| Clinical assessment of the efficacy of topical nano-formulation of tranexamic acid/niacinamide in melasma | Clinical assessment of the efficacy of tranexamic acid-niacinamide loaded niosome in comparison to tranexamic acid-niacinamide and hydroquinone conventional creams in melasma | IRCT20220609055116N1 |
| Comparing the effectiveness of a dermo-cosmetic product vs 4% hydroquinone cream for facial melasma treatment: a controlled clinical study | Randomized, double-blind, comparative clinical trial to evaluate the effectiveness of a dermo-cosmetic product versus 4% hydroquinone cream for treatment of facial melasma | ISRCTN16361887 |
| A Clinical trial to study the effects of two drugs , metformin lotion and modified kligman formula cream in patients with melasma , a type of facial pigmentation. | A split face study to compare efficacy and safety of Modified Kligman Formula (Hydroquinone 2% + Tretinoin 0.05% + Flucinolone Acetonide 0.01%) with Topical Metformin 30% in the patients with Melasma - A Prospective Comparative Study in Tertiary Care Hospital - NIL | CTRI/2024/10/075324 |
| The effectiveness of hydroquinone 4% versus hydroquinone 4% with intradermal injection of autologous platelet-rich plasma in the treatment of lichen planus pigmentosus: A comparative split-face clinical trial | The effectiveness of hydroquinone 4% versus hydroquinone 4% with intradermal injection of autologous platelet-rich plasma in the treatment of lichen planus pigmentosus: A comparative split-face clinical trial | TCTR20240430003 |
| A study for the treatment of melasma which compares the effectiveness and side effects of metformin cream with triple combination cream which contains steroid plus hydroquinone plus retinoid skin lightening agents and tranexamic acid cream. | A randomised comparative study to evaluate the efficacy and safety of thirty percent metformin cream versus triple combination cream versus tranexamic acid cream in the treatment of melasma - Nil | CTRI/2024/07/070009 |
| A study on patients suffering from Melasma (a skin problem caused by brown to gray-brown patches on the face) to determine efficacy and safety of 2 skin care products which are Cysteamine cream with Hydroquinone cream. | A prospective, randomized, comparative open label study to evaluate efficacy and safety of Cysteamine 5% cream with Hydroquinone 4 % cream in patients with Melasma. | CTRI/2024/04/066500 |
| To Assess the skin irritation potential of Non-Hydroquinone night cream,HA Face Serum,Moisturizer,Hair Strengthening Shampoo,Conditioner,Hair Oil, by repeated application of patches on human skin | To evaluate the skin irritation and sensitization potential of the 6 Investigational products by repeated application of occlusive patches - Not Applicable | CTRI/2023/07/054853 |
| Cysteamine Compared to Hydroquinone in Melasma | Compare the Efficacy and Safety Profile of Cysteamine and Hydroquinone in Melasma as Topical Application | NCT05969587 |
| To assess the test Non-Hydroquinone night cream is not known to produce pimples/Acne after application. | To assess the safety & efficacy of SKINOVATE- Non-Hydroquinone night cream for its non-comedogenic effect. - Not Applicable | CTRI/2023/07/054650 |
| Efficacy and Safety of Topical Metformin 30% in the Treatment of Melasma Compared to Triple Combination Cream(0.05% tretinoin, 2% hydroquinone, 0.01% fluocinolone acetonide) | Efficacy and Safety of Topical Metformin 30% in the Treatment of Melasma Compared to Triple Combination Cream(0.05% tretinoin, 2% hydroquinone, 0.01% fluocinolone acetonide) | IRCT20210823052264N9 |
| EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA | EVALUATION of the EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA OVER 3 MONTHS | NCT06787846 |
| Comparative analysis of Efficacy and Safety of Topical Metformin and Topical Hydroquinone in Melasma | Safety and Efficacy of Topical Metformin and Topical Hydroquinone in patients with Melasma : A Randomized Control Trial - NIL | CTRI/2025/05/086473 |
