IMPPAT Phytochemical information: 
Milk thistle

Milk thistle
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
The effect of Milk Thistle extract versus tea on serum iron increase after a meal containing non-haem iron in Hereditary Haemochromatosis: a pilot studyISRCTN10982081
Comparative Effects of Milk Thistle Extract With Vitamin-E in Hemodialysis PatientsComparative Effects of Milk Thistle Extract With Vitamin-E on Oxidative Stress Biomarkers in Hemodialysis PatientsNCT01001845
The Effect of Milk Thistle on the Pharmacokinetics of IndinavirThe Effect of Milk Thistle on the Pharmacokinetics of IndinavirNCT00011635
Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing ResectionPerioperative Administration of Oral Green Tea Extract/Milk Thistle Extract to Colorectal Cancer Patients Undergoing Colorectal Cancer Resection, a Phase 1 StudyNCT01239095
Milk Thistle in Pathological GamblingSilymarin Treatment of Pathological Gambling: A Double-Blind, Placebo-Controlled StudyNCT02337634
Milk thistle (Silymarin marianum) extract supplementation on nonalcoholic fatty liver diseaseEffect of milk thistle (Silymarin marianum) extract supplementation on nonalcoholic fatty liver disease in morbidly-obese patient candidates for bariatric surgeryIRCT20210817052218N1
Milk Thistle Clinical Trial in Pediatric NAFLDPilot Study of Milk Thistle for the Treatment of Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD)NCT06477146
Phase I interaction study of Docetaxel and Tolbutamide with supplementation of Milk ThistlePhase I interaction study of Docetaxel and Tolbutamide with supplementation of Milk Thistle - Interaction study of Docetaxel + Tolbutamide and Milk ThistleNL-OMON39305
Determining if ingestion of silybum marianum (milk thistle) influences the metabolisation of indinavir in healthy subjects: a randomised controlled phase I studyISRCTN78545137
Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom PoisoningA Phase II Multi-Center Open-Label Clinical Trial to Assess the Prevention of Liver Transplantation and/or Death Among Subjects Treated With Intravenous Silibinin (LegalonĀ® SIL) for Amatoxin Induced Hepatic FailureNCT00915681
Evaluating the Renoprotective Effect of Milk Thistle Extract on Patients With Type II Diabetic NephropathyEvaluating the Preventive Effect of Milk Thistle Extract (Silymarin) on Progression of Diabetic Nephropathy, a Randomized, Double-blind, Placebo-controlled Clinical Trial.NCT01003236
Comparison of relative bioavailability of two different milk thistle extract formulations: a randomized, two-way crossover study in healthy participantsComparison of relative bioavailability of two different milk thistle extract formulations: a randomized, two-way crossover study in healthy participantsDRKS00035555
Milk Thistle in Body Dysmorphic DisorderSilymarin Treatment of Body Dysmorphic Disorder: A Double-Blind, Placebo-Controlled, Cross-Over StudyNCT02843451
Effects of Silymarin (Milk thistle fruit extract) on liver fibrosis in Nonalcoholic Fatty Liver DiseaseEfficacy of Silymarin (Milk Thistle fruit extract) compared to placebo in improving liver fibrosis in patients with non-alcoholic fatty liver disease, a Pilot StudySLCTR/2017/016
Evaluation of the effect of Milk Thistle in the prevention of anti-tuberculosis drugs-induced hepatotoxicity: A randomized controlled clinical trialEvaluation of the effect of Milk Thistle in the prevention of anti-tuberculosis drugs-induced hepatotoxicity: A randomized controlled clinical trialIRCT20150721023282N9
Effect of Silibinin(A) as a Potential Anti-obesity AgentEffect of Milk Thistle Derivative Silibinin(A) as a Potential Anti-obesity AgentNCT05069298
Effect of Milk Thistle on relieving infertility in women with polycystic ovariesEvaluation the effect of silymarin on serum oxidative stress markers and in vitro fertilization outcome in patients with polycystic ovarian syndromeIRCT2015041321743N1
The effect of milk thistle extract (Legalon) versus tea on serum iron increase after a meal containing non-haem iron in hereditary haemochromatosis - Dietary management of hereditary haemochromatosis: A pilot studyThe effect of milk thistle extract (Legalon) versus tea on serum iron increase after a meal containing non-haem iron in hereditary haemochromatosis - Dietary management of hereditary haemochromatosis: A pilot studyEUCTR2006-002099-16-GB
A Clinical Research Study Designed To Determine If Treatment of Hepatitis C With Milk Thistle is More Effective Than No Treatment In Patients Infected With Both HIV And Hepatitis CA Pilot Randomized Placebo-Controlled Trial Designed to Determine the Tolerability and Efficacy of Silymarin (Milk Thistle) vs. Placebo for the Treatment of Chronic Hepatitis C in HIV Infected PatientsNCT00246363
Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving ChemotherapyA Pilot Study of Silymarin During Maintenance Therapy in Children With Acute Lymphoblastic Leukemia (ALL)NCT00055718
Exercise, Milk Thistle, and Lactobacillus to Influence Plasma BilirubinMilk Thistle and Lactobacillus Supplementation to Improve Exercise Outcomes in Obese PatientsNCT04717726
Milk Thistle in Trichotillomania in Children and AdultsSilymarin Treatment of Trichotillomania in Children and Adults: A Double-Blind, Placebo-Controlled, Cross-Over StudyNCT02473913