IMPPAT Phytochemical information: 
Nabiximols

Nabiximols
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
A Two-Part Study of Sativex� Oromucosal Spray for Relieving Uncontrolled Persistent Pain at any site of cancer related pain in Patients With Advanced CancerA Two-part, Placebo-controlled, Study of the Safety and Efficacy of Sativex Oromucosal Spray (Sativex®; Nabiximols) as Adjunctive Therapy in Relieving Uncontrolled Persistent Chronic Pain in Patients With Advanced Cancer, Who Have Inadequate Analgesia Even With Optimized Chronic Opioid Therapy.CTRI/2012/11/003160
Improvement of Quality of Life by Cannabinoids in Oncologic Patients (BELCANTO)Improvement of Quality of Life by Cannabinoids in Oncologic Patients (BELCANTO) - BELCANTOCTIS2024-518917-24-00
Cannabinoids for Behavioral Problems in Children With ASDCannabinoids for Behavioral Problems in Autism Spectrum Disorder: A Double Blind, Randomized, Placebo-controlled Trial With Crossover.NCT02956226
Pilot study on the effect of cannabinoids THC + CBD on resistant spasticity in patients with chronic spinal cord injury.Pilot study on the effect of cannabinoids THC + CBD on resistant spasticity in patients with chronic spinal cord injury.EUCTR2022-001777-31-ES
Effects of cannabis components (THC and CBD) on motor and non-motor symptoms of Parkinson's disease: a placebo-controlled clinical studyEffect of THC and CBD cannabinoids combined on motor and non-motor symptoms of Parkinson's disease: a double-blind, randomized, placebo-controlled clinical trial (cpf study)RBR-10n7gx74
Excretion and side effects for tetrahydrocannabinol and cannabidiol (Sativex) among patients with chronic kidney disease and patients on dialysis.Pharmacokinetics and side effects for tetrahydrocannabinol and cannabidiol (Sativex) among patients with chronic kidney disease and patients on dialysis. - PK cannabinoidsEUCTR2019-002786-35-DK
COPE: Cannabinoids to Obviate Pain Experiment After Knee ReplacementCOPE: Cannabinoids to Obviate Pain Experiment After Knee ReplacementNCT03675971
The Pharmacodynamics of Cannabinoid-Caffeine CombinationsA Double-Blind, Randomized, Placebo-Controlled, Within-Subject Crossover Study of the Effects of Combinations of Cannabinoids and CaffeineNCT05478863
Effect of Cannabis on E-Cigarette Use BehaviorEffect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Electronic Cigarette UseNCT06609109
Effect of Cannabis on Cigarette Use BehaviorEffect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Cigarette UseNCT06609083
Cannabinoids for Taxane Induced Peripheral NeuropathyThe Effect of Dispensed Cannabis on Taxane Induced Peripheral NeuropathyNCT03782402
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different CannabinoidsGene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids on the Endocannabinoid System, Cognition and Neuronal OscillationsNCT02487381
A study that evaluates the effectiveness of oral combined THC/CBD for people with advanced cancer experiencing a range of symptoms.Oral Medicinal cannabinoids to Relieve Symptom Burden in the Palliative care of Patients with Advanced cancer: a double-blind, placebo controlled, randomised clinical trial of efficacy and safety of 1:1 delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)ACTRN12619000037101
Safety and Effectiveness of Nabiximols Oromucosal Spray as Add-on Therapy in Participants With Spasticity Due to Multiple SclerosisA Double-blind, Randomized, Placebo-controlled, Parallel-group Trial of the Efficacy and Safety of Nabiximols Oromucosal Spray as Add-on Therapy in Patients With Spasticity Due to Multiple SclerosisNCT04203498
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET StudyGene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids on the Endocannabinoid System and Brain FunctionNCT02492074
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related PainDronabinol for the Reduction of Chronic Pain and Inflammation in People With Sickle Cell DiseaseNCT05519111
