IMPPAT Phytochemical information: 
Tocotrienol

Tocotrienol
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Human Tissue Distribution of Orally Supplemented Natural Vitamin E TocotrienolHuman Tissue Distribution of Orally Supplemented Natural Vitamin E TocotrienolNCT00678834
Anti-Inflammatory Effect of Tocotrienol Supplementation in Subjects With Moderately Elevated InflammationAnti-Inflammatory Effect of Tocotrienol Supplementation in Subjects With Moderately Elevated InflammationNCT03532763
Maximum Tolerated Dose, Safety and Pharmacologic Study of TRF in Women With Breast CancerMalaysian Tocotrienol Rich Fraction: Immunomodulatory Effect in Women With Breast CancerNCT03855423
Tocotrienol in Combination With Neoadjuvant Chemotherapy for Women With Breast CancerTocotrienol in Combination With Neoadjuvant Chemotherapy for Women With Breast CancerNCT02909751
Bevacizumab and tocotrienol in relapsed ovarian cancerBevacizumab and tocotrienol in recurrent ovarian cancer. A marker based phase II trialEUCTR2019-000618-13-DK
A randomized investigation of side effects to FOLFOXIRI in combination with tocotrienol or placebo as first line treatment of metastatic colorectal cancer.A randomized investigation of side effects to FOLFOXIRI in combination with tocotrienol or placebo as first line treatment of metastatic colorectal cancer.EUCTR2015-004850-17-DK
Tocotrienol and Bevacizumab in metastatic colorectal cancer.Tocotrienol and Bevacizumab in metastatic colorectal cancer. A randomized phase II marker trial - Toco-CoREUCTR2019-004207-13-DK
Bevacizumab and Tocotrienol in Recurrent Ovarian CancerBevacizumab and Tocotrienol in Recurrent Ovarian Cancer: A Marker Based Phase II TrialNCT04175470
Tocotrienol and Bevacizumab in Metastatic Colorectal CancerTocotrienol and Bevacizumab in Metastatic Colorectal Cancer. A Randomized Phase II Marker TrialNCT04245865
Elucidating the Effects of Tocotrienol rich Vitamin E on Metabolic Biomarkers in a Pre-diabetes Population in Malaysia.Elucidating the Effects of Tocotrienol rich Vitamin E on Metabolic Biomarkers in a Pre-diabetes Population in Malaysia.ACTRN12622000256774
Evaluating the vitamin E from palm oil on immune response to flu vaccineImmune modulation mechanisms in healthy human volunteers following influenza vaccination and daily supplementation palm tocotrienol-rich fractionACTRN12622000844741
Effects of Supplementation With Tocotrienol on Chronic Kidney Disease PatientsEffects of Supplementation With Tocotrienol on Inflammation, Oxidative Stress and Microbiota of Chronic Kidney Disease PatientsNCT04900532
Elucidating the Effects of Tocotrienol rich Vitamin E on Metabolic Biomarkers in a Pre-diabetes Population of different ethnicities in Malaysia.Elucidating the Effects of Tocotrienol rich Vitamin E on Metabolic Biomarkers in a Pre-diabetes Population of different ethnicities in Malaysia.ACTRN12622000256774
The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetes and Diabetic Microvascular Complications: Kidney Disease (Nephropathy), Eye Disease (Retinopathy) and (Nerve Impariment (Neuropathy)The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetes and Diabetic Microvascular Complications: Nephropathy, Retinopathy and NeuropathyACTRN12619001568101
The effect of tocotrienol-rich vitamin E (Tocovid Suprabio) compared to tocopherol on diabetic microvascular complications: A double-blinded placebo controlled, multicentre clinical trialThe Effect of Lower-dose 100mg and 200mg Tocotrienol-rich Vitamin E (Tocovid Suprabio®) and 200IU Alpha-Tocopherol on Diabetic Microvascular Complications in Patients with DiabetesACTRN12621001268831
Tocotrienol as a Nutritional Supplement in Patients With Advanced Lung CancerTocotrienol as a Nutritional Supplement in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)NCT02644252
Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the BloodEffects of a Tocotrienol-Enriched Fraction of Palm Oil on Serum Lipids in Hypercholesterolemic SubjectsNCT02634606
Clinical study of a Type of Vitamin E obtained from the annatto in the control of High CholesterolClinical study of a Formulation Containing 70% Tocotrienol, obtained from annatto, in the control of LipidemiasRBR-6jmr68m
Role of Tocotrienol supplementation on carotid intima media thickness in patients with Type 2 Diabetes Mellitus patientsEffect of Tocotrienol supplementation on carotid intima media thickness in patients with Type 2 Diabetes Mellitus â?? An Open label, Randomized-controlled clinical trialCTRI/2023/06/054548
A STUDY ON NON ALCHOLIC FATTY LIVER DISEASEA RANDOMISED, PROSPECTIVE, PARALLEL AND OPEN LABEL STUDY TO COMPARE EFFICACY AND SAFETY OF SYNBIOTICS WITH TOCOTRIENOL IN NON ALCHOLIC FATTY LIVER DISEASECTRI/2023/09/057604
