IMPPAT Phytochemical information: 
Glycerol

Glycerol
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at RestEffect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at RestNCT06654557
Double-blind, randomised, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS)Double-blind, randomised, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS) - PROFIL-2088-SIM-0032CTIS2024-516897-31-00
Glycerin Suppositories Used Prophylactically in Premature Infants (SUPP): a Pilot Randomized Placebo-controlled TrialGlycerin Suppositories Used Prophylactically in Premature Infants (SUPP): a Pilot Randomized Placebo-controlled TrialNCT02153606
Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International AthletesEffects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International AthletesNCT05295836
Mannitol versus mannitol and glycerol combination for brain relaxation during brain aneurysm surgeryCOMBINATION OF 10 PERCENT MANNITOL WITH 10 PERCENT GLYCERINE VERSUS 20 PERCENT MANNITOL FOR INTRAOPERATIVE BRAIN RELAXATION IN PATIENTS WITHACUTE ANEURYSMAL SUBARACHNOID HAEMORRHAGE UNDERGOINGCRANIOTOMY AND CLIPPING OF ANEURYSM - MANGLCTRI/2024/12/077678
Effect of Glycerol-Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at RestEffect of Glycerol-Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at RestNCT06185595
Does salt and glycerol improve tolerance to fainting compared to salt alone?The effect on orthostatic tolerance of glycerol and salt compared to salt loading alone: a double blinded randomised controlled trial.ISRCTN87675635
To investigate whether the glycerol test has a higher rate of positivity when administered intravenously than orally in the diagnosis of patients with Meniere's diseaseTo investigate whether the glycerol test has a higher rate of positivity when administered intravenously than orally in the diagnosis of patients with Meniere's diseaseChiCTR2300076143
The Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle EarThe Effects of Glycerol as an Optical Clearing Agent for Visualization of the Middle EarNCT05497934
Double-blind, randomised, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS)Double-blind, randomised, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS) - PROFILEUCTR2022-002988-30-DE
Different concentrations of glycerol enema for meconium evacuation in preterm infantsDifferent concentrations of glycerol enema for meconium evacuation in preterm infantsChiCTR2300079199
Treatment of bowel dysfunction after surgery for rectal cancer using transanal irrigation or laxativesComparison of transanal irrigation and glycerol suppositories in treatment of Low Anterior Resection SyndromeCTIS2024-519492-25-01
Comparison of effect of Mannitol andmannitol plus glycerol combination on brain relaxation andsystemic hemodynamics in elective tumorsurgeries- A Randomized Controlled TrialComparison of effect of equiosmolar doses of Mannitol andmannitol plus glycerol combination on brain relaxation andsystemic hemodynamics in elective supratentorial tumorsurgeries- A Randomized Controlled Trial - NILCTRI/2025/05/087889
The study to evaluate the efficacy and safety of using hyaluronic acid with glycerol filler to rejuvenates in ThailandThe study to evaluate the efficacy and safety of using hyaluronic acid with glycerol filler to rejuvenates in ThailandTCTR20230315001
Propylene Glycol/Glycerol Intake and Cardiorespiratory FunctionReversibility of Propylene Glycol/Glycerol Intake Effects on Cardiorespiratory FunctionNCT03410511
Treatment of bowel dysfunction after surgery for rectal cancer using transanal irrigation or laxativesComparison of transanal irrigation and glycerol suppository in treatment of Low Anterior Resection Syndrome: A multicentre randomised controlled trialEUCTR2019-001913-17-DK
Efficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized TrialEfficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized TrialNCT01799629
Clinical Trial Study to Evaluate Efficacy and Safety of a Filmogen Glycerol Throat Spray containing CW-CYANIDIN Plant PremixA Comparative, Randomized, Double Blind, Parallel Group, Observational Clinical Trial Study to Evaluate Efficacy and Safety of a Filmogen Glycerol Throat Spray Containing Cw-Cyanidin Plant Premix Versus Saline Spray as Placebo in the treatment of patients Suffering from Wet (Productive) Cough - Wet coughCTRI/2016/09/007265
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.G Protein-coupled Receptor in the Intestine (GPR 119) Stimulated GLP-1 SecretionNCT01043445
