IMPPAT Phytochemical information: 
Azelaic acid

Azelaic acid
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Azelaic Acid on Demodex Counts in RosaceaThe Effect of Azelaic Acid (Financea Gel 15%) on Demodex Folliculorum Counts in Adult Subjects With Mild to Moderate Papulopustular RosaceaNCT03035955
THE EFFECT OF AZELAIC ACID ON SYMPTOMS OF ACNE IN FEMALE PATIENTS AGE 20-45 WITH MILD TO MODERATE PAPULOPUSTULAR ACNE (ACNE TARDA)THE EFFECT OF AZELAIC ACID ON SYMPTOMS OF ACNE IN FEMALE PATIENTS AGE 20-45 WITH MILD TO MODERATE PAPULOPUSTULAR ACNE (ACNE TARDA)EUCTR2013-000416-24-DE
A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With RosaceaA Multicenter, Double-Blind, Randomized, Parallel-Group, Vehicle-Controlled Study to Evaluate Safety and Clinical Equivalence of a Generic Azelaic Acid Foam, 15% and the Reference Listed Finacea® (Azelaic Acid) Foam,15% in Patients With Moderate Facial RosaceaNCT03287791
Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne RosaceaEfficacy of 45mg Oral Minocycline (Solodyn) and 45mg Oral Minocycline (Solodyn) Plus 15% Azelaic Acid (Finacea) in the Treatment of Acne RosaceaNCT05014906
Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne VulgarisA Multi-centre, Single-blind, Parallel Group, Clinical Evaluation of the Efficacy and Safety of Clindamycin 1% / Benzoyl Peroxide 3% and Azelaic Acid 20% in the Topical Treatment of Mild to Moderate Acne VulgarisNCT02058628
Comparative study between efficacy of two combination peels in acne vulgaris grade II and IIIComparative study between efficacy of 18 percent Salicylic acid and 15 percent Azelaic acid combination peel vs 20 percent Salicylic acid and 10 percent Mandelic acid combination peel in Acne vulgaris grade II & III - A Randomized Controlled Trial - NILCTRI/2024/06/069015
A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial RosaceaA Multicenter, Double-blind, Randomized, Parallel-group, Vehicle-Controlled Study to Evaluate the Safety and Clinical Equivalence of a Generic Azelaic Acid Gel, 15% and the Reference Listed Finacea® (Azelaic Acid) Gel, 15% in Patients With Moderate Facial Rosacea.NCT02120924
Study to evaluate the Efficacy, Safety and Tolerability of Ivermectin Cream 1% w/w Vs. Azelaic Acid Gel 15% w/w in Patients with Inflammatory Lesions of Rosacea.A Comparative, Randomized, Two Arm, Multicentric, Active Controlled, Open label, Parallel Group, Phase III Study to Evaluate the Efficacy, Safety and Tolerability of Ivermectin Cream 1% w/w Vs. Azelaic Acid Gel 15% w/w in Patients with Inflammatory Lesions of Rosacea.CTRI/2017/02/007835
To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical GelA Multi-Center, Double-Blind, Randomized, Placebo Controlled, Parallel-Group Study, Comparing Azeliac Acid Gel and Active Treatments to a Placebo Control in the Treatment of Moderate Facial Rosacea.NCT03094403
A multi-centre, single-blind, parallel group, clinical evaluation of the efficacyand safety of clindamycin 1% / benzoyl peroxide 3% and azelaic acid 20% in thetopical treatment of mild to moderate acne vulgarisA multi-centre, single-blind, parallel group, clinical evaluation of the efficacyand safety of clindamycin 1% / benzoyl peroxide 3% and azelaic acid 20% in thetopical treatment of mild to moderate acne vulgarisEUCTR2013-004158-81-Outside-EU/EEA
Effect of topical 5% tranexamic acid solution versus 20% azelaic acid cream in the treatment of post-inflammatory hyper-pigmentation patients with acneEffect of topical 5% tranexamic acid solution versus 20% azelaic acid cream in the treatment of post-inflammatory hyperpigmentation patients with acne: a double-blind randomized clinical trialIRCT20120215009014N356
Treatment of Acne scarsA comparative study on the efficacy of glycolic acid v/s azelaic acid in the treatment of post acne hyperpigmentation - PIHCTRI/2018/02/012050
Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in MelasmaComparative Efficacy of Azelaic Acid 20% Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in MelasmaNCT05887219
Azelaic Acid Versus Hydroquinone in MelasmaEfficacy & Safety of Azelaic Acid 15% Gel vs. Hydroquinone 4% Cream in the Treatment of MelasmaNCT00927771
Clinical observation of the efficacy and safety of azelaic acid combined with alpha hydroxy acid and alpha hydroxy acid in the treatment of melasmaClinical observation of the efficacy and safety of azelaic acid combined with alpha hydroxy acid and alpha hydroxy acid in the treatment of melasmaChiCTR2400091074
Effect of metformin cream 30% versus azelaic acid cream 20% on the treatment of melasmaEffect of metformin cream 30% versus azelaic acid cream 20% on the treatment of melasma: a double-blind randomized clinical trialIRCT20120215009014N505
