| Evaluating Silymarin for Chronic Hepatitis C | Evaluating Silymarin for Chronic Hepatitis C | NCT00030030 |
| Silymarin Bioavailability Study | Novel Micellar Formulation of Silymarin with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial | NCT06882681 |
| Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris | Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study | NCT04490967 |
| Compairing of the effects of chicory extract and silymarin extract on the liver function of children | Compairing of the effects of chicory extract and silymarin extract on the liver function of children | IRCT20130812014333N235 |
| Milk Thistle in Body Dysmorphic Disorder | Silymarin Treatment of Body Dysmorphic Disorder: A Double-Blind, Placebo-Controlled, Cross-Over Study | NCT02843451 |
| Effects of Silymarin (Milk thistle fruit extract) on liver fibrosis in Nonalcoholic Fatty Liver Disease | Efficacy of Silymarin (Milk Thistle fruit extract) compared to placebo in improving liver fibrosis in patients with non-alcoholic fatty liver disease, a Pilot Study | SLCTR/2017/016 |
| Investigation of Livermed® drug in second and third degree non-alcoholic fatty liver compared to placebo and silymarin available in the market | Evaluation of the Safety and Efficacy of Livermed® Soft Capsules in Patients with Non-Alcoholic Fatty Liver Disease Grades 2 and 3: A Randomized, Double-Blind Clinical Trial Compared with Placebo and Marketed Silymarin | IRCT20231126060180N1 |
| Milk Thistle in Trichotillomania in Children and Adults | Silymarin Treatment of Trichotillomania in Children and Adults: A Double-Blind, Placebo-Controlled, Cross-Over Study | NCT02473913 |
| Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR | Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After Achieving Sustained Virological Response | NCT03659058 |
| Milk Thistle in Pathological Gambling | Silymarin Treatment of Pathological Gambling: A Double-Blind, Placebo-Controlled Study | NCT02337634 |
| THE HEP573 STUDY: A randomised, double-blind, placebo-controlled clinical trial of silymarin alone, and silymarin combined with antioxidants in chronic hepatitis C | In compensated chronic hepatitis C patients, what is the effect of silymarin alone or silymarin combined with antioxidants compared to placebo on the proportion of hepatitis C patients with ALT normalisation at week 24 compared to baseline? | ACTRN12614000966695 |
| Evaluating the Renoprotective Effect of Milk Thistle Extract on Patients With Type II Diabetic Nephropathy | Evaluating the Preventive Effect of Milk Thistle Extract (Silymarin) on Progression of Diabetic Nephropathy, a Randomized, Double-blind, Placebo-controlled Clinical Trial. | NCT01003236 |
| Effectivity of Silymarin in improving hepatic fibrosis among patients with non alcoholic fatty liver disease – placebo controlled RCT | Anti-fibrotic effects of Silymarin among the patients of Nonalcoholic Fatty Liver Disease, a randomized control trial | SLCTR/2024/011 |
| Analgesic effect of topical gel Silymarin versus placebo in patients with knee osteoarthritis | Analgesic effect of topical gel Silymarin versus placebo in patients with knee osteoarthritis: a double-blind randomized clinical trial | IRCT20120215009014N498 |
| Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases | Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases, a Double-blind Randomized Controlled Trial | NCT06277635 |
| Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving Chemotherapy | A Pilot Study of Silymarin During Maintenance Therapy in Children With Acute Lymphoblastic Leukemia (ALL) | NCT00055718 |
| A dose-finding clinical study investigating the effects of different doses of silymarin compared to placebo on elevated liver enzymes due to drug-induced liver enzyme elevation. | Impact of different silymarin dosages to decrease drug-induced elevated liver enzymes compared to placebo in a prospective controlled dose finding Phase IIb trial (SILVER) | EUCTR2020-004645-36-DE |