A Randomised Controlled Trial Comparing Topical Glycerol versus Narrow Band Ultraviolet Light B in Atopic Dermatitis: A Clinical and Bacteriological EvaluationA Randomised Controlled Trial Comparing Topical Glycerol versus Narrow Band Ultraviolet Light B in Atopic Dermatitis: A Clinical and Bacteriological EvaluationPACTR201810815694251
CLINICAL TRIAL STUDY TO EVALUATE EFFICACY AND SAFETY OF FILMOGEN GLYCEROL THROAT SPRAY CONTAINING CD-CYANIDIN PLANT PREMIX WITH ESSENTIAL OILâ??A COMPARATIVE, RANDOMIZED, DOUBLE BLIND, PARALLEL GROUP, OBSERVATIONAL CLINICAL TRIAL STUDY TO EVALUATE EFFICACY AND SAFETY OF FILMOGEN GLYCEROL THROAT SPRAY CONTAINING CD-CYANIDIN PLANT PREMIX WITH ESSENTIAL OIL VERSUS SALINE SPRAY AS PLACEBO IN THE TREATMENT OF PATIENTS SUFFERING FROM DRY COUGH.â?? - DRYCTRI/2016/08/007153
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)Investigational Study of Glycerol Tributyrate in MELAS and LHON-PlusNCT06792500
Billineaster and glycerin in neonatal jaundiceComparison of efficacy of Billineaster drop and Glycerin suppository on the neonatal jaundiceIRCT2013031312807N1
Glycerin Suppositories for Treatment of Feeding Intolerance in Preterm InfantsEfficacy and Safety of Glycerin Suppositories for Treatment of Feeding Intolerance in Very Low Birth Weight InfantsNCT02149407
Clinical Study on the Treatment of STXBP1 Gene-related Encephalopathy with Glycerol PhenylbutyrateClinical Study on the Treatment of STXBP1 Gene-related Encephalopathy with Glycerol PhenylbutyrateChiCTR2500098844
A Clinical Study of Glycerol Phenylbutyrate in Chinese Patients With Urea Cycle DisordersA Single-arm, Prospective, Multi-center Post-market Clinical Study of Glycerol Phenylbutyrate in Chinese Patients With Urea Cycle DisordersNCT06904027
PDH-RAVICTI - A PHASE II, MULTICENTRIC, PROSPECTIVE, NON-COMPARATIVE CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF THE TREATMENT OF PYRUVATE DEHYDROGENASE DEFICIENCY (PDH) PATIENTS WITH GLYCEROL PHENYLBUTYRATE (RAVICTI®)PDH-RAVICTI - A PHASE II, MULTICENTRIC, PROSPECTIVE, NON-COMPARATIVE CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF THE TREATMENT OF PYRUVATE DEHYDROGENASE DEFICIENCY (PDH) PATIENTS WITH GLYCEROL PHENYLBUTYRATE (RAVICTI®) - APHP230834CTIS2024-516410-38-00
A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: microdialysis studyAntilipolytic drug Acipimox during short-term exercise further increases plasma neuropeptide Y levels in patients with bulimia nervosa compared with healthy women: the role of lipolysisACTRN12611000955910
A randomised control experiment comparing the efficacy of traditional treatment for nail thickening issues with customised nail patches containing urea, glycerin, salicylic acid, and biotinEffectiveness of customized nail patches containing Urea, Glycerin, Salicylic acid and Biotin versus conventional treatment in disorders of nail thickening: A randomized control trial - NILCTRI/2024/12/078603
Effect of Glycerol Hyperhydration on Running Economy of Long-distance RunnersEffects of Glycerol Hyperhydration on Running Economy in Long-Distance RunnersNCT06818253
Pain Relieving Effect of Glycerol Trinitrate (GTN) in Renal ColicPain Relieving Effect of Glycerol Trinitrate (GTN) in Renal Colic: a Randomized Placebo-Controlled TrialIRCT20180428039443N2
EndoscoPic Submucosal dIssection Using geL Versus glycerOl for Submucosal iNjectionEndoscoPic Submucosal dIssection Using geL Versus glycerOl for Submucosal iNjection: a Randomized Controlled Multicentric Trial (EPSILON)NCT04977401
Glycerin Suppositories to Reduce Jaundice in Premature InfantsThe Use of Glycerin Suppositories to Reduce Hyperbilirubinemia in Premature Infants Requiring PhototherapyNCT01746511
What is the effect of glycerol-, sodium- or glycerol + sodium hyperhydration on physiological and gastrointestinal outcomes during endurance running in the heat?What is the effect of glycerol-, sodium- or glycerol + sodium hyperhydration on physiological and gastrointestinal outcomes during endurance running in the heat?ACTRN12621000711819
Rehydration with Intravenous Fluid and Oral Glycerol in Athletes: Effects on Cardiovascular, Hormonal, Thermoregulatory, Metabolic and Performance VariablesIn athletes, is intravenous fluid with oral glycerol comparable to either intervention alone or placebo, for rehydrationACTRN12610001057077
An urea, arginine and carnosine cream shows greater efficacy in the treatment of severe xerosis of the feet in type 2 diabetic patients in comparison with standard emollient glycerol cream.An urea, arginine and carnosine cream shows greater efficacy in the treatment of severe xerosis of the feet in type 2 diabetic patients in comparison with standard emollient glycerol cream: a randomized, 8-month, assessor-blinded, controlled trial.ISRCTN13923163