Comparison of azeliac acid 10% gel with microneedling versus tranexamic acid 5% gel with microneedling, on right and left side of face respectively, for treatment of melasma.An Open label Non-Randomized Split Face Interventional Study to Compare the Efficacy and Safety of Microneedling with Azelaic Acid 10% gel versus Microneedling with Tranexamic Acid 5% gel in the treatment of Melasma. - NILCTRI/2023/11/059632
A Double-Blind, Randomized, Placebo-controlled, Multicenter study of Azelaic acid 15% Gel fortreatment of mild to moderate papular-pustular acne of the facial area or facial rosacea.A Double-Blind, Randomized, Parallel Group, Placebo-controlled, Multicenter study to evaluate thebioequivalence (Clinical equivalence) of test formulation Azelaic acid 15% Gel of Kusum HealthcarePvt. Ltd., India with Skinoren 15 % Gel (Azelaic acid) Leo Pharma, EU among Subjects with mild tomoderate papular-pustular acne of the facial area or facial rosacea. - NILCTRI/2023/08/056777
Azelaic Acid Foam 15% in the Treatment of Papulopustular RosaceaAzelaic Acid Foam 15% in the Treatment of Papulopustula Rosacea: An Evaluation of Photographic EvidenceNCT03418610
Comparative study of effectiveness between 20% azelaic acid with low-fluence 1064-nm Nd:YAG picosecond laser and 20% azelaic acid alone in the treatment of melasma in Thai female patients, split-face, prospective studyComparative study of effectiveness between 20% azelaic acid with low-fluence 1064-nm Nd:YAG picosecond laser and 20% azelaic acid alone in the treatment of melasma in Thai female patients, split-face, prospective studyTCTR20230112004
Efficacy of azelaic acid 20% versus anthralin 1% in scalp alopecia areataEfficacy of azelaic acid 20% versus anthralin 1% in patients with scalp alopecia areataIRCT20091012002581N8
Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)A Pilot Study of Azelaic Acid as a Novel Treatment for Central Centrifugal Cicatricial AlopeciaNCT05416333
A study to compare two drugs benzoyl peroxide and azelaic acid for improvement in symptoms and skin tolerabilityA comparative study of efficacy and tolerability of topical benzoyl peroxide versus topical azelaic acid in patients with mild to moderate acne vulgaris at a tertiary care centreCTRI/2022/03/041085
Evaluate the efficacy and safety of picosecond laser combined with 20% azelaic acid in the treatment of melasmaCombination of topical azelaic acid and picosecond laser versus topical azelaic acid monotherapy for the treatment of melasma, a split-face,evaluator-blind randomized studyChiCTR2100051294
Comparative Study of Therapeutic Efficacy and Safety of Glycolic Acid 6% and Azelaic Acid 20% in MelasmaPROSPECTIVE RANDOMIZED COMPARATIVE STUDY OF THERAPEUTIC EFFICACY AND SAFETY OF GLYCOLIC ACID 6% AND AZELAIC ACID 20% IN MELASMACTRI/2021/06/034044
An efficacy and safety comparing topical 5% azelaic acid versus 2% minoxidil solution in treatment of androgenetic alopecia in female: a randomized controlled trialAn efficacy and safety comparing topical 5% azelaic acid versus 2% minoxidil solution in treatment of androgenetic alopecia in female: a randomized controlled trialTCTR20180319001
Effect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentationEffect of Phytochemical and skin lightening of herbal formulation of Punica granatum and Crocus sativus versus Azelaic acid cream in patients with post inflammatory hyperpigmentation: a double-blind randomized clinical trialIRCT20120215009014N450
Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular RosaceaA Randomized, Double-blind, Vehicle-controlled, Multicenter, Parallel-group Clinical Trial to Assess the Safety and Efficacy of Azelaic Acid Foam, 15% Topically Applied Twice Daily for 12 Weeks in Subjects With Papulopustular RosaceaNCT01555463
Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of RosaceaA Multicenter, Randomized, Controlled, Double-masked, Crossover Design Study to Compare Efficacy and Assess Safety of CD07805/47 Gel 0.5% Applied Once Daily vs Azelaic Acid Gel 15% Applied Twice Daily in Subjects With Erythema of RosaceaNCT01659853
Phase 3 Papulopustular Rosacea StudyA Phase 3 Randomized, Double Blind, 12 Week Vehicle Controlled, Parallel Group Study Assessing the Efficacy and Safety of CD5024 1 % Cream Versus Vehicle Cream in Subjects With Papulopustular Rosacea, Followed by a 40 Week Investigator Blinded Extension Comparing the Long Term Safety of CD5024 1% Cream Versus Azelaic Acid 15 % Gel.NCT01494467
A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once DailyA Multicenter, Double-Blind Clinical Trial to Assess the Efficacy and Tolerability of Topical Azelaic Acid 15% Gel Once Daily Compared to Topical Azelaic Acid 15% gelTwice Daily in Subjects With Papulopustular RosaceaNCT00417937
