IMPPAT Phytochemical information: 
Taurolidine

Taurolidine
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Influence of intraperitoneal application of taurolidine on the perioperative metastases, tumor recurrence and survival rate after surgical resection of colorectal cancerISRCTN43522674
Assessment of TauroLock™ in port catheterA comparison of the effect of taurolidine and 4 % citrate(TauroLock™-HEP500) and Heparin use in Port catheter on the function of catheter and prevention of catheter complications in children with malignancyIRCT20201107049296N4
Central Line-associated Bloodstream Infection Prevention Using TauroLock-Hep100 in Pediatric Oncology Patients.The Efficacy of a Lock Solution Containing Taurolidine, Citrate and Heparin for the Prevention of Tunneled Central Line-associated Bloodstream Infections in Pediatric Oncology Patients, a Randomized Controlled, Mono-center Trial.NCT05740150
Taurolidine Containing Antimicrobial CIED Wash to Prevent InfectionEffect of Intraoperative Topical Application of a Taurolidine Solution on CIED Related Infections in the Clinical Setting - a Prospective Observational Study With a Restrospective Historical ControlNCT05576194
A double-blind, placebo controlled randomised study to assess the tolerability, safety, and preliminary efficacy of taurolidine-citrate lock solution (TauroLock™) in patients with recurrent pleural effusions requiring management with Indwelling Pleural Catheters for recurrent effusion drainage.A double-blind, placebo controlled randomised study to assess the tolerability, safety, and preliminary efficacy of taurolidine-citrate lock solution (TauroLock™) in patients with recurrent pleural effusions requiring management with Indwelling Pleural Catheters for recurrent effusion drainage.ACTRN12622001280796
Central Line-associated Bloodstream Infection Prevention Using TauroLock-Hep100 in Pediatric Oncology PatientsThe Efficacy of a Lock Solution Containing Taurolidine, Citrate and Heparin for the Prevention of Tunneled Central Line-associated Bloodstream Infections in Pediatric Oncology Patients, a Randomized Controlled, Mono-center Trial.NL-OMON20136
Taurolock Hep 500 Versus Unfractionated Heparin as Anti-inflammatory in Hemodialysis Catheters.Taurolidine Citrate and Unfractionated Heparin Combination Versus Unfractionated Heparin Alone in Prevention of Inflammation in Hemodialysis Catheters.NCT03539718
Comparative effectiveness of two catheter locking solutions to reduce catheter-related bloodstream infection in hemodialysis patients.Comparative effectiveness of catheter locking solutions with gentamicin/cefazolin versus taurolidine to reduce catheter-related infection in hemodialysis patientsRBR-6vfg7r
Antibiotic-lock technique with Taurolidine for prevention of central venous catheter infection in neutropenic patientsAntibiotic-lock technique with Taurolidine for prevention of central venous catheter infection in neutropenic patients: a randomized, double-blind, placebo-controlled studyISRCTN47102251
Heparin Versus Taurolidine to Bloodstream Infection Prevention Related in Central Venous Catheter in ChildrenHeparin Versus Taurolidine to Bloodstream Infection Prevention Related in Central Venous Catheter in Children With Intestinal FailureNCT02515201
Prevention of Dialysis Catheter Malfunction With Prophylactic Use of a Taurolidine Containing UrokinasePrevention of Tunneled Cuffed Catheter Malfunction With Prophylactic Use of a Taurolidine Locking Solution Containing Urokinase : a Multicentric Randomized Controlled TrialNCT02036255
Taurolidine Lock in Long Term Parenteral NutritionThe Value of Taurolidine Lock in Long Term Parenteral NutritionNCT02009189
Study of need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurololidine-citrate and heparin catheter locks in patients treated with haemodialysisEvaluating the need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurololidine-citrate and heparin catheter locks in patients treated with haemodialysis: An open-label, observational study with retrospective comparator groupsISRCTN07668752
Taurolidine in Haemodialysis Catheter Related BacteraemiaA Randomised Controlled Trial of Taurolidine With Heparin for Prevention of Recurrence of Catheter Related Bacteraemia in Haemodialysis Patients.NCT01243710
Double-blind clinical trial of taurolidine-citrate for the prevention of infection in patients using tunnelled lines for haemodialysisTaurolidine-citrate catheter locks for the prevention of bacteraemia in patients using tunnelled intravascular catheters for haemodialysis: a randomised double-blind controlled trialISRCTN51902376
The anti-endotoxin agent, taurolidine, potentially reduces ischaemia-reperfusion injury through its metabolite taurineAn investigation into the efficacy of the anti-endotoxin agent, taurolidine in the attenuation of the post-reperfusion sequelae in patients subjected to cardio-pulmonary bypass: a double-blinded randomised clinical trialISRCTN58678663
Using taurolidine to attenuate the surgically-induced endotoxaemia and the subsequent inflammatory response in patients with primary non-metastatic colon cancerUsing taurolidine to attenuate the surgically-induced endotoxaemia and the subsequent inflammatory response in patients with primary non-metastatic colon cancerISRCTN77829558
Taurolidine in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal CancerPhase I Trial of Taurolidine After Positive Second Look Surgery for Recurrent Ovarian Epithelial, Fallopian Tube and Primary Peritoneal CancersNCT00021034
Taurolidine-citrate vs heparin as catheter lock solutions in paediatric patientsISRCTN86885538
A randomised controlled trial comparing taurolidine-citrate with heparin for locking tunnelled haemodialysis cathetersISRCTN13630682
The AOT (Acridine Orange and Taurolidine) TrialThe AOT (Acridine Orange and Taurolidine) Trial: a Survey on Diagnosis and Prevention of Catheter-Related Infections in Patients on Home Parenteral NutritionNCT00321165
Intra-operative administration of taurolidine reduces level of interleukin-1 beta rather than povidone-iodine in patients with colon, gastric, and pancreatic cancer. A clinical prospective randomised multicenter trial.ISRCTN66478538
Taurolidine in Treating Patients With Recurrent or Progressive GliomaAn Open-Label Dose-Ranging Study of the Safety of Taurolidine 2% Solution Administered Intravenously to Patients With Recurrent or Progressive High Grade GliomaNCT00022360
Effect of Taurolidin on Prevention of Bloodstream InfectionPrevention of Central Veinous Device Related Sepsis Relapse With Taurolidine in Patients on Parenteral Nutrition in Long-term HomeNCT00545831