IMPPAT Phytochemical information: 
Bromelain

Bromelain
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
The effect of Anahil 500 (bromelain 500) and vitamin C on episiotomy wound healingThe effect of Anahil 500 (bromelain 500) and vitamin C on episiotomy wound healing in primiparous womenIRCT20160523028008N25
The effect of bromelain capsules on stress and depressive anxiety in diabetic foot ulcer patientsThe effect of bromelain capsule on stress, anxiety , depression in patients with diabetic foot ulcerIRCT20190708044148N2
Analgesic Effect of Anahil and Ibuprofen on Pain After Root Canal Therapy in Patients With Pulpitis of the Molars in Qazvin(a City in Iran)Comparison of the Analgesic Effect of Bromelain and Ibuprofen on Pain After Root Canal Treatment(A Clinical Trial Study)NCT05349929
Efficacy of Bromelain in Post Endodontic PainComparative Evaluation of Bromelain And Diclofenac In The Management Of Postoperative Pain And Quality Of Life Following Root Canal Therapy - A Randomized Controlled TrialCTRI/2023/07/055392
A clinical study of Trypsin, Bromelain and Rutoside combination in wound management.An open label, prospective, multicentric, randomized, controlled, comparative clinical trial to evaluate the safety and efficacy of fixed dose combination of Trypsin 48mg, Bromelain 90mg and Rutoside 100mg tablets in comparison to Trypsin: Chymotrypsin tablets with 1,00,000 armour units of enzymatic activity in wound management.CTRI/2021/07/035082
Study to evaluate the safety and efficacy of Fixed Dose Combination of Trypsin-Chymotrypsin, Bromelain and Rutoside Trihydrate Tablets.ââ?¬Å?An Open Label, Prospective, Non-comparative, Multicentre, Phase IV Clinical Study to Evaluate the Safety, Tolerability and Efficacy of FDC of Trypsin - Chymotrypsin 50000 AU plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg Tablets in Subjects for the treatment of conditions associated with Inflammation and edema of traumatic origin.ââ?¬?CTRI/2021/10/037277
Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower PremolarsEffect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars (A Randomized Clinical Trial)NCT05687760
A study of Trypsin, Bromelain, Rutoside and Diclofenac combination in comparison with Diclofenac to observe rapid healing of the wound and reducing pain intensity in surgery patients.An open label, multicentric, randomized, comparative clinical trial to evaluate safety and efficacy of fixed-dose combination of Trypsin 48 mg, Bromelain 90 mg, Rutoside 100 mg and Diclofenac 50 mg tablet in comparison to Diclofenac 50 mg tablet in wound management.CTRI/2021/03/032053
COMPARISION OF EFFICACY OF BROMELAIN AND ACECLOFENAC IN REDUCING POST-OPERATIVE COMPLICATIONS AFTER THIRD MOLAR SURGERYCOMPARISION OF EFFECT OF BROMELAINAND ACECLOFENAC ON POST-OPREATIVESEQUELAE FOLLOWING SURGICALREMOVAL OF IMPACTED MANDIBULARTHIRD MOLARCTRI/2021/02/031510
Effects of bromelain and serrapeptase supplementation on surgical and traumatic wound healing and pain reductionEffects of bromelain and serrapeptase supplementation on surgical and traumatic wound healing and pain reduction (a double blind randomized controlled trial)IRCT20140804018677N6
Safety of nebulised delivery of BromAc® (Bromelain & Acetylcysteine) in healthy volunteers: a potential treatment for severe COVID-19Safety of nebulised delivery of BromAc® (Bromelain & Acetylcysteine) in healthy volunteers: a potential treatment for severe COVID-19ACTRN12622000022763
Investigating the effect of bromelain in patients with covid-19Investigating the effect of bromelain on inflammatory and immunological indicators of patients with covid-19IRCT20150725023332N6
Comparison of the effectiveness of calcium hydroxide, triple antibiotic paste, bromelain extract, and Triticum aestivum (wheat grass) extract as an intracanal medication against Enterococcus faecalis in single-rooted teethComparative evaluation of anti- microbial efficacy of calcium hydroxide, triple antibiotic paste, bromelain extract and Triticum aestivum extract (Wheat grass) as an intracanal medicament against Enterococcus faecalis in single rooted teeth: an in vivo study - NILCTRI/2023/09/057678
Comparison of Bromelain and Serrati peptidase as an add on therapy with Ibuprofen on post operative sequelae following surgical removal of impacted mandibular third molar - A Double blind Randomized Clinical TrialComparison of Bromelain and Serratiopeptidase as an add on therapy with Ibuprofen on post operative sequelae following surgical removal of impacted mandibular third molar - A Double blind Randomized Clinical TrialCTRI/2023/05/052489
