IMPPAT Phytochemical information: 
Isosorbide

Isosorbide
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
The Role of Imdur in Cortisol-Induced Hypertension in HumansThe effect oral isosorbide mononitrate on blood pressure in healthy human subjects treated with oral hydrocortisone.ACTRN12614000928617
Effect of isosorbide through intravaginal administration on the clinical pregnancy rate of cryopreserved embryo transfer in patients with elevated blood flow resistance in uterine arteriesEffect of isosorbide through intravaginal administration on the clinical pregnancy rate of cryopreserved embryo transfer in patients with elevated blood flow resistance in uterine arteriesChiCTR1900023968
Isosorbide Mononitrate for initiating delivery of patientsRole Of Isosorbide Mononitrate In Induction Of LabourCTRI/2019/07/020011
The effect of vaginal misoprostol and isosorbide mononitrate on under 20 week miscarriagesEfficacy of vaginal Misoprostol, Isosorbide Mononitrate and giving time without medication for preoperative cervical ripening in under 20 weeks abortionIRCT20190901044658N1
A STUDy TO MEASURE THE ROLE OF ISOSORBIDE MONONITRATE IN IUI CYCLESEFFECT OF ISOSORBIDE MONONITRATE ON PREGNANCY RATE IN WOMEN UNDERGOING INTRAUTERINE INSEMINATION-A RANDOMIZED CONTROL STUDYCTRI/2020/01/022618
Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery GraftsEffect of Nicorandil, Diltiazem or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts - a Pilot Randomized Controlled TrialNCT04310995
the Effect of Isosorbide Mononitrate in Reducing Pain During Cooper Intrauterine Device Insertionthe Effect of Vaginal Isosorbide Mononitrate Administration in Reducing Pain During Cooper Intrauterine Device Insertion in Nulliparous Women : a Randomized Controlled TrialNCT04312048
Safety and Efficacy of the Effect of Isosorbide Mononitrate in Reducing Pain During Levonorgestrel-releasing Intrauterine Device InsertionSafety and Efficacy of the Effect of Isosorbide Mononitrate in Reducing Pain During Levonorgestrel-releasing Intrauterine Device Insertion in Adolescents and Young WomenNCT04311658
The Effect of Vaginal Isosorbide Mononitrate Administration on Cervical Ripening before Induction of LaborThe Effect of Vaginal Isosorbide Mononitrate Administration on Cervical Ripening before Induction of Labor in primigravidaIRCT20191018045150N1
Comparison of a new Cilostazol treatment versus a Conventional therapy with Isosorbide mononitrate for clinical effectiveness in patients of variant angina: Prospective, Single center, Randomized, Open label, Controlled TrialComparison of a new Cilostazol treatment versus a Conventional therapy with Isosorbide mononitrate for clinical effectiveness in patients of variant angina: Prospective, Single center, Randomized, Open label, Controlled TrialKCT0005064
Isosorbide Mononitrate in Induction of LabourIsosorbide Mononitrate and Misoprostol in Induction of LabourNCT04482881
Evaluation of the effect of oral and vaginal isosorbide mononitrate tablets and oral propranolol tablets on cervical preparation.Evaluation of the effect of oral and vaginal isosorbide mononitrate and oral propranolol tablets on cervical preparation before induction in primiparous and term pregnancyIRCT20201003048910N1
The Effect of Isosorbide Diesters Based Moisturizer on Skin HealthThe Effect of Isosorbide Diesters Based Moisturizer on Skin HealthNCT04831892
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPLUterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With Unexplained Recurrent Pregnancy LossNCT05341856
Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial OatmealProspective Randomized Vehicle-Controlled, Double-Blind Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial OatmealNCT05688735
Comparison of the effectiveness of 2 cervical ripening agents Oral Mifepristone and vaginal Isosorbide Mononitrate (IMN) for induction of labor in pregnant women with gestational age 28 to 34 weeks.A Comparative study to determine effectiveness of Mifepristone and Isosorbide Mononitrate(IMN) as cervical ripening agents for induction of labor in pregnant women with gestational age 28 to 34 weeks.CTRI/2023/06/053401