Interaction between opioids and cannabinoids in the treatment of fibromyalgia painCannabis-opioid interaction in the treatment of fibromyalgia pain – an open label proof-of-concept study - SPIRAL studyEUCTR2019-001861-33-NL
Cannabinoids for Symptom Control in Advanced Cancer, an Open Label Prospective Clinical Trial in New South Wales (NSW)Cannabinoids for Symptom Control in Advanced Cancer, an Open Label Prospective Clinical Trial in New South Wales (NSW)ACTRN12619000265178
Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled TrialCannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled TrialNCT05632627
Pilot Trial Proposal looking at the use of Cannabinoids for analgesia in chronic myocardial ischaemic chest pain, using Sativex Oromucosal SprayIn a patient with chronic ischaemic chest pain, will Sativex Oromucosal Spray reduce their painACTRN12614000622606
The effects of medicinal cannabinoids on drivingThe effects of medicinal cannabinoids on driving in healthy adults with prior cannabis experienceACTRN12616000414415
A study to asses the effects of Nabiximols on spasticity associated with multiple sclerosis.A randomized double-blind placebo-controlled study of nabiximols in patients with spasticity in multiple sclerosis - RELEASE MSS4EUCTR2020-004306-58-LT
A clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on postoperative painISRCTN25994117
A study that evaluates the effectiveness of oral medicinal cannabis for people with advanced cancer experiencing a range of symptoms.Oral Medicinal Cannabinoids to Relieve Symptom Burden in the Palliative Care of Patients with Advanced Cancer: a double-blind, placebo controlled, randomised clinical trials of efficacy and safety of cannabidiol (CBD)ACTRN12618001220257
A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum DisordersA Phase IIb Study of the Safety and Efficacy of Nabiximols in Subjects With Spasticity Due to Neuromyelitis Optica Spectrum Disorders: A Double-blind, Randomized, Placebo-Controlled, Crossover StudyNCT05974293
A clinical trial adding Sativex (a cannabis-based medicine) to standard treatment, temozolomide, to find out if it is beneficial for patients whose glioblastoma brain tumour has returned after treatmentA randomised controlled phase II trial of temozolomide with or without cannabinoids in patientswith recurrent glioblastomaISRCTN11460478
Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress DisorderA Randomized, Double-blind, Parallel-group Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress DisorderNCT04592159
Spice II Plus: Acute toxicity of new synthetic cannabinoids and stimulant drugsSpice II Plus: Acute toxicity of new synthetic cannabinoids and stimulant drugs - Spice II PlusDRKS00005093
Study of Sativex for the Treatment of Cancer Related Pain.A double blind, randomized, placebo-controlled, parallelgroup study of Sativex oromucosal spray (Sativex®; Nabiximols) as adjunctive therapy in relieving uncontrolled persistent chronic pain in patients with advanced cancer, who experience inadequate analgesia during optimized chronic opioid therapy.EUCTR2009-016064-36-CZ
Inhaled Cannabinoids Versus Immediate-release Oral Opioids for the Management of Breakthrough Cancer PainInhaled PPP001 Versus Immediate-release Oral Opioids for the Management of Breakthrough Pain in Cancer Subjects: a Randomized, Open Label, Crossover, Comparison StudyNCT03564548
Study of Sativex for the Treatment of Cancer Related Pain.A double blind, randomized, placebo-controlled, parallel group study of Sativex oromucosal spray (Sativex®; Nabiximols) as adjunctive therapy in relieving uncontrolled persistent chronic pain in patients with advanced cancer, who experience inadequate analgesia during optimized chronicopioid therapy.EUCTR2009-016065-29-CZ
A multicenter, non-comparative, open-label extension study to assess the long term safety of Sativex oromucosal spray (Sativex®; Nabiximols) as adjunctive therapy in patients with uncontrolled persistent chronic cancer related pain.A multicenter, non-comparative, open-label extension study to assess the long term safety of Sativex oromucosal spray (Sativex®; Nabiximols) as adjunctive therapy in patients with uncontrolled persistent chronic cancer related pain.EUCTR2009-016529-32-BE