| Comparative study on the effectiveness of alpha bright serum versus 2% hydroquinone cream for melasma treatment in Thailand | Comparative study on the effectiveness of alpha bright serum versus 2% hydroquinone cream for melasma treatment in Thailand | TCTR20250217008 |
| A study to demonstrate the safety and efficacy of oral metformin in treatment of melasma in Indian population. | An assessor blinded, randomized controlled trial comparing the safety and efficacy of oral metformin with topical 4 percent hydroquinone vs topical 4 percent hydroquinone alone in treatment of melasma in Indian skin types. - NIL | CTRI/2025/02/080911 |
| Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study | Randomised Double-blinded Split-face Controlled Study to Evaluate the Effectiveness of Eflornithine Hydrochloride Cream Compared to Topical Hydroquinone 2% Cream for the Treatment of Melasma. | NCT06957834 |
| Comparison of the effect of cysteamine cream and hydroquinone cream in the treatment of acne pigmentation | Comparison of the therapeutic efficacy of cysteamine 5% cream with Hydroquinon 4% cream in acne-induced postinflammatory hyperpigmentation patients | IRCT20140212016557N5 |
| Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma | Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma | NCT03982849 |
| Comparison of the effect of cysteamine cream and hydroquinone cream in the treatment of melasma | Comparison of the therapeutic efficacy of cysteamine 5% cream with Hydroquinon 4% cream in epidermal melasma patients | IRCT20140212016557N4 |
| Comparision of topical 5 percent Cysteamine cream and 4 percent Hydroquinone cream in melasma | Comparative efficacy of topical 5 percent Cysteamine cream and 4 percent Hydroquinone cream in melasma - NIL | CTRI/2024/11/076217 |
| The benefit of Nicotinamide + Vitamin C + Hyaluronic Acid, compared to Hydroquinone in the treatment of Melasma | Efficacy and safety topical Nicotinamide 10%, associated with VCPMG 5% and Hyaluronic Acid 5%, compared to Hydroquinone 4% tested in Brazilian women with Melasma: a double-blind, randomized and controlled trial | RBR-4mkfmr8 |
| A randomized split-face double-blind control trial of the Efficacy of Hydroquinone-free skin brightening serum (Melacare) on Improvement of Melasma versus placebo in THAIS | Efficacy of Hydroquinone-free skin brightening serum (Melacare) on Improvement of Melasma: A randomized split-face double-blind control trial | TCTR20210604008 |
| Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma | Comparative Efficacy of Azelaic Acid 20% Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma | NCT05887219 |
| Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women | The Efficacy of Salicylic Acid Peels Combined With 4% Hydroquinone Cream Versus 4% Hydroquinone Cream Alone in the Treatment of Hispanic Women With Moderate to Severe Melasma | NCT00616239 |
| Efficacy of 5% cysteamine vs 4% hydroquinone in melasma | Efficacy of 5% cysteamine vs 4% hydroquinone in melasma | IRCT20210823052264N13 |
| Comparison of topical ?% Methimazole and 4 % Hydroquinone effect on melasma | Comparison of the effect of topical Methimazole 5% versus topical Hydroquinone 4% on the improvement of melasma lesions | IRCT20091012002581N9 |
| Interventional study comparing the effectiveness of topical metformin 30 % cream plus hydroquinone 4 % cream vs topical hydroquinone 4% cream alone in melasma -a randomised non inferiority open label study. | Comparison of effectiveness of topical metformin 30% plus 4%hydroquinone cream vs topical hydroquinone 4% cream alone in melasma -A randomised non inferiority open lable study - nil | CTRI/2024/11/076845 |
| evaluating effectivness of Plasma rich in growth factor (PRGF) in the treatment of melasma | Comparision of efficacy of 4% hydroquinone alone and combined with Plasma rich in growth factor (PRGF) in the treatment of melasma | IRCT20221016056188N1 |