The effect of isosorbide on the duration of Renal stone freeInvestigating the effect of isosorbide dinitrate on the duration of kidney stone free after Extra Corporeal Shock Wake LithotripsyIRCT20150317021497N9
To compare the efficacy of Misoprostol and Isosorbide Mononitrate combination with Misoprostol alone for initiation of labour.Intravaginal administration of Misoprostol with Isosorbide Mononitrate versus misoprostol alone for cervical ripening in induction of labor in low-risk term pregnancyCTRI/2024/11/076816
Effect of Oral Isosorbide Mononitrate Plus Amlodipine Antispasm Therapy on Outcomes of Radial Artery Grafts After CABGA Multicenter, Randomized, Outcomes Assessor Blind, Parallel Controlled Trial to Evaluate the Effect of Oral Isosorbide Mononitrate Plus Amlodipine Antispasm Therapy on Outcomes of Radial Artery Grafts After Coronary Artery Bypass GraftingNCT06730945
Efficacy and Safety of Isosorbide Oral Solution in Patients With Meniere's DiseaseA Multicenter, Randomized, Double-blind, Placebo-controlled Phase II/III Clinical Study of Isosorbide Oral Solution in the Treatment of Meniere's DiseaseNCT06765993
LACunar Intervention Trial 3The LACunar Intervention Trial 3 (LACI-3). Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke.ISRCTN44436843
Randomised comparison of the nitric oxide donor isosorbide mononitrate with prostaglandin E2 gel for cervical ripening prior to the induction of labour at termISRCTN58088708
Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date WomenEfficacy of Intravaginal Administration of Isosorbide Mononitrate Together With Misoprostol Versus Misoprostol Alone in Induction of Labor in Postdate WomenNCT03854383
Effect of misoprostol plus isosorbide mononitrate and misoprostol plus placebo in induction of second trimester abortionComparison of Misoprostol plus Isosorbide Mono Nitrate and Misoprostol plus placebo at the end of second trimester pregnancy.IRCT20100525004025N5
Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy SubjectsPhase I Clinical Trial to Evaluate the Pharmacokinetic Profile of a Formulation With Isosorbide Mononitrate 0.5% Gel - Manufactured by Sanus Pharmaceutical Ltda, to Intra Anal Application in Healthy Males and Females' SubjectsNCT04729088
Effect of Isosorbide with Misoprostol on the cervical ripeningComparison of the combined effect of Isosorbide with Misoprostol and Misoprostol alone on the cervical ripening in post-term pregnancyIRCT20180922041083N1
Alprostadil versus isosorbide dinitrate in ameliorating angina episodes in patients with coronary slow flow phenomenonAlprostadil versus isosorbide dinitrate in ameliorating angina episodes in patients with coronary slow flow phenomenonChiCTR2000033233
Effects of isosorbide mononitrate on cervical ripeningEvaluation of the efficacy of isosorbide mononitrate on cervical ripening in outpatient pregnant women with unfavorable cervix.IRCT20091023002624N27
Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart FailureA Prospective, Placebo-controlled, Double-blind, Randomized Study to Compare Hydralazine-isosorbide-dinitrate(HYIS) Versus Placebo on Top of Std Care in African Patients With Acute Heart Failure (AHF) and Left Ventricular DysfunctionNCT01822808
Study on the role of nitrate in the prevention of high blood pressure due to pregnancyEffect of prophylactic isosorbide mononitrate on the incidence of preeclampsia in high risk women รข?? A double blind randomized controlled trial. - NOPE (Nitric Oxide in Prevention of pre-Eclampsia) TrialCTRI/2012/12/003251
Assessment of the effect of sublingual isosorbide dinitrate with indomethacin suppository on post Endoscopic retrograde colangiopancreatography pancreatitisEvaluation of the effect of sublingual isosorbide dinitrate + indomethacin suppository in prevention of post Endoscopic retrograde colangiopancreatography (ERCP) pancreatitisIRCT138810082931N1