| A study on the effects of two drugs, silymarin and curcumin in patients with potentially malignant disorder involving mouth | Effectiveness of silymarin and curcumin in the management of oral submucous fibrosis â?? A randomized controlled trial | CTRI/2021/01/030470 |
| The efficacy and safety of Silymarin in chemotherapy-induced peripheral neuropathy (CIPN) | The efficacy and safety of Silymarin in chemotherapy-induced peripheral neuropathy (CIPN): a randomized double-blind clinical trial study | IRCT20201128049515N1 |
| PHASE 2 TRIAL: EVALUATION OF SILYMARIN FOR TREATMENT OF PATIENTS WITH COVID-19 | EVALUATION OF THE INHIBITORY ACTIVITIES OF SILYMARIN AGAINST SARS-CoV-2 . COVID-19 | PACTR202012898601759 |
| Effects of topical gel Silymarin versus placebo as an adjuvant therapy on pain management in patients with painful diabetic neuropathy | Effects of topical gel Silymarin versus placebo as an adjuvant therapy on pain management in patients with painful diabetic neuropathy: a double-blind randomized clinical trial | IRCT20120215009014N501 |
| The effect of aerobic training with silymarin consumption on some cardiovascular risk factors in men with type 2 diabetes | The effect of aerobic training with silymarin consumption on some cardiovascular risk factors in men with type 2 diabetes | IRCT20200215046506N3 |
| Silymarin in COVID-19 Pneumonia | Trial of Silymarin in Adults With COVID-19 Pneumonia | NCT04394208 |
| Comparison the effects of silymarin and N-acetylcysteine on improvement of, Hepatic and renal Abnormalities in Patients with SeverePreeclampsia in post-partum | Comparison the effects of silymarin and N-acetylcysteine on improvement of, Hepatic and renal Abnormalities in Patients with SeverePreeclampsia in post-partum | IRCT20191231045965N1 |
| The effect of eight weeks of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes | The effect of eight weeks of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes | IRCT20200215046506N1 |
| Evaluation of the efficacy of Silymarin in patients with COVID-19 | Evaluation of the efficacy of Silymarin nanomicelles in hospitalized patients with COVID-19 | IRCT20201024049130N1 |
| Effect of silymarin on the liver and pain of rheumatoid arthritis patients | Effect of Silybum marianum on methotrexate-induced hepatotoxicity and its analgesic effect in the patients with rheumatoid arthritis history | IRCT20180519039711N4 |
| A study on silymarin (a medicine from plant) on special indicators present in blood (inflammatory cytokines and genetic markers) and in reducing the problems associated with depression in patients suffering from depressive disorder | The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin | CTRI/2019/07/020010 |
| Exploring the effect of Silymarin on generalized hypoxia-induced liver damage | Exploring the effect of Silymarin on generalized hypoxia-induced liver damage | IRCT20141209020258N112 |
| Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma | Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma | NCT03982849 |
| Silymarin-Choline Combination Versus Ursodeoxycholic Acid in Non-Alcoholic Fatty Liver Disease | Silymarin-Choline Combination Versus Ursodeoxycholic Acid in Non-Alcoholic Fatty Liver Disease: A Randomised Double-Blind Clinical Trial | CTRI/2019/04/018550 |
| Evaluating the effectiveness of Silymarin on the prevention of gentamicin nephrotoxicity | Evaluating the effectiveness of Silymarin on the prevention of gentamicin nephrotoxicity in hospitalized patients at Imam Reza & Vali-Asr hospitals in Birjand | IRCT20161010030246N3 |
| Efficacy of oral silymarin formulation on prostate cancer | Evaluating the effect of oral nano formulation of silymarin in non metastatic prostate cancer patients after radical prostatectomy | IRCT20180517039694N1 |
| The effect of silymarin on Alzheimer’s diseases | The effect of silymarin on inflammatory factors TNF-a and IL-1ß and it’s probable relationship with cognitive function of Alzheimer’s patients. | IRCT20131219015870N3 |