| Oral and Topical Tranexamic Acid for the Treatment of Melasma | Oral and 5% Topical Tranexamic Acid in Monotherapy Compared With 4% Topical Hydroquinone for the Treatment of Melasma: Three-arm Randomized, Double-blinded Clinical Trial | NCT03585179 |
| Efficacy of oralTranexamicAcid in melasma | Comparison of efficacy of oralTranexamicAcid with4% topical hydroquinone in the treatment of melasma. | IRCT20180111038311N1 |
| Comparison of the effect of conventional and liposomal topical hydroquinone 4 % on melasma treatment | A comparative study between conventional and liposomal topical hydroquinone 4 % on melasma treatment | IRCT201405283862N13 |
| Efficacy of Hydroquinone 2% cream versus Tranexamic Acid Injection | Comparison of the Efficacy of Hydroquinone 2% cream versus Tranexamic Acid Injection in Treatment of Melasema | IRCT2017040533244N1 |
| A study to compare efficacy of intradermal Tranexamic acid injections versus topical Tranexamic acid gel versus topical triple combination (Hydroquinone 2 %, Tretinion 0.025%, Flucinolone acetonide 0.01%) cream in patients suffering from melasma | The comparative study of the efficacy of intradermal tranexamic acid V/S 3% topical tranexamic acid V/S topical triple combination (hydroquinone 2 %, tretinion 0.025%, flucinolone acetonide 0.01%) in melasma. | CTRI/2017/07/009158 |
| 5% Hydroquinone with Non-ablative fractional 1540 Erbium YAG Laser in the Treatment of Melasma | Comparison combination of hydroquinon 5% with laser Non-ablative fractional 1540 erbium YAG versus hydroquinon 5% in treatment of melasma | IRCT2017061727097N3 |
| A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma | A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma | NCT03049059 |
| Clinical trial of evaluation of Methimazole 5% cream effectiveness versus Hydroquinone cream 2% to reduce pregnancy spots (melasma) | Evaluation of Methimazole 5% cream effectiveness versus Hydroquinone cream 2% in patient with melasma, referred to Dermatology Clinic | IRCT2016073129145N1 |
| The effect of finasteride for the treatment of melasma | Comparison of the efficacy of oral finastride and topical hydroquinone versus placebo and topical hydroquinone in treatment of melasma | IRCT2016031627077N1 |
| Compare the effect of methimazole and hydroquinone cream in the treatment of melasma | A comparative study of hydroquinone cream 4% and methimasole cream 5% in melasma patients | IRCT2016041727445N1 |
| treatment of melasma | Compare the effect of hydroquinone 4% and 20% Zlvyyk acid in the treatment of melasma | IRCT2014110919885N1 |
| Comparison of topical and oral treatments of melasma | Comparison of therapeutic effect of oral and topical tranexamic acid in the treatment of patients with facial melasma receiving topical hydroquinone | IRCT201411033566N7 |
| Comparsion the effect of local application of parsley (petroselinium crispum) with hydroquinone cream on reduction the severity of epidermal melasma | Comparsion the effect of local application of parsley (petroselinium crispum) with hydroquinone cream on reduction the severity of epidermal melasma: A randomized clinical trial | IRCT2014070518358N1 |
| The extra benefit of using topical Clobetasol before Hydroquinone 4% in the treatment of Melasma | Topical Clobetasol as an adjunct treatment to 4% Hydroquinone in moderate to severe facial Melasma: a randomized, double-blind, controlled clinical trial | RBR-4mzcwpw |
| Combination Alexandrite Laser and Topical Therapy vs Topical Therapy Alone for Treatment of Melasma | A Randomized, Split-Face, Double-Blind Clinical Pilot Study of Combination Picosecond Alexandrite Laser and Non-Hydroquinone Topical Therapy Versus Topical Therapy Alone for the Treatment of Facial Melasma | NCT02095756 |
| Efficacy and safety of a 4% hydroquinone cream (Melanoderm 4%) for the treatment of melasma. | Efficacy and safety of a 4% hydroquinone cream (Melanoderm 4%) for the treatment of melasma: a randomized controlled split-face study. | EUCTR2013-003501-25-ES |
