For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the
DOWNLOAD page.
No ToxCast endpoints for intended target type: RNA
ToxCast Endpoints for intended target type: Protein
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
ERF_TW_NR_binding_hERa | | 2099 | ESR1 | P03372 | Gain | 15.68 μM |
CCTE_Deisenroth_AIME_96WELL_LUC_Inactive | Mammary Gland/Breast | 2099 | ESR1 | P03372 | Gain | 40.74 μM |
ATG_BRE_CIS | Liver | 4086 | SMAD1 | Q15797 | Activatory | 165.93 μM |
ATG_C_EBP_CIS | Liver | 1051 | CEBPB | P17676 | Activatory | 100.00 μM |
ATG_E_Box_CIS | Liver | 7391 | USF1 | P22415 | Activatory | 166.99 μM |
ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 8.03 μM |
ATG_Oct_MLP_CIS | Liver | 5451 | POU2F1 | P14859 | Activatory | 100.00 μM |
ATG_Pax6_CIS | Liver | 5080 | PAX6 | P26367 | Activatory | 100.00 μM |
ATG_PPRE_CIS | Liver | 5468|5467|5465 | PPARG|PPARD|PPARA | P37231|Q07869|Q03181 | Activatory | 64.63 μM |
ATG_RORE_CIS | Liver | 6096|6095|6097 | RORB|RORA|RORC | P51449|Q92753|P35398 | Activatory | 57.26 μM |
ATG_SREBP_CIS | Liver | 6720 | SREBF1 | P36956 | Activatory | 43.72 μM |
ATG_VDRE_CIS | Liver | 7421 | VDR | P11473 | Activatory | 42.84 μM |
ATG_Xbp1_CIS | Liver | 7494 | XBP1 | P17861 | Activatory | 100.00 μM |
ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 7.82 μM |
ATG_PPARa_TRANS | Liver | 5465 | PPARA | Q07869 | Gain | 20.53 μM |
ATG_PPARg_TRANS | Liver | 5468 | PPARG | P37231 | Gain | 52.10 μM |
ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 44.46 μM |
ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 78.85 μM |
ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 27.62 μM |
ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 27.53 μM |
ATG_ERE_CIS | Liver | 2099 | ESR1 | P03372 | Activatory | 42.61 μM |
ATG_ERa_TRANS | Liver | 2099 | ESR1 | P03372 | Gain | 34.28 μM |
NVS_NR_hER | | 2099 | ESR1 | P03372 | Loss | 4.61 μM |
NVS_NR_hER | | 2099 | ESR1 | P03372 | Loss | 10.53 μM |
TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 23.04 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 19.37 μM |
TOX21_ERa_LUC_VM7_Agonist | Breast | 2099 | ESR1 | P03372 | Gain | 49.00 μM |
TOX21_p450_CYP1A2_Antagonist | | 1544 | CYP1A2 | P05177 | Loss | 18.76 μM |
No ToxCast endpoints for intended target type: Molecular Messengers
ToxCast Endpoints for intended target type: Pathway
Assay Name | Tissue | Target Gene ID | Target HGNC Symbol | Target UniProt ID | Response | AC50 value |
---|
ACEA_ER_80hr | Breast | 2099 | ESR1 | P03372 | Gain | 11.38 μM |
ACEA_ER_80hr | Breast | 2099 | ESR1 | P03372 | Gain | 22.93 μM |
ACEA_ER_80hr | Breast | 2099 | ESR1 | P03372 | Gain | 10.75 μM |
ACEA_ER_80hr | Breast | 2099 | ESR1 | P03372 | Gain | 10.91 μM |
OT_ER_ERaERa_0480 | Kidney | 2099 | ESR1 | P03372 | Gain | 59.58 μM |
OT_ER_ERaERa_1440 | Kidney | 2099 | ESR1 | P03372 | Gain | 67.52 μM |
OT_ER_ERaERb_0480 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 28.05 μM |
OT_ER_ERaERb_1440 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 26.83 μM |
OT_ER_ERbERb_0480 | Kidney | 2100 | ESR2 | Q92731 | Gain | 31.71 μM |
OT_ER_ERbERb_1440 | Kidney | 2100 | ESR2 | Q92731 | Gain | 32.91 μM |
OT_ER_ERaERa_0480 | Kidney | 2099 | ESR1 | P03372 | Gain | 41.12 μM |
OT_ER_ERaERa_1440 | Kidney | 2099 | ESR1 | P03372 | Gain | 52.58 μM |
OT_ER_ERaERb_0480 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 27.08 μM |
OT_ER_ERaERb_1440 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 26.92 μM |
OT_ER_ERbERb_0480 | Kidney | 2100 | ESR2 | Q92731 | Gain | 33.13 μM |
OT_ER_ERbERb_1440 | Kidney | 2100 | ESR2 | Q92731 | Gain | 25.94 μM |
OT_ER_ERaERa_0480 | Kidney | 2099 | ESR1 | P03372 | Gain | 59.91 μM |
OT_ER_ERaERa_1440 | Kidney | 2099 | ESR1 | P03372 | Gain | 47.00 μM |
OT_ER_ERaERb_0480 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 30.59 μM |
OT_ER_ERaERb_1440 | Kidney | 2100|2099 | ESR2|ESR1 | Q92731|P03372 | Gain | 32.18 μM |
OT_ER_ERbERb_0480 | Kidney | 2100 | ESR2 | Q92731 | Gain | 27.84 μM |
OT_ER_ERbERb_1440 | Kidney | 2100 | ESR2 | Q92731 | Gain | 28.58 μM |
TOX21_ERb_BLA_Agonist_ch2 | Kidney | | | | Gain | 21.92 μM |
TOX21_ERb_BLA_Agonist_ch2 | Kidney | | | | Gain | 44.54 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Extracellular