Does combined used of Pentoxifylline and Tocotrienol help patients with thin endometriumThe effect of Pentoxifylline and Tocotrienol in endometrial rejuvenation in the case of thin endometrium opting for frozen embryo transferCTRI/2023/10/058640
Tocotrienol as a Treatment for Non-alcoholic Fatty Liver DiseaseA Randomised Double-blind Controlled Trial on Tocotrienol as a Treatment for Non-alcoholic Fatty LiverNCT06596382
Study of IPMN Progression Prevention With Tocotrienol (SIPP-T3)A Randomized, Placebo-Controlled Trial of Tocotrienol in the Prevention of Pancreatic Intraductal Papillary Mucinous Neoplasm ProgressionNCT06519097
Preoperative Use of Tocotrienol From Annatto Bixa Orellana L. in Breast Cancer Patients: a Prospective Clinical Trial.Preoperative Use of Tocotrienol Associated With Personalized Nutritional and Psychoeducational Support in Women With Primary Breast Cancer.NCT04496492
Tocotrienol as a nutritional supplement in patients with advanced pulmonal cancerTocotrienol as a nutritional supplement in patients with advanced pulmonal cancerEUCTR2015-002742-32-DK
Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal CancerA Randomized Investigation of Side Effects to FOLFOXIRI in Combination With Tocotrienol or Placebo as First Line Treatment of Metastatic Colorectal CancerNCT02705300
Tocotrienol as a nutritional supplement in patients with advanced ovarian cancerTocotrienol as a nutritional supplement in patients with advanced ovarian cancerEUCTR2013-004858-18-DK
Tocotrienol Against the Progression of End Stage Liver DiseaseTocotrienol Against the Progression of End Stage Liver DiseaseNCT02581085
Vitamin E d-Tocotrienol Multiple Dose in Healthy SubjectsA Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Vitamin E d-Tocotrienol Following Multiple Dose Administration in Healthy SubjectsNCT01450046
Vitamin E d-Tocotrienol (VEDT) Single Dose in Healthy SubjectsA Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Vitamin E d-Tocotrienol Following Single Dose Administration in Healthy SubjectsNCT01446952
Study of Tocotrienol Absorption and Distribution Under Different Fat StatusMechanism of Absorption and Distribution of Tocotrienols Under Different Food StatusNCT01185769
A Pilot Clinical Trial With Tocotrienol on Breast CancerEffectiveness of Tocotrienol-rich Fraction Combined With Tamoxifen in the Management of Women With Early Breast Cancer: A Pilot Clinical TrialNCT01157026
Vitamin E d-Tocotrienol Administered to Subjects With Resectable Pancreatic Exocrine NeoplasiaA Phase I Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Vitamin E d-Tocotrienol Administered to Subjects With Resectable Pancreatic Exocrine NeoplasiaNCT00985777
Tocotrienol in combination with preoperative chemotherapy for women with breast cancerTocotrienol in combination with neoadjuvant chemotherapy for women with breast cancer - NeoTocEUCTR2016-000080-16-DK
NUTRITION: Natural Tocotrienol Against Ischemic Stroke EventHuman Blood Outcomes Following Tocotrienol Supplementation - NUTRITION Phase I and Phase IIANCT01578629
Efficacy Of Tocotrienol a Natural Vitamin E In Biopsy WoundEfficacy Of Tocotrienol a Natural Vitamin E In Biopsy Wound.NCT01579227
Gamma-delta Tocotrienol as Potential Maintenance Treatment in Women With Metastatic Breast CancerPhase 1a: A Randomized, 2-period Cross-over Study to Compare the Bioavailability of Gamma-Delta Tocotrienol (GDT) With That of Tocotrienol Rich Fraction (TRF) in Twelve Healthy SubjectsNCT01571921
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)Single-site, Open-label, Dose-ranging, Efficacy, and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated CFNCT00889434
Nutrition Blood Outcomes Following Tocotrienol N2BHuman Blood Outcomes Following Tocotrienol Supplementation - Nutrition Phase IIB NUTRITION PHASE IIBNCT01858311
Effects of a Supplement Derived From Palm Oil on Cholesterol Levels and Chinese Red Yeast Rice in the BloodEffects of a Tocotrienol-Enriched Fraction of Palm Oil and Chinese Red Yeast Rice on Serum Lipids in Hypercholesterolemic SubjectsNCT02142569
Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical ScarsEfficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical ScarsNCT00700791
Alterations in skin hydration, moisture and genomic in patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIATM) supplementationAlterations in skin hydration, moisture and genomic in adult patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIATM) supplementationACTRN12624001057572
Stroke and Tocotrienol: Unique Role in NeuroprotectionPhase III, Single Centre, Double Blind, Randomised, Placebo Controlled, Parallel Group Trial to Evaluate the Efficacy and Safety of Oral Vitamin E (Mixed Tocotrienol) for 6 Months in Patients With Moderate Acute Ischemic StrokeNCT02263924