Tetrabutyltin

Target genes for Tetrabutyltin is obtained based on ToxCast assay component endpoints.
Chemical nameGene identifierToxCast assay component endpoint name
TetrabutyltinNR1H3ATG_DR4_LXR_CIS_dn
TetrabutyltinCEBPBATG_C_EBP_CIS_up
TetrabutyltinCYP24A1TOX21_VDR_BLA_antagonist_ratio
TetrabutyltinEGR1ATG_EGR_CIS_up
TetrabutyltinESR1ATG_ERE_CIS_up
TetrabutyltinESR1TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2
TetrabutyltinESR1OT_ERa_EREGFP_0480
TetrabutyltinESR1TOX21_ERa_BLA_Antagonist_ratio
TetrabutyltinESR1TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2
TetrabutyltinESR1OT_ERa_EREGFP_0120
TetrabutyltinESR2TOX21_ERb_BLA_Antagonist_ratio
TetrabutyltinESRRATOX21_PGC_ERR_Antagonist
TetrabutyltinESRRATOX21_ERR_Antagonist
TetrabutyltinESRRGATG_ERRg_TRANS_dn
TetrabutyltinFOSATG_AP_1_CIS_up
TetrabutyltinNR3C1TOX21_GR_BLA_Antagonist_ratio
TetrabutyltinHIF1ATOX21_HRE_BLA_Agonist_ratio
TetrabutyltinHIF1AATG_HIF1a_CIS_dn
TetrabutyltinHSF1TOX21_HSE_BLA_agonist_ratio
TetrabutyltinHSF1ATG_HSE_CIS_up
TetrabutyltinIRF1ATG_ISRE_CIS_dn
TetrabutyltinARTOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881
TetrabutyltinARACEA_AR_antagonist_80hr
TetrabutyltinAROT_AR_ARSRC1_0480
TetrabutyltinAROT_AR_ARSRC1_0960
TetrabutyltinARTOX21_AR_BLA_Antagonist_ratio
TetrabutyltinARTOX21_AR_LUC_MDAKB2_Antagonist_10nM_R1881
TetrabutyltinARACEA_AR_agonist_80hr
TetrabutyltinJUNTOX21_AP1_BLA_Agonist_ratio
TetrabutyltinJUNATG_AP_1_CIS_up
TetrabutyltinFOSTOX21_AP1_BLA_Agonist_ratio
TetrabutyltinSMAD1ATG_BRE_CIS_up
TetrabutyltinNFIAATG_NFI_CIS_dn
TetrabutyltinNFE2L2TOX21_ARE_BLA_agonist_ratio
TetrabutyltinNFE2L2ATG_NRF2_ARE_CIS_up
TetrabutyltinNFKB1ATG_NF_kB_CIS_dn
TetrabutyltinNRF1ATG_NRF1_CIS_dn
TetrabutyltinNR4A2ATG_NURR1_TRANS_up
TetrabutyltinPAX6ATG_Pax6_CIS_up
TetrabutyltinLEF1ATG_TCF_b_cat_CIS_dn
TetrabutyltinPGRTOX21_PR_BLA_Antagonist_ratio
TetrabutyltinPOU2F1ATG_Oct_MLP_CIS_up
TetrabutyltinPPARAATG_PPRE_CIS_up
TetrabutyltinPPARDTOX21_PPARd_BLA_antagonist_ratio
TetrabutyltinPPARDATG_PPRE_CIS_up
TetrabutyltinPPARDATG_PPARd_TRANS_up
TetrabutyltinPPARGTOX21_PPARg_BLA_Agonist_ratio
TetrabutyltinPPARGATG_PPARg_TRANS_up
TetrabutyltinPPARGTOX21_PPARg_BLA_antagonist_ratio
TetrabutyltinPPARGATG_PPRE_CIS_up
TetrabutyltinRARAATG_RARa_TRANS_dn
TetrabutyltinRARAATG_DR5_CIS_up
TetrabutyltinRARBATG_DR5_CIS_up
TetrabutyltinRARGATG_DR5_CIS_up
TetrabutyltinRORBATG_RORb_TRANS_dn
TetrabutyltinRXRATOX21_RXR_BLA_Agonist_ratio
TetrabutyltinRXRAATG_RXRa_TRANS_up
TetrabutyltinRXRBATG_RXRb_TRANS_up
TetrabutyltinSOX1ATG_Sox_CIS_up
TetrabutyltinSP1ATG_Sp1_CIS_up
TetrabutyltinSREBF1ATG_SREBP_CIS_up
TetrabutyltinSTAT3ATG_STAT3_CIS_dn
TetrabutyltinTCF7ATG_TCF_b_cat_CIS_dn
TetrabutyltinTCF7L2ATG_TCF_b_cat_CIS_dn
TetrabutyltinTFAP2AATG_AP_2_CIS_dn
TetrabutyltinTFAP2BATG_AP_2_CIS_dn
TetrabutyltinTP53ATG_p53_CIS_dn
TetrabutyltinTP53TOX21_p53_BLA_p1_ratio
TetrabutyltinTP53TOX21_p53_BLA_p4_ratio
TetrabutyltinTP53TOX21_p53_BLA_p3_ratio
TetrabutyltinTP53TOX21_p53_BLA_p5_ratio
TetrabutyltinNR1H2ATG_DR4_LXR_CIS_dn
TetrabutyltinUSF1ATG_E_Box_CIS_dn
TetrabutyltinVDRATG_VDRE_CIS_up
TetrabutyltinVDRTOX21_VDR_BLA_antagonist_ratio
TetrabutyltinVDRATG_VDR_TRANS_up
TetrabutyltinXBP1ATG_Xbp1_CIS_up
TetrabutyltinTCF7L1ATG_TCF_b_cat_CIS_dn
TetrabutyltinTFAP2DATG_AP_2_CIS_dn
TetrabutyltinNR1I2ATG_PXRE_CIS_dn
TetrabutyltinNR1I2ATG_PXR_TRANS_up
TetrabutyltinNR1I3ATG_CAR_TRANS_dn
TetrabutyltinNR1I3ATG_PBREM_CIS_up
TetrabutyltinNR1I3TOX21_CAR_Antagonist
TetrabutyltinNR1H4OT_FXR_FXRSRC1_0480
TetrabutyltinNR1H4ATG_IR1_CIS_up
TetrabutyltinNR1H4OT_FXR_FXRSRC1_1440
TetrabutyltinNR1H4TOX21_FXR_BLA_antagonist_ratio

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.