| Efficacy and Safety of Crocin Supplementation in Patients With Central SerousChorioretinopathy (CSCR) | Efficacy and Safety of Crocin Supplementation in Patients With Central SerousChorioretinopathy (CSCR) | IRCT20110811007297N7 |
| Antioxidant effects of crocin in patients undergoing angiography | Evaluation of the Effect of Crocin on Oxidative Stress Biomarkers in Patients under Angiography with Contrast Agents: A Randomized Controlled Clinical Trial | IRCT20200721048159N5 |
| Effect of crocin in cigarette smokers | The effects of crocin on nicotine dependence, depression, anxiety and metabolic biomarkers in cigarette smokers | IRCT20170420033551N11 |
| Effect of crocin on depression induced by amphetamine withdrawal | Assessment of additive effects of crocin in men with depression induced by amphetamine withdrawal | IRCT20160804029191N3 |
| Effects of saffron extract and its two main carotenoids (crocin, crocetin) on coronary heart disease | Effects of saffron aqueous extract and its main carotenoids (crocin and crocetin) on expression of some genes involved in atherosclorosis in peripheral blood mononuclear cells of patients with coronary heart disease | IRCT201512102017N26 |
| Evaluation of the effect of crocin on prevention of atrial fibrillation after heart surgery | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting (CABG) or valve replacement: a triple-blind, randomized, placebo-controlled trial | IRCT20120520009801N4 |
| Crocin Supplementation in CSCR | Efficacy and Safety of Crocin Supplementation in Patients With Central Serous Chorioretinopathy (CSCR) | NCT04936490 |
| Assessment of effect of crocin on Covid-19 patients | Assessment of additive effect of crocin in Covid-19 patients | IRCT20210203050233N1 |
| Effect of Crocin on macular and optic nerve head vascular density in non-proliferative diabetic retinopathy | Effect of Crocin on macular and optic nerve head vascular density in non-proliferative diabetic retinopathy patient with non-central macular involvement | IRCT20210310050669N1 |
| Effect of Crocin and Metformin in patients with type 2 diabetes | Exploring the effect of Crocin supplementation on glycemic indexes, oxidative stress factors and inflammation biomarkers in patients with type 2 diabetes treated by metformin | IRCT20170611034458N2 |
| The effect of crocin on retinal arteries | Evaluation of the effect of crocin on macular, peripapillary and optic nerve head blood flow in healthy individuals using coherence tomography optical angiography (OCTA) | IRCT20130418013058N15 |
| Effect of saffron aqua-extract and its carotenoids in atherosclerotic patients. | Study of the effect of saffron aqueous extract and its carotenoids (crocin and crocetin) on plasma proteome pattern, expression of LOX1 gene and miRNA223, and serum homocystein levels in atherosclerotic patients. | IRCT20161102030649N1 |
| Investigate the effect of Crocin in Multiple Sclerosis patients | Investigate the effect of Crocin on Cognitive impairment, mental health,Oxidative Stress and inflammatory factors in Multiple Sclerosis patients | IRCT20220221054087N1 |
| Evaluation of crocin in patients with refractory focal epilepsy | Evaluation of the effectiveness of crocin as a supplement in patients with refractory focal epilepsy in a randomized double-blind clinical trial | IRCT20130418013058N16 |
| The effect of crocin on weight gain in patients taking clozapine | The effect of crocin on weight gain in patients taking clozapine | IRCT20211202053250N2 |
| Investigating the Effect of Crocin and Risperidone on Symptoms of Withdrawal Syndrome | Evaluation of the Effects of Crocin and Risperidone Separately and Synergistically on the Improvement of Pain Syndrome and Anxiety Caused by Addiction Withdrawal | IRCT20200721048159N9 |
| Evaluation of the Efficacy of Crocin on metabolic and Weight Loss of Obese Patients Undergoing Sleeve Gastrectomy Bariatric Surgery | Evaluation of the Efficacy of Crocin on metabolic and Weight Loss of Obese Patients Undergoing Sleeve Gastrectomy Bariatric Surgery | IRCT20241023063475N1 |
| Investigating the effect of crocin in ulcerative colitis | Investigating the effect of crocin on metabolic indices, inflammatory biomarkers and oxidative stress factors in ulcerative colitis patients. | IRCT20240831062917N1 |
| Formulation of a topical gel containing Lawsonia inermis and Crocin and evaluation its effects on preventing radiation-induced dermatitis. | Formulation of a topical gel containing Lawsonia inermis and Crocin and evaluation its effects on preventing radiation-induced dermatitis in breast cancer patients: A randomized double-blinded placebo-controlled trial. | IRCT20191106045356N20 |
| Effect of crocin supplementation in patients with diabetic nephropathy | The effect of crocin supplementation on glycemic control, inflammatory factors, oxidative stress biomarkers, glomerular and tubular markers in patients with diabetic nephropathy: A randomized controlled clinical trial | IRCT20170611034458N3 |
