TICToK | Tattoo Ink Chemicals and associated Toxicities Knowledgebase

4-Methylbenzenamine

4-Methylbenzenamine

ToxCast Endpoints

For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
LTEA_HepaRG_CYP2B6	Liver	1555	CYP2B6	P20813	Activatory	16.46 μM

ToxCast Endpoints for intended target type: Protein

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
STM_H9_CystineISnorm_perc					Activatory	23.08 μM
STM_H9_OrnithineISnorm_perc					Inhibitory	61.21 μM
STM_H9_OrnCyssISnorm_ratio					Inhibitory	30.40 μM
TOX21_PXR_LUC_Agonist	Liver	8856	NR1I2	O75469	Gain	41.49 μM
TOX21_p450_CYP2D6_Antagonist		1565	CYP2D6	P10635	Loss	47.06 μM
TOX21_p450_CYP2C19_Antagonist		1557	CYP2C19	P33261	Loss	38.89 μM
TOX21_p450_CYP2C9_Antagonist		1559	CYP2C9	P11712	Loss	55.87 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	46.73 μM
TOX21_AhR_LUC_Agonist	Liver	196	AHR	P35869	Gain	64.95 μM
TOX21_CAR_LUC_Agonist	Liver	9970	NR1I3	Q14994	Gain	22.08 μM
TOX21_PXR_LUC_Agonist	Liver	8856	NR1I2	O75469	Gain	30.18 μM
TOX21_p450_CYP3A4_Antagonist		1576	CYP3A4	P08684	Loss	31.87 μM
TOX21_p450_CYP2D6_Antagonist		1565	CYP2D6	P10635	Loss	57.47 μM
TOX21_p450_CYP2C19_Antagonist		1557	CYP2C19	P33261	Loss	87.51 μM
TOX21_p450_CYP2C9_Antagonist		1559	CYP2C9	P11712	Loss	33.58 μM
TOX21_p450_CYP1A2_Antagonist		1544	CYP1A2	P05177	Loss	57.47 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway

Assay Name	Tissue	Target Gene ID	Target HGNC Symbol	Target UniProt ID	Response	AC50 value
OT_FXR_FXRSRC1_1440	Kidney	6714\|9971	NR1H4\|SRC	P12931\|Q96RI1	Gain	20.14 μM
OT_NURR1_NURR1RXRa_1440	Kidney	4929\|6256	NR4A2\|RXRA	P19793\|P43354	Gain	50.00 μM
TOX21_RXR_BLA_Agonist_ch2	Kidney				Gain	22.94 μM
TOX21_RXR_BLA_Agonist_ratio	Kidney	6256	RXRA	P19793	Gain	27.61 μM

ToxCast Endpoints for intended target type: Cellular

Assay Name	Tissue	Response	AC50 value
STM_H9_NormalizedViability		Loss	40.92 μM

No ToxCast endpoints for intended target type: Extracellular

DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.