| Effect of Silymarin, Metformin, and life style in non-alcoholic fatty liver disease | Effect of silymarin, metformin, and life style in patients with non-alcoholic fatty liver disease in Marvdasht Hospital | IRCT20121105011375N5 |
| Investigation the effect of herbal supplement on lead concentration | Investigation the effect of Silymarin on reducing lead blood concentration and oxidative stress biomarkers in opioid addicts. | IRCT20171122037584N1 |
| Triple-blind clinical trial on the effect of a combination of garlic, silymarin and curcumin in comparison with placebo in the treatment of non-alcoholic fatty liver disease | Triple-blind clinical trial on the effect of a combination of garlic, silymarin and curcumin in comparison with placebo in the treatment of non-alcoholic fatty liver disease | IRCT20190602043787N1 |
| Silymarin in multiple Sclerosis | Evaluation of Silymarin therapeutic effect in multiple sclerosis patients receiving CinnoVex | IRCT20171220037977N1 |
| A randomized, double-blind, split-face study of topical silymarin versus 2% hydroquinone cream in melasma | A randomized, double-blind, split-face study of topical silymarin versus 2% hydroquinone cream in melasma | TCTR20210729003 |
| The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules | The Efficacy and Safety of Ornithine Aspartic Acid Granules in Non-Alcoholic Fatty Liver Disease Against Silymarin Capsules: a Randomized, Double-Blind, Multicenter Clinical Trial | NCT05042245 |
| COMPARING EFFECTIVENESS OF CAPSULE SILYMARIN WITH THAT OF SM FIBRO CAPSULE IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS | COMPARING CLINICAL EFFICACY OF SILYMARIN WITH THAT OF A STANDARD THERAPEUTIC COMBINATION OF LYCOPENE, ALPHA LIPOIC ACID AND TOCOPHEROL IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS-A RANDOMIZED CLINICAL TRIAL - NIL | CTRI/2024/01/061326 |
| Beneficial Effect of Silymarin in Ulcerative Colitis | Clinical Study Evaluating the Possible Beneficial Effect of Silymarin in Patients With Ulcerative Colitis | NCT06213857 |
| effects of Silymarin in the Prevention of hyperbilirubinemia | Investigating the effects of Silymarin in the Prevention of hyperbilirubinemia: a randomized, double-blind, placebo-controlled, clinical trial | IRCT20231120060123N1 |
| Silymarin for the Prevention of Atrial Fibrillation After Cardiac Surgery | The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Graft Surgery | NCT06114719 |
| The Effect of Pilates training along with Silymarin consumption on Non-Alcoholic Fatty Liver | The effect of eight weeks of Pilates training along with silymarin consumption on the levels of liver enzymes in women with non-alcoholic fatty liver disease | IRCT20230216057435N1 |
| Evaluating the effectiveness of silymarin in preventing vancomycin nephrotoxicity | Evaluating the effectiveness of silymarin in preventing vancomycin-induced nephrotoxicity in hospitalized patients | IRCT20161010030246N6 |
| Effect of silymarin in inflammatory bowel disease | Evaluation of the effect of silymarin in patients with inflammatory bowel disease | IRCT20101107005123N3 |
| Comparison Between Isotretinoin, Silymarin and Both in the Treatment of Acne Vulgaris | Comparative Study Between the Effect of Isotretinoin, Silymarin and Their Combination in the Treatment of Patients With Acne Vulgaris | NCT05666765 |
| Effect of Silymarin in Metastatic Colorectal Cancer Patients | The Possible Anticancer Effect of Silymarin in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy. | NCT05631041 |
| Evaluation of prophylactic effect of Livergol (Silymarin) on liver function tests in patients with outpatient cancer undergoing chemotherapy | Evaluation of prophylactic effect of Livergol (Silymarin) on liver function tests in patients with outpatient cancer undergoing chemotherapy: a randomized controlled clinical trial | IRCT20201123049474N2 |
| Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients | The Possible Protective Role of Silymarin Against Chemotherapy Induced Toxicities and Cognitive Impairment in Breast Cancer Patients | NCT05595109 |