Examination of the efficacy of glycerol, two topical steroids and a topical immune modulator in experimentally induced skin irritationExamination of the efficacy of glycerol, two topical steroids and a topical immune modulator in experimentally induced skin irritationEUCTR2008-001678-34-DK
Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial MeningitisOral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis - A Prospective, Randomized, and Double-Blind Clinical Study Using a Two-by-Two Factorial DesignNCT00619203
Evaluation of the effect of Glycerin suppository on anal fissure healingEvaluation of the effect of Glycerin suppository application in patients with Chronic anal fissureIRCT20210717051915N1
Efficacy Study of Oxygenated Glycerol Triesters to Treat XerostomiaMulticenter Controlled Parallel-Groups Trial to Evaluate the Efficacy, Safety and Acceptability of TGO Buccal Spray Versus a Saliva Substitute in the Treatment of Psychotropic Medicines-Induced XerostomiaNCT00332618
Randomised controlled trial of glycerol adjuvant therapy in adult bacterial meningitis in MalawiISRCTN70121840
Efficacy and safety of Polyspectran® drops, preserved with benzalkonium chloride vs. glycerol ear drops in patients with acute bacterial otitis externa – A double-blind, multicenter, prospective, randomized, and controlled clinical phase III study.Efficacy and safety of Polyspectran® drops, preserved with benzalkonium chloride vs. glycerol ear drops in patients with acute bacterial otitis externa – A double-blind, multicenter, prospective, randomized, and controlled clinical phase III study.EUCTR2005-001180-65-DE
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.The Administration of Saline Enema Versus Glycerin Suppository as a Treatment Intervention for Meconium Obstruction of Prematurity (MOP) and to Study the Impact on the Resolution of MOP, Time to Reach Full Enteral Feeds, Gut Microbiome, and Gut-brain Axis, a Randomised Control Trial.NCT06048614
Glycerol and sodium pentaborate in prevention of postoperative peritoneal adhesionEffects of glycerol and sodium pentaborate formulation on prevention of postoperative peritoneal adhesion formationIRCT20190618043923N5
The skin irritation test of Bathing BarA clinical study to evaluate the skin irritation potential of Ecovibez Glycerin Bathing Bar on healthy human subjects - NILCTRI/2024/02/062975
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)NCT05019417
Skin irritation test of Bathing bar.A Clinical Study to evaluate the skin irritation potential of Ecovibez Glycerin Bathing Bar on healthy human subjects. - NILCTRI/2024/04/066575
Examination of the efficacy of Conheal® artificial tears in dry eye patients suffering Sjögren's syndromeExamination of the efficacy of Conheal® glycerol and sodium hyaluronate containing artificial tears in dry eye patients suffering Sjögren's syndromeISRCTN17717813
Absorption and Tolerability Studies of an Emulsion Containing the Coconut Oil-derived Glycerol Tridecanoate in Healthy MenAbsorption and Tolerability Studies of an Emulsion Containing the Coconut Oil-derived Glycerol Tridecanoate in Healthy MenNCT03255889
To study the effect of use of prophylactic Glycerin enema versus Glycerin suppository versus no intervention on time required to reach full feeds in very low birth weight neonatesAn open-label randomized controlled trial to compare the time to reach full enteral feeds between the use of prophylactic Glycerin enema and Glycerin suppository and standard of care in neonates less than 1500 grams at birth - NILCTRI/2024/07/070434
Intramuscular Concentrations of Glucose, Lactate, Glutamate, and Glycerol Comparing Chronic Exercise Induced Compartment Syndrome Patients to Controls Before and Following ExerciseIntramuscular Concentrations of Glucose, Lactate, Glutamate, and Glycerol Comparing Chronic Exercise Induced Compartment Syndrome Patients to Controls Before and Following Exercise - CECS-MDDRKS00021589
Clinical Application of a Dermal Substitute based on glycerol preserved Allograft: GLYADERM® A multicentre, prospective, controlled, randomized, comparative trial of Glyaderm® and split thickness skin graft versus split thickness skin graft alone in full thickness skin defectsClinical Application of a Dermal Substitute based on glycerol preserved Allograft: GLYADERM® A multicentre, prospective, controlled, randomized, comparative trial of Glyaderm® and split thickness skin graft versus split thickness skin graft alone in full thickness skin defects - Multicentre evaluation Glyaderm®NL-OMON36554
