IMPPAT Phytochemical information: 
Xylitol

Xylitol
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Efficacy and Safety assessments of a peritoneal dialysis solution containing Glucose, Xylitol and L-Carnitine compared to standard PD solutions in Continuous Ambulatory Peritoneal Dialysis (CAPD) - NDEfficacy and Safety assessments of a peritoneal dialysis solution containing Glucose, Xylitol and L-Carnitine compared to standard PD solutions in Continuous Ambulatory Peritoneal Dialysis (CAPD) - NDEUCTR2009-016801-40-IT
Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High RiskAntimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled TrialNCT04399161
effect of xylitol lollipops on pH of salivaEstimating the effectiveness of xylitol containing lollipops on salivary pH in 3-6 years olds: A randomized controlled trialCTRI/2020/04/024583
Effect of Xylitol nasal spray in treatment of chronic rhinosinusitisEvaluation of the effect of Xylitol nasal spray in treatment of patients with chronic rhinosinusitisIRCT20171030037093N35
Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and Xylitol-containing chewing gum on salivaryComparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and Xylitol-containing chewing gum on salivary flow rate, pH and concentration of calcium and phosphateIRCT20140601017935N8
Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant PatientsHealthcare Associated Infection Reduction in Stem Cell Transplant Patients: a Randomized, Double-blind, Placebo-controlled Study Evaluating Twice Daily Xylitol AdministrationNCT04117477
Is Xylitol Toothpaste Effective in Preventing Tooth Decay?Is Xylitol Toothpaste Effective in Preventing Dental Caries Among Young Children With Moderate-to-high Caries Risk? - a Randomized Controlled TrialNCT04096599
Ultrafiltration Efficacy of a PD Solution Containing Icodextrin-Xylitol-CarnitineUltrafiltration Efficacy of a PD Solution Containing Icodextrin-Xylitol-Carnitine Compared to Icodextrin Alone, an Exploratory Study.NCT04086212
Efficacy and Safety Assessments of a Peritoneal Dialysis Solution Containing Glucose, Xylitol, and L-Carnitine in CAPDEfficacy and Safety Assessments of a Peritoneal Dialysis Solution Containing Glucose, Xylitol and L-Carnitine Compared to Standard PD Solutions in Continuous Ambulatory Peritoneal Dialysis (CAPD)NCT04001036
Xylitol Chewing-gums: Concentration in Saliva and Antibacterial EffectXylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect (In-vivo and In-vitro Study)NCT03971981
Antibacterial Effect of Probiotic Yogurt Compared to XylitolComparison of Antibacterial Effect of Probiotic Yogurt Against Xylitol-containing Chewing Gum on Salivary Streptococcus Mutans Count, Bacterial Adherence and Salivary pH in Geriatric Patients: A Randomized Controlled TrialNCT03889015
Microbiome Alterations With Xylitol (MAX) in PregnancyPeriodontal Disease and Alterations in the Oral and Vaginal Microbiome Communities Among Gravidae Chewing Xylitol-gum in Malawi: Microbiome Alterations With Xylitol (MAX) in Pregnancy Trial.NCT06329596
Clinically controlled comparative study on plaque suppressive effect between L8020 lactic acid bacteria tablets and xylitol tablets for childrenClinically controlled comparative study on plaque suppressive effect between L8020 lactic acid bacteria tablets and xylitol tablets for children - Clinically controlled comparative study on plaque suppressive effect between L8020 lactic acid bacteria tablets and xylitol tablets for childrenJPRN-UMIN000035510
Effect of Xylitol Varnish in Caries Prevention Around Orthodontic BracketsEvaluation the Preventive Effect of Two Concentration of Xylitol Varnish vs Fluoride Varnish on Enamel Demineralization Around Orthodontic Brackets: A randomized controlled trialIRCT20180913041032N1
Xylitol in milk to prevent tooth decay in childrenPeru's Glass of Milk Program (Programa Social Vaso de Leche): Using xylitol in milk in a community-based nutrition program to prevent dental caries in childrenISRCTN34705772
Xylitol and Sorbitol Effects on the Oral MicrobiomeXylitol and Sorbitol Effects on the Microbiome of Saliva and PlaqueNCT03668015
Comparison of Xylitol and fluoride toothpaste and their effect on plaque, salivary pH and Streptococcus mutansâ??To assess and compare the effectiveness of commercially available 25% xylitol and 1000 ppm fluoride toothpastes on salivary pH, plaque and Streptococcus mutans count among 12-16 year old childrenâ?? - A clinical trial.CTRI/2018/02/011866