The Effect of Bromelain on Pain, Swelling and Trismus after Orthognathic SurgeryThe Effect of Bromelain on Pain, Swelling and Trismus after Surgery in Orthognathic PatientsIRCT20230517058214N1
The effect of bromelain in inflammatory bowel diseaseThe effect of bromelain supplementation on disease activity and quality of life in patients with inflammatory bowel diseaseIRCT20191105045340N2
Comparison of the effect of bromoline drug on pain and trismus after dental surgeryComparison of the effect of two drugs bromelain and ibuprofen in combination with acetaminophen and corticosteroid on pain and trismus after mandibular third molar surgeryIRCT20230131057290N1
Comparison of the effectiveness of proteolytic enzymes and diclofenac in patients with impacted third molars in the mandible.Comparison of efficacy of combinations of proteolytic enzymes (trypsin, bromelain, and rutoside) and diclofenac versus serratiopeptidase and diclofenac versus diclofenac alone in patients with similar Pederson’s difficulty index impacted mandibular third molars in a randomised control double blind trial - NILCTRI/2023/08/056907
To Assess Efficacy and Safety of Enzomac in patients with OsteoarthritisA Prospective Single center Open label Randomized Parallel group Comparative Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin Bromelain Rutoside trihydrate versus FDC of Glucosamine sulphate Chondroitin sulfate and Collagen peptide in the Treatment of Patients with OsteoarthritisCTRI/2020/10/028616
The effect of pineapple gel on palatal wound healing after gingival graftInvestigating The Effect Of Bromelain Gel Added To Periodontal Pack Compared To Periodontal Pack Alone On The Healing Of Palatal Wound Resulting From Harvesting The Free Gingival Graft On Patients With Keratinized Gingival Width Deficiency Who Are Candidates For Gingival Grafting; A Parallel Clinical Trial StudyIRCT20231118060098N1
Investigating the effect of bromelain in preventing mucositis caused by 5 fluorouracil (5-FU( in patients with gastrointestinal cancerInvestigating the effect of bromelain in preventing mucositis caused by 5 fluorouracil (5-FU( in patients with gastrointestinal cancerIRCT20240601061970N1
The effect of curcumin and bromelain in patients with diabetic neuropathyThe effect of curcumin and bromelain on anxiety, stress, depression, quality of life and sleep quality in diabetic neuropathy patients.IRCT20191105045340N5
Investigating the effect of bromelain on primary dysmenorrhea painComparing the effect of bromelain and placebo on primary dysmenorrhea pain on female studentsIRCT20160813029327N23
Effect of bromelain supplementation in head trauma patientsThe effect of bromelain supplementation on oxidative stress, inflammatory markers and clinical outcomes in patients with traumatic brain injury admitted to the intensive care unit of Besat hospitalIRCT20181219042047N2
Study on evidence-based evaluation and therapeutic mechanism of integrated Chinese and Western medicine for treatment of diabetic foot -- An evidence-based evaluation of The combination of Rubber Shengji Paste and compound bromelain to promote the healing of the exposed wound of diabetic foot tendonStudy on evidence-based evaluation and therapeutic mechanism of integrated Chinese and Western medicine for treatment of diabetic foot -- An evidence-based evaluation of The combination of Rubber Shengji Paste and compound bromelain to promote the healing of the exposed wound of diabetic foot tendonITMCTR2100004318
The effect of Bromelain on episiotomy pain and wound healingThe evaluation of oral Bromelain (pineapple) on episiotomy pain and wound healing in primiparus womenIRCT138810112952N1
Study of the mechanism of action of a medicinal product based on Bromelain, Trypsin and Rutoside, compared to the same medicinal product without active ingredient called Placebo in subjects suffering from osteoarthritis.A Randomized, Double-blind, Placebo-controlled, Crossover Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment with Bromelain, Trypsin and Rutoside versus Placebo in Subjects with OsTeoarthritis (WOBE-SMART) - WOBE-SMART studyEUCTR2020-003154-80-BE
Bromelan's effect on the pain and bleeding of Primary dysmenorrheaComparing effect of bromelain and Mefenamic acid on primary dysmenorrhea pain and bleedingIRCT2016112131000N1
Disinfection achieved during root canal treatment by 2 disinfecting agents -bromelain (pineapple stem extract), and sodium hypochlorite (the current treatment standard).â??Comparison of anti-microbial efficacy of Bromelain extract and Sodium hypochlorite used as root canal irrigant in primary root canal treatment: a Randomized Controlled Clinical trialâ??.CTRI/2017/07/009015
