients after myocardial infarction | IRCT201702262394N36 |
| The effect of hesperidin supplement in the treatment of myocardial infarction | The effects of Hesperidin supplementation on metabolic profile,stress oxidative and inflammatory markers (P-selectin? ox-LDL? hs-CRP) and paraxonase 1 in post myocardial infarction patients | IRCT201704099472N12 |
| The Effects of Hesperidin and Flaxseed on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease | Evaluation of the Effects of Hesperidin and Flaxseed Supplementation on Hepatic Enzymes, Inflammatory Factors, Lipid Profile, Blood Glucose, Insulin Sensitivity, and Hepatic Steatosis Grade in Patients With Non-alcoholic Fatty Liver Disease | NCT03377153 |
| The Effects of Hesperidin on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease | Evaluation of the Effects of Hesperidin Supplementation on Hepatic Enzymes, Inflammatory Factors, Lipid Profile, Blood Glucose, Insulin Sensitivity, and Hepatic Steatosis Grade in Patients With Non-alcoholic Fatty Liver Disease | NCT03377140 |
| The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human dose-finding study:Double-blind, placebo-controlled trial | The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human dose-finding study:Double-blind, placebo-controlled trial - The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human | JPRN-UMIN000019241 |
| Bioavailability of Hesperidine and Narirutin From Orange Juice to Identify Metabotypes in Hypertension | Study of the Bioavailability of Hesperidine and Narirutin Provided by an Orange Juice to Identify Various Metabotypes in Prehypertensive and Hypertensive Grade 1 Individuals (FLAVOTIP) | NCT04234100 |
| Effects of Hesperidin on Bone Biomarkers in Postmenopausal Women | Short-term Effects of Hesperidin on Bone Biomarkers in Postmenopausal Women: a Randomized Placebo-controlled Trial | NCT00545116 |
| Study of the efficacy of a food supplement based on extracts of lemon and orange, hesperidin and chromium for the maintenance of normal carbohydrate metabolism | Study of the efficacy of a food supplement based on extracts of Lemon (Citrus limon (L.) Osbeck) and Orange (Citrus sinensis (L.) Osbeck), Hesperidin and Chromium, for the maintenance of normal carbohydrate metabolism through the reduction of mildly altered plasma glucose levels: a single-center, controlled, randomized, parallel-arm, double-blind clinical study | ISRCTN15062713 |
| Effect of simultaneous continuous intake of non-digestible oligosaccharides and glycosylated hesperidin on the absorption of glycosylated hesperidin | Effects of simultaneous continuous intake of non-digestible oligosaccharides and monoglucosyl hesperidin on the bioavailability of monoglucosyl hesperidin in humans. - Effect of simultaneous ingestion of non-digestible oligosaccharides and monoglucosyl hesperidin on the bioavailability of monoglucosyl hesperidin | JPRN-UMIN000051239 |
| Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy | Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy | NCT05243706 |
| Dietary Supplementation and Cognitive Functions in the Elderly | Evaluation of Dietary Supplementation With Hesperidin and Proanthocyanidins on Cognitive and Motor Functions in Elderly Subjects | NCT06352099 |
| Evaluation of the combined effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19 | effect of Hesperidin,Artemisinin- Artemisia annua, Noscapine, N-acetylcysteine, Resveratrol supplements and high dose of vitamin C on treatment, clinical symptoms of non-hospitalization and hospitalization patients with symptomatic COVID-19 | IRCT20181030041504N1 |
| The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients | The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients | NCT06811220 |
| Influence of Hesperidin and Vitamin C on Uric Acid Concentration | Influence of Hesperidin and Vitamin C on Uric Acid Concentration | NCT04316390 |
| Bioequivalence study of Diosmin 450mg + Hesperidin 50 mg film-coated tablet in healthy, adult human, subjects under fed conditions. | An Open label, balanced, randomized, truncated, two treatment, two-period, two-sequence, single dose, crossover, oral bioequivalence study of Pilestop Tablet (Diosmin 450 mg + Hesperidin 50 mg film-coated tablet) by The ACME Laboratories Ltd., with Daflon 500 Tablet (Diosmin 450 mg + Hesperidin 50 mg film-coated tablet) of LES Laboratories Servier Industrie in healthy, adult human, subjects under fedconditions. - NIL | CTRI/2025/02/080636 |
| Hesperidin and Diosmin for Treatment of COVID-19 | Randomized Double-blind Controlled Parallel Study of (Hesperidin and Diosmin Mixture) for Treatment of COVID-19 Newly Diagnosed Patients in Egypt | NCT04452799 |
| Effects of flaxseed and hesperidin in patients with prediabetes | Effects of concomitant administration of flaxseed and hesperidin on cardiac and metabolic parameters in patients with prediabetes | IRCT20181120041710N2 |
| study the additional effect of snuhi tail with daflon in woman with varicose vein | study the add on effect of snuhi taila with diosmin and hesperidin in managment of vericose vein in parous woman - STD | CTRI/2020/09/027586 |
| Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists | Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists | NCT04597983 |
| Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis | Clinical Study Evaluating the Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis | NCT05756179 |
| Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product | Bioavailability of a Formulation of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to the Marketed Reference Product | NCT05158192 |
| Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty | Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Primary Total Knee Arthroplasty | NCT06753448 |