| Protective effect of oral nano-silymarin on vancomycin-induced nephrotoxicity | Evaluation of protective effect of nano-silymarin oral formulation on vancomycin-induced nephrotoxicity | IRCT20200408046990N9 |
| The effect of Silymarin in type 2 diabetes. | The effect of Silymarin on the level of lipid profile and fasting blood sugar and HbA1c in patients with type 2 diabetes. | IRCT20230318057749N1 |
| Silymarin capsule in COVID-19 | Evaluation of the effectiveness of Silymarin (Silybum marianum) capsule on the clinical symptoms of outpatients with COVID-19 | IRCT20180103038199N10 |
| The effect of silymarin on methadone poisoning | Evaluation of the therapeutic effect of Silymarin in combination with naloxone in improving methadone poisoning | IRCT20210216050377N1 |
| Investigating the effects of Silymarin in the treatment of neonatal jaundice | Investigating the effects of Silymarin in the treatment of idiopathic hyperbilirubinemia:a randomized,double-blind, placebo-controlled, clinical trial | IRCT20211122053144N1 |
| Effect of silymarin in the treatment of patients with depression | Evaluation of the additive effect of silymarin in the treatment of patients with moderate depression | IRCT20160804029191N4 |
| Milk thistle (Silymarin marianum) extract supplementation on nonalcoholic fatty liver disease | Effect of milk thistle (Silymarin marianum) extract supplementation on nonalcoholic fatty liver disease in morbidly-obese patient candidates for bariatric surgery | IRCT20210817052218N1 |
| The effect of Silymarin on dyslipidemic patients with Alzheimer's disease | Clinical trial of the effect of Silymarin on blood and imaging biomarkers of Alzheimer's patients with dyslipidemia | IRCT20210901052360N1 |
| Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma | Topical Silymarin Versus Combined Topical Silymarin and Microneedling in Treatment of Melasma: Split Face Study | NCT05099601 |
| Dietary silymarin improves nonalcoholic fatty liver disease via gut microbiota | The effect of silymarin on NAFLD by regulating intestinal flora and its mechanism | ChiCTR2200059043 |
| Evaluation of the effects of silymarin and calciferol on LUTS in patients with benign prostatic hyperplasia | Evaluation of the effects of silymarin and calciferol on LUTS in patients with benign prostatic hyperplasia with normal and lower than normal serum vitamin D levels | IRCT20200906048641N1 |
| The effect of silymarin on Parkinson's disease | Evaluation of the effect of Sillymarin on motor manifestations of Parkinsonian patients : A randomized clinical trial | IRCT2017081435697N1 |
| Impact of Silymarin Adjunct Therapy on Proteinuria in Type 2 Diabetic Patients on RAS Inhibitors | Evaluating the Outcome of Silymarin as an Adjunct Therapy to Renin-Angiotensin System Inhibitors in Proteinuric Type 2 Diabetic Patients | NCT06425705 |
| Effects of Silybum Marianum on Treatment of Patients With Chronic Hepatitis C | Study of Silymarin for Improving Hepatitis C | NCT01292161 |
| Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate | Clinical Study Evaluating Anti Rheumatic Activity and The Role of Silymarin in Attenuating Methotrexate Toxicity in Patients With Rheumatoid Arthritis | NCT06724952 |
| Clinical Study With Silymarin in the Patients With Chronic Hepatitis C Infection Who Failed Conventional Antiviral Therapy | A Double-blind Phase III Study With Silymarin in the Patients Infected With HCV Who Failed Conventional Antiviral Therapy | NCT01258686 |
| Effect of silymarin in treatment of adverse effects of anti tuberculosis drugs. | Evaluation of Silymarin in treatment of anti tuberculosis drug induced hepatitis in patients newly diagnosed with tuberculosis. | ACTRN12610000643077 |
| Dextromethorphan and Silymarin in Chronic Kidney Disease (CKD) Patients | The Reno-protective and Cardiovascular Effect of Dextromethorphan and Silymarin in Patients With Chronic Kidney Disease | NCT01091324 |