Efficacy of Isosorbide dinitrate in cervical ripeningA comparision of out patient oral and vaginal Isosorbide dinitrate in cervical ripening befor induction of labor in post term pregnancy with low bishop scoreIRCT201108157334N1
Randomized, double-blind, placebo-controlled trial to compare the effect, three months of follow-on pulse pressure and vascular function of isosorbide mononitrate extended release, associated with antihypertensive treatment in patients over 65 years refractory isolated systolic hypertension.Randomized, double-blind, placebo-controlled trial to compare the effect, three months of follow-on pulse pressure and vascular function of isosorbide mononitrate extended release, associated with antihypertensive treatment in patients over 65 years refractory isolated systolic hypertension - isosorbide mononitrate extended release, associated with antihypertensive treatment in patients overEUCTR2012-002988-10-ES
Clinical trial of effects of isosorbide mononitrate on vascular functionClinical trial of effects of isosorbide mononitrate on vascular function - Isosorbide mononitrate studyJPRN-UMIN000007721
Bioequivalence Study of Torrent Pharmaceutical Limited's ISMN 120 mg ER Tablets Under Fasting ConditionAn Open Label, Randomized, Two Treatment, Two Sequence, Two Period, Cross-over, Single-dose Comparative Oral Bioavailability Study of Isosorbide Mononitrate 120 mg ER Tablets (Test) of Torrent Pharmaceuticals Ltd., India and Isosorbide Mononitrate 120 mg ER Tablets (Reference) of Kremers Urban, USA in Healthy, Adult, Male, Human Subjects Under Fasting ConditionsNCT01418534
Bioequivalence Study of Torrent Pharmaceutical Limited's Isosorbide Mononitrate 120 mg ER Tablets Under Fed ConditionsAn Open Label, Randomized, Two Treatment, Two Sequence, Two Period, Cross-over, Single-dose Comparative Oral Bioavailability Study of Isosorbide Mononitrate 120 mg ER Tablets (Test) of Torrent Pharmaceuticals Ltd., India and Isosorbide Mononitrate 120 mg ER Tablets (Reference) of Kremers Urban, USA in Healthy, Adult, Male, Human Subjects Under Fed ConditionsNCT01418547
The effect of misoprostol with isosorbide mononitrate on the induction of first-trimester abortionThe effect of misoprostol with isosorbide mononitrate on the induction of first-trimester abortionIRCT20130812014333N138
EVALUATION OF ISOSORBIDE MONONITRATE FOR CERVICAL RIPENING PRIOR TO INDUCTION OF LABOUR FOR POSTDATED PREGNANCY IN OUTPATIENT SETTINGEVALUATION OF ISOSORBIDE MONONITRATE FOR CERVICAL RIPENING PRIOR TO INDUCTION OF LABOUR FOR POSTDATED PREGNANCY IN OUTPATIENT SETTINGCTRI/2011/091/000121
The effect of Isosorbide Mononitrate on induction successThe effect of Isosorbide Mononitrate (vs. placebo) on induction success in pregnant womenIRCT138803311946N3
Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of MembranesNitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor in Term or Post Term Pregnancies in Females With Pre-labor Rupture of MembranesNCT03665779
The Effect of Losartan and Losartan Plus Isosorbide Mononitrate on Central Blood Pressure Measurements (0954-317)A Double-Blind, Randomized, Placebo-Controlled, 5-Period Crossover Study to Evaluate the Effects of a Single Dose of Losartan, a Single Dose of Isosorbide Mononitrate (ISMN), and Single Doses of Losartan + ISMN on Central Blood Pressure Measurements in Mildly Hypertensive PatientsNCT00943852
Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)A Randomized, Double-Blind, Placebo-Controlled, 2-Part Study to Evaluate the Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis in Obese Patients With HypertensionNCT00871871
Endoscopic Variceal Ligation (EVL)+ Drugs Versus Endoscopic Variceal Ligation (EVL) Alone For Secondary ProphylaxisEndoscopic Variceal Ligation Plus Propranolol And Isosorbide Mononitrate Versus Endoscopic Variceal Ligation Alone For Secondary Prophylaxis Of Variceal Bleeding: A Randomized Controlled TrialNCT00766805
Secondary Prophylaxis After Variceal Bleeding in Non-RespondersSecondary Prophylaxis After Variceal Bleeding: Combined Treatment With Endoscopic Ligation and Nadolol Against Nadolol Associated With Mononitrate of Isosorbide or Prazosin According to Hemodynamic Response.NCT00450164
Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide MononitrateRandomized Clinical Trial of Cervical Ripening and Labor Induction Using Stepwise Oral Misoprostol With or Without Intravaginal Isosorbide MononitrateNCT00374621
A randomized phase IV clinical trial comparing Nadolol and Isosorbide Mononitrate (ISMN) with the combination of Endoscopic Banding Ligation plus Nadolol and ISMN in the prevention of variceal rebleedingA randomized phase IV clinical trial comparing Nadolol and Isosorbide Mononitrate (ISMN) with the combination of Endoscopic Banding Ligation plus Nadolol and ISMN in the prevention of variceal rebleedingISRCTN26221020
Randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour - clinical trial with analyses of efficacy, cost effectiveness and acceptabilityRandomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour - clinical trial with analyses of efficacy, cost effectiveness and acceptabilityISRCTN39772441
Investigation of combined phosphodiesterase 5 inhibitor and isosorbide mononitrate for the treatment ofresistant hypertension - Sildenafil and isosorbide mononitrate in resistant hypertensionInvestigation of combined phosphodiesterase 5 inhibitor and isosorbide mononitrate for the treatment ofresistant hypertension - Sildenafil and isosorbide mononitrate in resistant hypertensionEUCTR2005-001004-39-GB
The effect of isosorbide dinitrate in preventing of severe pre-eclampsiaThe effect of isosorbide dinitrate in preventing of severe pre-eclampsiaIRCT138809302907N1
RANDOMIZED COMPARISON OF 2 DRUGS FOR CERVICAL RIPENING IN TERM PREGNANCYRANDOMIZED COMPARISON OF ISOSORBIDE MONONITRATE AND PGE2 GEL FOR PRE- INDUCTION CERVICAL RIPENING IN TERM PREGNANCYCTRI/2013/07/003808
Effect of Isosorbide Mononitrate on Hypertension to Improve Left Ventricular Hypertrophy, Fibrosis and Myocardial FunctionTargeting Wave Reflections to Improve Left Ventricular Hypertrophy, Fibrosis and Myocardial Function in HypertensionNCT01961453
7-day hemodynamic response to carvedilol combined with isosorbide mononitrate (ISMN) versus carvedilol alone in cirrhotic patients: a randomized controlled trial7-day hemodynamic response to carvedilol combined with isosorbide mononitrate (ISMN) versus carvedilol alone in cirrhotic patients: a randomized controlled trialChiCTR-TRC-10001091
Efficacy and tolerability of ibuprofen and isosorbide dinitrate (20 mg, 40 mg, 60 mg, 80 mg)Multicentre, randomised, double-blind, dose titration design in patients with Duchenne muscular dystrophy to evaluate the efficacy and the tolerability of the combinations of Ibuprofen (200 mg bid) and Isosorbide Dinitrate (20 mg, 40 mg, 60 mg, 80 mg) - ESPP001EUCTR2013-004427-37-IT
cervical ripening and termination of term pregnancyComparison the Effect of Isosorbide Mononitrate, Laminaria and Trans Cervical Catheter on cervical ripening and termination of term pregnancyIRCT2014012616368N1
A Comparison of nitroglycerine skin patch and sublingual tablets of isosorbide di-nitrate for prevention of preterm laborA comparison of TNG skin patch and Isosorbide di-nitrate for prevention of preterm labor.IRCT2017071535090N1
Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester AbortionMeasuring Response of Adding Isosorbide Mononitrate to Misoprostol in Induction of Second Trimester AbortionNCT03407521
The effect of isosorbide mononitrate and frusemide on heart's function after major heart attack.The Effect of Reduction of End Diastolic Pressure with Isosorbide Mononitrate and frusemide on mortality and infarct size in Acute Myocardial Infarction.ACTRN12618000096257
Intravaginal Isosorbide Mononitrate in Addition to Misoprostol Versus Misoprostol Only for Induction of LaborIntravaginal Isosorbide Mononitrate in Addition to Misoprostol Versus Misoprostol Only for Induction of Labor: A Randomized Controlled TrialNCT03523754