Injection of Bromelain and Acetylcysteine in combination into recurrent mucinous tumour or pseudomyxoma peritonei: a phase I/II studyA phase I/II study to evaluate the safety and efficacy of injection of Bromelain and Acetylcysteine in combination into recurrent mucinous tumour or pseudomyxoma peritonei and aspiration of tumourACTRN12617001612303
Evaluating the efficacy of Bromelain on donor wound healing after free gingival surgeryEvaluating the efficacy of Bromelain on donor wound healing after free gingival surgeryIRCT201502089002N5
A study to evaluate the Safety and Effectiveness of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg enteric coated tablet versus Serratiopeptidase 10 mg enteric coated tablet in patients with surgical wounds after minor surgeryA Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg enteric coated tablet versus Serratiopeptidase 10 mg enteric coated tablet in patients for healing potential in surgical wounds after minor surgeryCTRI/2018/04/013151
Bromelain, Comosain as a New Drug for Treating and Preventing Various Types of Cancer in the HumansThe Methods and Compositions for Treating / Preventing Various Types of Cancer Which Comprise Administered an Effective Amount of Glyco-Polypeptides, Such as Comosain, Bromelainases, Ananase, and a Mixture Thereof. By Way of (a) MMAPKinase (Major Mitogen Activiting Protein Kinase), (b) TPKinase (Tryosine Phosphorylation Kinase) Inhibitors Which Induce Cascade Production of Interleukin II B, 6, 8 & TNFs Through TCRs/ CD-2, TCRs/ CD-3 of WBCNCT02340845
Phlogam and Disperzyme use for reducing pain and swelling after small surgeryA multicentre, randomized, assessor blind, active controlled, comparative, phase IV study to assess the safety and efficacy of two fixed dose combinations (FDC) formulations of trypsin BP 48/96mg plus bromelain 90/180 plus Rutoside trihydrate BP 100/200 mg viz Phlogam and Disperzyme in post-operative inflammation in subjects undergoing minor surgery and dental proceduresCTRI/2017/12/010804
Comparative study for stem bromelain and diclofenac sodium of early knee osteoarthritisComparative Study for Stem Bromelain and Diclofenac Sodium treatment of Early Knee Osteoarthritis: Randomized Controlled StudyTCTR20140424001
Bromelain and Cardiovascular Risk Factors in DiabetesBromelain and Cardiovascular Risk Factors in DiabetesNCT01524159
A study to find whether irrigation with pineapple stem extract can be effective reducing microorganisms in the treatment of periodontitisComparative evaluation of antimicrobial efficacy of intrapocket irrigation with 0.2% Chlorhexidine and 4.8 % Bromelain extract on Porphyromonas gingivalis levels in the periodontal pockets - RCT ---- An exploratory studyCTRI/2018/07/014721
Perioperative Ödemtherapie mit Bromelain nach Weisheitszahnosteotomien – Überprüfung der Wirksamkeit in Abhängigkeit von unterschiedlichen Dosierungen (Dosisfindungsstudie) - Dosisfindungsstudie zu Bromelain-POS bei WeisheitszahnextraktionenPerioperative Ödemtherapie mit Bromelain nach Weisheitszahnosteotomien – Überprüfung der Wirksamkeit in Abhängigkeit von unterschiedlichen Dosierungen (Dosisfindungsstudie) - Dosisfindungsstudie zu Bromelain-POS bei WeisheitszahnextraktionenEUCTR2009-015804-24-DE
Study on evidence-based evaluation and therapeutic mechanism of integrated Chinese and Western medicine for treatment of diabetic foot -- An evidence-based evaluation of The combination of Rubber Shengji Paste and compound bromelain to promote the healing of the exposed wound of diabetic foot tendonStudy on evidence-based evaluation and therapeutic mechanism of integrated Chinese and Western medicine for treatment of diabetic foot -- An evidence-based evaluation of The combination of Rubber Shengji Paste and compound bromelain to promote the healing of the exposed wound of diabetic foot tendonChiCTR2000039327
Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCTEvaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis -Randomized Control Clinical TrailNCT06505759
Use of Bromelain in the treatment od pain and swelling on impacted third molar SurgeryUse of Bromelain in the control of pain, oedema and trismus om impacted third molar SurgeryRBR-54kjdc
Injection of Bromelain and Acetylcysteine in Combination Into Recurrent Mucinous Tumour or Pseudomyxoma PeritoneiInjection of Bromelain and Acetylcysteine in Combination Into Recurrent Mucinous Tumour or Pseudomyxoma PeritoneiNCT03976973