| Safety, Metabolism, and Antioxidant Activity of Silymarin and Green Tea Extract in Patients With Chronic Hepatitis C | Steady-State Pharmacokinetic Interactions of Green Tea Catechins and Silymarin Flavonolignans in Treatment Naïve Patients With Chronic Hepatitis C Infection | NCT01018615 |
| The therapeutic effect of silymarin in decompensated cirrhosis : A randomized double-blind placebo controlled trial | The therapeutic effect of silymarin in decompensated cirrhosis : A randomized double-blind placebo controlled trial | TCTR20241009003 |
| Investigating the efficacy of simultaneous administration of N-acetylcysteine and Silymarin in liver function improvement in patients with drug-induced liver injury | Investigating the efficacy of simultaneous administration of N-acetylcysteine and Silymarin compared to N-acetylcysteine alone in liver function improvement in patients with drug-induced liver injury-clinical trial | IRCT20240720062482N1 |
| Therapeutic effect of silymarin in beta-thalassemia major | Combined therapy of silymarin and desferrioxamine in patients with b-thalassemia major: a randomized double-blind clinical trial | IRCT138804022067N1 |
| The comparison of metformin, pioglitazon and Silymarin on biochemical indices | The comparison of metformin, pioglitazon and Silymarin on biochemical indices in patient with nonalcoholic fatty liver | IRCT201105084849N2 |
| Evaluation of silymarin solution efficacy on prevention of radiotherapy induced mucositis | Evaluation of silymarin solution efficacy on prevention of radiotherapy induced mucositis in patients with head and neck cancer | IRCT20241014063364N1 |
| Randomized Controlled Trial of Silymarin in Asthma | Antioxidant Enzyme Induction as a New Approach to Therapy in Patients With Asthma | NCT01049178 |
| Comparative evaluation of acteoside and silymarin as hepatoprotective agents in acute hepatitis patients. | COMPARATIVE EVALUATION OF ACTEOSIDE AND SILYMARIN AS HEPATOPROTECTIVE AGENTS IN ACUTE HEPATITIS PATIENTS-A RANDOMIZED PROSPECTIVE OPEN FRAME STUDY | CTRI/2008/091/000247 |
| Randomized Placebo-controlled Trial Evaluating the Safety and Efficacy of Silymarin Treatment in Patients With Acute Viral Hepatitis | A Multicentre, Double-blind, Randomized, Placebo-controlled, Phase II/III Study to Evaluate the Safety and Efficacy of 280 mg and 420 mg Silymarin TID (Legalon® Capsules) Administered for Four Weeks in Subjects With Acute Viral Hepatitis With a Four Week Follow-up Period | NCT00755950 |
| Phase II Trial of Silymarin for Patients With Chronic Hepatitis C Who Have Failed Conventional Antiviral Treatment | A Multicenter, Randomized, Double-masked, Placebo-controlled Phase II Study to Assess the Safety and Efficacy of a Standardized Orally Administered Silymarin Preparation (Legalon) for the Treatment of Patients With Chronic Hepatitis C Who Failed Conventional Antiviral Therapy | NCT00680342 |
| Phase II Trial of Silymarin for Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitis | A Multicenter, Randomized, Placebo Controlled Study to Assess the Safety and Efficacy of Orally Administered Silymarin Preparation (Legalon®) for the Treatment of Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitis | NCT00680407 |
| Protective effect of Silymarin on liver during cardiac surgery | Protective effect of Silymarin on liver during coronary artery bypass surgery | IRCT20200825048515N77 |
| Phase I Trial of Silymarin for Chronic Liver Diseases | Single and Multiple Dose Escalation Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Administered Silymarin (Legalon) in Non-Cirrhotic Subjects With Chronic Hepatitis C or Non-Alcoholic Fatty Liver Disease | NCT00389376 |
| A Clinical Research Study Designed To Determine If Treatment of Hepatitis C With Milk Thistle is More Effective Than No Treatment In Patients Infected With Both HIV And Hepatitis C | A Pilot Randomized Placebo-Controlled Trial Designed to Determine the Tolerability and Efficacy of Silymarin (Milk Thistle) vs. Placebo for the Treatment of Chronic Hepatitis C in HIV Infected Patients | NCT00246363 |