Cannabinoids in progressive inflammatory brain disease (CUPID)The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trialISRCTN62942668
Dronabinol As an Adjunct for Reducing Pain (DARP)-Texas Children's HospitalA Randomized, Double-Blind, Placebo-Controlled, Parallel Groups Study to Explore The Safety And Therapeutic Potential Of Cannabinoids As An Adjunct For Reducing Pain (Carp)- TCHNCT06834997
Cannabinoids in Bipolar Affective DisorderCannabinoids in Bipolar Affective Disorder: A Controlled Pilot StudyNCT00397605
Cannabinoids for Pain Control During Medical AbortionCannabinoid Analgesia for Medical Abortion: A Randomized Controlled TrialNCT03604341
A trial to test how efficient Nabiximols is for treatment of spacticity in patients with Multiple SclerosisA Randomized, Double-blind, Placebo-controlled, 2-way Crossover Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Patients with Multiple SclerosisEUCTR2020-003271-18-CZ
Investigating the effect of medicinal cannabis on the symptoms and side effects of chemotherapy in people with cancer.The CANnabinoids in CANcer (CANCAN) trial: Investigating the effect of medicinal cannabis on symptoms and side effects of chemotherapy in people with cancerACTRN12622000419763
Cannabinoid Supplementation on Vascular and Cognitive FunctionThe Effects of Cannabinoids on Vascular and Cognitive Function in Young and Old Healthy Adults.NCT03295903
A randomized multi-centre double-blind placebo controlled trial to demonstrate the efficacy and safety of nabiximols in the treatment of adults with chronic tic disorders (CANNA-TICS)A randomized multi-centre double-blind placebo controlled trial to demonstrate the efficacy and safety of nabiximols in the treatment of adults with chronic tic disorders (CANNA-TICS)EUCTR2016-000564-42-DE
A trial to test how efficient Nabiximols is for treatment of spacticity in patients with Multiple SclerosisA Randomized, Double-blind, Placebo-controlled, 2-way Crossover Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Patients with Multiple Sclerosis - Study in MS patient Naïve to treatment with NabiximolsEUCTR2019-002625-29-GB
A Two-Part Study of Sativex® Oromucosal Spray for Relieving Uncontrolled Persistent Pain in Patients With Advanced CancerA Two-part, Placebo-controlled, Study of the Safety and Efficacy of Sativex® Oromucosal Spray (Sativex®; Nabiximols) as Adjunctive Therapy in Relieving Uncontrolled Persistent Chronic Pain in Patients With Advanced Cancer, Who Have Inadequate Analgesia Even With Optimized Chronic Opioid Therapy.NCT01424566
Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple SclerosisA Randomized, Double-blind, Placebo-controlled, 2-way Crossover Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Patients With Multiple SclerosisNCT04657666
The effect of Cannabinoids on Oral Mucositis during Cancer treatmentThe use of Cannabinoids and Photobiomobulation therapy in the prevention and control of radio-induced Oral Mucositis in patients with Head and Neck Cancer: A randomized controlled clinical trialRBR-8g2q8q5
Effect of CBD and THC substances present in the cannabis plant as maintenance therapy for parkinson's diseaseEffect of THC and CBD cannabinoids combined as maintenance therapy for parkinson's disease: an open-label exploratory clinical trial (cpf study)RBR-92v86nn
Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol)Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoid Combination (?9 -Tetrahydrocannabinol (THC) and Cannabidiol (CBD) In 1:1 Ratio)NCT01893424
Glioma: Reducing Anxiety by conSuming cannabinoidS - GRASS study. Treating anxiety with CBD in glioma patients - A randomized-controlled trialGlioma: Reducing Anxiety by conSuming cannabinoidS - GRASS study. Treating anxiety with CBD in glioma patients - A randomized-controlled trial - GRASS study: Treating anxiety with CBD in glioma patientsNL-OMON54278