TICToK | Tattoo Ink Chemicals and assocaited Toxicities Knowledgebase

Citric acid

Citric acid

Associated High Confidence AOPs

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Associated AOPs with Level of Relevance 1

AOP Identifier	AOP Title	AO Classification	OECD Status	Coverage Score	KE Identifier	KE Name
AOP:27	Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)	Gastrointestinal System Disease	Under Development	0.12	KE:288	Activation of specific nuclear receptors, Transcriptional change
AOP:272	Deposition of energy leading to lung cancer	Cancer	WPHA/WNT Endorsed	0.14	KE:1636	Increase, Chromosomal aberrations
AOP:443	DNA damage and mutations leading to Metastatic Breast Cancer	Thoracic Disease; Cancer	Under Development	0.1	KE:1554	Increase Chromosomal Aberrations
AOP:478	Deposition of energy leading to occurrence of cataracts	Nervous System Disease; Monogenic Disease	Under Review	0.1	KE:1636	Increase, Chromosomal aberrations

Associated AOPs with Level of Relevance 2

AOP Identifier	AOP Title	AO Classification	OECD Status	Coverage Score	KE Identifier	KE Name
AOP:296	Oxidative DNA damage leading to chromosomal aberrations and mutations	Genetic Disease; Chromosomal Disease	WPHA/WNT Endorsed	0.2	KE:1636	Increase, Chromosomal aberrations

Associated AOPs with Level of Relevance 3

AOP Identifier	AOP Title	AO Classification	OECD Status	Coverage Score	KE Identifier	KE Name
AOP:520	Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory	Developmental Disorder Of Mental Health	-	0.2	KE:2201	Agonism, Retinoic acid receptor
AOP:523	Retinoic acid receptor agonism during neurodevelopment leading to microcephaly	Congenital Nervous System Abnormality; Nervous System Disease	-	0.2	KE:2201	Agonism, Retinoic acid receptor
AOP:532	Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function	Unclassified	-	0.2	KE:2201	Agonism, Retinoic acid receptor

No associated AOPs with Level of Relevance 5

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.