Xylitol or CPP-ACP, which is the better caries preventive agent?Effectiveness of Casein Phosphopeptide Amorphous Calcium Phosphate and Xylitol Chewing Gums on the salivary pH, Buffer Capacity and Streptococcus mutans count â?? An Interventional StudyCTRI/2017/06/008895
Comparison of the effect ofcasein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and Xylitol Chewing gums and probiotic yogurt on streptocuccos mutans and microbial dental plaqueComparison of the effect of casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) and Xylitol Chewing gums and probiotic yogurt on streptocuccos mutans and microbial dental plaqueIRCT2016100730193N1
Xylitol Clinical Studies for Prevention - Xylitol Frequency Study (Gum 2)ISRCTN43479664
Xylitol Clinical Studies for Prevention - Xylitol Dose Study (Gum 1)ISRCTN73818624
Safety and tolerability of the synbiotic product in elderly personsSafety and tolerance testing of the synbiotic product of L. plantarum INDUCIA® and xylitol in elderly personsISRCTN18123188
Effect of the Use of Xylitol Gum in the Prevention of Caries Lesions in Children Living in LadakhStudy Protocol for a Randomized Clinical Trial to Evaluate the Effect of the Use of Xylitol Gum in the Prevention of Caries Lesions in Children Living in Ladakh - the Caries Prevention Xylitol in Children (CaPreXCh) TrialNCT04420780
Xylitol for healthy teeth and ears projectXylitol for acute otitis media and early childhood cariesISRCTN84269958
Treatment Alternatives for acute Sore Throat in Everyday practiceA primary care randomised controlled trial of probiotics, xylitol and sorbitol for acute sore throatISRCTN51472596
Effect of Xylitol on Oral Microbiota in ChildrenThe Effect of the Frequent Xylitol Chewing Gum Use on the Oral Microbiota in Children With High MS CountsNCT01528969
Xylitol for Chronic SinusitisXylitol Topical Irrigation for Treatment of Recalcitrant Chronic SinusitisNCT03229551
Effectiveness of school-based xylitol chewing gum program on dental caries prevention among students with disabilitiesEffectiveness of school-based xylitol chewing gum program on dental caries prevention among students with disabilitiesTCTR20120000001
Considering the effect of a new chewing gum in preventing dental plaque formationComparison of Plaque Control Efficacy Of Chewing Gum Containing Ethylenediaminetetraaceticacid(EDTA),methylsulfonylmethane(MSM) and Xylitol with Chlorehexidine MouthrinseIRCT2017070234849N1
Effect of Xylitol chewing gums on oral bacteriaTo evaluate the effect of use of chewing gum containing 100% xylitol on mutans streptococci salivary levels among dental students in bangalore city - a randomised controlled trial.CTRI/2018/03/012632
Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release PacifierBifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release PacifierNCT00638677
Prevention of caries in teeth appliances: comparison of the effect of fluoride and xylitol dental gelPrevention of white spot lesions in orthodontics: comparison of efficacy of fluoride varnish and xylitol varnishRBR-6mdxfq
Efficacy of Fluoride Varnish Containing Xylitol Coated Calcium Phosphate Versus Conventional Fluoride Varnish in Management of Hypersensitivity of Exposed Root Surfaces in Adult PatientsEfficacy of Fluoride Varnish Containing Xylitol Coated Calcium Phosphate Versus Conventional Fluoride Varnish in Management of Hypersensitivity of Exposed Root Surfaces in Adult Patients: A Randomized Clinical TrialNCT04472182
Safety of an aerosol having as its active ingredient 8.4 % sodium bicarbonate and xylitol 5% when administered to the nasopharynx and oropharynxA prospective, open label, single arm consumer research to study the safety and tolerability of an aerosol having as its active ingredient 8.4 % sodium bicarbonate, when administered to the nasopharynx and oropharynx; and to assess the preventive strength of the aerosol against the development of Influenza Like Illness (ILI) including the Covid-19 infection in the general as well as high risk population.CTRI/2020/11/029396
Effects of Oral Xylitol on Subsequent Energy IntakeEffects of Oral Xylitol on Subsequent Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite-related Sensations, and Gastrointestinal ToleranceNCT05671965
Nasal spray for patients with chronic rhinosinusitis undergoing (Functional Endoscopic Sinus Surgery) FESSXylitol and sodium hyaluronate nasal spray to improve postoperative healing in patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery.ACTRN12621000707864
