ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

ToxCast Endpoints for intended target type: RNA
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
LTEA_HepaRG_CYP2B6Liver1555CYP2B6P20813Activatory16.46 μM

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
STM_H9_CystineISnorm_percActivatory23.08 μM
STM_H9_OrnithineISnorm_percInhibitory61.21 μM
STM_H9_OrnCyssISnorm_ratioInhibitory30.40 μM
TOX21_PXR_LUC_AgonistLiver8856NR1I2O75469Gain41.49 μM
TOX21_p450_CYP2D6_Antagonist1565CYP2D6P10635Loss47.06 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss38.89 μM
TOX21_p450_CYP2C9_Antagonist1559CYP2C9P11712Loss55.87 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss46.73 μM
TOX21_AhR_LUC_AgonistLiver196AHRP35869Gain64.95 μM
TOX21_CAR_LUC_AgonistLiver9970NR1I3Q14994Gain22.08 μM
TOX21_PXR_LUC_AgonistLiver8856NR1I2O75469Gain30.18 μM
TOX21_p450_CYP3A4_Antagonist1576CYP3A4P08684Loss31.87 μM
TOX21_p450_CYP2D6_Antagonist1565CYP2D6P10635Loss57.47 μM
TOX21_p450_CYP2C19_Antagonist1557CYP2C19P33261Loss87.51 μM
TOX21_p450_CYP2C9_Antagonist1559CYP2C9P11712Loss33.58 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss57.47 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
OT_FXR_FXRSRC1_1440Kidney6714|9971NR1H4|SRCP12931|Q96RI1Gain20.14 μM
OT_NURR1_NURR1RXRa_1440Kidney4929|6256NR4A2|RXRAP19793|P43354Gain50.00 μM
TOX21_RXR_BLA_Agonist_ch2KidneyGain22.94 μM
TOX21_RXR_BLA_Agonist_ratioKidney6256RXRAP19793Gain27.61 μM

ToxCast Endpoints for intended target type: Cellular
Assay NameTissueResponseAC50 value
STM_H9_NormalizedViabilityLoss40.92 μM

No ToxCast endpoints for intended target type: Extracellular
DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.