| Effectiveness and safety of Crocin tablets in the treatment of cardiac manifestions (syndrome of blood stasis) in patients with post-coronavirus disease 2019 condition: a randomized, double-blind, placebo-controlled clinical tria | Effectiveness and safety of Crocin tablets in the treatment of cardiac manifestions (syndrome of blood stasis) in patients with post-coronavirus disease 2019 condition: a randomized, double-blind, placebo-controlled clinical tria | ChiCTR2400082396 |
| Effect of nano crocin on cognition among MS patients | Investigating the effect of nano formulation of crocin from saffron in comparison with placebo on cognitive function, plasma level of total antioxidant capacity, malondialdehyde and glutathione reductase in plasma of patients with relapsing-remitting multiple sclerosis: A randomized triple blinded clinical trial | IRCT20140804018677N14 |
| Follow up Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram | Study of Crocin on Cardiac Function Protection in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy Based on Color Doppler Ultrasound Combined With Myocardial Zymogram | NCT06187818 |
| Investigating the effect of crocin in multiple sclerosis patients | Investigating the effect of crocin on the severity of fatigue, pain and quality of life in patients with multiple sclerosis | IRCT20130418013058N17 |
| The combined effect of mesalazine-crocin in the treatment of inflammatory bowel disease | Comparison of the combined effect of mesalazine-crocin with mesalazine alone in the treatment of inflammatory bowel disease | IRCT20230511058153N1 |
| The effect of crocin of saffron on sleep quality, general health and happiness in elderly population | Clinical trial of the effect of crocin of saffron on sleep quality, general health and happiness in elderly population | IRCT20200616047800N1 |
| Evaluating the Efficacy of Crocin on Movement Disorders and Neuronal Oxidative Stress of Parkinson's Disease | Evaluating the Efficacy of Crocin on Movement Disorders and Neuronal Oxidative Stress of Parkinson's Disease; A Double-blind, Randomized, Placebo-controlled Clinical Trial | IRCT20170608034390N12 |
| Evaluation of the effect of crocin in the treatment of cystoid macular edema secondary to retinitis pigmentosa | Evaluation of the effect of crocin in the treatment of cystoid macular edema secondary to retinitis pigmentosa : randomized clinical trial | IRCT20201219049753N2 |
| Protection of Cardiovascular Function With Crocin in BrEast Cancer Patients Undergoing Radiotherapy and Chemotherapy | Protection of Cardiovascular Function With Crocin in BrEast Cancer Patients Undergoing Radiotherapy and Chemotherapy | NCT05504148 |
| Investigating the effect of crocin on patients with multiple sclerosis | Investigating the effect of crocin on quality life, anxiety and depression in patients with multiple sclerosis in a placebo-controlled randomized double blind clinical trial | IRCT20221109056447N1 |
| Effect of Crocin in treatment of depression | Comparison of Crocin and Sertraline in treatment of major depressive disorder | IRCT20191222045851N1 |
| Effects of Crocin in Treatment of Diabetes | The effects of Crocin supplementation on metabolic parameters, systemic inflammation and AMP- activated protein kinase, TNF-a and NF-Kß in patients with type 2 diabetes. | IRCT20170408033308N2 |
| Evaluation effect of crocin in cardiac complication due to doxorubicin in patients with breast cancer | Evaluation effect of crocin in cardiac complication due to doxorubicin in patients with breast cancer | IRCT20131017015044N5 |
| crocin and metabolic syndrome, general, positive, negative an cognitive symptomes in schizophrenic patients treated with olanzapin | Evaluation of the effect of crocin capsule on positive,negative,general and cognitive symptomes and prevention of metabolic syndrome in patients with schizophrenia on olanzapin treatment | IRCT2013081912351N2 |
| Effects of ? Crocin on depression | Effects of ? Crocin on major depressive disorder | IRCT2013041813058N1 |
| the effect of crocin on patients with metabolic syndrome | the effect of crocin on fasting blood sugar, lipid profile, inflammatory cytokines, pro-oxidants-antioxidants balance, depression and anxiety in the patients with metabolic syndrome | IRCT2013080514279N1 |
| Effects of ? Crocin on Diabetic Retinopathy and Cataract | Effects of ? Crocin on Diabetic Retinopathy and Cataract; A Double Blind Placebo Controlled Randomized Clinical Trial | IRCT2015062113058N2 |
| Effects of ? crocin and saffron on type 2 diabetic patients | Effects of ? crocin and saffron on glycemic control in type 2 diabetic patients; a double blind placebo controlled randomized clinical trial. | IRCT2015101713058N3 |
| The effect of crocin in multiple sclerosis patients | The effect of crocin on biomarkers of oxidative stress in the Saliva and Urine of patients with multiple sclerosis | IRCT2016122013194N3 |
| The effect of crocin on MS | The effect of crocin on inflammation factors,DNA damage and biomarkers of oxidative injury in the blood of patients with multiple sclerosis | IRCT2016092713194N2 |
| Effect of Crocin on patient with open angle glaucoma | Study of the effect of Crocin on patient with open angle glaucoma by double blinded, randomized and placebo-controlled clinical trial | IRCT2017030113058N6 |
| Effect of Crocin in treatment of methadone maintenance treatment patients | Effect of Crocin on psychological symptoms in methadone maintenance treatment patients | IRCT2017110537243N1 |