Phase 3 Papulopustular Rosacea StudyA Phase 3 Randomized, Double Blind, 12 Week Vehicle Controlled, Parallel Group Study Assessing the Efficacy and Safety of CD5024 1 % Cream Versus Vehicle Cream in Subjects With Papulopustular Rosacea, Followed by a 40 Week Investigator Blinded Extension Comparing the Long Term Safety of CD5024 1% Cream Versus Azelaic Acid 15 % Gel.NCT01493687
A 6-week vehicle-controlled, randomized, double-blind, parallel-group multicenter pilot study of the efficacy and safety of Azelaic Acid (AzA) 15% gel in the topical treatment of mild to moderate perioral dermatitis.A 6-week vehicle-controlled, randomized, double-blind, parallel-group multicenter pilot study of the efficacy and safety of Azelaic Acid (AzA) 15% gel in the topical treatment of mild to moderate perioral dermatitis.EUCTR2006-002471-40-DE
A double-blind, randomized, vehicle-controlled, 6-week exploratory multicenter pilot study of the efficacy and safety of Azelaic Acid (AzA) 15% gel in the topical treatment of mild to moderate seborrheic dermatitis of the face - -A double-blind, randomized, vehicle-controlled, 6-week exploratory multicenter pilot study of the efficacy and safety of Azelaic Acid (AzA) 15% gel in the topical treatment of mild to moderate seborrheic dermatitis of the face - -EUCTR2006-002060-26-DE
Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate AcneA 12-week, Randomized, Double-blind, Multicenter Study Comparing the Clinical Efficacy and Safety of Azelaic Acid 15% Gel (SH H 655 BA) With Its Vehicle (SH H 655 PBA) in Patients With Mild to Moderate Acne.NCT00031096
Efficacy and Safety of Azelaic Acid and Azelaic Acid Combined with Compound Acid in the Treatment of Post-Inflammatory Erythema and Pigmentation of Acne: A Single-center, Prospective, Randomized Controlled Clinical Study ProtocolEfficacy and Safety of Azelaic Acid and Azelaic Acid Combined with Compound Acid in the Treatment of Post-Inflammatory Erythema and Pigmentation of Acne: A Single-center, Prospective, Randomized Controlled Clinical Study ProtocolChiCTR2500097361
A clinical trial to study the effects of a novel combination pimple patch versus conventional topical gel in acne patients.To study the effectiveness of novel combination hydrogel pimple patch containing Azelaic acid, Salicylic acid and Zinc oxide versus conventional topical spot treatment available for the treatment of acne vulgaris : a randomized control trial - NILCTRI/2025/02/080180
Exploration of Safety and Efficacy of AzA 15% Foam Twice a Day in RosaceaA 12-week Exploratory, Multicenter, Double-blind, Vehicle-controlled Study to Investigate the Efficacy and Safety of Topical Azelaic Acid 15% Foam Twice Daily in Patients With Papulopustular RosaceaNCT00617903
Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular RosaceaAn Exploratory, Multicenter, Investigator-blinded, Active-controlled Study to Investigate the Efficacy of Topical Azelaic Acid (AzA)15% Gel Twice Daily or Metronidazole Topical Gel 1% Once Daily, Plus Anti-inflammatory Dose Doxycycline (40mg) Once Daily in Subjects With Moderate Papulopustular RosaceaNCT00855595
21 Day Irritancy Test of Azelaic Acid Pre-foam FormulationA Randomized, Double-blind, Vehicle-controlled Phase 1 Dermal Safety Study Using a 21 Day Cumulative Irritant Patch Test Design to Evaluate the Local Tolerability of Azelaic Acid Pre-Foam Formulation in Healthy VolunteersNCT01430312
Human Repeated Insult Patch Test (HRIPT) of Azelaic Acid Pre Foam FormulationA Randomized, Double-blind, Vehicle Controlled Phase 1 Dermal Safety Study to Evaluate the Sensitizing Potential of Topically Applied Azelaic Acid Pre-foam Formulation in Healthy Subjects Using a Human Repeated Insult Patch Test DesignNCT01430533
Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular RosaceaInvestigator-blinded, Randomized, Cross-over, Multiple Dose Phase I Study on Safety and Pharmacokinetics of Topically Applied Azelaic Acid Foam, 15% Compared to Azelaic Acid Gel, 15% in Subjects With Papulopustular RosaceaNCT01257919
Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular RosaceaRandomized, Double-blind, Vehicle-controlled, Multicenter, Parallel-group Study to Investigate Safety and Efficacy of Azelaic Acid Foam, 15% Topically Applied Twice Daily in Subjects With Papulopustular RosaceaNCT01025635
Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of MelasmaAzelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma - An Open Randomized, Controlled, Prospective, Single Blinded Clinical TrialNCT00848458