| Clinical efficacy of hydroquinone in glaucoma patients with prostaglandin-induced eyelid pigmentation | Clinical efficacy of hydroquinone in glaucoma patients with prostaglandin-induced eyelid pigmentation - Clinical efficacy of hydroquinone in prostaglandin-induced eyelid pigmentation | JPRN-UMIN000011524 |
| Clinical Trial of Hydroquinone Versus Miconazol in Melasma | Double Blind Randomized Study of 2% Miconazol Versus 4% Hydroquinone in the Treatment for Melasma. | NCT01661556 |
| A clinical trial to study the effect of triple combination of Triglow cream containing Hydroquinone, Tretinoin and Fluocinolone acetonide in patients with facial melasma. | Assessment of efficacy and safety of ?Triglow? Cream (Combination of Hydroquinone 2%, Tretinoin 0.05% and Fluocinolone acetonide 0.01%) in the treatment of Facial Melasma. | CTRI/2011/091/000054 |
| Azelaic Acid Versus Hydroquinone in Melasma | Efficacy & Safety of Azelaic Acid 15% Gel vs. Hydroquinone 4% Cream in the Treatment of Melasma | NCT00927771 |
| Evaluation of a new substance (isobutylamido thiazolyl resorcinolcream) compared to the use of hydroquinone 4% cream to treat facial blemishes | Efficacy and safety of topical 0,2% Thiamidol versus 4% Hydroquinone in the treatment of facial Melasma in women: a randomized and evaluator blinded clinical trial | RBR-87kphy |
| Combination of Hydroquinone and Fractional CO2 Laser vs. Hydroquinone Monotherapy in Melasma Treatment: A Randomized Split-face Clinical Trial | Comparison of Effectiveness of Hydroquinone 4% and Fractional CO2 Laser combination vs. Hydroquinone 4% Monotherapy in women from the age range of 20-50 years with melasma. | IRCT20171222037987N1 |
| Monobenzyl Ether of Hydroquinone in Depigmentation of Vitiligo. | Monobenzyl Ether of Hydroquinone (MBEH) 20% and 40% Cream in Depigmentation of Vitiligo Patients: Randomized controlled trial. | PACTR201808699550182 |
| Efficacy and Safety of a 4% Hydroquinone Cream for the Treatment of Melasma | Efficacy and Safety of a 4% Hydroquinone Cream (Melanoderm 4%) for the Treatment of Melasma: a Randomized Controlled Split-face Study | NCT02095990 |
| Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma | Randomized, Controlled, Double-blind Study of Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma | NCT03751163 |
| Evaluation of Hexyresorcinol vs Hydroquinone for Photoaging | Randomized, Double-Blind Evaluation of Hexyresorcinol vs Hydroquinone for Photoaging | NCT04345094 |
| Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial | Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial | NCT04597203 |
| evaluating effectiveness of combination therapy with niosomal kojic acid and arbutin in melasma | Comparision of niosomal kojic acid and arbutin with hydroquinone 4% in the treatment of melasma patients | IRCT20200623047891N1 |
| A randomized, double-blind, split-face study of topical silymarin versus 2% hydroquinone cream in melasma | A randomized, double-blind, split-face study of topical silymarin versus 2% hydroquinone cream in melasma | TCTR20210729003 |
| A Multi-Center, Randomized, Double-Blind, Three-Arm, Parallel-Group, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream in Patients with Moderate to Severe Melasma | A Multi-center, Randomized, Double-blind, Three-arm, Parallel-group, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream in Patients with Moderate to Severe Melasma | ChiCTR2100043798 |
| Prospective Evaluation of Topical Almond Oil vs Hydroquinone | Prospective Evaluation of Topical Almond Oil vs Hydroquinone on the Appearance of Facial Pigmentation and the Stability of the Microbiome | NCT04875715 |
| Evaluation of a new substance (cysteamine 5% cream) compared to the use of hydroquinone 4% cream to treat facial blemishes | Cysteamine 5% cream versus hydroquinone 4% cream in the treatment of facial melasma: a clinical parallel trial, controlled and blind assessment | RBR-5khj37 |
| Effect of hydroquinone 4% topical cream versus glucosamine 2% topical cream on treatment of melasma | Effect of hydroquinone 4% topical cream versus glucosamine 2% topical cream on treatment of melasma: a double-blind randomized clinical trial | IRCT20120215009014N399 |