| A multicenter, randomized controlled study of silymarin and chiglitazar sodium in patients with T2DM and MASLD | A multicenter, randomized controlled study of silymarin and chiglitazar sodium in patients with T2DM and MASLD | ChiCTR2500099866 |
| Effect of Silymarin on Non Alcoholic Steatohepatitis | Effect of Silymarin on Non Alcoholic Steatohepatitis | IRCT138805172308N1 |
| Protective effects of silymarin on cardiac and hepatic side effects of chemotherapy drugs | Evaluating silymarin effects on cardiac and hepatic side effects of chemotherapy drug in children with acute lymphoblastic leukemia | IRCT2017071935175N1 |
| Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs | Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs | NCT01436929 |
| silymarin and cisplatin induced nephrotoxicity | Evaluation of protective effects of silymarin on cisplatin induced nephrotoxicity in patients with upper gastrointestinal adenocarcinoma | IRCT201207013043N6 |
| SIlymarin vs BEnzydamine in Radiation-Induced orophAryngeal mucositis | A comparison of silymarin vs benzydamine rinse in the prevention of radiation-induced oropharyngeal mucositis in head and neck cancers: A randomized controlled trial | IRCT20211202053252N2 |
| Inuline Supplement in Patients With Irritable Bowel Syndrome | Clinical Assessment of the Benefits of the Combination Inuline, Choline and Silymarin in Mitigating the Symptomatology in Patients With Irritable Bowel Syndrome | NCT03174561 |
| The Efficacy of Silymarin as Adjuvant Therapy on Colorectal Cancer Patients Undergoing FOLFIRI Treatment | | NCT03130634 |
| evaluation of topical silymarin on dermal side effect induced by capecitabine in patients with gastrointestinal cancers | Evaluation of efficacy of topical formulation of silymarin in prevention and management of hand-foot syndrome induced by capecitabine in patients with gastrointestinal malignancies | IRCT2016110730621N1 |
| The effect of oral Silymarin in wound healing in burns | The effect of adjuvant treatment with oral Silymarin in wound healing in burns patients admitted to the burn unit of Vali-asr Hospital, Arak, Iran | IRCT2015070923138N1 |
| Silymarin in NAFLD | Silymarin® - Efficacy in Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) Controlled by Laboratory and and Elastographic Parameters | NCT02973295 |
| The Blood concentration confirmation study on silymarin formulation of process materials. | The Blood concentration confirmation study on silymarin formulation of process materials. - The Blood concentration confirmation study on silymarin formulation of process materials. | JPRN-UMIN000022333 |
| Effect of Silymarin on Serum Ferritin and Iron Level in ß-thalassemia Patients | Evaluation the Effect of Silymarin on Serum Ferritin and Iron Level in Comparison with Placebo in ß-thalassemia Patients undergoing Iron Chelation Therapy | IRCT2015101211819N2 |
| Effect of Silymarin on Oxidative Stress Status in ß-thalassemia Patients | Evaluation the Effect of Silymarin on Oxidative Stress Markers in Comparison with Placebo in ß-thalassemia Patients undergoing Iron | IRCT2015101411819N4 |
| The treatment of melasma by silymarin cream | Safety and efficacy of topical Silymarin (SM) cream in a randomized double-blind placebo controlled study for treatment of melasma patients. | ACTRN12612000602820 |
| Effect of Silymarin on Inflammatory Markers in ß-thalassemia Patients | Evaluation the Effect of Silymarin on Inflammatory Markers in Comparison with Placebo in ß-thalassemia Patients undergoing Iron Chelation Therapy | IRCT2015101411819N3 |
| Effect of Milk Thistle on relieving infertility in women with polycystic ovaries | Evaluation the effect of silymarin on serum oxidative stress markers and in vitro fertilization outcome in patients with polycystic ovarian syndrome | IRCT2015041321743N1 |
| the evaluation of effectiveness of oral silymarin on memory status of patients with dementia | the evaluation of effectiveness of oral silymarin on memory status of patients with dementia | IRCT201505091856N5 |