Effect of Different Concentrations of Xylitol and Erythritol on Gut Peptide Release and Gastric Emptying in HumansEffect of Different Concentrations of Xylitol and Erythritol on the Release of Gastrointestinal Peptides and on Gastric Emptying Rates in Healthy Normal Weight HumansNCT03039478
Effect of the Natural Sweeteners Erythritol and Xylitol on Gut Microbiota and Glucose Metabolism in Obese VolunteersEffect of the Natural Sweeteners Erythritol and Xylitol on Gut Microbiota and Glucose Metabolism in Obese VolunteersNCT02824614
Effect of the Natural Sweeteners Erythritol and Xylitol on Vascular Function in Obese VolunteersEffect of the Natural Sweeteners Erythritol and Xylitol on Vascular Function in Obese Volunteers: A Pilot StudyNCT02821923
Effect of Erythritol and Xylitol on Dental Caries Prevention in ChildrenEffect of Erythritol and Xylitol on Dental Caries Prevention in ChildrenNCT01062633
Giving sweet tasting solutions before dental injection may reduce the pain on injectionComparative evaluation of sucrose versus xylitol application in minimizing pain related to dental injection in 4-9 year-old children -a randomized control trialCTRI/2022/10/046389
Effect on Cytokines IL-1ß, TNF-a, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a ToothpasteEffect on Cytokines IL-1ß, TNF-a, IL-4 and Total Bacterial Load of an Oral Topical Composition Comprising Olive Oil, Trymethylglycine and Xylitol: a Randomized Controlled Double-blind Clinical Trial Part of the Stop Dysbiosis Project (SDP)NCT06786910
To compare the effectiveness of two treatments: Decay preventive solution with a sugar substitute and with a milk protein derivative in children having cavities at an early age.Comparative Evaluation of the Antimicrobial Efficacy of Fluoride Varnish with Xylitol and Fluoride Varnish with CPP-ACP in children with Early Childhood Caries : A Randomized Clinical Study. - NILCTRI/2025/04/085276
Fermented rice water prevents Clostridium difficle infectionPrevention of Clostridium Difficile infection among hospitalised elderly patients using Torani (fermented rice-water) and Xylitol mixture drink - NILCTRI/2025/03/083479
Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients with Inflammatory Bowel DiseasePilot Trial of Xylitol for C. Difficile De-Colonization in Patients with Inflammatory Bowel DiseaseNCT06799039
Effect of Xylitol Gum Chewing on Postoperative Bowel ActivityEfficacy of Chewing Xylitol Gum on Restoring Postoperative Bowel Activity After Laparoscopic Cholecystectomy: A Three-Arm Randomised Controlled TrialNCT06579339
Comparative Evaluation of Two Different Formulations of Xylitol used in children with early childhood caries to see the effect on Streptococcus mutans and Candida albicansComparative Evaluation of Two Different Formulations of Xylitol on Streptococcus mutans and Candida albicans in Children with Early Childhood Caries: A Randomized Controlled Trial - NILCTRI/2024/08/072642
Study of Cranberry, Cinnamon and Xylitol in prevention of Childhood CariesComparative evaluation o f efficacy o f Wipes containing Cranberry extract, Cinnamon extract and Xylitol in prevention of Early Childhood Caries - A Randomized Controlled Trial - NILCTRI/2024/07/071092
Comparison of the effect of CCP-ACP & Xylitol chewing gum & probiotic yogurt on periodontal indicesComparison of the effect of CCP-ACP & Xylitol chewing gum & probiotic yogurt on periodontal indicesIRCT2017020432380N1
Effect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young AdultsEffect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young Adults: Randomized Controlled Clinical TrialNCT06370091
Effect of various toothpastes on growth of oral bacteria in handicapped childrenComparative evaluation of effect of Xylitol and Xylitol-probiotic containing toothpastes on salivary Streptococcus mutans and Lactobacillus count in handicapped children: A Randomized Controlled Trial - NilCTRI/2024/02/062684
Efficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus SurgeryEfficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus Surgery: A Randomized Controlled StudyNCT06108921
Effectiveness Of Swishing Xylitol Solution And Topical Application Of Betel Leaf Extract In Pain Control During Local Anaesthesia In Pediatric Dental Patients.Effectiveness Of Swishing Xylitol Solution And Topical Application Of Betel Leaf Extract In Pain Control During Local Anaesthesia In Pediatric Dental Patients : A Randomized Clinical Trial.CTRI/2023/06/054044