| Evaluation of therapeutic effects of Crocin in reducing progression of diabetic nephropathy | Evaluation of therapeutic effects of Crocin in reducing progression of diabetic nephropathy: A randomized triple-blind placebo-controlled trial | IRCT20190810044500N4 |
| Effect of Crocin on Neoadjuvant Chemoradiotherapy in Patients with Esophageal Cancer | Sensitization Effects of Crocin to Radiation in Neoadjuvant Chemoradiotherapy in Patients with Esophageal Cancer | IRCT20130418013058N7 |
| The effect of saffron on lipid ,FBG and depression and anxiety in patients with metabolic syndrome | Investigation the effect of Crocin saffron on four index include lipid profile ,FBG and depression and anxiety in patients with metabolic syndrome | IRCT20160308026961N4 |
| Effect of Crocin in treatment of breast cancer | Assessment of the effectiveness of addition of Crocin to doxorubicin containing chemotherapy regimen on survival of breast cancer patients | IRCT20160706028815N4 |
| Effect of nano formulation of saffron crocin in patients with multiple sclerosis | Effect of nano formulation of saffron crocin on depression symptoms and cognitive impairment in patients with multiple sclerosis | IRCT20120227009157N7 |
| Effect of Crocin on non-alcoholic fatty liver disease | Evaluation of the effect of Crocin on the serum levels of liver enzymes and Lipid Profile in patients with non-alcoholic fatty liver disease | IRCT20180513039634N1 |
| Therapeutic effect of crocin along with chemotherapy regimens in breast cancer | Evaluation of therapeutic effect of crocin along with chemotherapy regimes in patients with breast cancer, A clinical trial | IRCT20131017015044N3 |
| Evaluation of the therapeutic effect of crocin along with standard regimes in colorectal cancer | Evaluation of the therapeutic effect of crocin along with standard regimes in patients with colorectal cancer, A double blind randomized controlled trial | IRCT20131017015044N2 |
| Effect of Saffron in treatment of Burning Mouth Syndrome | Evaluation of the Effectiveness of Crocin of Saffron in treatment of Burning Mouth Syndrome | IRCT20180416039318N1 |
| Effect of Crocin on mild to moderate maculopathy | Monotherapy effect of Crocin on mild to moderate maculopathy; a clinical trial study | IRCT20130418013058N13 |
| Effect of crocin supplementation in treatment of methadone maintenance treatment patients | The effect of crocin supplementation on cognitive functions, craving and withdrawal syndrome in methadone maintenance treatment patients | IRCT20170420033551N6 |
| Effect of crocin on ocular complications of Behcet's disease | Pilot Study on the effectiveness of crocin as a drug supplement in the treatment of ocular complications of Behcet's disease; a clinical trial | IRCT20130418013058N12 |
| The Effects of Crocin Supplementation on Metabolic Parameters, Oxidative Stress, AMP- Activated Protein Kinase and Inflammation-promoting Genes Expression in Peripheral Blood Mononuclear Cells in Patients With Type 2 Diabetes | The Effects of Crocin Supplementation on Metabolic Parameters, Oxidative Stress, AMP- Activated Protein Kinase and Inflammation-promoting Genes Expression in Peripheral Blood Mononuclear Cells in Patients With Type 2 Diabetes | NCT04163757 |
| The effect of crocin and sertraline in mild to moderate postpartum depression | The effect of crocin and sertraline in mild to moderate postpartum depression in two treatment groups (Sertraline and Crorin); A randomized placebo controlled clinical trial | IRCT20130418013058N11 |
| Effect of Crocin and Fluoxetine in Patients of Obsessive-Compulsive Disorder | Comparison of the effect of Crocin and Fluoxetine on Patients with Obsessive-Compulsive Disorder, in two treatment groups (Fluoxetine and Crorin); A Randomized Double Blind Clinical Trial | IRCT20130418013058N10 |
| Comparing crocin and misoprostol effects on cervical ripening | Comparing effects of crocin and misoprostrol consumption on cervical ripening in women undergoing operative hysteroscopy: a randomised clinical trial | IRCT20150909023949N9 |
| Study of the Effect of Crocin-containing Drugs in Male Sexual Dysfunction | The Effect of Enhancement of Drug-containing Crocin-containing Drugs in Male Sexual Dysfunction Due to Antidepressant Drugs (SSRIs) in A Randomized Placebo Controlled Clinical Trial | IRCT20130418013058N9 |
| Effect of crocin supplementation in treatment of methadone maintenance treatment patients | A Clinical trial to assess the effect of crocin supplementation compared with the placebo on mental health parameters, metabolic profiles and genetic response in methadone maintenance treatment patients | IRCT20170420033551N4 |
| Comparison between the effectiveness of Crocus sativus and Crocin in the treatment of patients with major postpartum depression under common medical care. | Investigation into the effectiveness of Crocus savitus and its active ingredient Crocin as a complementary approach in the treatment of patients with major postpartum depression receiving treatment, using triple blind random clinical trial controlled with placebo, plus assessment of the change in patients' Beck II score. | IRCT20130826014477N5 |