| Comparative study between topical hydroquinone 4% alone versus its combination with intradermal autologous platelet-rich plasma in the treatment of melasma: a split-face controlled trial | Comparative study between topical hydroquinone 4% alone versus its combination with intradermal autologous platelet-rich plasma in the treatment of melasma: a split-face controlled trial | TCTR20210925002 |
| To Compare the efficacy of Transamic acid (TA) injection vs Hydroquinone, Flucinolone acetonide and Tretinoin for melasma | To Compare the efficacy of Transamic acid (TA) mesotherapy vs Hydroquinone, Flucinolone acetonide and Tretinoin for melasma | IRCT20210823052264N1 |
| Evaluation of NLC nanoparticles containing hydroquinone, tretinoin, and fluocinolone in the treatment of melasma | Evaluation of safety and efficacy of Nanostructured lipid carrier( NLC) nanoparticles containing hydroquinone, tretinoin, and fluocinolone compared with conventional formulation in the treatment of melasma | IRCT20161207031288N13 |
| Efficacy of Tranexamic Acid Versus Topical 4% Hydroquinone in Melasma | Comparison of Efficacy of Intralesional Tranexamic Acid Versus Topical 4% Hydroquinone in Treating Melasma | IRCT20220709055422N1 |
| Effect Of Tranexamic acid By Microneedling in Melasma. | Comparison of Transxamic Acid( 4mg/ml) Effects By Microneedling with Hydroquinone( 4%) Ointment in Treatment of Melasma Patients. | IRCT20180811040761N1 |
| Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos | A Randomized, Observer-Blinded, Vehicle-Controlled Study on the Safety and Efficacy of Twice Daily Application of Ruboxistaurin (DBI-102) Gel Vs.Vehicle Gel Vs. Hydroquinone Cream on Sun-Exposed and Sun-Protected Skin of Adults | NCT05511948 |
| comparsion between two drugs for the treatment of facial pigmentation | A comparartive study of the efficacy of once daily 4 % hydroquinone and 2% kojic acid cream for the treatment of facial melasma: A Randomized control trail | CTRI/2021/08/035625 |
| The effect of tranexamic acid and hydroquinone in melasma | Comparison of the efficacy of intradermal injecting of tranexamix acid and hydroquinone cream in the treatment of melasma | IRCT20180909040979N5 |
| A clinical trial to study the effects of two drugs, Tranexamic acid and Hydroquinone in patients with melasma | A COMPARATIVE STUDY ON THE EFFICACY OF TOPICAL 5% TRANEXAMIC ACID SOLUTION VS 3% HYDROQUINONE CREAM IN MELASMA. | CTRI/2017/10/010049 |
| Clinical Study to Evaluate Unani Compound Topical Formulation Compared With Topical Cream Hydroquinone 4% | A Randomized, Controlled, Parallel Group, Single Blind Clinical Study to Evaluate The Efficacy and Safety of a Unani Compound Topical Formulation in the Treatment of Kalaf (Melasma) - PGIF | CTRI/2019/09/021159 |
| A randomized, split-face, comparative clinical study on the efficacy of Eucerin ultraWHITE+ spotless and the combination of 2%hydroquinone and 4%arbutin for the treatment of skin hyperpigmentation | A randomized, split-face, comparative clinical study on the efficacy of Eucerin ultraWHITE+ spotless and the combination of 2%hydroquinone and 4%arbutin for the treatment of skin hyperpigmentation | TCTR20190614008 |
| Treatment of Melasma with Cysteamine cream compared to Hydroquinone cream | Evaluation of the efficacy of cysteamine cream compared to hydroquinone cream in the treatment of melasma: a randomised, double-blind, multi-centre trial. | ACTRN12619000406101 |
| """Effect of Terminalia Chebula in treatment of melasma""" | Evaluating the effect of Myrobalan (Terminalia Chebula.) cream, 5% compared to hydroquinone cream, 2% in the treatment of melasma | IRCT20110310006026N10 |
| Efficacy and tolerability of a topical skin-lightening cosmetic product combination on facial dyspigmentation compared with 4% hydroquinone | Efficacy and tolerability of a topical skin-lightening CPP on subjects presenting facial dyspigmentation compared with 4% hydroquinone | ISRCTN33310512 |