Pain Relief During IUD Insertion in Women Delivered Only by Elective Cesarean SectionEffect of Adding Vaginal Isosorbide Mononitrate to Misoprostol Prior to Intrauterine Device Insertion in Women Delivered Only by Elective Cesarean Section: a Randomized Double-blind Controlled Clinical TrialNCT03587077
Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of LaborNitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of LaborNCT03544606
Lacunar Intervention Trial 2LACunar Intervention (LACI-2) Trial-2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease. - LACI-2EUCTR2016-002277-35-GB
Compare the effects of isosorbide mono nitrate and misoprostol for cervical ripening for labor in term pregnancyCompare the effects of isosorbide mono nitrate and misoprostol for cervical ripening for labor in term pregnancyIRCT2017031233025N1
Can treatment with nitric oxide donors improve pregnancy outcome in patients with history of unexplained recurrent early pregnancy loss?Comparative study between placebo vaginal tablets and the nitric oxide donor isosorbide mononitrate 20 mg tablet applied vaginally for treatment of unexplained recurrent early pregnancy lossACTRN12616001494426
Comparison the effect of vaginal isosorbide dinitrate in pre-induction cervical ripening in term pregnancyComparative study of the effect of vaginal isosorbide dinitrate in pre-induction cervical ripening in term pregnancyIRCT20130812014333N90
Adequate Hydration Therapy Combined With Intravenous Infusion of Isosorbide Dinitrate Prevention for CINChinese People's Liberation Army General HospitalNCT02718521
Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot UlcersEfficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot UlcersNCT02789033
The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced HeadacheThe Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache. Development of a Pragmatic Migraine ModelNCT02485340
cervical ripening and termination of term pregnancyThe Effects of vaginal Misoprostol, Laminaria and Isosorbide Dinitrate on cervical ripening before labor induction among the term parturientsIRCT2016050527643N2
Medical Management of Late Intrauterine Death.Medical Management of Late Intrauterine Death Using a Therapeutic Combination of Isosorbide Dinitrate and Oxytocin.NCT02488642
Preventing cognitive decline and dementia from cerebral small vessel diseasePreventing cognitive decline and dementia from cerebral Small Vessel Disease (Prevent-SVD): a phase II pilot, factorial, randomised, open label blinded end-point trial to investigate short-term effects of cilostazol and isosorbide mononitrate on tolerability, safety, and vascular function in patients with small vessel disease associated stroke. (Lacunar Intervention Trial 1 (LACI-1))ISRCTN12580546
Comparison the effects of the isosorbide mononitrate with misoprostol and misoprostol with placebo for cervical ripening in induction of labour in 41 week pregnancies.Comparison the effects of the isosorbide mononitrate with misoprostol and misoprostol with placebo for cervical ripening in induction of labour in 41 week pregnancies.IRCT2016022426745N1
Comparison of effect of three methods of Rectal Naproxen Suppository, Isosorbide Dinitrate tablets and concurrent use of Rectal Naproxen Suppository with Isosorbide Dinitrate tablets in Prevention of Post- Endoscopic Retrograde Cholangio Pancreatography (ERCP) pancreatitis in patientsEffect of three methods of Naproxen ,Isosorbide Dinitrate and concurrent use of them in prevention of Post- ERCP PancreatitisIRCT201409251155N22
Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHFComparison of Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in Patients With Acute Decompensated Heart Failure: A Randomized Controlled TrialNCT02649998
PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal FissurePharmacokinetics, Pharmacodynamics and Safety Comparative Trial of Isosorbide Mononitrate Gel in Participants With Anal Fissure and Healthy Volunteers.NCT02667535
Termination Of Anembryonic PregnancyMisoprostol Plus Isosorbide Mononitrate Versus Misoprostol For Termination Of Anembryonic PregnancyNCT02573051