To Assess Efficacy and Safety of Enzomac in patients with OsteoarthritisA Prospective, Single-center, Open label, Randomized, Parallel-group, Comparative Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin + Bromelain + Rutoside trihydrate versus FDC of Glucosamine sulphate + Chondroitin sulfate and Collagen peptide in the Treatment of Patients with OsteoarthritisCTRI/2020/03/024039
The effect of Bromelain and Montelukast in Covid-19 patientsThe effect of Bromelain and Montelukast on Clinical and non-Clinical parameters in Covid-19 patientsIRCT20150725023332N3
The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19NCT04468139
"""Explorative triple-arm dosis-finding study for examination about the effectivity and tolerance of Bromelain by acute sinusitis"" - Effectivity of different dosis of Bromelain by sinusitis"EUCTR2005-005654-53-DE
Comparing the usefulness of two drugs in providing relief for swelling and pain after surgical removal of lower third molar teeth.COMPARISON OF EFFECTIVENESS OF BROMELAIN WITH DICLOFENAC SODIUM IN THE MANAGEMENT OF POSTOPERATIVE SWELLING AND PAIN FOLLOWING MANDIBULAR THIRD MOLAR SURGERY-A CROSSOVER TRIALCTRI/2020/07/026443
Reduction of pain under pressure of an experimentally induced hematoma in healthy volunteers by two Bromelain preparations (Bromelain-POS(R) and Traumanase(R) forte). - Bromelain-Häma-2PReduction of pain under pressure of an experimentally induced hematoma in healthy volunteers by two Bromelain preparations (Bromelain-POS(R) and Traumanase(R) forte). - Bromelain-Häma-2PEUCTR2005-002369-35-DE
Safety and efficacy of intranasal delivery of BromAc® (Bromelain & Acetylcysteine) in swab positive SARS-CoV-2 COVID-19 patientsSafety and efficacy of intranasal delivery of BromAc® (Bromelain & Acetylcysteine) in swab positive SARS-CoV-2 patients – a phase I, single-arm, dose escalation studyACTRN12620000788976
Study to compare efficacy and safety of trypsion plus bromelain plus rutoside tablet along with cefuroxime axetil tablet versus cefuroxime axetil tablet given alone in patients with surgical wound after minor surgeryA Prospective, Single-center, Open label, Randomized, Parallel-group, Active-controlled Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin plus Bromelain plus Rutoside trihydrate given along with Cefuroxime axetil versus Cefuroxime axetil for Healing in Patients with Surgical Wound after Minor SurgeryCTRI/2020/08/027070
Effect of Bromelain and Turmeric on orthodontic painEvaluation of the the efficacy of bromelain and turmeric on pain after orthodontic separator placement: A single center, triple blind, randomized clinical trialIRCT20181121041713N3
Arnica Montana and Bromelain in RhinoplastyEffects of Arnica Montana and Bromelain in RhinoplastyNCT03586232
The effectiveness of bromelain on the amount of edema and ecchymosis after rhinoplastyInvestigating the effectiveness of bromelain on the amount of edema and ecchymosis after rhinoplasty versus placeboIRCT20180519039720N2
The Effect of Three Different Medications on Anesthetic Success and Postoperative PainThe Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical TrialNCT06298383
Effectiveness of Bromelain and Hyalgen Combination in Healing Pressure Ulcers in Intensive Care Unit Patients at Labbafinejad HospitalEfficacy of Bromelain and Heallagen Combination in Improving Bed Sores in Patients in Labafi Nejad Hosoital Intensive Care unitIRCT20190215042716N7
A Study to evaluate the Safety and Efficacy of FDC of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg plus Diclofenac Sodium 50 mg enteric coated tablet versus Diclofenac Sodium 50 mg enteric coated tablet in patients with surgical wounds after minor surgery.A Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg plus Diclofenac Sodium 50 mg enteric coated tablet versus Diclofenac Sodium 50 mg enteric coated tablet in patients for healing potential in surgical wounds after minor surgery.CTRI/2017/11/010384
Effect of bromelain and curcumin supplement in osteoarthritisEvaluation of bromelain and curcumin supplement in osteoarthritis outpatients, Randomized clinical trialIRCT20230629058615N4
Effectiveness of proteolytic enzymes in controlling the post operative sequelae of surgical third molar disimpactionsProspective, Observer Blinded, Randomized Clinical Study to Evaluate the Effectiveness of Trypsin, Bromelain, Rutoside Fixed Dose Combination and Trypsin, Chymotrypsin Fixed Dose Combination on Post-Operative Pain, Swelling and Trismus following the Surgical Removal of an Impacted Mandibular Third Molar.CTRI/2017/10/010076