Evaluation of Xylitol Wipes as an Oral Hygiene Protocol for Haemophilic ChildrenEvaluation of Xylitol Wipes as an Oral Hygiene Protocol for Haemophilic Children: A Randomized Clinical TrialNCT05899075
Comparing two different methods of cleaning oral cavity of preterm babies and to check its effect on caries causing microoraganisms.COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF XYLITOL ON STREPTOCOCCUS MUTANS IN PRETERM BIRTHS AND THEIR MOTHERS: A RANDOMISED CONTROLLED TRIAL.CTRI/2023/06/053365
Xylitol Use for Decolonization of C. Difficile in Patients With IBDXylitol Use for Decolonization of C. Difficile in Patients With Inflammatory Bowel DiseaseNCT05852587
Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell TransplantReduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant: a Randomized, Multicenter, Double-blind , Placebo-controlled Study Evaluating Twice Daily Oral XylitolNCT05579639
Xylitol vs Saline Nasal Irrigations in CF-CRSXylitol Nasal Irrigations in the Treatment of Chronic Rhinosinusitis in Cystic Fibrosis Patients: a Randomized Crossover TrialNCT05531630
Prevention of Developmental Delay and Xylitol (PDDaX) StudyPrevention of Developmental Delay and Xylitol (PDDaX) StudyNCT05361122
Effect of xylitol in treatment of post-orthodontic white spot lesionsTreatment of post-orthodontic white spot lesions with 10% xylitol varnish: A randomized Clinical TrialIRCT20180913041032N2
Effect of fluoride and xylitol varnish on oral microorganismThe effect of combination of xylitol and fluoride varnish on microbial biofilm and saliva in fixed orthodontic patients: a randomized clinical trialIRCT20181121041713N4
Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 PatientsImpact of GSE and Xylitol (Xlear) in Symptoms and Time to PCR Negativisation of Patients With Acute COVID-19 InfectionNCT04854486
Prospective Randomized trial of the effectiveness of 25 % xylitol toothpaste in prevention of severe carious lesions of Kosovar infantsProspective Randomized trial of the effectiveness of 25 % xylitol toothpaste in prevention of severe carious lesions of Kosovar infants - Xylitol toothpaste in caries preventionDRKS00024367
Effect of two chewing gum in caries active childrenEfficacy of xylitol and IgY impregnated chewing gum on streptococcus mutans in caries active children - A PCR StudyCTRI/2021/01/030633
evaluation of Probiotic lozenges, fluoride Mouthwash and Xylitol gum on Streptococcus mutansComparative evaluation of Probiotic lozenges tablets with Mouthwash containing fluoride and cetyl pyridinium chloride and chewing gum containing Xylitol on oral Streptococcus mutans coloniIRCT20231127060200N1
Effect of Xylitol-Containing Chewing Gum With/Without Bicarbonate Versus Paraffin Pellet on Salivary pHEffect of Xylitol-Containing Chewing Gum With/Without Bicarbonate Versus Paraffin Pellet on Salivary pH in High Caries Risk Patients (A Randomized Clinical Trial)NCT03061422
A longitudinal study about Xylitol, its influence and preventive effectiveness on mutans streptococci and Streptococcus pneumoniaeA longitudinal study about Xylitol, its influence and preventive effectiveness on mutans streptococci and Streptococcus pneumoniae - Effect of Xylitol on oral bacteriaJPRN-UMIN000003112
Consideration of effects of commercial xylitol chewing gum on improvement in oral environmentConsideration of effects of commercial xylitol chewing gum on improvement in oral environment - Effect of xylitol chewing gum on improvement in oral environmentJPRN-UMIN000007962
Xylitol Adult Caries Trial (X-ACT)Xylitol Adult Caries Trial (X-ACT)NCT00393055
Xylitol Clinical Studies for Prevention - Xylitol Snack Foods among Adults Study (Gum 3)ISRCTN25845456
A primary care randomised controlled trial of probiotics and xylitol for acute sore throatISRCTN09887045
The comparison of chlorhexidine and fichs Mouthwashs on salivary Cariogenic bacterias in dental students of Zanjan university of medical sciencesThe comparison of chlorhexidine 0.2% and combination of xylitol and fluoride 920 ppm mouthwashs on salivary Streptococcus mutans count (in vivo)IRCT2016073129133N1
Inhaled Xylitol Versus Saline in Stable Subjects With Cystic FibrosisRandomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic FibrosisNCT01355796
Nasal Xylitol in the Prevention of Otitis MediaNasal Xylitol for Recurrent Otitis MediaNCT02592382
