ToxCast Endpoints
For more information regarding the endpoints, refer to the 'ToxCast Endpoints' file on the DOWNLOAD page.

No ToxCast endpoints for intended target type: RNA

ToxCast Endpoints for intended target type: Protein
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
ERF_TW_NR_binding_hERa2099ESR1P03372Gain15.68 μM
CCTE_Deisenroth_AIME_96WELL_LUC_InactiveMammary Gland/Breast2099ESR1P03372Gain40.74 μM
ATG_BRE_CISLiver4086SMAD1Q15797Activatory165.93 μM
ATG_C_EBP_CISLiver1051CEBPBP17676Activatory100.00 μM
ATG_E_Box_CISLiver7391USF1P22415Activatory166.99 μM
ATG_ERE_CISLiver2099ESR1P03372Activatory8.03 μM
ATG_Oct_MLP_CISLiver5451POU2F1P14859Activatory100.00 μM
ATG_Pax6_CISLiver5080PAX6P26367Activatory100.00 μM
ATG_PPRE_CISLiver5468|5467|5465PPARG|PPARD|PPARAP37231|Q07869|Q03181Activatory64.63 μM
ATG_RORE_CISLiver6096|6095|6097RORB|RORA|RORCP51449|Q92753|P35398Activatory57.26 μM
ATG_SREBP_CISLiver6720SREBF1P36956Activatory43.72 μM
ATG_VDRE_CISLiver7421VDRP11473Activatory42.84 μM
ATG_Xbp1_CISLiver7494XBP1P17861Activatory100.00 μM
ATG_ERa_TRANSLiver2099ESR1P03372Gain7.82 μM
ATG_PPARa_TRANSLiver5465PPARAQ07869Gain20.53 μM
ATG_PPARg_TRANSLiver5468PPARGP37231Gain52.10 μM
ATG_ERE_CISLiver2099ESR1P03372Activatory44.46 μM
ATG_ERa_TRANSLiver2099ESR1P03372Gain78.85 μM
ATG_ERE_CISLiver2099ESR1P03372Activatory27.62 μM
ATG_ERa_TRANSLiver2099ESR1P03372Gain27.53 μM
ATG_ERE_CISLiver2099ESR1P03372Activatory42.61 μM
ATG_ERa_TRANSLiver2099ESR1P03372Gain34.28 μM
NVS_NR_hER2099ESR1P03372Loss4.61 μM
NVS_NR_hER2099ESR1P03372Loss10.53 μM
TOX21_ERa_LUC_VM7_AgonistBreast2099ESR1P03372Gain23.04 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss19.37 μM
TOX21_ERa_LUC_VM7_AgonistBreast2099ESR1P03372Gain49.00 μM
TOX21_p450_CYP1A2_Antagonist1544CYP1A2P05177Loss18.76 μM

No ToxCast endpoints for intended target type: Molecular Messengers

ToxCast Endpoints for intended target type: Pathway
Assay NameTissueTarget Gene IDTarget HGNC SymbolTarget UniProt IDResponseAC50 value
ACEA_ER_80hrBreast2099ESR1P03372Gain11.38 μM
ACEA_ER_80hrBreast2099ESR1P03372Gain22.93 μM
ACEA_ER_80hrBreast2099ESR1P03372Gain10.75 μM
ACEA_ER_80hrBreast2099ESR1P03372Gain10.91 μM
OT_ER_ERaERa_0480Kidney2099ESR1P03372Gain59.58 μM
OT_ER_ERaERa_1440Kidney2099ESR1P03372Gain67.52 μM
OT_ER_ERaERb_0480Kidney2100|2099ESR2|ESR1Q92731|P03372Gain28.05 μM
OT_ER_ERaERb_1440Kidney2100|2099ESR2|ESR1Q92731|P03372Gain26.83 μM
OT_ER_ERbERb_0480Kidney2100ESR2Q92731Gain31.71 μM
OT_ER_ERbERb_1440Kidney2100ESR2Q92731Gain32.91 μM
OT_ER_ERaERa_0480Kidney2099ESR1P03372Gain41.12 μM
OT_ER_ERaERa_1440Kidney2099ESR1P03372Gain52.58 μM
OT_ER_ERaERb_0480Kidney2100|2099ESR2|ESR1Q92731|P03372Gain27.08 μM
OT_ER_ERaERb_1440Kidney2100|2099ESR2|ESR1Q92731|P03372Gain26.92 μM
OT_ER_ERbERb_0480Kidney2100ESR2Q92731Gain33.13 μM
OT_ER_ERbERb_1440Kidney2100ESR2Q92731Gain25.94 μM
OT_ER_ERaERa_0480Kidney2099ESR1P03372Gain59.91 μM
OT_ER_ERaERa_1440Kidney2099ESR1P03372Gain47.00 μM
OT_ER_ERaERb_0480Kidney2100|2099ESR2|ESR1Q92731|P03372Gain30.59 μM
OT_ER_ERaERb_1440Kidney2100|2099ESR2|ESR1Q92731|P03372Gain32.18 μM
OT_ER_ERbERb_0480Kidney2100ESR2Q92731Gain27.84 μM
OT_ER_ERbERb_1440Kidney2100ESR2Q92731Gain28.58 μM
TOX21_ERb_BLA_Agonist_ch2KidneyGain21.92 μM
TOX21_ERb_BLA_Agonist_ch2KidneyGain44.54 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Extracellular
DISCLAIMER

TICToK is a database of tattoo ink chemicals compiled from different regulatory resources. The authors are not liable for any inaccuracies or omissions of any chemicals in this resource. Importantly, our sole goal to build this resource on tattoo ink chemicals is to enable future basic research on this topic, and it does not necessarily reflect the views or objectives of our employers or funders.