Effect of Bromelain , Curcumin and Epigallocatechin in the treatment of outpatient Covid-19 patientsA Randomized, Double-blind, Placebo-controlled study to Evaluate the Efficacy and Safety of the Bromelain, Curcumin and Epigallocatechin in the treatment of outpatient Covid-19 patientsIRCT20210724051971N1
Effectiveness of two different chemicals in managing extraction socket after tooth removalEfficacy of aloe vera-bromelain and hyaluronic acid in the management of post extraction socket: a randomized controlled trial - NILCTRI/2025/06/088058
Comparative antimicrobial efficacy of Triple Antibiotic Paste, 2% Chlorhexidine gel and Bromelain paste against Enterococcus faecalis in mandibular premolars - A Randomized clinical trialComparative evaluation of the Efficacy of Triple Antibiotic Paste, 2% Chlorhexidine gel and Bromelain paste as Intracanal Medicament against Enterococcus faecalis in carious permanent mandibular premolars of patients aged 18 to 40 years - A Randomized controlled clinical trial. - NILCTRI/2025/05/087311
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous StomatitisEvaluation of Topical Bromelain Versus Topical Corticosteroids in Management of Recurrent Aphthous Stomatitis: A Randomized Controlled TrialNCT06993337
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen PlanusEffect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus : A Randomized Clinical TrialNCT06981767
A study to evaluate the Safety and Effectiveness of Fixed Dose Combination of Trypsin 96 mg plus Bromelain 180 mg plus Rutoside Trihydrate 200 mg versus Trypsin - chymotrypsin (1,00,000 AU) in patients with surgical wounds after minor surgeryA Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 96 mg plus Bromelain 180 mg plus Rutoside Trihydrate 200 mg enteric coated tablet versus Chymoral Forte (Trypsin - chymotrypsin (1,00,000 AU)) enteric coated Tablet in patients for healing potential in surgical wounds after minor surgeryCTRI/2017/10/010004
Effectiveness of a Gel with Glucosamine and Other Ingredients in Reducing Pain from Jaw Muscle and Disc Problems A Clinical StudyEvaluation of the Effectiveness of Glucosamine and Bromelain-Trypsin-Rutoside Combination Gel in the Management of Myogenous and Disc Disorders of Temporomandibular Joint- A Randomised Clinical Trial - NILCTRI/2025/04/085392
Pineapple enzyme extract as a gel in treatment of gum disease.Evaluation of 4.8% bromelain extract local drug delivery gel as an adjunct to scaling and root planing in treatment of chronic periodontitis-a split mouth randomized control trial.CTRI/2025/03/082672
Non-interventional trial on the postoperative use of bromelain tablets hysan in an ENT settingNon-interventional trial on the postoperative use of bromelain tablets hysan in an ENT setting - BROHNO-2015DRKS00010112
Asssessment of Bromelain gel in treatment of Gum diseases.Evaluation of clinical efficacy of locally delivered novel composite gel containing Bromelain as an adjunct to non surgical periodontal therapy - NILCTRI/2025/02/080514
The Effects of Bromelain Supplement in Patients with Diabetic Foot UlcersInvestigating the Effectiveness of the Supplement Containing Enteric-coated Bromelain (Anaheal 1200 GDU) in Healing Wounds, Pain, and Inflammation in Patients Over 18 Years Old with Diabetic Foot Ulcers Compared to PlaceboNCT06786403
Comparative Evaluation of Bromelain-Quercetin Gel With Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing In Stage I /II and Grade B Periodontitis - Randomized Control Clinical TrailComparative Evaluation of Bromelain-Quercetin Gel With Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing In Stage I /II and Grade B Periodontitis - Randomized Control Clinical TrailNCT06775392
Investigating the effectiveness of the supplement containing enteric-coated bromelain (Anaheal 1200 GDU) in patients with diabetic foot ulcersInvestigating the effectiveness of the supplement containing enteric-coated bromelain (Anaheal 1200 GDU) in healing wounds, pain, and inflammation in patients over 18 years old with diabetic foot ulcers compared to placeboIRCT20230629058615N6
Removing caries with chemical agentsEfficacy of different concentrations of bromelain gel in removing carious lesions in primary teeth using the chemical-mechanical caries removal (CMCR) technique: an in vivo studyISRCTN21124259
Investigation of the effect of bromelain supplementation on the healing of skin flapsInvestigation of the effect of bromelain supplementation on the healing of skin flaps applied after the resection of non-melanoma cancers in the head and neck regionIRCT20240903062943N1