| Bioequivalence study of Diosmin 450mg + Hesperidin 50 mg film-coated tablet in healthy, adult human, subjects under fed conditions. | An Open label, balanced, randomized, truncated, two treatment, two-period, two-sequence, single dose, crossover, oral bioequivalence study of Pilestop Tablet (Diosmin 450 mg + Hesperidin 50 mg film-coated tablet) by The ACME Laboratories Ltd., with Daflon 500 Tablet (Diosmin 450 mg + Hesperidin 50 mg film-coated tablet) of LES Laboratories Servier Industrie in healthy, adult human, subjects under fedconditions. - NIL | CTRI/2025/02/080636 |
| Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty | Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Primary Total Knee Arthroplasty | NCT06753448 |
| Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome | Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome | NCT02134249 |
| Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs | Assessment of the Efficacy and Safety of Diosmin 600mg on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs: a Multicentric, Randomised, Double-blind, Placebo-controlled Trial in Parallel Groups | NCT01532882 |
| A phase III, double-blind, placebo-controlled, randomized, three-arm parallel, study assessing efficacy and safety of 4 months of diosmin administration for the treatment of lower extremity teleangiectasias and gynoid lipodystrophy (edematous fibrosclerotic panniculopathy commonly known as cellulite) | A phase III, double-blind, placebo-controlled, randomized, three-arm parallel, study assessing efficacy and safety of 4 months of diosmin administration for the treatment of lower extremity teleangiectasias and gynoid lipodystrophy (edematous fibrosclerotic panniculopathy commonly known as cellulite) | EUCTR2013-004539-57-PL |
| Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency | A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months | NCT02927483 |
| Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy | Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy | NCT05243706 |
| Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product | Bioavailability of a Formulation of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to the Marketed Reference Product | NCT05158192 |
| study the additional effect of snuhi tail with daflon in woman with varicose vein | study the add on effect of snuhi taila with diosmin and hesperidin in managment of vericose vein in parous woman - STD | CTRI/2020/09/027586 |
| A multicenter, randomized, parallel patients’ group, comparative clinical trial for the assessement of efficacy and safety of Pelethrocin®/HELP 500 mg (generic diosmin & hesperidin MPFF) versus Daflon®/Servier 500 mg (original diosmin & hesperidin MPFF) in the treatment of chronic venous insufficiency patients (a therapeutic equivalence trial). | A multicenter, randomized, parallel patients’ group, comparative clinical trial for the assessement of efficacy and safety of Pelethrocin®/HELP 500 mg (generic diosmin & hesperidin MPFF) versus Daflon®/Servier 500 mg (original diosmin & hesperidin MPFF) in the treatment of chronic venous insufficiency patients (a therapeutic equivalence trial). | EUCTR2007-001947-23-GR |
| Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis | Clinical Study Evaluating the Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis | NCT05756179 |
| Oral Tranexamic Acid Versus Diosmin for Treatment of Menorrhagia in Women Using Copper IUD | Oral Tranexamic Acid Versus Diosmin for Treatment of Menorrhagia in Women Using Copper IUD: Randomized Controlled Trial | NCT02616731 |
| Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency | Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study | NCT03471910 |
| A clinical trial of Diosmin's effects in the treatment of low back pain | A randomized controlled trial evaluating the effects of Diosmin in the treatment of radicular pain caused by lumbar intervertebral disc protrusion | ISRCTN97157037 |
| To estimate the bioavailability of diosmin in FLAVOSPRINT 500 PRO versus FLAVOSPRINT in healthy adult human subjects. | An open label, randomized, balanced, two-period, two-treatment, cross over, single dose oral bioavailability study of FLAVOSPRINT 500 PRO (containing microSMIN PLUS) (T) of GIELLEPI S.p.A., and FLAVOSPRINT (containing micronized diosmin) (R) of GIELLEPI S.p.A. in healthy, adult, human subjects under fasting conditions. | CTRI/2017/07/008952 |
| Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis | The Efficacy of Rivaroxaban With Diosmin in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis | NCT03413618 |
| Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren®) in addition to conventional treatment, in the management of patients with persistent hand edema following trauma or surgery of distal forearm or hand. A randomized controlled trial. | Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren®) in addition to conventional treatment, in the management of patients with persistent hand edema following trauma or surgery of distal forearm or hand. A randomized controlled trial. | ACTRN12618001033235 |
| to observe the difference between Diosmin (900 mg) with Traneximic acid (500 mg) and Mefanamic acid (250 mg) in reducing menstural blood loss in pateints of Abnormal Uterine Bleeding | Efficacy and safety of Diosmin (900 mg) given along with Tranexamic acid (500 mg) and Mefenamic acid (250 mg) in reducing menstural blood loss in patients of Abnormal Uterine Bleeding A Prospective double blind randomized controlled trial(RCT) - NIL | CTRI/2019/11/021844 |
| Is Diosmin (Venusmin) effective in treating haemorrhoids | A prospective randomized double blind controlled study to evaluate the efficacy and safety of Venusmin 900mg, a 100% pure and micronized Oral Diosmin in the cessation of bleeding and symptoms associated with haemorrhoids | CTRI/2020/11/028921 |
| Hesperidin and Diosmin for Treatment of COVID-19 | Randomized Double-blind Controlled Parallel Study of (Hesperidin and Diosmin Mixture) for Treatment of COVID-19 Newly Diagnosed Patients in Egypt | NCT04452799 |
| Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer | Diosmin as Adjuvant Therapy in Treatment of Non-bleeding Peptic Ulcer | NCT05670457 |
| the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis | Clinical Study Evaluating the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis Treated With Mesalamine | NCT05626166 |
| the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis. | Clinical Study Evaluating the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis. | NCT05942547 |
| Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis | Treatment of Digital Ulcers in Systemic Sclerosis With Diosmin: A Randomized, Double-blind, Placebo-controlled Multi-centre Pilot Study | NCT06256575 |
| 100% Pure Diosmin versus Micronised Purified Flavonoid Fraction in the treatment of chronic venous disease | 100% Pure Diosmin versus Micronised Purified Flavonoid Fraction (MPFF) in the treatment of chronic venous disease: A Randomized Control Study - NIL | CTRI/2024/03/064003 |
| Diosmin plus cabergoline for prevention of Ovarian Hyperstimulation Syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) | Diosmin plus cabergoline for prevention of Ovarian Hyperstimulation Syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) | ACTRN12614000535673 |
| Assessment of the efficacy of flavonoid complex supplementation on improvement of leg discomfort: a double-blind, randomized, placebo-controlled clinical study | Efficacy of a diosmin-based dietary supplement on signs of telangiectasia improvement | ISRCTN15667863 |
| The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients | The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients | NCT06811220 |