The effect of maltitol and xylitol sweetened chewing gum on caries risk factors of dental plaque and saliva, and on the development of gingivitis in a 21 day non-brushing study modelThe effect of maltitol and xylitol sweetened chewing gum on caries risk factors of dental plaque and saliva, and on the development of gingivitis in a 21 day non-brushing study model - Maltitol and oral healthNL-OMON36248
Study on Use of Xylitol-wipes to Prevent Dental CariesEffectiveness of Xylitol Wipes on Infants in Reducing Bacterial Transmission and Colonization From Mother to ChildNCT01468727
Is toothpaste containing xylitol + fluoride more effective than toothpaste containing only fluoride in preventing dental caries among pre-schoolers?A clinical trial comparing fluoride toothpaste and xylitol+fluoride toothpaste in reducing dental caries among pre-schoolers at increased risk for tooth decay: a randomised prospective trialISRCTN51682476
Xylitol clinical studies for prevention: In-school xylitol gummy bear snack studySchool-based xylitol gummy bears snacks: a randomized controlled trialISRCTN63160504
The effects of pure mastic gums, mastic gums enriched with probiotics and mastic gums with xylitol on cariogenic microflora and PH of salivaThe effects of pure mastic gums, mastic gums enriched with probiotics and mastic gums with xylitol on the number of Mutans streptococci, Lactobacilli and PH of salivaIRCT201110267910N1
The effect of Xylitol gumThe effect of chewing Xylitol gum on saliva mutans streptococci in childrenIRCT2013010111960N1
Xylitol Disk Use in Adults With Dry MouthXyliMelts Ability to Reduce Mutans Streptococci in Adults With the Perception of Dry MouthNCT01823445
Xylitol for Caries Prevention in Inner-City ChildrenXylitol for Caries Prevention in Inner-City ChildrenNCT01901250
Impact of Maternal Xylitol Consumption on Mutans SterptococciImpact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in ChildrenNCT02036151
Intraarticular Xylitol Injections for Knee OsteoarthritisIntraarticular Xylitol Injections for Knee OsteoarthritisNCT02104596
The effect of two types of chewing gum containing CPP - ACP and xylitol on caries-causing bacteria in the mouth.The effect of two typs of chewing gum containing casein phosphopeptide-amorphous calcium phosphate and xylitol on amounts of streptococcus mutans.IRCT2014063018296N1
Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in MalawiSaving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi (Prevention of Prematurity and Xylitol)NCT02333227
The Effect of Xylitol and Saline Nasal Irrigations on the Sinus Microbiome in Patients with Chronic RhinosinusitisThe effect of xylitol and saline nasal irrigations on the microbiome of patients with chronic sinusitis, a study by the Department of Surgery, University of Auckland.ACTRN12615000154505
comparison of the effect of probiotic yogurt and gums containing xylitol on salivary mutans streptococcus reductioncomparison of the effect of probiotic yogurt and gums containing xylitol on salivary mutans streptococcus reductionIRCT2014091319131N1
ASSESSMENT OF XYLITOL SERUM LEVELS DURING THE COURSE OF PARENTERAL NUTRITIONASSESSMENT OF XYLITOL SERUM LEVELS DURING THE COURSE OF PARENTERAL NUTRITIONDRKS00004238
Xylitol for the Prevention of Acute Otitis Media Episodes in ChildrenXylitol for the Prevention of Acute Otitis Media Episodes in Children 2-4: A Pragmatic RCTNCT03055091
Xylitol for Otitis MediaA Prospective, Randomized, Double-blinded, Placebo-controlled Pilot Study for Evaluating the Effectiveness of Intranasal Xylitol in Treating Otitis Media With Effusion (OME) in ChildrenNCT02950311
Prevention of Dental caries through use of fluoridated mouthrinse with sugar substitutes.A comparison of anticaries efficacy of 0.2% sodium fluoride mouthrinse with and without xylitol and tirclosan : a residential school based clinical trialCTRI/2010/091/001334
Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone ChildrenXylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone ChildrenNCT01044030
Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) SubjectsRandomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic FibrosisNCT00928135
Maternal Consumption of Xylitol to Reduce Early Childhood Decay (MaXED Study)Maternal Consumption of Xylitol to Reduce Early Childhood Decay (MaXED Study)NCT01038479
Xylitol Versus Saline in Chronic SinusitisRandomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic SinusitisNCT00924404