Oral Glycerol in newborn brain infectionsRandomized comparison of oral glycerol and standard treatment versus standard treatment alone in management of neonatal bacterial meningitisCTRI/2015/04/005668
The effects of transdemal glycerol trinitrate administration on the ischemic limb for vascular intermittent claudicationThe effects of transdemal glycerol trinitrate administration on the ischemic limb for vascular intermittent claudication - Transdemal glycerol trinitrate administration on the ischemic limbJPRN-UMIN000003707
A study to compare RAVICTI® against Sodium Phenylbutyrate (NaPBA) in the treatment of Urea Cycle Disorders (UCDs) in patients who have not received Phenylbutyrate treatment before.A Randomised, Controlled, Open-Label Parallel Arm Study of the Safety, Pharmacokinetics and Ammonia Control of RAVICTI® (Glycerol Phenylbutyrate [GPB]) Oral Liquid and Sodium Phenylbutyrate (NaPBA) in Phenylbutyrate Treatment Naïve Patients with Urea Cycle Disorders (UCDs)EUCTR2015-000075-27-AT
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection SyndromeComparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome: A Multicentre Randomised Controlled TrialNCT04087421
Evaluation of Glycerin Suppositories to Improve Bowel Function in GastroschisisEvaluation of Routine Administration of Glycerin Suppositories to Improve Bowel Function in Patients With Uncomplicated GastroschisisNCT03355326
A study to compare RAVICTI® against Sodium Phenylbutyrate (NaPBA) in the treatment of Urea Cycle Disorders (UCDs) in patients who have not received Phenylbutyrate treatment before.A Randomised, Controlled, Open-Label Parallel Arm Study of the Safety, Pharmacokinetics and Ammonia Control of RAVICTI® (Glycerol Phenylbutyrate [GPB]) Oral Liquid and Sodium Phenylbutyrate (NaPBA) in Phenylbutyrate Treatment Naïve Patients with Urea Cycle Disorders (UCDs)EUCTR2015-000075-27-BE
Evaluation of Effect of glycerin suppository in prevention of neonatal jaundice in besat hospital in sanandaj in 2016-17Study of the effectiveness of glycerin suppository on prevention of neonatal jundice in neonatalIRCT20180306038980N1
Safety and Acceptability Study of Oral Emtricitabine/Tenofovir Disoproxil Fumarate Tablet and Rectally-Applied Tenofovir Reduced-Glycerin 1% GelA Phase 2 Randomized Sequence Open Label Expanded Safety and Acceptability Study of Oral Emtricitabine/Tenofovir Disoproxil Fumarate Tablet and Rectally-Applied Tenofovir Reduced-Glycerin 1% GelNCT01687218
Clinical study on the effect of glycerol fructose on cerebral edema and clinical efficacy in patients with small amount of intracerebral hemorrhageClinical study on the effect of glycerol fructose on cerebral edema and clinical efficacy in patients with small amount of intracerebral hemorrhageChiCTR2000039923
Lactate and Glycerol Contribution to GluconeogenesisLactate and Glycerol Contribution to GluconeogenesisNCT06955130
Safe Excipient Exposure in Neonates and Small ChildreNSafe Excipient Exposure in Neonates and Small ChildreN - a Retrospective, Descriptive Study Off the Amount of Ethanol, Propylene Glycol, Benzyl Alcohol, Parabens, Acesulfam k, Aspartame, Glycerol, Sorbitol and Polysorbate-80 Exposed to Pediatric PatientsNCT02545712
The effects of hyaluronicacid gel injection on skin rejuvenationEvaluating the effects of Pluryal® BOOSTER (a non cross-linked hyaluronic acid product stabilized with glycerol) injection on improvement of skin elasticity and hydration in people with visible signs of dry and aged skinIRCT20190210042676N1
Acute Effects of Propylene Glycol/Glycerol Intake on Blood ParametersAcute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood ParametersNCT03404011
Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical TechniqueGlycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical TechniqueNCT02624661
In patients suffering from acute or chronic Rhino-sinusitisA Comparative, Randomized, Double Blind, Parallel Group, Placebo Controlled, Observational clinical trial study to Evaluate Efficacy and Safetyof Test Product Nasal spray containing VB-Gy (Glycerol)and HPC-Cyanidins(HPC + Essential oils) versus 0.9% NaCl saline solution spray as Placebo inpatients suffering from acute or chronic Rhino-sinusitis.â??CTRI/2017/03/008016
Comparison of effectiveness of Glycerin - Paraffine combination to Mustard oil on skin problems(dryness and itching) of patient with kidney failure.Assessment of efficacy of Glycerin Paraffine combination in comparison to Mustard oil on skin related quality of life (SR-QOL) among CKD patients with CKD associated pruritus(CKD -ap) and Xerosis.CTRI/2021/02/030981