| Effect of Silymarin in prevention of contrast nephropaty | Evaluation of short-term effect of adding Silymarin versus placebo to standard treatment, in prevention of contrast induced nephropathy in patient undergoing coronary angiography | IRCT2014051117648N1 |
| A clinical trial to compare the effects of coded Unani research drug UNIM-118 with Silymarin in patients with Hepatitis A/B/C/E | A Multi centric, Single Blind, Randomized, parallel group study to compare efficacy and safety of coded unani formulation UNIM-118 with Silymarin in patients with Waram al-Kabid/ Hepatitis A/B/C/E | CTRI/2013/12/004256 |
| Evaluating the Effect of Silymarin on CAPD Patients | Evaluating the Antioxidative Effect of Silymarin on CAPD Patients | IRCT2013110315256N1 |
| The effects of Silybum marianum (L.) Gaertn. (Silymarin) supplement consumption on metabolic status, Hs-CRP and oxidative stress in type 2 diabetic patients with overweight or obesity | The effects of Silybum marianum (L.) Gaertn. (Silymarin) supplement consumption on metabolic status, Hs-CRP and oxidative stress in type 2 diabetic patients with overweight or obesity | IRCT201309243140N13 |
| The Efficacy of Silymarin on the Prevention of Hepatotoxicity From Antituberculosis Drugs | The Efficacy of Silymarin on the Prevention of Hepatotoxicity From Antituberculosis Drugs | NCT01800487 |
| Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma | Phase 2-3 Study of Silymarin on Cisplatin Induced Nephrotoxicity | NCT01829178 |
| Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia Major | | NCT01752153 |
| Comparison of phototherapy and drop silymarin on reducing neonatal icter | Comparison of phototherapy and drop silymarin on reducing neonatal icter | IRCT2015070510222N4 |
| Effect of silymarin in prevention of adverse effects of anti tuberculosis drugs | Effect of silymarin in prevention of adverse effects of anti tuberculosis drugs | IRCT138903294209N1 |
| Efficacy of Silymarin for Acute Hepatitis | Efficacy of Silymarin for Treatment of Acute Hepatitis In Egypt: A Randomized, Double-Blinded, Controlled Trial | NCT00412763 |
| Efficacy of Silymarin and Vitamin E in the Treatment fatty liver | The Efficacy of Silymarin and Vitamin E in the Treatment of the Non-Alcoholic Fatty Liver Disease: A Clinical Trial | IRCT20081110001444N6 |
| Evaluation of the effect of silymarin on volume Expression Milk of mothers with Preterm Infant | Evaluation of the effect of silymarin on volume Expression Milk of mothers with Preterm Infant in the Neonatal Intensive Care Unit | IRCT20100411003679N4 |
| Intravenous Silibinin in Combination With Peg-interferon and Ribavirin in Nonresponders | Multicenter Study To Evaluate The Efficacy Of Silymarin In Addition To Combination-Therapy With Pegylated Interferon Alfa 2a (Peg-Ifn Alfa 2a) And Ribavirin In Patients With Chronic Hepatitis C | NCT00684268 |
| An Intervention Study of Compound Silymarin in Patients With Non-alcoholic Fatty Liver Disease | Effects of Compound Silymarin on Biomarkers of Lipid Metabolism and Inflammation in Patients With Non-alcoholic Fatty Liver Disease: A Randomized Controlled Double-blind Trial | NCT05497765 |
| Evaluation of effect of Livergol and vitamin E on liver enzyme of nonalcoholic steatohepatitis patients | Evaluation of effect of silymarin and vitamin E on liver enzyme of nonalcoholic steatohepatitis patients: results of a randomized clinical trial | IRCT2016111322869N2 |
| Evaluating the effect of Empagliflozin or Silymarin and vitamin E on the course of fatty liver disease | Evaluating the effect of Empagliflozin or Silymarin and vitamin E on the course of fatty liver disease in non-diabetic patients | IRCT20241126063860N1 |
| Comparison between Ursodeoxy cholic acid, silymarin and vitamin E in Anticonvulsive drugs induced hypertransaminasemia | Comparison between efficacy and adverse effects of Ursodeoxy cholic acid, silymarin and vitamin E and placebo (Folic acid) in Anticonvulsive drugs induced hypertransaminasemia in 4 months to 13 years old patients | IRCT2015010711392N2 |
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